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Query: PF05918.11; D7TJH2_VITVI/11-547; Apoptosis inhibitory protein 5 (API5), from PfamA32U

Results of FFAS03 search in PfamA32U
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst IEKLYEYGERLNEAKDKSQNVEDYRGIIAAAKGSIKAKQLAAQLIPRFFKFFPDLSDAAVDSHLDLCEEEELGVRVQAIRGLPLFCKDTPEYVSKIVDILAQLLTAEENVERDAVHKALLSLLRQDVKASLTGLFKHIMTVDDPSTDENLREKVLNFIRDKVFPLKAELLKPQEQMERHITNLIKKSLEDVTGAEFKMFMDFLRSLTLFGEKAPPERVQELIEIIEGQADLDAQFNVSDGDHIDRLISCLYMALPFFVRGASNSKFLNYLNKHIIPVFDKLPEERKLDLLKNLAESSPYSAPQDSRQILPSVVQLLKKYMPRRKTGEETNFTYVECLLYTFHHLAYKAPNATNSLCGYKIVTGQPSDRLGEDFSEYYKDFTERLTHVEELARATMKKLTQGMAEHNKAMAAAKSDEAKDNIKTQKQNTTTGLRTCNNILAMTQPLHSKSPSFIGDKRINLSWKEATKPSVPSTAMAAGGKRPASTTNGASNAAAKKGRGAGGLQNQLVNRALEGLSHGGRSGIRGRGRGWGGRGRGRLast
1 -108.000PF05918.11; D7TJH2_VITVI/11-547; Apoptosis inhibitory protein 5 (API5)  ali  100  1IEKLYEYGERLNEAKDKSQNVEDYRGIIAAAKGSIKAKQLAAQLIPRFFKFFPDLSDAAVDSHLDLCEEEELGVRVQAIRGLPLFCKDTPEYVSKIVDILAQLLTAEENVERDAVHKALLSLLRQDVKASLTGLFKHIMTVDDPSTDENLREKVLNFIRDKVFPLKAELLKPQEQMERHITNLIKKSLEDVTGAEFKMFMDFLRSLTLFGEKAPPERVQELIEIIEGQADLDAQFNVSDGDHIDRLISCLYMALPFFVRGASNSKFLNYLNKHIIPVFDKLPEERKLDLLKNLAESSPYSAPQDSRQILPSVVQLLKKYMPRRKTGEETNFTYVECLLYTFHHLAYKAPNATNSLCGYKIVTGQPSDRLGEDFSEYYKDFTERLTHVEELARATMKKLTQGMAEHNKAMAAAKSDEAKDNIKTQKQNTTTGLRTCNNILAMTQPLHSKSPSFIGDKRINLSWKEATKPSVPSTAMAAGGKRPASTTNGASNAAAKKGRGAGGLQNQLVNRALEGLSHGGRSGIRGRGRGWGGRGRGR 537
2 -12.900PF01602.20; Q22601_CAEEL/28-590; Adaptin N terminal region  ali follow..  10  7.KELANIRSKFKGDKTLDQKKKYVCKLL-LSSNKYTEKQIGYLFISVLIEQQSDLMKLIVQGIRNDLTSRNPVHVNLALQCISNM--GSREMVEAFCTDLPKLLVSGETIVKQSAALCILKLFRNSPDSFQPGDYASRIVHLLNDSHMGVVTSAASLIEALSKKWPEEYKGAVPLAISRLSRIVTATYTDLQDYTY-KLLRLLQNYPPPDDPSNKARLLECLEGILNKAQDAPKSKKVQHSNAKNAV--LFEAIALIIHMDSEPQLLVRACNQLGTFLSHRETNLRYLALESMCLLATSLYAMCDRSNANQIVAEMLAYLETA--DYSIREEMVLKVAILAEKYATDYTWYVDVILKLIRIAGDYVSE------EVWYRVIQIVVNREDVQGYAAKTVFEALQRPACHENMVKV........................................................................................................................... 471
3 -12.500PF10508.9; A7SP09_NEMVE/2-505; Proteasome non-ATPase 26S subunit  ali follow..  9  2AEKCKELVENISNA-SGDEIVAFLRDLSVLISSSPNIRDLCKNILKNILKFEKAPATKYHDAVIEGLNHPTEDVRELCLIELERCSGTVNGVLEDLLSYIARGMADEHLKNAQIASNVFTNLAKHEARMRVYDMYITVQAHSPKAFDVCKESGIFEKLISELDGRDVLVQMNCLELLTKLVTKLNNLLLEVETDPLITLIGIIKFFGTLATAHPLETTQQYPQFLEQTYSMISCGDPTLMPIAMETIGVIAHSEDGLRAVFNNQGRNKHIMKTIFGHATSSQVDLRKRALEALASIFYSEQLTPSEELCEFALEAIFTVAKQPFEELRCCPGFLEYLLDRRTEFEKSGKEHKYDLIKELVHFPPAKQIFDRPYFLRLQEYERE.......................................................................................................................................................... 487
4 -12.400PF12717.7; G8Y240_PICSO/105-271; non-SMC mitotic condensation complex subunit 1  ali follow..  12  2....................................IRALAIRTMGCV----ARMVDFIEIPLKRTLSDDNPYVRKTAAICVAKLFDLSPKACVEFLDQLRGLIKDSNPMVVANALNSLFEIKDMNVDSSLVVLLIKTLLMCLNECTEWGRITILDTLT--------KYEASSSEEASHIIDRATPQLQHANPSVVLSSIKVI.............................................................................................................................................................................................................................................................................................................................................. 165
5 -11.800PF12348.8; B8M2E9_TALSN/325-551; CLASP N terminal  ali follow..  7  5LRNMLPHFEGRETEHNWIPREKSVETLRRLVRGNAPQ---------TYSQHFIAGIKSLLDGILKVVNSLRTTLSTTGCLLIQEIAKV-DNMVEILLQNMIKLCAGMKKISAQNANATVDAIIS---NVTYVPRILQHLSFACQDKNVQPRLFAAGWLKTLLNKQARHKSSIEHGGGDLVEKCIKKCLGDPNPGVRESMRGTFWTFYKIWPDRAEEIISTLDAKSKTLLE................................................................................................................................................................................................................................................................................................................... 227
