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Query: PF03059.16; A3DUI9_MALBX/3-277; Nicotianamine synthase protein, from PfamA32U

Results of FFAS03 search in PfamA32U
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst CQGDALVQRVCELYEKISSLESLKPSQDVDMLFTQLVLTCIPPSPIDVSKLCQGVQEIRSNLIRLCGEAEGLLENHFSTILGSYEHPLDHLDIFPYYSNYLKLSKLEFNILSQHFTRMPIKIAFVGSGPLPLTSIVLASNHLTKTSFDNYDINASANSKALGLVSSDPDLSKRMVFHTTDIMDVTTALKDYEIVFLAALVGMDKMEKLKIIDHLAKYMAPGATLMLRSAHGARAFLYPVIDPCDDLRGFEVLSVFHPTDEVINSIVIARKYALPVLast
1 -89.300PF03059.16; A3DUI9_MALBX/3-277; Nicotianamine synthase protein  ali  100  1CQGDALVQRVCELYEKISSLESLKPSQDVDMLFTQLVLTCIPPSPIDVSKLCQGVQEIRSNLIRLCGEAEGLLENHFSTILGSYEHPLDHLDIFPYYSNYLKLSKLEFNILSQHFTRMPIKIAFVGSGPLPLTSIVLASNHLTKTSFDNYDINASANSKALGLVSSDPDLSKRMVFHTTDIMDVTTALKDYEIVFLAALVGMDKMEKLKIIDHLAKYMAPGATLMLRSAHGARAFLYPVIDPCDDLRGFEVLSVFHPTDEVINSIVIARKYALPV 275
2 -28.500PF13649.6; D8K355_DEHLB/33-128; Methyltransferase domain  ali follow..  11  1.........................................................................................................................VLDVCCGTGDQAIRLAEQ----GIEVHGIDLNGSMLATAESHKRRAG---DNVSFGQADASALLFPNRSFDYATTSLALHEKPREQLQVLEEMRRVVKKGG..................................................... 96
3 -28.200PF13847.6; B2J9C6_NOSP7/55-253; Methyltransferase domain  ali follow..  9  2....................................................................................................................TKEKVILDAGCGTGYKS--LVLAEANPGAKIVGIDISEESIKLAQQRLEHHG---DNAEFHVLPIQELPKLNYQFDYI-NCDELLYLFPDLAAALQGMISVLKPNGIIRS................................................. 106
4 -27.000PF07091.11; KRM_FRACC/28-281; Ribosomal RNA methyltransferase (FmrO)  ali follow..  8  2.........................SRRYGAVAPETVRLAERALVASRGDEPEAVKRTKRSLHEIYGAYLPERAPGYPGLLRDIGAAVGGGDPDAVAAAVSRAMRVHASTRERLPVPTPAVVQDLACGLNPLAFGSMGL--PAQTTYLASDIDSQQMEFLDRALDLLE----EHRVEVVDLVSGAVPAQHADVTLVLKTLPLLERQRAGAGWELVDALRSPFVVV.................................................. 209
5 -25.900PF08241.12; Q83DM1_COXBU/77-169; Methyltransferase domain  ali follow..  10  1..........................................................................................................................LDIGCAKGFLVKDFMKAC--PGLEAYGIDISEYALMNCEPEVVG--------RLHLGNADHLPFPDNSFDAVISLNTVHNPRERVIIALREIQRVSGGKAYI................................................... 93
6 -24.500PF03291.16; MCES_YEAST/109-424; mRNA capping enzyme  ali follow..  13  1...........................................................EMTANRSINVDQIVREHYNERTIIANRAKRNLSPIIKLRNFNNAIK---YMLIDKYTKPGDVVLELGCGKGGDLRKYGAAGIS---QFIGIDISNASIQEAHKRYRSMRNLDYQVVLITGDCFGFPDCRFPCDIVSTQFCLHYAFETEERALLNVAKSLKIGGHFFGTIPDS............................................ 178
7 -24.400PF12147.8; Q2K5I6_RHIEC/285-593; Putative methyltransferase  ali follow..  10  1..VRRFIDARFAEPRAPADLRTAHVQGYTKDEADRLASPLDATSPRGIYWALSRASEGIKTGVKTGFDSGSTLDYVYENKPRGLGPGGRLIDKVFLEAIGWRGIRQRKLHLQEKAAGRSTHLLDIAAGHGRYVLDAIEAAGVRPDSARLQDYSPINVDAGRNSIARRG-LNDFVSFHQQDAFDLAAITPAPDLAIVSGLYELFSDNAAASLSGIARAMQPGGLLIYRTQEEMDQLVAAA--------GFRKLEQRIDQWGIF-TVSLAER..... 309
