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Query: PF07539.12; E5AF73_LEPMJ/886-1482; Down-regulated in metastasis, from PfamA32U

Results of FFAS03 search in PfamA32U
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst RWARKDQKAMLSVFAKFQNPKVLYRTDEVRQALLALLSNGDVDIQKAALKALLTWKDSAVIAHQEQLLNLLDDARFRDELPLFLSDGKLHDDEVAHILPIVLRLLYGKIISGKRGLESKRKAVFVGLKNRFGDEAIHQFLDIAFGPLSRISLIQNSSLDEELLQKSAVETRKQAGMLNLLDDLLGTLENTFAPFTSAVVDPVLYCAIKSSRSLTAVGTIEKNGDCTMQTSLLKAVRQRALHILAKLFTNSPDFDWGLYMQAIINELVEPRLEQLPIETAQSVSGILRLFAAWSKSPHTALFLVEYNKDVLIKAIDCLDVPSAKDVVRCFVLEEIIRNIVFLVTNQGATTTTESKLLQNRVQTEIIQQYSNVMLSRVGNLLRRSPSKDVLESGVQTVADMAPYVTGSVEARSMIEIATFLLRQPAKRVNSRTKLGLLKILHEFIKRCDQQNLHELFSTIYDAICPMFAFVHERTARNLLCDIVQDLAGTQEDLVSIAKLCYALNSFTKGRLDEPDFQCRSLAFDEINEHNYRLYSMKQWRPLAYNMLFFIKDNDELSIRVNASLSLRRLIEVSNSDEFKNFISTAVLPGIQSGVRETSLast
1 -141.000PF07539.12; E5AF73_LEPMJ/886-1482; Down-regulated in metastasis  ali  100  1RWARKDQKAMLSVFAKFQNPKVLYRTDEVRQALLALLSNGDVDIQKAALKALLTWKDSAVIAHQEQLLNLLDDARFRDELPLFLSDGKLHDDEVAHILPIVLRLLYGKIISGKRGLESKRKAVFVGLKNRFGDEAIHQFLDIAFGPLSRISLIQNSSLDEELLQKSAVETRKQAGMLNLLDDLLGTLENTFAPFTSAVVDPVLYCAIKSSRSLTAVGTIEKNGDCTMQTSLLKAVRQRALHILAKLFTNSPDFDWGLYMQAIINELVEPRLEQLPIETAQSVSGILRLFAAWSKSPHTALFLVEYNKDVLIKAIDCLDVPSAKDVVRCFVLEEIIRNIVFLVTNQGATTTTESKLLQNRVQTEIIQQYSNVMLSRVGNLLRRSPSKDVLESGVQTVADMAPYVTGSVEARSMIEIATFLLRQPAKRVNSRTKLGLLKILHEFIKRCDQQNLHELFSTIYDAICPMFAFVHERTARNLLCDIVQDLAGTQEDLVSIAKLCYALNSFTKGRLDEPDFQCRSLAFDEINEHNYRLYSMKQWRPLAYNMLFFIKDNDELSIRVNASLSLRRLIEVSNSDEFKNFISTAVLPGIQSGVRETS 597
2 -11.100PF05804.12; KIFA3_HUMAN/13-720; Kinesin-associated protein (KAP)  ali follow..  10  124..............................DEYIELL-YEDIPDKVRGSALILQ-----LARNPDNLEELLLNETALGALARV----REDWKQSVELATNIIYIFFCFSSFSQFHGLITHYKIG------------ALCMNIIDHELKRHELWQEELSKKKKAVDEDPENQTLRKDYEKTFKKYQGLVVKQEQLLRVALYLLLNLAEDTRTELKMRNKNIVHMLVKALDRDNFELLILVVSFLKKLSIFMENKN-----DMVEMDIVEKLVKMIPCEHEDLLNITLRLLLNLSFDTGLRNKMVQVG--LLPKLTALLGNDNYKQIAMCVLIPQLMKMLFECSDERIDLELISFCINLAANKRNVQLICEGNGLKMLMKRALKFKDPLL----MKMIRNISQ--HDGPTKNLFIDYVGDLAAQISNDEEEEFVIECLGTLANLTIPDLDWELVLKEYKLVPYLKDKLKP-AEDDLVLEVVIMIGTVSMDDSCAALLAKLIELLNA------QQEDDEFVCQIIYVFYQMVFHQATRDVII--APAYLIDLMHDKNNEIRKVCDNTLDIIAE........................... 650