6 -11.200PF12719.7; M3XT68_MUSPF/558-858; Nuclear condensing complex subunits, C-term domain  ali follow..  11  1.KCLILCYELLKQMSTSTGIGATMNGIIEIVSVHPVIRNLAVLCLGCCGLQNQDFASKHFVLLLQVLQIDDVTIKISALKAIFDQLKEETATAKNVLKLLSDFLDSEVSELRTGAAEGLAKLMFSGLLVSSRILSRLVLLWYNPVTEEDVR--LRHCLGVFFPMFAYASRTNQECFEEAFLPTLQTLASAPASSPLAEV-------------DITNVAELLVDLTRPSGLNLQAKNSQDYQ-----------------ALSVHDNLAIKICNEILTCPCSPEIRVYTKALGSL.................................................................................................................................................................................................................................................... 299
7 -11.100PF17741.1; A0A151PBS4_ALLMI/1-268; Family of unknown function (DUF5578 topsan)  ali follow..  14  126IKLLQLVANAGRKYKELICESYGVRSIAEFMSKSEKAQRQVQILLDSLGHGNPKYQNQVYKGLIALLPCTSPHAQQLSLQTLRVVQAIVGKSHPSIVEAVLGVLRSMELEVQYEAIQLIKDLTSYDVRPALLRGLVALLK............................................................................................................................................................................................................................................................................................................................................................................................................. 267
8 -10.900PF05804.12; KIFA3_HUMAN/13-720; Kinesin-associated protein (KAP)  ali follow..  9  229LSKKKKAVDEDPENQTLRKDYEKTFKKYQLVVKQEQLLRVALYLLLNLAEDTRTRNKNIVHMLVKALDRDNFELLILVVSFLKKLSIFMEN--MDIVEKLVKMIPCEHEDLLNITLRLLLNLSFDTGLRNKMVQVGLLPKLTALLGNDNYKQIAMCVLYHISMDDRFKSMFAYTDCIPQLMKMLFE---CSDERIDLELISFCINLAANKRNVQLICEGNGLKMLMKRALKFKD-------------PLLMKMIRNISQHDGPTKNLDYVGDLAAQISNDEEEEFVIECLGTLANLTIPDLDWELVLKEYKLVPYLKDKLKPGAAEDDLVLEVVIMI........................................................................................................................................................................................................ 560
9 -10.200PF13646.6; C3YB05_BRAFL/324-412; HEAT repeats  ali follow..  14  5..........................KKLLVDEDPNIRAVASIALGKT-----TCTPDIVEALVNLLKDEDRLVRESTCVSLGYL--------QDAVPHVINAWRNDISHVREAAQAALR................................................................................................................................................................................................................................................................................................................................................................................................................................. 89
10 -10.100PF14631.6; U3I414_ANAPL/1-1417; Fanconi anaemia protein FancD2 nuclease  ali follow..  11  154ITLLLEKIPEFFFDVVGTFGTNFPRLIVNQFK--LDSQDLVKKLMQMLSVSPVPIQHDIITSLPEILEDSQ---QSEVARELGCLLKEGRRLTVPILDALSRL----DAELLAEVQQSAMTIVPSVKLEDLPVVVKFILHNVKAANAVEVISDLRKNLDLSSCVLPLQIVGSQKKLKSQVQTSSSTSQVTTSQNCVKLLFDVIKLAVRFQ----KDVSEAWIKAIENTTSVSDHKKVLDLIVLLLIHST-KQAEKVLRSKIRLGCMPEQLMQNAFQDHSMVIRDFFPSILV-LAQTFLHAAHPAIVSFGSCMYKQAFAVFDSYCQQ--------EVVSALVTHVCSGNEAELDIALDVLTDLVVVHTSLLMRYATFVKTILDSTQKLNPCQIRKLFYILSTLAFSQRQEGSYIQDDMHMVIRKWLSSTVPNHKQMGIIGAVT............................................................................................... 584