8 -23.900PF08003.11; CMOB_VIBVY/7-322; Protein of unknown function (DUF1698 topsan)  ali follow..  10  7.QDTRLQPWLNVLPQQLTDWQNAEHGPRWLKALNKIPEGAPDQIDIKHSVTISNDTPFHQGELKKLESLLRTFHPWRKGPYTVHGIHIDTEWRSDWK-----------RVLPHISPLKNRSVLDVGCGNGYHMWRMLGE---GARLCVGIDPSHLFLIQFEAIRKLMG-GDQRAHLLPLGIEQLPKL-EAFDTVF-SMGVLYHRRSPLDHLIQLKDQLVSGGELILET............................................... 220
9 -23.600PF08242.12; MLCA_PENCI/1437-1538; Methyltransferase domain  ali follow..  21  1..........................................................................................................................LEIGLGTGIATKRVLASPQLGFNSYTCTDISADVIGKAREQLSEFDGMQFEALDINRSPAEQGFKPHSYDLI-IASDVLHASSNFEEKLAHIRSLLKPGGHL................................................... 102
10 -23.000PF01170.18; Q9RTT7_DEIRA/193-364; Putative RNA methylase family UPF0020 topsan  ali follow..  11  15........................................................................................................TIAYAMHKLAGQRDEDRIFNPMSGSG--TLLIERALLGPYAALVGVDIDPVAVACARTNLRAAG----EVEVAQVDALHTGLPSRSFDLVISDLPWGDAIGSHQSFLKEMHRLTSRRGRLCLLTHE............................................. 142
11 -22.500PF06080.12; Q8YZS2_NOSS1/8-210; Protein of unknown function (DUF938 topsan)  ali follow..  9  22...................................................................................................................LPASGTILEIASGTGEHAIFFAPRL--KPRKWLPSDPNPELRASITAWIAQFP-SDNLYPPVELDASQAILQDAPIAAIVNINMI-SPWSACLGLLAGAGRILPPGGILYLYGNPEWGVRNLEDVIAAAKQQNLQLHKTYQMPAN--NLSVVFQR..... 203
12 -22.400PF05891.12; NTM1_ORYSJ/61-283; AdoMet dependent proline di-methyltransferase  ali follow..  13  43.........................................................................................................RPLLAERFGAARRHLVALDCGSGIGRVTKNFLLRHFN---EVDLVEPVSHFLEAAQENLTECMEVGKAANFYCVPLQDFTPDEGRYDVIWIQWCIGQPDDDFISFFNRAKIGLKPNGFFVLKE............................................... 167
13 -22.400PF01269.17; A8M8R8_CALMQ/9-236; Fibrillarin  ali follow..  11  54....................................................................................................SKLGAAIMNKLEAMPISEGSKVLYLGAASG-TTVSHVSDIVGLNGLIYGVEFSPRVFREFMQNIIDQG---LNVIPILADARYPEQYISLVKGVDVAYIDVAQPFQAKILADNADVYLVKGGYIILIDVTKEPSETFKREIDTIKERGFDIINMVHLEPYDVAHALVVGKR.... 227
14 -22.200PF05401.11; Q98A39_RHILO/5-200; Nodulation protein S (NodS)  ali follow..  12  23.....................................................................................................ERERHTQILRLSLAQGRVANALEVGCAAGAFTERLAPI------RLTVIDVVEPAITRARLRMKETP----HISWIISDVQQF-SSDELFDLIVVAEVLVGDLVQIRAAVRNLVGLLAPGGQLVF................................................. 140
15 -21.900PF01209.18; COQ5_YEAST/56-306; ubiE/COQ5 methyltransferase family  ali follow..  9  1..............................................................KTVLKSTKQKLVGDVFSSVANRYDLMNDVMSLGIHRLWKDHFINKLDAGKRPNSTTPLNFIDVAGGSGDIAFGLLDHAGDTESTMDIVDINPDMLKEGEKRAMEQGKYDPRVRFLVSNGEKLEIDSDSKDIYTVSFGI-RNFTDIQKGLNTAYRVLKPGGIFYCLE............................................... 172