3 -10.000PF14228.6; F6GVU1_VITVI/618-1735; Cell morphogenesis central region  ali follow..  7  169..WLMYAMFACSCPFDSREASSLGAAKDLYHLIFPSLKSGSEAHIHAATMALGHSHLEVCEIMFGELASFIDEVSMETE----GKPKWKSQKARREELRVHIANIYRTVSENIWPGMLGRKPIFRLHYLK--------FIEETTRQILTAPSENFQEIQ-----------PLRYALASVLRSLAPEFVDSKSEKFDLRTRKRLFDLYKSSQHSRSKDSVDKLSFDKEVSEQVEAIQWASMNAMASLLY--NARKMSGRVISWINSLFNEPAPRAPFGYSPADPRTPSLKNLLLTNLDLFPACIDQDAAIADGYFSVLAEVYMRQEIPKCEIQRLLSLILYKVVDPNRQIRDDALQMLETLSVREWAEDGGEGSGSYRAAVVGNLPDSYQQFQYKLSCKLAK-----DHPELSQLLCEEIMQRQLDAVDIIAQHQVLTCMAPWIENLNKLKDSGWSERLLKSLYYVTWRHGDQFPDE-IEKLWSTIASKPRNISPVLDFLITKGIEDCDSNASAEISGAFATYFSVAKRVSLYLARICPQRTIDHLVYQLAQRMLEESVEPLRPSANKG............................. 772
4 -10.000PF03378.15; Q4WDA0_ASPFU/522-981; CAS/CSE protein, C-terminus  ali follow..  9  1.............................................................................ERVLYLADSQGQPIIAPATVTPLLLQHIFSLIQKDPAPEKVQENEFLMRCAMRV-KEDVVPYTDIVLQHLINITDVISKNPSNPRFY---------YFHFEAMGAFIRFAAPANPEKLEQALYPPFANILQGDVQGIVQSERNRGLGTSLSANVCAEFMPYVFQLFAALLEANPSGSLPNYYQNLIAPMLMPVM-----ESKGNIPALVRLLSSIIPRGS--FILENQQLVPILGIFQKLLSTKANEGFGFDLLESV-----------------------ENFPPTALEQYFVSIMQVILTRLQNSKTEHLTLRFVRFYHFISAHDDKGYSADYFIQVT--------DKVQADLFTPIY--LNIILPETQKLARPLDRKTAVLSFTKTLANSEANRYKKGWAFTCEALLKL---LELAPLPASKDDIIAEHDVEDMAFG---VGFTALNTVRPQPRDPWP------------------DTGADLKAWVGRYLKEADKKRVSACVQERLGAEARTVLSS.. 459
5 -9.850PF12460.8; H6C711_EXODN/528-954; RNAPII transcription regulator C-terminal  ali follow..  11  2...............................AFLARLPDSEDEAVPDDYNPVL-----------EGLAEISVERGLQETLMRCKSDNRTSFPYTCSVLGTIFYVLNRATTAANSSLDAYYDRVVIGISRRTTEAK-EAVLDLVGRIMNLIIRHSAPDKVQLAAENIYLLFRDSTEDKQSVDLLSLLEPPTVTILSTWLLAAIPRNTQSFVLNKTQIPQTITQLILFASKSTSRGITQSCLLQIALYVNKHVETADLDFVDNLLSNTLSNLQDEPMDGSPPRDFNIRAAFTL---IKALILRLSPKTDQYLTSLVGLLDEGHYPAEVCRKAAMGFATILSSDDVLSRKNFAQIRLLAPQRV--------FQMLTPLISEKFRASQSPTEKENYLIALSGILASVPSNIVMPEL-PTLLPLLLQSLDVTDQMVKTATLETLAVVISNNPAAEESGHIPALVKRLIAV.................................................................................................................................... 427
6 -9.490PF12722.7; C5FVH3_ARTOC/1-827; High-temperature-induced dauer-formation protein  ali follow..  8  3..ASESKLVFKQGIFRLSEQANIPPDDQYWTGFWELPESVEDVFSLFSPVDIRRTRDT----SLSNLETLL--LAICSRLVALRHHPSFPDPEIAPAKDALIRIL---------------TRLLPYIYETDNLEEWED--EFFWRRRRKLSRKAQLSSRVLFDESRHEDDEEEGNGQTGRRGVAREDYEDVKPLAEELLDTLLDLLFFSGFTIPQVPASKGKVVY--------SIWQSGVGCNTAMGSNKELESNRTEVLRLLLTITGQSMYMQPNLLPVKGVKSLTYLVTCGEKKLVMSLLCSLLNTTIKY-YDHVVWKDPKQILVIYCLQFLLALLLYPIPEDGRGAGRLHQPQDFQFLVEGMTRILNQPMQATSSYLPGSQKSIKWAPEMLMLKRFRSFIVDSNRAHDFIVICTFYAIEYKTDPSKNGLVKMKFEAQDTLPPSIRLENFGGTYGDFLIISIHTLMTTSKGKLDAVYPALLAI------INNVAAYAQRLSPACAFKI--------LQLFVSMSSPSFLLANETN-----HLLLSSLLEFINTVLEHQFSKNAYMVYVVLKSRHRFESLRAFTLESGQQEIEQ.. 572
