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Query: PF05297.11; LMP1_EBVB9/1-386; Herpesvirus latent membrane protein 1 (LMP1), from PfamA32U

Results of FFAS03 search in PfamA32U
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MEHDLERGPPGPRRPPRGPPLSSSLGLALLLLLLALLFWLYIVMSDWTGGALLVLYSFALMLIIIILIIFIFRRDLLCPLGALCILLLMITLLLIALWNLHGQALFLGIVLFIFGCLLVLGIWIYLLEMLWRLGATIWQLLAFFLAFFLDLILLIIALYLQQNWWTLLVDLLWLLLFLAILIWMYYHGQRHSDEHHHDDSLPHPQQATDDSGHESDSNSNEGRHHLLVSGAGDGPPLCSQNLGAPGGGPDNGPQDPDNTDDNGPQDPDNTDDNGPHDPLPQDPDNTDDNGPQDPDNTDDNGPHDPLPHSPSDSAGNDGGPPQLTEEVENKGGDQGPPLMTDGGGGHSHDSGHGGGDPHLPTLLLGSSGSGGDDDDPHGPVQLSYYDLast
1 -78.000PF05297.11; LMP1_EBVB9/1-386; Herpesvirus latent membrane protein 1 (LMP1)  ali  100  1MEHDLERGPPGPRRPPRGPPLSSSLGLALLLLLLALLFWLYIVMSDWTGGALLVLYSFALMLIIIILIIFIFRRDLLCPLGALCILLLMITLLLIALWNLHGQALFLGIVLFIFGCLLVLGIWIYLLEMLWRLGATIWQLLAFFLAFFLDLILLIIALYLQQNWWTLLVDLLWLLLFLAILIWMYYHGQRHSDEHHHDDSLPHPQQATDDSGHESDSNSNEGRHHLLVSGAGDGPPLCSQNLGAPGGGPDNGPQDPDNTDDNGPQDPDNTDDNGPHDPLPQDPDNTDDNGPQDPDNTDDNGPHDPLPHSPSDSAGNDGGPPQLTEEVENKGGDQGPPLMTDGGGGHSHDSGHGGGDPHLPTLLLGSSGSGGDDDDPHGPVQLSYYD 386
2 -12.000PF10754.9; B4EVZ4_PROMH/16-152; Protein of unknown function (DUF2569 topsan)  ali follow..  19  1............KAPITGWLLAPLAYLLLSIVGLGLMYFSDFSIIHQLPFHVVVLTTWAMFAFTAYLLRQFFYRAKNFP--RLFIIWLLINLLLAIKSFGFAPVDDQTAVKSLLWAVMATVCFVPYIKYAKRVRETF......................................................................................................................................................................................................................................................... 136
3 -11.900PF17461.2; Y005_CHLTR/16-363; Family of unknown function (DUF5423 topsan)  ali follow..  14  11..............PDRHPKLRYVYDIALIAI--SILCIVSIIL--WTQGSGLALFAIAPALAI----------------GALGVTLLV-TVAAVSLFILTGTAAGL-----MFSAIAVGGGAVILANPLFLMG------------------SMTLGFAL------MSLHRVTYQYLSNREQWKQQKKLEQVELAAWESHLPKESKSSALEEVRYSPRLMKRGKTWRKRAIRRKNYTPIPLVDKTLQTMQPDALFSSTTTHSTDSEQILTSVSPQSSDTESSSSSSFHTPPNSDKELSDSNSSDSSSSSEYMDALETVAAGDVSGITPPSKPSSSPKTTRRVVKLSRSERNAQHHRNKDQEQRQDSSESSEEDSSSDSSQKKKPSR 347
4 -11.700PF09726.9; H2MT57_ORYLA/2-679; Macoilin family  ali follow..  11  11............RRPLKRNRITEGIYGSTFLYLKFLVVWALVLLADFLEFRFEYLWPFWLFIFSVFFVCVAFTSDIICPVQWL-FFAASTYVWVQYVWHTER-----GV------CLPTVSLWILFVEAAIRFKDL--DLCRPFAAHCIGYPVVTLGFYVKQKEVQKENEFYMQLLQQALPPEQQMLQRQEREAEEAAKGASEVETLPVTQNGAPPNKKTSVPLPELEYREKGKDGRGGGEAKKQHNSNNILQPSLDSKIHEMEYMENHMNKRLTTELDSTESLLLKEDNNSSCSSSSSSSSKNYKNASSNAAALNSSPRGHSTTNGSVAFSASSSTTNTAKNDKKHKLPVGKGTAGGSHKDPADNWIPNNQLSKPE......... 397
5 -11.700PF09529.10; T0VFH5_9STRE/10-213; Integral membrane protein (intg_mem_TP0381)  ali follow..  13  26............FSIKYAQSKSYQRFWYWAQLIQVLTINAWYILAHMPLTDNLPFY---HCRLAMLAILFAPRGTYIKQYFALLGVLGSIAALVYPAFDPFPFPHITVLNLIFSHWALFANSLIYLQDFYQSEKQDTLRIVKITFGMNA--VIFLVNLLTRGDYGFL........................................................................................................................................................................................................................... 175
6 -11.300PF04279.15; A5WGY5_PSYWF/1-176; Intracellular septation protein A  ali follow..  15  1..........................MKALLDFIPLL--AFFYVAKTQGILAGAGAILIATVAVAVIHLITQKG----RLTKQQAITLVLTVVFCGLTLLFHDDIYLTVINGIFAVALLISVLIMAMKSVFNLTHSGWNKLTLAWVGYMAGLQYYFAFYTSEQTWINFKTYGWLPFMLVFMV............................................................................................................................................................................................................ 163
7 -11.200PF10810.8; A0A0V2F2Q8_SALNE/1-80; Protein of unknown function (DUF2545 topsan)  ali follow..  23  1..................................................................................MIYLWTFLAISILAVSGYIGQVMGAFSAVSSFTGMVILAALIYLLNVWLQDGDDIVSGLLLFLAPACGLIIRFMVGYGKR................................................................................................................................................................................................................................ 80
8 -11.200PF14017.6; V9XAB1_9NOCA/23-126; Protein of unknown function (DUF4233 topsan)  ali follow..  16  6................................................................................GTLVLEAIVVLLVLPVIATVGGGLSAWSTT-YVVGLAVLMFLGAGVQKKSWAIPFNITLQVLAVLGFFVDLAFGAVGVLFAAVWAYIF.......................................................................................................................................................................................................................... 92
