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Query: PF05221.17; D9SB20_FIBSS/15-498; S-adenosyl-L-homocysteine hydrolase, from PfamA32U

Results of FFAS03 search in PfamA32U
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst EYKIKDINLAIEGRKELDLAETEMPGLMALRKEYAGKKPLAGARIMGSLHMTVQTAILIETLVDLGADVRWVSCNIFSTQDNAAAAVVVGKNGSVSNPQGVPVFAWKGESLEEYWENTARALVWPDGKTADLIVDDGGDATMLVTCGAEFEDAGKVPEFNPETDSEEWGVFLATCRKIFEKDPKQWTRAREALKGVSEETTTGVHRLYQMAQAKRLKFPAINVNDSVTKSKFDNLYGCRHSLIDGINRATDVMMAGKIAVVCGYGDVGKGCAQSLRGQGARVIITEIDPICALQAAMEGYEVKTLDEVVSYADIFVTTTGNTGIISAAQMEKMKNRAIVGNIGHFDNEIDMAGLKKIPGIKRNEIKPQYDEWIFADGHSILVLAEGRLLNLGCATGHPSFVMSASFTNQTIAQIDLWLNAQGKDTVAGIKYESGVVYTLPKILDEKVARLHLEKLGVHLTRLTQAQADYIGVPVEGPYKADHYRLast
1 -124.000PF05221.17; D9SB20_FIBSS/15-498; S-adenosyl-L-homocysteine hydrolase  ali  100  1EYKIKDINLAIEGRKELDLAETEMPGLMALRKEYAGKKPLAGARIMGSLHMTVQTAILIETLVDLGADVRWVSCNIFSTQDNAAAAVVVGKNGSVSNPQGVPVFAWKGESLEEYWENTARALVWPDGKTADLIVDDGGDATMLVTCGAEFEDAGKVPEFNPETDSEEWGVFLATCRKIFEKDPKQWTRAREALKGVSEETTTGVHRLYQMAQAKRLKFPAINVNDSVTKSKFDNLYGCRHSLIDGINRATDVMMAGKIAVVCGYGDVGKGCAQSLRGQGARVIITEIDPICALQAAMEGYEVKTLDEVVSYADIFVTTTGNTGIISAAQMEKMKNRAIVGNIGHFDNEIDMAGLKKIPGIKRNEIKPQYDEWIFADGHSILVLAEGRLLNLGCATGHPSFVMSASFTNQTIAQIDLWLNAQGKDTVAGIKYESGVVYTLPKILDEKVARLHLEKLGVHLTRLTQAQADYIGVPVEGPYKADHYR 484
2 -48.700PF00670.21; SAHH_DICDI/191-351; S-adenosyl-L-homocysteine hydrolase, NAD binding domain  ali follow..  61  1.........................................................................................................................................................................................................................................NLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQSLSKMGARVLVTEIDPINALQACMDGYQIVTMETAAPLSNIFVTTTGCRDIVRGEHFAVMKEDAIVCNIGHFDCEIDVAWLNANA--KKDTVKPQVDRYTLANGVHIILLAEGRLVNLGCGTG........................................................................................ 161
3 -15.000PF07991.12; ILVC_METAC/15-178; Acetohydroxy acid isomeroreductase, NADPH-binding domain  ali follow..  18  1.............................................................................................................................................................................................................................................................LKDKTIAIMGYGSQGHAHARNLHESGLNVVVGLRKGSSSWAAESDGLKVMTVEEAAKAADVIMILLPDESVYYSQIEPSLEAGNALVFAHGF........................................................................................................................................... 96
4 -13.500PF02826.19; Q98GE4_RHILO/107-283; D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain  ali follow..  26  33..........................................................................................................................................................................................................................................................NIELAGKTIGIVGLGAVGQAVGHAAHGFDLKVVATT----RSMQPAPEKVGFLSIDALVEQSDIIVLTPETRGLISRERIARMKPNALLINVSRGDDDALIEALRE................................................................................................................................ 142
5 -12.500PF02882.19; FOLD1_ARATH/184-349; Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain  ali follow..  23  3............................................................................................................................................................................................................................LNVGNLAMRGREPLFVSCTPKGCVELLIRTGVEIAGKNAVVIGRSNVGLPMSLLLQRHDATVSTVHA-------------FTKDPEHITRKADIVIAAAGIPNLVRGS----LKPGAVVIDVGTTPVE........................................................................................................................................ 115
6 -12.100PF00389.30; Q9KCG9_BACHD/20-325; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain  ali follow..  21  61...................................................................................................................................................................................................IIARAGVGVDNI-DIDAATKHGIVVVNAPDGNTISTAEHTFAMICSLLRKIPQAQGTELRGKTLGIIGFGRIGSQIAKRAKAFEMTPYVFDP--LTKARAEKLGVTVASLDDVLQVADIITVTKETKGLLGMKNIGKTKKGVFLINCARGDEEALKHYLRE................................................................................................................................ 240
7 -10.800PF01262.21; Q9S227_STRCO/141-353; Alanine dehydrogenase/PNT, C-terminal domain  ali follow..  21  26.............................................................................................................................................................................................................................................................VLAGRAVVIGGGVSGWNAAQIAIGLGFHVTLLDKDITKLREADKIF-NAFELEKACLEADLVIGAVKAPKLVTNELVSRMKPGSVLVDIA............................................................................................................................................. 128
8 -10.700PF02254.18; Q92CZ9_LISMO/5-120; TrkA-N domain  ali follow..  13  1..................................................................................................................................................................................................................................................................FAVIGLGRFGGSICRSLVEQGMEVLAIDSDEERVNEYMSIATHAVIANSTIRNFEHVIVAIGESSILTTLILKEMGVKYVTAKATNDKHAKLLDKI.................................................................................................................................. 108
