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Query: PF05834.12; LCYB_ARATH/84-479; Lycopene cyclase protein, from PfamA32U

Results of FFAS03 search in PfamA32U
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst DLAIVGGGPAGLAVAQQVSEAGLSVCSIDPSPKLIWPNNYGVWVDEFEAMDLLDCLDTTWSGAVVYVDEGVKKDLSRPYGRVNRKQLKSKMLQKCITNGVKFHQSKVTNVVHEEANSTVVCSDGVKIQASVVLDATGFSRCLVQYDKPYNPGYQVAYGIVAEVDGHPFDVDKMVFMDWRDKHLDSYPELKERNSKIPTFLYAMPFSSNRIFLEETSLVARPGLRMEDIQERMAARLKHLGINVKRIEEDERCVIPMGGPLPVLPQRVVGIGGTAGMVHPSTGYMVARTLAAAPIVANAIVRYLGSPSSNSLRGDQLSAEVWRDLWPIERRRQREFFCFGMDILLKLDLDATRRFFDAFFDLQPHYWHGFLSSRLFLPELLVFGLSLFSHASNTSRLLast
1 -95.700PF05834.12; LCYB_ARATH/84-479; Lycopene cyclase protein  ali  100  1DLAIVGGGPAGLAVAQQVSEAGLSVCSIDPSPKLIWPNNYGVWVDEFEAMDLLDCLDTTWSGAVVYVDEGVKKDLSRPYGRVNRKQLKSKMLQKCITNGVKFHQSKVTNVVHEEANSTVVCSDGVKIQASVVLDATGFSRCLVQYDKPYNPGYQVAYGIVAEVDGHPFDVDKMVFMDWRDKHLDSYPELKERNSKIPTFLYAMPFSSNRIFLEETSLVARPGLRMEDIQERMAARLKHLGINVKRIEEDERCVIPMGGPLPVLPQRVVGIGGTAGMVHPSTGYMVARTLAAAPIVANAIVRYLGSPSSNSLRGDQLSAEVWRDLWPIERRRQREFFCFGMDILLKLDLDATRRFFDAFFDLQPHYWHGFLSSRLFLPELLVFGLSLFSHASNTSRL 396
2 -26.700PF04820.14; Q9A4M5_CAUVC/6-464; Tryptophan halogenase  ali follow..  11  1KIVIVGGGTAGWISASGLAALPITIELIESAETIKLGIQFCDWGRKGEAYLPIMAGLAGKFAPPSSDPRSLGSTFNYAYQ-FDASLYAQYLRAYSEARGVTRTEGKITSVQQRPNDGGVTLEDGRVVEGDLFIDCSGFRGLLIEGA------------LQAGYEDWTQWLPCDRAVAAPCASVEAPTPYTRATADRFGWRWRIPLQHR---VGNGHVYCSSYVSDDEAARALVENLDGELQQDPRFLRFVTGR-----RKKQWFKNVVAVGLSSGFLEPLESTSIHLIQVAVTTLLELFPHRGFDPADEDEYNRVMDLEF----------------------------ERIRDFLVLHYHANQRDDSPFWIEEGPIPDSLAYKMALFRE....... 419
3 -25.400PF01494.19; TCMG_STRGA/16-391; FAD binding domain  ali follow..  11  3PVLIVGGGLTGLSAALFLSQHGVSCRLVEKHRGTTVLTR-ASGISSRTMELLRGVLERTVIERGPKLVEDVGHLSPTRPYWCGQDRLEPILRDEAVRRGARIDFNTRMEAFTADESGVTATGEQSTVRARYLIAADGVRSPVRETLGITHGTIGNAMSVLFKADLRDTVKGRRFVICYLPNPDEPGVL------QLPEVPAVLQLFDEDRWIFGFFFDPRETSPEQFTDERCAQIIRTAPGLPVEVQMARPWEMSHNSARSYRSGRVFLAGDAAHVHPPAGAFGANGGIQDAHNLAWKLAAVLK-GTAGDALLDTYEQE............................................................................. 364
4 -19.800PF01266.24; Q89E97_BRADU/6-350; FAD dependent oxidoreductase  ali follow..  14  1DAIVIGGGIHGCSTTLHLCLAGLKPVLIEKDYAGRHASGVNALIDATELRRLVPAVAETCPGGVVSRRDGA----------ANPAQTTTAFRRKAEQLGATVREGVAASNIRYSDGLWYVDVGSDTYAAPVLVNAAGAAGKIAAALGEPVPVETVAPMLMITSRVPHFIDPVVILRGRK--------------------LSFKQFSNGTVLIGGGH-RNETVLDWKSLAISARTVFELFVMRSATIVRAWAGIIPVFGPSSRHKGLYHQFG--------FSLHGFQLGPGAGAVMAEL.................................................................................................. 345
5 -18.400PF12831.7; D3E9Q8_GEOS4/21-437; FAD dependent oxidoreductase  ali follow..  14  1DVVVVGGGPTGIAAAIAAANNGANTLLIEQRGFLGGMGTTACPFTDHEKPVIRGIGLELMERMKANCKPSYITEYKLDWVPIDVEVLKRVYDEALLESGAKVLFHTFVGQLVMNPGGHGVNSGRSIVEAKYVIDATGDADIAALAGAPFQKGGDAGELQPGTMCYLLTNVNRERFRQYMRDSGDTGQIPQFEDAHLVSTGEQIGIRETRRIVGDYMLVQDDFISMRSFEDDIHMATSKENMEIHHLPPGRSHGVPYRSLLPQGLANVWVAGRAASADRVVQGSCFAMGQAAGTAAAICAMTGSTSREVDIKQLQR................................................................................. 415