9 -11.200PF17369.2; A7GUD3_BACCN/1-135; Family of unknown function (DUF5391 topsan)  ali follow..  22  5.....................SKKSSIVFVTLVSAFFFCSVLVVSSLS-GTILLFYSVPLLLYIAGIRAIRFIMAILCGMGIFINLVILAVVYMIIHTSDYHAYSFLGVIIVCMALIITNIIWFFV.................................................................................................................................................................................................................................................................... 129
10 -11.100PF00499.20; K9Z3G3_CYAAP/22-166; NADH-ubiquinone/plastoquinone oxidoreductase chain 6  ali follow..  18  11...................IVYSAFLLGGVFLSISGLY--ILLNADFVAAAQILIYVGAINVLILFAIMLVNKTEVSTALVCVGLFALLGTMVLATPWQLSETSPAVVE-----NTIVAIGKHFF-------------YLLPFEIASVLLLMAMVGAIIL.................................................................................................................................................................................................................................. 145
11 -11.100PF02293.15; G8MDZ1_9BURK/1-168; AmiS/UreI family transporter  ali follow..  18  2......................LGLCLLYVGAVLFLNGLWLLGRIGDREIWVINVFAGGVTLLASLKLAFGSGADAASIKAAALTLLFTFTYFWVAINRYNG-SLFVAITIIPVGIDSIASTWSVWFALCWFGWAFLWFLFFVLLALQRPIVKLTGAVTVIAGIVTGWLPGYLLL................................................................................................................................................................................................................... 165
12 -10.900PF11045.8; Q6D3R2_PECAS/3-119; Putative inner membrane protein of Enterobacteriaceae  ali follow..  18  5.......................................................WVGATCCFLLFTVVFLSQKIEVSEVGSPGMLLFLLPGMVACFLSARGRLLLFGALAAMPVCLLLLHLWNFWQELAYVMSAVFWCVLGAMGVLCLRSLY......................................................................................................................................................................................................................................... 116
13 -10.900PF06541.11; E3GF10_EUBLK/32-189; Putative ABC-transporter type IV  ali follow..  21  5....................IGCFLGTILEMIFCFVTQHGLI-RSGLIYGPFNPVYGFGAVVLTIVLRPLAHKRDLIIFLFSMVI-AFQQYFMGTVSWNIGGRTCLLYGLFWLLGLLWVKDIYPYFSKWIEKIPNKVGIVLTWVLVVFMIFNMAISA..................................................................................................................................................................................................................................... 158
14 -10.900PF17080.5; B9E9V9_MACCJ/10-153; Multidrug Resistance efflux pump  ali follow..  21  2.................................IALLFVLSVVLISGTAFILMVMYGLSRLLIYFHLAEFTYNEDNSFYYGSYLIIGYVLLFIIEYIMDLPENKFFHGWYFHIISVSISTIVFYFGVHINY---------QHIRINFFVVLAIISALYYLTELFYPDSVDL....................................................................................................................................................................................................................... 141
15 -10.800PF13795.6; C6CS40_PAESJ/197-345; HupE / UreJ protein  ali follow..  16  2........................FILGIEHLITGYDHILFVLS--------LLIGARSIKQILGVVTAFTAAHTVTLLLAGFGVIVIALSIIYVALNSILNKNASKHFLAFGFGLIHGCGFAATLSEMRLDGGQMAASLLTFNVGIEFGQLMIVLLLYP.................................................................................................................................................................................................................................. 140
16 -10.700PF07457.11; U5L9U3_9BACI/2-108; Protein of unknown function (DUF1516 topsan)  ali follow..  15  5......................................................IFTWVVALVLFFAALGMHNSGKAKGVKVVQMILRLFYLLII----GTGIWMLTSGINILYVLKALLGLWIAMIEMIIIRTTKGKKTSILWVQFV---VAAILVIYL.................................................................................................................................................................................................................................. 106
17 -10.700PF11086.8; C5BR94_TERTT/5-161; Protein of unknown function (DUF2878 topsan)  ali follow..  15  2............................LINSILFQGVWWVAVQ----GDNTLAVAALAVYFLLQISFLPRNTKFWG-----FCFCGGVAGWLLDSVLAHSNIIHYQTAISVFGVQDLLAPVWLLCI---WAFMPLLLFGLRWLLSYIGGAKFANASLNLPLSIYYLVEGLVWALVLPA............................................................................................................................................................................................................... 157
18 -10.700PF01027.20; A5CDM3_ORITB/21-240; Inhibitor of apoptosis-promoting Bax1  ali follow..  18  47.....................QTPIGLLVNVAPIGILFWVYAVLVGMSLSALGYIYTGESLVSSFFITASAFQRDLTSLGALL--LMGLWGIIISSLVNIFLGSPAIHFATSVLGVGIFMGLIAWDTQKLKHIYYSVVGAFTLYL--FINLFLYVLRFF................................................................................................................................................................................................................................... 220