9 -10.600PF03446.15; Q8FTI1_COREF/15-184; NAD binding domain of 6-phosphogluconate dehydrogenase  ali follow..  11  1.................................................................................................................................................................................................................................................................QIGVVGLAVMGSNLARNFARNGHTVAVYNRSTDKTDKLISDYATDGNFIPTKTVEDFVAALEKPRRAIVMVQADAMEEGDIIIDGGNALYTDTVCREKEMAARGRHFVGAGISGGEEGALNGPSIMPGGPKESW............................................................................................. 146
10 -10.100PF06690.11; D7DUD4_METV3/2-259; Protein of unknown function (DUF1188 topsan)  ali follow..  11  1........................................................................................................................................................................................................KYGITENVKTIESKVKVRDIIKKIAEKKANAIKYYLEGEEF---------------EQAIIFGAYLSGNYIANTLKADCGEVILIDSQPIKFMDLNTFMLKLRNNKDKEINPDLIIDVTG--GGVDPNMLKDFDPKVLIIEDPKS........................................................................................................................................... 139
11 -9.740PF01488.20; HEM1_PSEAE/169-304; Shikimate / quinate 5-dehydrogenase  ali follow..  18  1....................................................................................................................................................................................................................................................SLAKQIFSDLHRSQALLIGAGETITLVARHLFEQGVRIVVANRTLERASLLAEQAVLLSEIPEELANSDIVISSTASQLILGKGAVERAKPMFMVDIAVPRDIEPEVGELDDV............................................................................................................................... 125
12 -9.700PF13241.6; Q2FTK6_METHJ/4-113; Putative NAD(P)-binding  ali follow..  16  5.............................................................................................................................................................................................................................................................FTGKKVIIFGGGVIGARKARYFAY-EADVLVYSRSFHPEFQEIPVRTEVCNLTGDLEHDASLVIAATSDPELNELIESACAREHIWCNVAAGK.......................................................................................................................................... 102
13 -9.530PF02558.16; Q9K9R6_BACHD/6-154; Ketopantoate reductase PanE/ApbA  ali follow..  11  1..................................................................................................................................................................................................................................................................VAVIGSGSIGLLLYAYLKLANWPALLVTNRPEQADHLNKEGLTFVAKSGEHQPISV--------TATPLSSFSAEEAEVGFITVKSFAVKALLPQLQRKK------------------WDGLVFFQNG.................................................................................................. 102
14 -9.490PF00208.21; DHE3_ORYSJ/176-408; Glutamate/Leucine/Phenylalanine/Valine dehydrogenase  ali follow..  13  17.................................................................................................................................................................................................................................................ATEALLTEYSESISGSTFVIQGLGNVGSWAAKLIHQKGGKIVAVGDVTGAIRNK--SGIDIPALLKHRSEGGSLEDFYGAEVMDAAELLVHECDVLVPCALGGVLNRENAAEVKAIIEGANHPTDTEADEILAKKGVIVIYANSGGVVNIQGFMWDEEKVNRELQKYMKNAFQNIKDMCKSQNCNLRMGAFTLGVNRVAKATLLR...................................... 232
15 -9.310PF10727.9; Q743Y6_MYCPA/8-128; Rossmann-like domain  ali follow..  17  6.................................................................................................................................................................................................................................................................KVGIISAGRVGTALGVALERADHVVVACSHASRQRAQRRLPDTPVATPPEVAAGAELLLLAVPDSEL-GLAATEAVRAGTIVAHTSGA........................................................................................................................................... 100
16 -9.070PF16912.5; I7BJ28_NATSJ/144-370; Glucose dehydrogenase C-terminus  ali follow..  12  1.................................................................................................................................................................................................................................APMGFLVEPISITEKAIQHARATRSAFDWQPASALVLGTGSLGLLTAAMLTETLEYDRVYDRPHPTIDIVDRLGATYIDSRET-EPMDLVYEATGYAKHAF-EAIEALAPNGVAALLGDWAFEVDGGHLHRELVLSNKALVGSVNSNRGHFEAAIDTLSALPDWVL............................................................................................. 181
17 -9.060PF00056.23; MDH_CHLAA/3-142; lactate/malate dehydrogenase, NAD binding domain  ali follow..  18  1................................................................................................................................................................................................................................................................KKISIIGAGFVGSTTAHWLAAKEGDIVLLDFVEGVPQGKALDLYEASPIEADTANSDVIVVTSGAPRKPGMSREDLIKVNADITR............................................................................................................................................... 98
18 -9.030PF02737.18; Q2YR99_BRUA2/5-183; 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain  ali follow..  16  1.................................................................................................................................................................................................................................................................TVGIIGAGQMGSGIAHVCALAGYNVLLHDAAPDRLRADAMKLIRPANSMEDLAGVDLAIEAATEDETIKRKIFAQLNPEAILATNTSS---ISITRLASTTD............................................................................................................................. 127
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Jaroszewski L, Rychlewski L, Godzik A. Improving the quality of twilight-zone alignments. Protein Sci. 2000 Aug;9(8):1487-96.