16 -21.400PF09243.10; Q2YRR8_BRUA2/49-320; Mitochondrial small ribosomal subunit Rsm22  ali follow..  7  2......................................................................................AAKAYLAARLPATYAAVRASLDSAAESCPEFAPQSMLDVGAGPG-TALWAAKQCWPELQSATMIEASPAIRAVGSDLARHSG--LTMLDWRAGDVVRERLEFPYADLVTIAYVL-DELAPDEREKLIERLWASARQMFVIVEP.............................................. 140
17 -21.000PF05148.15; RRP8_CAEEL/125-343; Hypothetical methyltransferase  ali follow..  10  1........................................................DPIAEAKKRLDAGRFRFLNEKLYTCTGSEAFDFFKEDPTAFDLYHKGFADQVKIRWLQSKPDQQSVFDLGCGEA-----KIAEAVGEKHKIRSFDLVAV-----------------NDRVESCDMSKLPAEDSSADIVIYCLSL--MGTNLYDFIREARRVLKIGGILKIAEVT............................................. 160
18 -20.900PF03269.14; A0A2H2IKF9_CAEJA/181-356; Caenorhabditis protein of unknown function, DUF268 topsan  ali follow..  12  1......................................................................................................................GQSGVVIGSMQPWVEVSALVNGA---KKILTVEYNKLTIQEEFRDRMS-------SILPVDFAKGWANYADTFNFAASFSSIEHDPIGDIREILKIKCVLKKGGLLFLGFPLGTDSIIYGPIRLAMMFYGFEWIATF.................... 143
19 -20.800PF03848.14; TEHB_HAEIN/91-282; Tellurite resistance protein TehB  ali follow..  12  4...........................................................................................KKEDYFSKKYNTTAIHGDVVDAAKIISPCKVLDLGCGQG--NSLYLSLL---GYDVTSWDHNENSIAFLNETKEKEN----NISTALYDINAANIQ-ENYDFIVSTVVFMFNRERVPSIIKNMKEHTNVGGYNLI................................................. 131
20 -18.500PF05219.12; METL9_HUMAN/56-317; DREV methyltransferase  ali follow..  9  81............................................................................................................RLLKINPDWKTHRLLDLGAGDGEVTKIMSPH------EIYATELSETMIWQLQKK-----------KYRVLGINEWQNTGFQYDVI-SCLNLLDRCDQPLTLLKDIRSVLEPTRGRVILALVLPFHPYVENVGGKWEKPSEILEIKGQNWEEQVNSLPVFRKAGFVI 232
21 -18.400PF01135.19; PIMT_CAEEL/8-220; Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)  ali follow..  14  69...................................................................................................................LVAGAKALDVGSGSGYLTVC-MAMMVGRNGTVVGIEHMPQLVELSEKNIRKHHS-RGNVIIIEGDGRQGFAEKAPYNAIHVGAAS-------KGVPKALTDQLAEGGRMMI................................................. 174
22 -17.900PF13679.6; Q12FV8_POLSJ/56-202; Methyltransferase domain  ali follow..  14  17.............................................................................................................LNEVSANNPAPTLADHGAGKSYLGFILAHQGRKDAGHIYGIETRTELVDKSRALAARLG---ERMSFLNLSVQQATASADLPERIDIVTALHA----DTATDDAIAFGLAKQARHMV................................................. 135
23 -17.700PF07021.12; Q89UL6_BRADU/24-217; Methionine biosynthesis protein MetW  ali follow..  12  11...................................................................................................................VKPGSKVLDVGCGDGDLLQLLETR----GIDGRGIELSREGVNRCVAK-------GLAVVQGDADTDLVNYPDDAFDYVILSQ-TLQATRQPRVVLENL---LRIGRRAIVSFPN............................................. 110