19 -10.700PF00510.18; COX3_NEUCR/12-269; Cytochrome c oxidase subunit III  ali follow..  22  1..HPFHLVSPSP-------PLNTSVCIALIGLVSAMFLWFRDIISEGT-GIILFIVSEALFFLAIFWAFFHSALTNPFELPLLNTVILLSSGATITY-GEREGALYGSIATILLAIIFTGFQGVEYSVSSFTISDGAFGTCFFFSTGFIGTIFLAVALWRIFAYW--FVDVVWLFLYISV.............................................................................................................................................................................................................. 253
20 -10.700PF13231.6; Q2YBZ2_NITMU/191-351; Dolichyl-phosphate-mannose-protein mannosyltransferase  ali follow..  20  2.............HPP-------------------MVAWLIWLGTSIFGSEFGVRVGAFLCGLITMGYLFALTRNLYDSATGIRAVLLLAILPFFFA---TGALMTTDAPLVAAWAATLYYLEQALIAERAWLGVGIAFGLGILSKYTLGLVGIAALVFV-RHPYPYLAVLLALLLFSPVIIW........................................................................................................................................................................................................... 161
21 -10.600PF04178.12; E0VKI0_PEDHC/48-159; Got1/Sft2-like family  ali follow..  22  1................................................................................GIFCSLLGSFCFFIGLGLGSFAIFYTLGNIVSLGSTCFLMGPVNQIKKMF-RAIATILVIVMFCLTLFAAFLLVIIFVVLQ------SLAMTWYSL.................................................................................................................................................................................................................. 97
22 -10.600PF04819.12; A9RY74_PHYPA/122-262; Family of unknown function (DUF716 topsan)  ali follow..  13  2.........................DASFLFASISFGLEWLSVTHESARNQGLESQCNLLLAYIAGLCAVTSGLLALRPKLFLVDVVLCMGIILQGTWLFQ-----IGLYLYV-GCHYRLIDGSTVCDVEVSRIRAVALMNLAFNFHVIMVVCFSVLMF................................................................................................................................................................................................................................... 140
23 -10.500PF16882.5; Q2G177_STAA8/4-226; Domain of unknown function (DUF5079 topsan)  ali follow..  17  8................RKPGAQALSLASLFMILFSCLTFFFGLDYERFPNYLKITTIIELIIIIISLLQWIRFIDIINVLTTITAVFATCNLYLFNYWLMGTISIIISYLLLVIGGMFTLLKLPKVTKRWGGKTKTHFGLLLTALSSFIKIIEYILVPNVVESKFIIIVSMLVIAGAQFVAF............................................................................................................................................................................................................ 204
24 -10.500PF10277.9; SFK1_SCHPO/21-232; Frag1/DRAM/Sfk1 family  ali follow..  15  6...................PLVSFL-MWTIGLIVLLGLWSPVYLSD-MGAYTKGFFIPMCVITGVFYFLTFIVETYLGWFAALTGAAAASCLISLSIRDVHWKFTAAFVVLAFVSAASNIFEWLSATRYYPQSSLLRVSFIFKFVIIVVGIICAIAFGGLHHNYRGRSARFEWVVCFLWSIY............................................................................................................................................................................................................ 201
25 -10.500PF04750.14; Q5RIV5_DANRE/12-219; FAR-17a/AIG1-like protein  ali follow..  17  31..........................LTFIDLVIQAVFFGVCVLTDLSSLLAVLAFPVGVFVVTMFWTLYLYDRDLIYPMHTTVLPFIIIEMRTTHHRYPSRPCGLLAVCAFAVGYVVWMGVWVYLLEHI----GPTARILFFFCLMALINVYYVLGEILNN................................................................................................................................................................................................................................ 208
26 -10.400PF13042.6; Q81NY7_BACAN/2-162; Protein of unknown function (DUF3902 topsan)  ali follow..  23  7.....................................................ILISFVFSAVSMCWLLFLLFKGLLSWVGVFMAYLSLYTLIDLYCKNTYDKKI-TAVTSFSFAVLGISFCIIHELLTPWSLSLMVWYWLVMLVLFLTTIISLVSLVFVNRNVLLTLGPVLWPLLLSII.............................................................................................................................................................................................................. 157
27 -10.300PF15971.5; D2RW44_HALTV/57-219; DolP-mannose mannosyltransferase  ali follow..  16  11............VNPP------------VPFAITAALAVLS--GNMYVLHGLSVILTLLVAAANILLVGWVAFLVTGEDAAAVAAGLTMLVVPELFLLPLAGWAQFYALFFGVLSLALALRDRPFLAGVAAALSAGSWQSGIAFAPLVV--GMTYQRTGGKDVLRAIAGGGVVTGVVV................................................................................................................................................................................................................ 162