6 -18.100PF08491.10; Q6CJX6_KLULA/205-477; Squalene epoxidase  ali follow..  10  1...............................................................................................................................KAHLTFVCDGIFSRFRKELSPDHIPSVGSSFVGM------------SLFHANIPSKNHGHVILGTSHMP---VLVYQISSEETRISARLPKDIKSWLTTDVKPYLPKSLLPSFDKAVEDGKFRSMPNSYLPAKQNTVTGLCVIGDALNMRHPLTGGGMAVGLNDVALLIKTVGDLDFSDRETVLDELLEYHFALYSLFAADNRNLQVLQRGCFKYFERGGLPKPFLLTKVFFSVALYSIYVNFQERGILGSPLALL............. 273
7 -16.700PF13738.6; E4RQY1_LEAB4/3-286; Pyridine nucleotide-disulphide oxidoreductase  ali follow..  17  1..VIIGGGPIGMACGIECKKAGLDYVILEKGCLVNS-------------------LYHYPTTMTFFSTSERLELDNIPFVSPTRAEALEYYRRVAQNQQLNIHLFEEVSDVYKVEKGFEVKTSKRTYSAEKVILATGFYDI............................................................................................................................................................................................................................................................... 124
8 -16.700PF03486.14; Q8EKN8_SHEON/4-393; HI0933-like protein  ali follow..  12  2DVIIIGAGAAGLMCAATAGYRGRDVLVLDNAKQAGRKILISG-EPANFICGNPHFVKSALARIELVERHGIEYHERDHGQLFSAKEIVTMLLTECEWAGVSIKLRTDILSVGKNEAGRELNTSNGELSCDSLVIATGGLSMPKLGATPYGYQLAEQFGLKVLPTHAGLKAGETIKINLLPNMDEQQLAAHPKQSLRNTLSLWLPKRLVEVLFDEVLLNKALNQLVHAERAKLVDDLHRWTVLMNGTEGYRTAEVTLGGMEAIKVPGLFFIGEVMDVSGWLGGFNFQWAWASGVAAGKA.................................................................................................. 390
9 -16.600PF01946.17; THI4_SCHPO/60-299; Thi4 family  ali follow..  17  19DIVIVGAGSAGLTAAYYIGTRDLKIAIIEASVAPGGGAWLGGQLNEIGVPYEDEGDYVVVKHAALFTSTVMARTLALPVKLFNATAVEDLIVKEGKDGKQRIAGVVTNWTLVSLNHGLQSCMDPNTINAHLVVSATGHDGPFGAFC.......................................................................................................................................................................................................................................................... 181
10 -16.000PF13434.6; Q4K9A7_PSEF5/9-357; L-lysine 6-monooxygenase (NADPH-requiring)  ali follow..  13  4DLIGIGFGPSNLALAIALEERGLDALFLDKQADYRWHGNTLVTQSELQISFLKDLVTLRNPTSPYSFVNYLKHHINLGTFYPCRMEFNDYLRWVAGHFQEHSRYGEEVLAIEPVLHNQQVQGSELVRTTRSVVVSAGGTARVPETFKGLKGDARVFHHSQYSQPCVSGKPMNIAIIGGGQSAAEAFIDLNDSFPSVTDLVFQQTGSERERLVSEYQNTNYSVVDIDLIERIYGIFYRQKVSGIARHATATDLGIELILRNSASGEREVR---HYDAVVLATGY................................................................................................................. 347
11 -15.600PF13450.6; B4RE46_PHEZH/425-493; NAD(P)-binding Rossmann-like domain  ali follow..  34  1...IVGAGFAGSVLAERLTQLGKRVLLVDRRPHVG......................................................................................................................................................................................................................................................................................................................................................................... 33