11 -10.100PF11864.8; K1XYE9_MARBU/105-586; Domain of unknown function (DUF3384 topsan)  ali follow..  8  5LAAAEALRHAVQDYPLSGVTSKQGKDLIE-SRNPREVRVAGFELLTAYVRQSTPERLAFFHVLTAPANPEDFQFQLTALVELAKHGKDLSGFHYETLPLLTSWLRHSEETNLSLLFAFIVDVIKFSSEETTGGLIDVVLYICVNTPLSSDLKTCIDVINAIVT---------YGDIPGEKLSGCVKVLCSIHCLVSDVQSEAWRSISNLCRSHNAQKTVRILLNILQEPPADSASGRQTVREIRGALSVLEKLFAKDGQKGYPLVPFTLLIAALEKVVNVEHTKVENDVLNLILSLLSDEKKEIKENVIQEDWSMMFDVV......................................................................................................................................................................................................................... 347
12 -9.830PF12530.8; D8SAX6_SELML/484-706; Protein of unknown function (DUF3730 topsan)  ali follow..  9  19..AFLNALPDICGHPTTVPLSMHLLQHMVDYKGNLRIQATSIRLIYKIWQHTDRAYSFLQKTLVP--AKEETDVLLSRATSLRDLCGHDPDVGIELILSVQACVECRSPVVKALGLQSLSFLCGHDAIDFYTAWKVIAKLFSPLPISPSISESFCMLLK-----HGALDANLNAEDAHAVLNALWEFASCDKQPS...................................................................................................................................................................................................................................................................................................................................................... 209
13 -9.710PF05536.11; NCDN_CHICK/4-610; Neurochondrin  ali follow..  11  5.ATLKKCLEVLRDARNDSEQLAALLLVTKAVRAGDLFDAIGFTFPNRLLSS-HTFRALGLTLLACFCTEPELAGHSQVLNKIPTFADDCTSMVDDAYQCLAAVLATPRGPREMVTKGAASALCQAYGSERALALLLGLLAVSEAKCWQRDAPHLLAVLSKLSEEFVRAEDGSQFELCELLPRFIPLSPPLAEVSQGSECVRQLYKLGSKLSQSQRDPALKLAASLTQACGSEWIPAGSTGSKFLALLVNLACVVRLTLEEPEPLELIEMGIQECLKE-SLLDEAQRMQLMRIMEEAFGAVEEELQDPFVFASVRILGAWMAEETSSLKQEICELLPFLVRYARKLFKEGGPAENLPQTAGLVSSDSSILGQDALRFLLPGFCHLTAEDRPRDILISEGAPALLCDYFLHQWGVLTSQPGSLTSTEMSLQTLCGIFLNLVVTAPNLIRQEKTFSSLMDTLLKSLPFLLPQKD.................................................................. 531
14 -9.680PF12755.7; C4QYN7_KOMPG/59-156; Vacuolar 14 Fab1-binding region  ali follow..  16  1...................................NSRNGGLIGLAATAIALPKYLEKIIHPVLACFGDQDARVRYYACESLYNISKVAKGYFNEIFDNLCKLTADSEVSVKKGA-DLLDRLIK............................................................................................................................................................................................................................................................................................................................................................................................................................. 97
15 -9.660PF14500.6; R4X873_TAPDE/43-304; Dos2-interacting transcription regulator of RNA-Pol-II  ali follow..  13  1...........................................................VSDLGDYLIEEDVSLRSKAMRLLEGVLGALPRLSGQHVTVMVQFFCDSDDACTMEALSALVSLSRMRAPEDADKVASFVIGRTEGFNNQRTRFYLYTLYERLMSTHRKALRTLDSQFVSGFMSLIS------GEKDPRNLMLAFSIMRIILAENIDDSIENIFDSVYCYFPITFRPQPNEPSTITTLKMRLRQCL------SATPKFAPFLIPALIEKLNAVAVSVKKDTLLTLVACCDIYESSIMDTYNNELWVALKYEL......................................................................................................................................................................................................................... 260
16 -9.350PF04826.13; ARMX3_MOUSE/110-363; Armadillo-like  ali follow..  10  12.QELQKVLCLVEMSEKPYILEAALIALGNNAAYAFNRDIIGLPIVAKILNT-PIVKEKALIVLNNLSVNANSSVQLAGLRLLTNMTVTNEHILANSISDFFRLFSAGNEETKLQVLKLLLNLAENPAMTREAQVPSSLGSLFNKKEYKEVILKLLIIFENINDNFKWEENEPAQN--HFSEGSLFFFLKEFQV------ADKVLGIESRHDFQVRVKVG.............................................................................................................................................................................................................................................................................................................................. 254
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Ginalski K, Grishin NV, Godzik A., Rychlewski L. Practical lessons from protein structure prediction. Nucleic Acids Res. 2005 Apr 1;33(6):1874-91.