28 -10.300PF07187.11; U5LD20_9BACI/24-182; Protein of unknown function (DUF1405 topsan)  ali follow..  15  1.................................................GTVYGYYWYGWQLKDTPPHFLAFVPD--SPTASLFFCFVLAAFLMRRNWPL--------LEALAAVTLFKYGVWVVMNLLVYKVTGELDPIALMLIGSHAAMAVILYSPFYRIKWIHLLIAAVWTLH.................................................................................................................................................................................................................. 120
29 -10.300PF14770.6; G1NMG5_MELGA/18-135; Transmembrane protein 18  ali follow..  16  2........................................ILAKTDWAEPWLLGLAGFHVLCFLLTCFS---FQHYRVQIGHFLCMVCLV----------------------------------YCAEYINELAAMNWRMFSMFISLVFSAPLLVNTIIIVVNWVYRTLNVM...................................................................................................................................................................................................................... 105
30 -10.200PF00810.18; A0A0D2VV35_CAPO3/28-169; ER lumen protein retaining receptor  ali follow..  16  1......................SCKGISLRSQGLFALVFTLFTTYISLYNTVMKILFITSSYGTCYLIFKKFRATYDHNVDNFPLQYPLGACVILAL--IFNHSWDPVELLWTVSIYL-----VAIMPQLWMIQKT--GEAESVTSHYLFALGAYRALYL--NW.............................................................................................................................................................................................................................. 139
31 -10.200PF04093.12; MRED_HAEIN/3-155; rod shape-determining protein MreD  ali follow..  17  2............RFILQWFTILSFFVIAFVLELAPWPVGFQMLKPAWL---VLVLLYWVLAIPNKVSIGWSFLLGLTWTLGVHALVLSTSMYIIAKNYLILRNLSLWFQSLLVVLFVFIIRLLIFLVEFSLHTAFFHWQ---AILGAFASGLL-----------WPWVFLLMRKI................................................................................................................................................................................................................... 153
32 -10.200PF09842.9; S6AFK0_9PROT/10-112; Predicted membrane protein (DUF2069 topsan)  ali follow..  19  1.......................ASIASLIALIVLCLAWELWLAPLRPGGSSLVFKVLPLLLPL------ILRGKRYTYQWASMLILLYLAEGVVRAMSDKGMSGTLAGVEIALAVVFFFSTIFYA.................................................................................................................................................................................................................................................................... 99
33 -10.200PF13722.6; D5WQ95_KYRT2/461-589; 5TM C-terminal transporter carbon starvation CstA  ali follow..  20  2........................................................AFWYHFAILFEAVFILTTDAGTRVGRFMLLLGNVWKPLGRTESFGANVFASAVIALGWGYFLYQGV----INTLWPLFGISNQMLA--------IALVVATTVLARYSWITILPLVWLLAVTLTA............................................................................................................................................................................................................. 129
34 -10.100PF10329.9; G9MFW5_HYPVG/26-253; Region of unknown function (DUF2417 topsan)  ali follow..  15  9.RVNSNRDFLAPDDPAVSPSIRMLRYLTLFFTALTFLWWVILLVSAFTKGSGFFAFGYTSLTLSNMFFTLLFKAVRILGI-VIAAILALDTILLASVQKTRYEEGWVGIVSVIWALLMS--VWAVIVDRTVKWGKSLSEWLEVLLSTIGYSVMVLAVVLITLSIILRALD........................................................................................................................................................................................................................ 205
35 -10.100PF17158.4; W0BW11_ENTCL/63-298; Membrane-associated sensor, integral membrane domain  ali follow..  14  1....................MTTYLIVMIALFFLDTIISIFIQMQ-FLSGLIYFIETIIVIQLPETAVFYFFRQLSFIFL-LISLIPLVMFPVLAHALSSYNPTWTLTIAAYVRYVNALIVLWSALACYM-RFSSGVWNSIIVVLSAITYNFFLLLLDTYNLSLWYIAVEVFSKLFVICTLLL........................................................................................................................................................................................................... 230
36 -10.100PF07133.11; Q8IJ54_PLAF7/184-370; Merozoite surface protein (SPAM)  ali follow..  4  1...................................................................................................................................................................................................GWEFGGGAPQNGAAEDKKTEYLLEQIKIPSWDRNNIPDENEQVIEDPQEDNKDEDEDEETETENLETEDDNNEEIEENEEDDIDEESVEEKEEEEEKKEEEEKKEEKKEEKKPDNEITNEVKEEQKYSSPSDINAQNLISNKNKKNDETKKTAENIVKTLVGLFNEKNEIDSTINNLVQEMIHLFSN.... 187
37 -10.100PF15049.6; Q32LD5_BOVIN/11-171; Protein of unknown function (DUF4534 topsan)  ali follow..  10  1...................AKMGSLLSGVFTITAVDLYLIFEQKYLRRNNCTEQMSQIKNTSILIKVFIICWSLTI-----VFLLSFITILVSCLLLYSVYAH-MHRGLLIYI--------VWIFFYETVIVVQCLTNDNSSAAEVRVMRWFGLVSRICMHSFWMFFVITYAYMIY.................................................................................................................................................................................................................. 144