24 -17.600PF13489.6; C5G7B3_AJEDR/109-340; Methyltransferase domain  ali follow..  10  28........................................................................................................................NVLEVACGTGRNMQYY-KAEIQGCRSVTFVDQSPQMVEIAREKFEKMYVKDSKAISLQTPEICAQQQSGKFDTV-IQTMGLCSLPDPVSYLTHLGTLVEPRGEILLLE............................................... 186
25 -17.400PF01596.17; A9PCU8_POPTR/22-233; O-methyltransferase  ali follow..  11  43.................................................................................................................LKLMNAKRTLEVGVG---YSLLSTALALPEDGQVTAIDKDREAYEIGLPFIQKAG-VEEKINFIQSEATPINDKQPEFDFAFVDA----DKSSYKHYHEQLLKLVKIGGIIAYDNTLWYGLVAKEVDDEAPVRTVIMEFNKLLSSDPRVEISQISIGDGVTL 209
26 -17.100PF03141.16; PMTB_ARATH/186-689; Putative S-adenosyl-L-methionine-dependent methyltransferase  ali follow..  9  109.............................................................................................................VSDITFGKHIRVAMDVGCGVASFGA-YLLSRDVMTMSVAPKDVHENQIQFALER---------PAMAAAFATRRLLYPSQAFDLIHCSRCRINWTRDDGILLLEINRMLRAGGYFAWAA............................................... 219
27 -17.100PF05175.14; A6WWW0_OCHA4/169-336; Methyltransferase small domain  ali follow..  17  20.............................................................................................................LVPHMEKIFFGNVADLGAGWGYL-AAQCLKFADRIKSIDLYEADYEALEAARGNLERLG-ASVPISFNWFDVTS-EKMAGIYDTVIMNPPFHEGRVTDVSLIAAAASRLKPGGRLLM................................................. 137
28 -16.800PF01234.17; INMT_MOUSE/1-260; NNMT/PNMT/TEMT family  ali follow..  12  3.............................................................................GKVYIGGEDYEKEFTPKDYLTTYVKFSLQNLYQTFSTGGVGGDVLIDIGSGPTIYQLLSACEVFR---EIIVTDYTPQNLQELQKWLKKEPGAYDWSSIVTKTPPLGSAQVPLADCVLAMECACPDIDTYRAALRRLAGLLKPGGHLVTLV............................................... 198
29 -16.600PF11968.8; A1C9Q5_ASPCL/61-283; 25S rRNA (adenine(2142)-N(1))-methyltransferase, Bmt2  ali follow..  8  4.....................................................................DARIEASGGLESYQLASKLGQSLERGGDSSKVLIDWIGPNLVELKHSPFKLRMLEVGALST-----KNACTRSYLFDVTRIDLNSQEPGILKQDFMKRP---------------PRADNDRFHIISLSLVLNYVPSAIGDMLKRCVEFLTDKLPSGLSLNIRPNLFLVLPLACVKNSRYLTEGRLQDILSSMGFVLAKSKETSK.. 190
30 -16.500PF08704.10; Q6DFS3_XENTR/64-300; tRNA methyltransferase complex GCD14 subunit  ali follow..  12  32.............................................................................................................ITMMLELKPGSVVCESGTGSGSLS-HAIIRTVAPTGHLYTVEFHQQRAEKAIEEFRQHK-VDHLVTVKNQDVCKHGFGVTIADAVFL------DIPSPWEAIGHAKSAMKSEGGRIC................................................. 141
31 -16.300PF05724.11; TPMT_VIBCH/2-217; Thiopurine S-methyltransferase (TPMT)  ali follow..  15  27...........................................................................................................IRFWSDLAPKRSEKVLVPLCGKS-EDLIWLANQ---HDSVQGVELSQIAVRSFFAEHFYTPTVTRELTLFTGDFFTA--PVESVDLVY-AALVALPEEMRAEYAQRVLQLLKPGGRILL................................................. 151