12 -15.200PF07992.14; I6L922_STRMU/209-496; Pyridine nucleotide-disulphide oxidoreductase  ali follow..  12  2DVLVIGGGPAGNSAAIYAARKGVKTGLLAETM---------------------------------QVMETVGIENMIGTPYVEGPQLMAQVEEHTKSYSVDIMKAPRAKSIQKTDLVEVELDNGAHLKAKTAVLALGAKWR---------------INVPGEKEFFNKGVTYCPHCDGPLFTDKKVAVIGGGNSGLEAAIDLAGLASHVYILATKEIIGNDHVEGLRYSDRTTNEEYLLDLKDSGLALNEKGEIIVAKDGATNIPAIFAAGDCTDQIIISMGSG................................................................................................................ 288
13 -14.900PF13454.6; A1R325_PAEAT/10-186; FAD-NAD(P)-binding  ali follow..  16  1..ALIGAGPRGTSVLERLLANTLHIDVVDPYPPPLAGGSFDQWREARRRDGMGLNDAEKAELSTLESHNFPSRAIYGRYL---RQTLDGLLERLPDGVKVTFHETLAVAARPVADGFDVELASGATLTVGSVVLALG................................................................................................................................................................................................................................................................... 175
14 -14.400PF06039.15; C1DJ81_AZOVD/24-513; Malate:quinone oxidoreductase (Mqo)  ali follow..  8  4DVLLIGGGIMSASLGTYLKEPDWTIDIYERLDQVAEESSNPWNNAGTGHSAFPKSFINDVPHISFVWGDENVAFLKKRHTDVNFGEITRQLMGALTRHGVTLNLKHEVRDFVRNDDGTWNVTEEKTVKAKFVFIGAGGGAPLLQKTGIPEADGYAGFGQFLYTTNPEVVERHLAKVYGKASVGA-------PPMSVPHLDTRVIDGKRAILFGPFATFSTKFLKKGSLLDMPRSLIGQLMLSQEERIEELREYFPQAKAEDWKLL---TAGQRVQVIKKGASPGASTAAPIMLTVLEKTFKDRIGTPEWQAKLKEIVPSYGQKLNNNIELTNNIR............................................................. 481
15 -13.100PF01134.22; MNMG_DESPS/17-409; Glucose inhibited division protein A  ali follow..  14  1DIVVIGAGHAGCEAALAAARLGHKTLLAVMNVDTIGAMSKGHLVREIDALGGEMARVIDATSIQFRLNTSKGPAVQSSRAQADRLLYRLQMKSVIEHENLTVSQTEVNGFIVEDGKITVTTTIDEKISVKAAIVATGPAGRLGDGPSTGLADWFYDNGFAVRIDSLTIDYSELEAQESDMPPAHFSFDSQGKGYTLPQLPCYITYTNEKTHEIIRKGIDQSPLYAGIIQGIGARYCPSIEDKIMRFPEKDRHQVFLEPIKGLENARIIRPGYAAGQINGTSGYAAAQGLMAGINATRYLEE............................................................................................... 391
16 -11.300PF00996.18; I1K489_SOYBN/1-433; GDP dissociation inhibitor  ali follow..  13  6DVIVLGTGLKECILSGLLSVDGLKVLHMDRND------YYGGESTSLNLIQLWKRFRGDDKPPPHLGASRDYNIDMNPKFIMANGNLVRVLIHTDVTKYLYFKAVDGSYVFNKGKVHKVPANDMEALKSPLM---------------FEKRRARKFFIYVQNYNES--DPKTHEGMDLTRVTTKELIAKYGLDDNTIDFI--------GHALALHSDDRYLAEPALDTVKRMKLYAESLA----------------------------RFQGGSPYIYPLYGLGLPQAFARLSAVYGGT................................................................................................. 248
17 -10.800PF00070.27; AHPF_ECOLI/357-437; Pyridine nucleotide-disulphide oxidoreductase  ali follow..  20  1RVAVIGGGNSGVEAAIDLAGIVEHVTLLEFAPEMKADQV..................................................................................................................................................................................................................................................................................................................................................................... 39