38 -10.100PF14093.6; F4C7S3_SPHS2/129-333; Domain of unknown function (DUF4271 topsan)  ali follow..  12  53..........................FLYLLFGFTIGLFLYLYVSYGQLQLGYSEIGLFFTITALVLMLFVVKILITRAIGFV--IIFLPLLLVLSLVPTNHVKVWILVSCAVGLFVFAMQFLRASNTVLKSYQFSKFYLFIYLCTLEVGPILILIKL.................................................................................................................................................................................................................................... 204
39 -10.100PF03073.15; E3I2Y5_RHOVT/25-168; TspO/MBR family  ali follow..  16  27............NKPSWQPP-DWAFGPAWTIIYAFTALAAVYAWREAPTLTIIVLFLCTAFFNLLWSLLFFRLQRPDWALIEVGALWASVFIPIIVLARYSKTASWL---------LMPYLVWVTFAGFL---NYTVVQ....................................................................................................................................................................................................................................................... 144
40 -10.100PF17439.2; Y554_METJA/1-151; Family of unknown function (DUF5418 topsan)  ali follow..  26  5........................................HKAHASFMFKIINVFVSFGFNLILGILIYDIF--NIDENLVVACILIAMAFLILILTGGVHKELTYLQIY-YKLMCEFIREITISTISELATIATMILYQLQNPIKTITFLLLLIAFLAFGLIFTKLLIDAYFITL.................................................................................................................................................................................................................. 144
41 -10.000PF05934.11; CLCC1_RAT/3-541; Mid-1-related chloride channel (MCLC)  ali follow..  7  178....................VDPYNVFMVLLCLLCIVALVATELWTYVRWHTQLKRVCIISFLVSLGWNWLYKVAFACAKKMDWTENLWEWFRISWTYK-YYELLIVNPIWLV---ALAVTFTNFVTEPLKYIGKGTGE---FIKALMKEIPVLL----------QIPVLVILALAVLGFCYGAGQSVPMLRHFRGPEREPPRALEPDDRRRQKELDYRFHGGAGDADFSYRGPAGSIEQGPYDKMHVCERDVLRQRQVNMRFPSGNKSPEVLRAFDLPDTEAQEHPEVVPSHKPSIVNTSLKETSELPRESTLAECSQCAKDGSGQVPSTAESSPIVEKAQLKTDSECRPHSTEAAAAAARGTDPVSSPCG.............. 539
42 -10.000PF17608.2; Q74KI2_LACJO/1-124; Family of unknown function (DUF5504 topsan)  ali follow..  25  8........................IGLRILSWVITIT--LIIFIGNVHEYGLHFTYNQVLAIIIVILLL-------------VTTMYFSVTPKLLK-WN--------KYELVWWLCYLCAPIYLFLTNLY---STDLGYTIKFWLFFGGGAALIIISKYILKN............................................................................................................................................................................................................................... 122
43 -10.000PF14808.6; E2BTU3_HARSA/2-249; TMEM164 family  ali follow..  18  62.....................QDHVGRRVLLIMMSLVLGMEIGFKFTSRTVIYLLNPCHITTAIQLYLLAAAPSPTVTAVFRIHLNLLNGPVLAYLFPETESRIIFADRAMYYIQHGLMLVIPYYLLRLIEPLSDMSWSVLGFLNVGYHFWILQSVALPVQVNLSHMLC......................................................................................................................................................................................................................... 215
44 -9.940PF13687.6; A6TSA5_ALKMQ/158-379; Domain of unknown function (DUF4153 topsan)  ali follow..  19  3........................LGIAAILGTINLLFDAGIPGKFFFDVFLIVVFIILPLLSIYTLILYIYFGQILLPQGLIGNLVLWYSIVSTVVLPLRKNSQWMKYFITCLPKLIIPLLGMMFVALWIRIGITEGRYFVLLIGLWVTCMMIYYALKRDVKNIVLAMTLAIVALATVT.............................................................................................................................................................................................................. 202
45 -9.940PF09933.9; B8IFB7_METNO/4-160; Predicted small integral membrane protein (DUF2165 topsan)  ali follow..  19  3........................LSKTLVVAAVALLFSLVAFITDFGTNLPFVQHVLMMQAAYLIIIMIEISSAALCWIGFIQLLRHL-AVAFNRAKSVAIAGLTLGYLLWQVGLIAIGGEWF----GMWMSHEWNGIESSFRFLVMTLGALIYVSL.................................................................................................................................................................................................................................... 156
46 -9.880PF07376.11; M1CYC0_SOLTU/1-202; Prosystemin  ali follow..  5  2........................................................................................................................................................................................ETPSYDIKNKGDDMQEELKVKLHHEKGGDEKEKIIEKETPSQDIKNKDTITSYVLRDDAPEIPKVEHEEGGDGKEKIVEKETISKCIIKIEGDDAQEKLKVEYEEEEYEKEKIVEKGSPSQDINNKGDDPQEKPMVEHEEGDEKETPSQDIIKIEGEGAQEITKVVCEEREKIVVQVDLAVHSTPPSKRDPPKMQTDNNK.. 201
47 -9.870PF04235.12; A5UQH7_ROSS1/237-401; Protein of unknown function (DUF418 topsan)  ali follow..  22  23....................GSVCLAVGLIANLALAWQMRVTDLSSPLAGLWSILTLIALSYGYLALFVTLTRTDALAAAGRMALSYITQSIICTLIFYSYGLGLFLVISVTIWLVQLGVSVWL--LEWAWRS-LTYGK....................................................................................................................................................................................................................................................... 165