32 -16.300PF03686.13; Y73A_ARCFU/3-126; Uncharacterised protein family (UPF0146 topsan)  ali follow..  12  3............................................................................................................QIADYIAENYRGKVVEVGIGRFTAVAELLARR---GFEVFATDVVERRAP-------------EGCRFYVDDVTKPNLKYEGASLIYSLRPPPELFSAIVEVSRKV------GADCLIKP............................................... 101
33 -15.200PF08123.13; DOT1_DEBHA/959-1163; Histone methylation protein DOT1  ali follow..  11  1............................................................................YSRIVSTESRKLRSYKAFTAEVYGELLPSFTSEVLTKVNLQPQHKFYDLGSGVG--NTTFQAALEFGVHLSGGCEIMEHASKLTELQTMLLNNFALSQSFVENDIVRQAV--IECDVLLVNNYLFD--VNLNTAVGKMLYGLKPGTKIISLRN.............................................. 160
34 -15.100PF05185.16; ANM5_ORYSJ/308-478; PRMT5 arginine-N-methyltransferase  ali follow..  14  40................................................................................................YTQYQRAIAKALVVSDDDVSTTKTVLMVVGAGRGPLVSLQAAEETGRKLKVYAVEKNPNAVITLHSLIKLEG-WESLVTIISSDMRCWEAP-EKADIL-VSELLGSFGDNEPECLDGAQRFLKPDGISI.................................................. 171
35 -15.000PF02353.20; CMAS2_MYCTU/12-298; Mycolic acid cyclopropane synthetase  ali follow..  4  1.....................................................QLKPPVEAVRSHYDKSNEFFKLWLDPSMTYS-----AYFERPDMTLEEAQYAKRKLALDKLNLEPGMTLLDIGCGWGSTMRHAVAEY---DVNVIGLTLSENQYAHDKAMFDEVD-SPRRKEVRIQGWEEFD---EPVDRIVSLGAFEHFADGAGDAFKKFYNLTPDDGRMLLHT............................................... 172
36 -14.500PF01861.16; Q8U1U4_PYRFU/105-348; Branched-chain polyamine synthase A C-terminal domain  ali follow..  11  1.....................................................DLLEQFREIVKDRPEPLHEFDQAYVT---------------------PETTVARVILMHTRGDLENKDIFVLGDDDL--TSIALMLSGLPK-RIAVLDIDERLTKFIEKAANEIG---EDIEIFTFDLRK----LHKFDTFITD----ETLEAIRAFVGRGIATLKGPRCAGY................................................. 147
37 -14.000PF01739.18; CHER1_PSEAE/72-269; CheR methyltransferase, SAM binding domain  ali follow..  17  10.................................................................................................YPFEVLKQRVLPELIKANGGQRLRIWSAACGQEPYSSMAIDEFEKTGVQIVATDLSGSMLTAAKARWAVKPAIRSRVEFRALNLLDSYASLGKFDMVFCNVLIYFSAEVKRDILLRIHGTLKPGGYLFLGASEALNNL........................................ 185
38 -13.900PF00891.18; ASMT_BOVIN/117-327; O-methyltransferase domain  ali follow..  14  54............................................................................................................TVLAAFDLSPFPLICDLGGGSGALAKACVSLY--PGCRAIVFDI-PGVVQIAKRHFSA--SEDERISFHEGDFFKDALPEA--DLYILARVLHDWTDAKSHLLQRVYRACRTGGGILVIE............................................... 167
39 -13.500PF07942.12; Q6L536_ORYSJ/216-485; N2227-like protein  ali follow..  8  38...................................................................................................YKPILEELNRLFPNRSKERPPSCLVPGAGLGRL-ALEISTL-----VSQGNEFSYYMMICSSFILNHTQGITEGFSMCAGDFVEVESQESSWDAVVTCFFL-DTAHNIVEYIEIISKVLKDGGVWI.................................................. 198