18 -10.800PF06690.11; D7DUD4_METV3/2-259; Protein of unknown function (DUF1188 topsan)  ali follow..  13  43QAIIFGAYLSGNYIANTLKADCGEVILIDSQPHL-----------DIVTGNGIKFMDLNTFMLKLRNNKDKEINPDL-----------------IDVTGLG---GVDPNMLKDFDPKVLIIEDPKSSFDKELMEADNTHKRLC............................................................................................................................................................................................................................................................. 156
19 -10.600PF06100.11; G8PAJ4_PEDCP/22-520; MCRA family  ali follow..  12  3SAYLVGSGLASLAAATFLVRAGDRIHVLEELGLPGQDKQIDEVFSQEF---FDSNFWLYWSTMFAFEPWASALEMRRYLLRF-YESLIIPMVKFLESKGVHFQYNTTVDNILVNRVGTGKVATKLEMTESTTYGDNTHAAPVEHELGATWQLWKNLFGHPEKFYDNIPDANWTISGTITFNDDRVTPYIEKISQKDPHSGWLLGYKPNELVVWVYGLFSDKECTGIELCEEWLYHIGVPEDQIVDIATNSASTIPA-LVVPEGSVNLAFIGN---FAE--TERDTVFTTEYSVRTAMEAV................................................................................................ 498
20 -10.100PF00670.21; SAHH_DICDI/191-351; S-adenosyl-L-homocysteine hydrolase, NAD binding domain  ali follow..  11  26.AVVAGYGDVGKGCAQSLSKMGARVLVTEIDPINALQAC----MDGYQIVTMETAAPLS--NIFVTTTGCRDIVRGEHFAVMKEDAIVCNIGHFDCEIDVAWLNANAKKDTLANGVHIILLAEGRLVN---LGCGTG................................................................................................................................................................................................................................................................... 161
21 -9.880PF02558.16; Q9K9R6_BACHD/6-154; Ketopantoate reductase PanE/ApbA  ali follow..  21  1.VAVIGSGSIGLLLYAYLKLANWPALLVTNRPE........................................................................................................................................................................................................................................................................................................................................................................... 32
22 -9.660PF00743.19; FMO1_HUMAN/2-532; Flavin-binding monooxygenase-like  ali follow..  14  4.VAIVGAGVSGLASIKCCLEEGLEPTCFERSDDLG-----GLWRFTEHV---EEGRASLYKSVVSNSCKEMSCYSDFPFNYVPNSQFLEYLKMYANHFDLLIQFKTKVCSVTKCSDVTMHEEKQESAIFDAVMVCTGFLTN-PYLPLDSFPGINAFKGQYFHSHPDIFKDKRVLVIGMGNSGTDIAVEASHLAEK----GWVISYPWDMVFMTRFQNMLRNSLPTPIVTWLMERKINNW-LNDELPGRIITGKVFIRPSIKEVKENSVIFNNTSKEEP-ATGYTFAFPFLDESVV..................................................................................................... 342
23 -9.270PF02254.18; Q92CZ9_LISMO/5-120; TrkA-N domain  ali follow..  17  1.FAVIGLGRFGGSICRSLVEQGMEVLAIDSDEEYMSIATHAVIANSTDENALRQLGIRNFEHVIVAIGEDIQSSIEMGVKYVTAKATNDKHAKLLDKIGAD....................................................................................................................................................................................................................................................................................................... 111
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Li W, Pio F, Pawlowski K, Godzik A. Saturated BLAST: an automated multiple intermediate sequence search used to detect distant homology. Bioinformatics. 2000 Dec;16(12):1105-10.