48 -9.870PF04544.12; UL20_PSHV1/59-243; Herpesvirus egress protein UL20  ali follow..  12  1...DLFTSAAYSWSEEDELGTRMRVASMFAKIICCLFLLWAKSCTG-TGLTACTGAYAIASLLCSFVVYYNVRTDNM-PFGTYTKLFQIAACIGCYALGLTMEKLFGDSEMYFA--LVGATAKGSALILPQGCSVAPYVPLAVSVAYCAAVVYDIADTIFPLLWVRTTLN........................................................................................................................................................................................................................ 185
49 -9.860PF17094.5; YOAG_BACSU/8-126; Uncharacterised protein family (UPF0715 topsan)  ali follow..  22  4.......................TLGLSSLTFGLLLGFYSFVMYGDM----IIALFTAAIALLYGFVVYGLFAVPLQMKLQKKARTFNVMYLLIYSV------------VAFIAAFLFF--VINEPASIAWTLQSYFYYMLSIAAAWLWDSLIL........................................................................................................................................................................................................................................ 119
50 -9.830PF00119.20; W8EVW8_9BACT/121-328; ATP synthase A chain  ali follow..  16  43IRDEVAKKSIGPKYERYMPYLLTVFFFIWFNNLMGLMPGGANLTGN-----IAVTLTLAVLTLLITLFSSNKNYWHHIFATPGVPKALLPIMIPVELIGIVVKPFSLMVRLFITAGHIVILSFISLIFIFGSVTVAPVTLAFGLFINMLELLVAILQAYI----FTLLTAMY...................................................................................................................................................................................................................... 207
51 -9.810PF07695.11; Q72MW7_LEPIC/129-333; 7TM diverse intracellular signalling  ali follow..  14  67.....................MNPFLAGLLEFSILLFTRDFLDTKNTFPTLHKYNHVLIILCAMASFSSFFVNLTQGALQVAILGLLTAISILASGIKALMSGFRPARYFMIAFSALLL-GGAFYALKTIGAIPVSFVTEYSMQIGSGLEVTLLSLGL.................................................................................................................................................................................................................................... 202
52 -9.780PF05279.11; ASPH_MOUSE/52-307; Aspartyl beta-hydroxylase N-terminal region  ali follow..  9  11.................................................................................................................................................SFFT---------------WFMVIALLGVWTSVAVVWFDLVDYEEVLGKLGVYDADGDGDFDVDDAKVLLGLKERSPSERTFPPEEEAETHAELEEQAPEGADIQNVEDEVKEQIQSLLQESVHTDHDLEADGLAGEPQPEVEDFLTVTDSDDRFEDLEPGTVHEEIEDTYHVEDTASQNHPNDMEEMTNEQENSDPSEAVTDAGVLLPHAEEVRHQDYDEPVYEPSEHEGVAISDNTIDD 236
53 -9.750PF04138.14; Q88RU4_PSEPK/14-127; GtrA-like protein  ali follow..  8  3..................................................LGIGFIATGVHYAVFLLLVTTEFVTPLLASICGGMVGAIASFIGNRALCFVADGSRKFPVRFALVALTTNFGNGVGMWFLIKSN------LSPLISQVVVTLSLTALGFIAHRFWTF........................................................................................................................................................................................................................... 114
54 -9.730PF14935.6; R4FKZ8_RHOPR/41-158; Transmembrane protein 138  ali follow..  19  1...................................................LFVVFQDAFLLMAVTCLCFSLFRTNVFKAGFVELLLYGFKGTIIFA------ALYIILTVSLQTFLLLL-NWLSALYIIQRFFAVL-----FYYFYKRSSLRLSDHRFYDEEWVK............................................................................................................................................................................................................................ 116
55 -9.730PF04403.13; B3EAR6_GEOLS/49-206; Paraquat-inducible protein A  ali follow..  17  1....................LRRCWALLLASYILYIPANLMVMMETGTLIGVIHLWHNGNPGIATIVFIA----SILVPLFKLVVLTLLLLSVRRGSTWGIKHRIKLYRIVELVG-IFVVTLLAALVQIQSFATVRAGAGAIAFGAVVVLTMFAAMEFDPRLMWDPL........................................................................................................................................................................................................................... 157
56 -9.710PF11877.8; Q8Y5L3_LISMO/9-120; Protein of unknown function (DUF3397 topsan)  ali follow..  19  4.........................................................IIILPVVVFILTMFFQRRIMLAADLSTIFLIIVHFFMIVLFN-RSFLLYILLFLFILGIVIVVTAAKKEGEIQFKILRGYWRL-CFFIFALLYVALYLYGI.................................................................................................................................................................................................................................... 112