40 -13.500PF07279.11; Q9LZY5_ARATH/1-218; Protein of unknown function (DUF1442 topsan)  ali follow..  12  33.............................................................................................................LSATAAGWNTRLIVETWSDPIATSVGLAVAAIHTCGRHVCIVPDEESRSEYEAVMRGAV-TSDSTEVMVLDSAEVVERISGVDFMVVDSKRHEFVN-----ALGLAKTSKMGAVLVCKNA.............................................. 149
41 -13.200PF09445.10; Q6CRW0_KLULA/100-266; RNA cap guanine-N2 methyltransferase  ali follow..  12  1......................................................................................................................GNCIVDVFCGGGG-NTIQFARLFE---KVYGIDSNIDHLYCAYKNAECYN-SAVKLKLIYGDWEESKNLGKTPDCIFASPPWGGVDYLRQDTYDLEEHLQPSPLSKILSVFFSVCQNVVLFLPRNSDLDQLSSIDLLGPDEKCKVVYVKDNGYMKGI 160
42 -12.800PF04672.12; Q9WX26_STRCO/10-300; S-adenosyl methyltransferase  ali follow..  14  31........................................................................ADLAAAAAGLAANPRGYLDVR----HNRDFLRRAVTALAREDGIR---QFLDIGTGPTAENVHQIAQRIAPESRVVYVDDDPVVLAHARALLTSGP--EGRTDYIDADLKSLEQAAATLDLCLVAILHFVEDEEAYPIVRELMDALPAGSRLVLSHLTE............................................ 191
43 -12.800PF01564.17; SPEE_SCHPO/71-256; Spermine/spermidine synthase domain  ali follow..  10  17....................................................................................................................PNPKKVLVIGGGDGGVLREVVKHECVEEAIL--CDIDEDVIKVSKQYLPEMSAGHPKVKVHIGDGFKLQDYQNTFDVIITDSSDPDGPAEAKPYFQLLSDALRGGGVITTQAEC............................................. 134
44 -12.400PF06325.13; PRMA_STRA5/3-308; Ribosomal protein L11 methyltransferase (PrmA)  ali follow..  13  167...................................................................................................................LRGGETVIDVGTGSGVLS--IASSLLGAK-DIYAYDLDDVAVRVAQENI-DMNPGTENIHVAAGDLLKGV--QQEVDVIVANIL----ADILIHLTDDAYRLVKDEGYLIM---SGIISEKWDMVRESAEKAGFFLETHMVQGE----NACVFKKT.... 306
45 -12.400PF16912.5; I7BJ28_NATSJ/144-370; Glucose dehydrogenase C-terminus  ali follow..  14  18.........................................................................................................QHARATRSAFDWQPASALVLGTGSLGLLTAAMLTETLEYDRVYCLDRPHPTIDIVDRL-------ATYIDSRETPVSEIPAAYEPMDLVY-------EATGYAKHAFEAIEALAPNGVAAL................................................. 128
46 -12.400PF10672.9; Q87QG2_VIBPA/25-310; S-adenosylmethionine-dependent methyltransferase  ali follow..  13  120..................................................................................................................ENAKHKNVLNLFAYTCGFS---VAAIAGGADKVVNVDMAKASLSKGRENHKLNGHNINQVSFMGHDIFKS--KSGQYDLIIIQKGSFALTKDYKKILRRLPDLLAEGGQVMA................................................. 236
47 -12.200PF01189.17; RSMB_ECOLI/239-427; 16S rRNA methyltransferase RsmB/F  ali follow..  11  1..............................................................................................................MTWLAPQNGEHILDLCAAPGGKTTHILE--VAPEAQVVAVDIDEQRLSRVYDNLKRLG-MKATVKQGDGRYPSQWCGEQQFDRILLDA-IPELAQLQSEILDAIWPHLKTGGTLVYAT............................................... 136
