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Query: PF03949.15; MAO3_BACSU/274-535; Malic enzyme, NAD binding domain, from PfamA32U

Results of FFAS03 search in PfamA32U
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst IQGTGAVSLAAVLSCAKASKVPLRDHRVVIFGAGTAGIGIAEQLREALVREGLSEEESYKRFWCIDRNGLLTDDMDQLLDFQKPYARSADEVKDYQRNGDGGGIDLLEVVRQAKPTILIGTSTVSGAFTEEIVKEMASHVKRPAILPMSNPTTLSEAKPEDLIEWTEGRALITTGSPFPPVEYNGVTYHIGQANNALVFPGLGLGTIVTKSKLITDGMFEACARAIAGMVNVGVPGAPMLPKVEDLRTVSATVAVEVAKTAMLast
1 -113.000PF03949.15; MAO3_BACSU/274-535; Malic enzyme, NAD binding domain  ali  100  1IQGTGAVSLAAVLSCAKASKVPLRDHRVVIFGAGTAGIGIAEQLREALVREGLSEEESYKRFWCIDRNGLLTDDMDQLLDFQKPYARSADEVKDYQRNGDGGGIDLLEVVRQAKPTILIGTSTVSGAFTEEIVKEMASHVKRPAILPMSNPTTLSEAKPEDLIEWTEGRALITTGSPFPPVEYNGVTYHIGQANNALVFPGLGLGTIVTKSKLITDGMFEACARAIAGMVNVGVPGAPMLPKVEDLRTVSATVAVEVAKTAM 262
2 -8.920PF00056.23; MDH_CHLAA/3-142; lactate/malate dehydrogenase, NAD binding domain  ali follow..  15  1.........................KKISIIGAGFVGSTTAHWLAAKELGD----------IVLLDFVEGVPQGKALDLYEASPIEGFDVRVTGTNNYADTANSDVIVVTSGAP----EDLIKVNADITRACISQAAPLSPNAVIIMVNNPLDAMTYLAAEVSGFPKERVI........................................................................................... 139
3 -8.160PF00208.21; DHE3_ORYSJ/176-408; Glutamate/Leucine/Phenylalanine/Valine dehydrogenase  ali follow..  15  8.AATGRGVMYATEALLTEYSESISGSTFVIQGLGNVGSWAAKLIHQKGGK-----------VAVGDVTGAIRNKSGIDIPALLKHRSEGGSLEDFYGAEVMDAAELLVH----ECDVLV--CALGGVLNRENAAEVKA----RFIIEGANHPTDTEAD--------------------EILAKKGVIVLPDIYANS--------GVVVSDEEKVNRELQKYMKNAFQNIKDMCKSQNC------NLRMGAFTLGVNRVAKAT 229
4 -7.660PF01734.22; Q09D74_STIAD/17-214; Patatin-like phospholipase  ali follow..  13  6..GPSALITLRVLRQLEARFPGFVERAQMFSGTSTGAF-VSLYLAHALSLRQRQGVQAPGCLDIIDGCIAFNERMTRQFKVKAINILRLISGLVPMYDGKAIREILEET---------FGEAKLCELEKMVVIEAFDSTVWRKATYHQFPPDADFVTTLVDAALASS-----AFPVLMPIYRSGNTVGRHKNNNS----TAM............................................................ 195
5 -7.380PF00670.21; SAHH_DICDI/191-351; S-adenosyl-L-homocysteine hydrolase, NAD binding domain  ali follow..  11  1..NLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQSLSKMGARVLVTEIDPINAL--------------------------------QACMDGYQIVTMETAAPLSN--IFVTTTGCRDIVRGEHFAVMK---EDAIVCNIGHFDCEIDVAWLNANA-GVHIILLAEGRLVNLGCGTG............................................................................. 161
6 -6.340PF01175.18; R5IDX1_9BACT/214-430; Urocanase Rossmann-like domain  ali follow..  13  6VHGTTIT----VMNAARMHTGENRGKLFVSSGLGGMS-GAQGKASVIAGVVGIIAEINPKAIRTRYSQGWVDEVYTELDPLIDRALEAREKKEAVALAYQGNIVDLWERLAKRDVDLGSDQTSLHNPWA-TFEESNEMMASDPDKFKREVQKSLRRQVAAINKLTERGMYFFDYGNAFLLEASRA-------ADGAFRYPSY............................................................ 202
7 -5.950PF00899.21; SAE2_HUMAN/11-443; ThiF family  ali follow..  17  3....................EAVAGGRVLVVGAGGIGCELLKNLVLTGF----------SHIDLIDLDTI------DVSNLNRQFLFQKKHV------GRSKAQVAKESVLQFYPKANIVAYHDSIMNPDYNVEFFRQFI---VMNALDNRAARNHVNRM----LAADVPLIESGT...................................................................................... 131
8 -5.890PF05221.17; D9SB20_FIBSS/15-498; S-adenosyl-L-homocysteine hydrolase  ali follow..  13  235LYGCRHSLIDGIN---RATDVMMAGKIAVVCGYGDVGKGCAQSLRGQGA-----------RVIITEIDPI---------------------CALQAAMEGYEVKTLDEVVSYAD--IFVTTTGNTGIISAAQMEKMK---NRAIVGNIGHFDNEIDMAGLKKIPGIKRNEIKPQYDEW--IFADGHSILVLAEGRLLNL--GCATGHPSFVMSASFTNQTIAQIDLWLNAQGKDTVAGIKYESGVVYTLPKILDEKVARLHL 452
9 -5.860PF13450.6; B4RE46_PHEZH/425-493; NAD(P)-binding Rossmann-like domain  ali follow..  40  1.............................IVGAGFAGSVLAERLT----------SQLGKRVLLVDRRPHV............................................................................................................................................................................................... 32
10 -5.840PF02056.16; CHBF_ECOLI/6-188; Family 4 glycosyl hydrolase  ali follow..  14  1..........................KVVTIGGGSSYTPELLEGFIKRYHE------PVSELWLVD----VEGGKPKLDIIFDLCQRMIDNAGVPMK---YKTLDRREALKDADFVTTNGAGGLFKGLRTDIVKDVEELCPNAWVINFTNPAG............................................................................................................. 148
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Li Z, Ye Y, Godzik A. Flexible Structural Neighborhood--a database of protein structural similarities and alignments. Nucleic Acids Res. 2006 Jan 1;34(Database issue):D277-80.