57 -9.660PF16883.5; Q2G176_STAA8/4-200; Domain of unknown function (DUF5080 topsan)  ali follow..  20  2............................LLIVVAGLYYIIYLTAVMYSEKIVVLPIIIYAIVFVIIGITYIFIGDSYDQLTNFNVILYMGSLFYANLWN--EIAKYKGIISLIVAIVLTVLMTLKSTPQI-TAETRDLSISFFILSLFIIIIFAVWDLFIRVRKGAFILFSCWLFILNMIL............................................................................................................................................................................................................. 196
58 -9.650PF10688.9; F0LZT0_VIBFN/6-164; Bacterial inner membrane protein  ali follow..  12  1.........................SLAQALGFVSFGLGISTFYQKNDRRLKIVMFVFNLNHLLHFILLGSAVSALSAALSAMVAALFLLAGAGLGLAIADHWWDLWPVIGTMIGTFAIFMLRGIQMRIAFLVGACCWLTNNILVGSIGGTLLEMTVI.................................................................................................................................................................................................................................... 145
59 -9.610PF16311.5; H2L5R6_ORYLA/1-133; Transmembrane protein 100  ali follow..  20  1MPEEVNKDAMRTPSTSDKATNSERPAATATAVNIPLVNEVQLTAA--TGGAELSCYRCTI------------------PFGVVVLIAGIVVTVVAYSFNSHGSTIYFGLVLLSAGLLLLASSAI-----CWKV............................................................................................................................................................................................................................................................. 109
60 -9.570PF04144.13; I3KED7_ORENI/121-296; SCAMP family  ali follow..  13  2.....NNWPPLPERFPVAPCFYHDITVDIPVEFQKTVKIMYYL---WMLHTGTLFANLIACLSWFAVDGNRGVDFGLAILWLLLFTPCSFVCWYRPIYAAFRSDSSFRFFIFFFVYVCQIGIYVIQSIGIASWGAS---WISALTGLNKSIPVGLIMILVAALFTTLAVLSLIMFK.................................................................................................................................................................................................................. 167
61 -9.550PF17178.4; I2B9L9_SHIBC/27-213; Membrane-associated sensor  ali follow..  23  64.....................ALSLSLSMVLLLAIGLMWSYSCYYFIVWWHLPSGWPLMVILMLSALALYYHPRALLLFLFPLWVAALVFGTWLNPGARGHFLLMWILLTATLAGGWYILQRWFSLIARLDLL............................................................................................................................................................................................................................................................. 187
62 -9.530PF09925.9; R6I1F8_9PROT/8-142; Predicted membrane protein (DUF2157 topsan)  ali follow..  16  1............................................SDWQKRGLILLFLSCFCIGIGVIAVIAANWEAIPAAVKLGVDFTLLCTAAWGVWHSRRKGRNLAAEALLTAFALLVLGSIGLVGQIYHLPAHGLSALLFWSVLTFPLLFLS....................................................................................................................................................................................................................................... 134
63 -9.490PF11143.8; B7VIL3_VIBTL/8-153; Protein of unknown function (DUF2919 topsan)  ali follow..  14  10..........GFLKAPI------LLWLGWLFLAKALVVFIVAGASRESGTDILETIGIALSVPSLLLMWLFGLRSPDRKRLNKVVSWGRWVTMMAILAQGSHTIYLIYLDNGWFRWSNAITLLLLLWLALYLTNSH--AARDCF.................................................................................................................................................................................................................................................. 144
64 -9.490PF04647.15; R7GF61_9CLOT/6-183; Accessory gene regulator B  ali follow..  14  24.......................NYGLQNIIGEIPKIFITLGI------AYLLGIFKLTLITFLVIMPYRSFSGGFHLKTHLGCIIFYCGIAFASKYIVLEQAIKYLLIFLVWVFGMFMVKLYAPADTENVPILRKKDRRKKQILSYIALSVGLIVAAFVPSNELANILIFGNLVQTLFI.............................................................................................................................................................................................................. 178
65 -9.480PF14126.6; Q5LC29_BACFN/2-148; Domain of unknown function (DUF4293 topsan)  ali follow..  14  5......................QTIYLLLVTALLITSMCLPVGSFIGADAAMYVFKPLGVEMNGTLYSTW--------GVFGILLLSAIIAFATIFLFKNRMLQIRMTIFNSILLIGYYLTFLAFMFVLKKDLSATFQISWALCLPLISIILNWLAVRAIGRD............................................................................................................................................................................................................................... 137
66 -9.400PF10101.9; B2U841_RALPJ/177-938; Predicted membrane protein (DUF2339 topsan)  ali follow..  13  1.................GGNSVVRVGILVLFFGVAFLL--YAADNSLLPVEFRLAGVAVGAIVLLGIGWRLREK--LVLQGGGVGVLYLTVFAATRVVPLLSPAFPLLVLICALAAGLAVKQNAPALAFTGSAGGFLAPILIALFSYYALLNAGIFAIAWFRAWFTFGIATAWGV................................................................................................................................................................................................................... 179