48 -12.200PF02390.17; TRMB_DROME/71-251; Putative methyltransferase  ali follow..  12  5.........................................................................................................................FADIGCGYGGFLVTLGEMF--PEKLSIGMEIRVKVSDYVVDRIAALRRRCQNIACLRTNAMKY-FVKGQLEKMFFLY---KRAKHKWRILSEYAYILRKGGLLYTMT............................................... 125
49 -12.000PF10294.9; Q6C9L2_YARLI/34-201; Lysine methyltransferase  ali follow..  12  31............................................................................................................YYLLRKGIQSYPRVLEIGSGTG-LTGLAIALSESANLKVWVTDQENMIPLMNQNI--ELNNLQDKVVAEVGEELPEFLEGQPVDLV-LAADCVYLESAFPLLEKTLIDLSNKDTKILM................................................. 149
50 -12.000PF11599.8; A0A0J1DJF7_9FIRM/1-235; RRNA methyltransferase AviRa  ali follow..  11  33.................................................................................................RLGSEIIQRCLERVRKARGKVPLTIYDCGGAYLLTTIALLHGREFSK--LYASDVDGEILELAKANLALLTPAGMARRDVLRPGLAGKIAPQSIDIVIIASWSQDITDPIGVMLSNLRPAVRDQGVVAL................................................. 211
51 -11.600PF12847.7; A9KI22_LACP7/3-153; Methyltransferase domain  ali follow..  12  12...................................................................................................................VTKGNVVADVGCDHAYISIYLVEG--KIAPKTIALDVNEGPLLRAQENIISYG-MENLITTRLSDGLH-MLKPNEVDSIVIAGMGGALM---IRILEEGSECVAAAKELILQPQSEIWRV........................................ 124
52 -11.600PF04816.12; Q9A050_STRP1/22-222; tRNA (adenine(22)-N(1))-methyltransferase  ali follow..  12  1.........................................................................................................................LLDVGSDHAYLPIFLVET--NQISAAIAGEVVRGPYESALKNVTQSG-LAEHIQVRLANGLAAFEEADDVTAITICGMGGRLI---ADILEAGKEKLQGIERLVLQPNNREDDL........................................ 108
53 -11.100PF03721.14; UGDH_CAEEL/10-205; UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain  ali follow..  13  1.......................................................................................................................SKVVCVGAGYVGGPTCAMIAHKCPHITVTVVDMNTAKIAEWNSDKLPIPGLDEIVFAARGRSSDIPKAIAEADLIFISVNTAPDLKYVESVSRTIAQYAGGPKIVVEKST.............................................. 127
54 -11.100PF01262.21; Q9S227_STRCO/141-353; Alanine dehydrogenase/PNT, C-terminal domain  ali follow..  14  19.............................................................................................................LPGGVPGVLAGRAVVIGGGVSGWNAAQIAIGLG--FHVTLLDKDITKLREADKIFGTK------IQTVVSNAFELEKACLEADLVIGAVLIPGAKAPK--VTNELVSRMKPGSVLV.................................................. 125
55 -11.100PF02527.15; RSMG_HAEIN/20-200; rRNA small subunit methyltransferase G  ali follow..  11  31......................................................................................................LVKHILDSLVVSPYLQGDRFIDVGTGPGPGLPLAIIN---PSKQFVLLDSLGKRISFIRNAIRELR---TNVTPVLSRVEEYQPE-DKFDGV-----LSRAFASLKDMTDWCHHLPKENGYFYALKG.............................................. 147
56 -10.900PF06460.12; R1AB_CVMA5/6879-7175; Coronavirus NSP16  ali follow..  11  60...................................................................................................................VPANMRVLHLGAGSDKPGSAVLRQWLPAGSILVDNDVNPFVSDSVASYYGNCITLDCQWDLIISDMYDPLTKNIGEYNVSKDGFF-------TYLCHLIRDKLALGGSVAIKITEFSWN------ELYSLMGKFAFWTIFCTNVNASSSEGFL....... 205
57 -10.200PF02475.16; O28306_ARCFU/90-284; Met-10+ like-protein  ali follow..  9  3.............YKVIGDIVVVKLDERAREYAKVIGEALMQINPCKAVWCDYGRYGMKRKPRMELIAGEGSVTEHRENGCRFRIDVAKVMFSLGNQAERMRIARL---------VEDGEVVVDMFAGIGYFS--IPIAVHSKARRIYSIEINPESYKLLLENIKLND---GNIVPILGDSQFV-TPEGVADRVVMG------HIYCHDYLHTAIRALKERGVV................................................... 193
58 -10.000PF04989.12; A8ZT86_DESOH/39-259; Cephalosporin hydroxylase  ali follow..  14  32.....................................................................................................................KPDLILETGIGGSLIFSASMLALLEYCDAAEKGEIDIDIREHNRAAIEAHP-MAGRIQMIQGSSVDAEAKEFSRILVCLDS--MHTHDHVLAELEAYAPLVSPGSYCMVFD............................................... 162
59 -9.850PF05958.11; TRMA_SHEON/10-365; tRNA (Uracil-5-)-methyltransferase  ali follow..  7  74.LINEMMAALIAELKPNPSLRHKLFQVDFLSTLSGEILVSLLYHRQLDDQWRAEAIALKAKLSSQFKKQKIDLDKDFVVESLQVNDK--KQIENSFTQPNAKVAIKMLEWAIDVTQNSQGDLLELYCGNGNFS-IALAQNFN---RVLATELAKPSVDAAQYNIEING---DNLQIIRMSAEEFDLDSYLCNTIFV--------PPRAGIDPATLDLVQGYERILYISCNPDTLK-----NLQQLYKTHKVTRFQFPYTDHMETGVLLER..... 355
60 -9.830PF10017.9; L0GU32_9GAMM/37-337; Histidine-specific methyltransferase, SAM-dependent  ali follow..  15  1.............................................................IRAEVLAGLAAPAKYLPPKLFYDERGSQLFDAITELSEY--PTRTEIGILRAHGLGRGSVLIELGSGSSLKIQTLLAAL--EPRVYIPVDISREHLLKSARALATR-----RIRATCADYSRLDPDWRDLAAFFPGSSIGNEPTEARRLLTRVANLIGDGGRLLI................................................. 173
61 -9.710PF00398.20; RSMA_BACSU/19-283; Ribosomal RNA adenine dimethylase  ali follow..  10  10.................................................................................................QNFLIDTNILNRIVDHAEVTEKTGVIEIGPGIGALTEQLAKR----AKKVVAFEIDQRLLPILKDTLSPY----ENVTVIHQDVLKADVKSDEIMVVYVTTPIIMKLLEEHLPLKGIVVMLQKAERMAADPSSKEYGSLSIAVQFYTEAKTVMIVTVFVPQPNVDSAVIRLILRDGP. 196
62 -9.100PF10354.9; M7SVX6_EUTLA/61-229; Domain of unknown function (DUF2431 topsan)  ali follow..  11  1..........................................................................................................................LLVGDGDLSFSASLVEHHYCADVTATVLEKNLEELTEAPENIAKIEAEDSKVLFNV-DATTMRDGVGIMDRIIFNRQVRYNQELLVAFFKQAMFSLAPGGSIVVTLFEG............................................ 132
63 -9.050PF02737.18; Q2YR99_BRUA2/5-183; 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain  ali follow..  13  1........................................................................................................................TVGIIGAGQMGSGIAHVCALAGYNVLL--HDAAPDRLEKGIATINGMARQVASGKLQEEQRADA--DLAGVDLAIEA--ATEDETIKRKIFAQLCPVLNPEAILATNTSS............................................. 116
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Jaroszewski L, Rychlewski L, Godzik A. Improving the quality of twilight-zone alignments. Protein Sci. 2000 Aug;9(8):1487-96.