67 -9.390PF17336.2; A1BB62_PARDP/1-112; Family of unknown function (DUF5368 topsan)  ali follow..  25  1................................MKELTFGTLIAVFEEIFGRGLFWIMVALAALVTLAYLYVLIRDLSMPFGAILAVIFVQRMTHSGLRDIGGPI----IVLLGVAVLGAVGILVYTLQSLLR.............................................................................................................................................................................................................................................................. 112
68 -9.380PF10242.9; LHPL5_RAT/25-202; Lipoma HMGIC fusion partner-like protein  ali follow..  13  2.......................GVMWGTLTICFSVLVMALFIQPYWIGDSVSTPQAGYFGLFSYCVIPSRAFKTAMFFVALAMFLIIGSIICFSLFFVCNTATVYCAWMQLAAATGLMIGCLVYPDGWKYTLGHC-WAFMLAILSIGDALILSFLAFVLGYR............................................................................................................................................................................................................................... 178
69 -9.370PF04538.12; H0W9V3_CAVPO/1-176; Brain expressed X-linked like family  ali follow..  6  2...............................................................................................................................................................................................KKLCSGNEGKPEKERKAEDKLEPDDEGKIEKEEKTDHEGKPAFEGKLEGEGEPNVERQGKNEGKPEMQSKLGDEGSPQGEGNAESQARPENKQLPAEKHLAEDYVPRKAKRKTDRGTEDSPKDSQENLQDTHLSREEMMREFADMSRGQEELRKKQRINNFYWMQRELLDAYPPR.................... 176
70 -9.370PF07666.11; Q8EWG6_MYCPE/16-144; M penetrans paralogue family 26  ali follow..  28  15....................................ILWLYLVF-------------FIAFFIMLLSYVFIMVPIISNPEEASLKSSVLIGIALIAISSL----LLMGIGIAIFVLEIMLTVRVSGAE---------------FRNTSTHTVLLIIGIIL---WPCVVIDCFILN................................................................................................................................................................................................................... 124
71 -9.360PF07284.11; Q16DR8_ROSDO/15-153; 2-vinyl bacteriochlorophyllide hydratase (BCHF)  ali follow..  20  12............................................TVWT--GVLAPLQFAVFLVSLVLVVRYLWNGEGYVIATWSIVLKTMLLYLIMVTGAIWEKIVFGQYLFVFSFAVIALHTAYIWALFSDAMSTMILALTAYGAYVINAIQFILKL.................................................................................................................................................................................................................................... 137
72 -9.350PF06513.11; Q25920_PLAFA/526-740; Repeat of unknown function (DUF1103 topsan)  ali follow..  6  13.......................................................................................................................................................................................EKNDGKKDKVIGSEKTQKEIKEKVEKRVKKKCKKKVKKGIKENDTEGNDKVKGPEIIIEEVKEEIKKQVEDGIKENDTEGNDKVKGPEIITEEVKEEIKKQVEDGIKENDTEGNDKVKGPEIITEEVKEEIKKQVEEGIKENDTEGNDKVKGPEIITEEVKEEIKKQVEEGVKENDTESKDKVIGQEIITEEVKKEIEKQEEK 215
73 -9.350PF03798.16; A8BKJ1_GIAIC/51-260; TLC domain  ali follow..  10  41...............PLRLSFSANVHKFFICSLLFLFSETRKNNKDFT---VMLAHHVIACTLIVAGYSFRHYN-----FGLILANLHDVSDIFLEASKIINLTIGEPWSLVTFVLFAL--TFFIARIVVYPT--YLIIPPIAGKLHRWGFYGVLTSLYVIDVYWMVMI......................................................................................................................................................................................................................... 208
74 -9.330PF11200.8; A7AQJ9_BABBO/2-370; Protein of unknown function (DUF2981 topsan)  ali follow..  8  4...................................................................LFYIAIQQFLLGISLYSVIHYL---------SLTQLAWLLFGTNAISAVLGFMG--------ALKRNIVM----CVYLVFYAISLFLIFLTVLD------MAELVHLLPRGPQLKDVSDFASIRSAALPSTALMRSNAFLRQRELPYAFDQNDSLELGDSFPALVSDDNKTLEDSISTASTDAEDNIPSKNLRMPQTEEMPINQHVGNDLNMPGNGAMPISGNIDAVTGNLEPASKAIQQTTPNVNESMKIPNEMPMPYGNSKEAKSAELPIAIPEQTVAKNTYDAKTETFYDRLPLVPHIGETEGEAEEVSKDELPPE 298
75 -9.310PF11076.8; A6T6N4_KLEP7/1-134; Putative inner membrane protein YbhQ  ali follow..  22  11...............................................TG---LSCWQIMLHLLVVAVLVMGWMSGALVRVGLGLCVLYSVTLLAMLFLQRHHEARWRDV-----------GDFLEELTTTWYFGAAMIALWLLSRVLHNNLLLALAGLVILAG--PAVVSLL...................................................................................................................................................................................................................... 119
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Pawlowski K, Pio F, Chu Z, Reed JC, Godzik A. PAAD - a new protein domain associated with apoptosis, cancer and autoimmune diseases. Trends Biochem Sci. 2001 Feb;26(2):85-7.