7 -9.330PF05004.13; T1J854_STRMM/21-332; Interferon-related developmental regulator (IFRD)  ali follow..  5  43......................................................................................................................................................................................................................................................................LIDKLKDAIDGATQKNAKGRQTCLESIQNVLSRKYLPDVIDTRRETITECIKSSLKRGKVDEQSAAAILAVLTCIQLGPGSSSDS----------------MFAELCPVLTTSLNDKSLTFKTRGTCATALALLALIIG-EMEQGTIISLMSTFEALFSASHALEVTALHSSALAAWSLLLTVVSINDVSSMAERHVMRLSELLES-SDVELRIVAGETIALLYEIGETLDDLSFKLKQLATDSHKYRAKKERKQQRSSFRDILRTV.................................................................... 311
8 -9.060PF04931.13; K2SXE2_MACPH/89-879; DNA polymerase phi  ali follow..  9  46.....NIHGLVKLVAELTTPEGKASGQEKRDYLLGRVFGYKAIIQSSILV---NAPEECWANVLEQLFKLAREKPWLREECGMILCEAVKAIAQEKGQQRLVKQIVDGLCSDGLAKTPEGVSVWITVQRELSTKDRQTLANVMKENFTKTSDGANETGKKVKGSSQTTALSFSDVVISAFFQRHGDDPSRFANFWADIVDNNLFSASSSPEQKSKGLQLFTRMLGNAPKWALPSI--FSPNLMRCLINQRNDSE------RFLHNAAKAPLDEMRTRSKKEPETAAPFLENLITKHGSLHFDQITKNKTVEGVLGHANDVALEQ-----IVPLFKRLIYRPEEQDSKAAEAQRR-------------TVADMVVSAVRSRNKENAIGNDSWLREVLVGLTELA-SEASRNMFQGRLTSCLAHLLSSKLDTEMDYPYIVVSAIRSKSKSSKSLSLVFQADKGISKAVK-----QAHKQVEEITEKLLKAKDKKKPALRAFKLLFSLTIVQVGDPDAVSILEELAVCYESAFQKGADKSAFQLLTEVLLSFAAKPSVLFRKLSEQVFTVFASELTAEGLHSMID............... 626
9 -9.040PF04826.13; ARMX3_MOUSE/110-363; Armadillo-like  ali follow..  9  14....................................................................................................................................................................................................................................................................................................................................................................................LQKVLCLVEMSEKPYILEAALIALGNNAAYAFNRDIIRDLLPIVAKILNTR----DPIVKEKALIVLNNLS--VNAENQRRLKVYMNQVCDDTVTSRLNSSVQLAGLRLLTNMTVTNEYQHILANSISDFFRL----FSAGNEETKLQVLKLLLNLAENPAMTRELL-VPSSLGSLFNKKEYKEVILKLLIIFENINDNFKWEENEPAQNHFSEGSLFFFLKEFQ 232
10 -8.890PF10508.9; A7SP09_NEMVE/2-505; Proteasome non-ATPase 26S subunit  ali follow..  10  1.........................AAEKCKELVENISNASGDEIVAFLRDLSV-----LISSSPNIRDLASLIPSERLFNCLRTTNT-------DQITYCKNILKNILKFEKPDAPATKYHDAVIEGLNHPTEDVRELCLIELERCSGTVNGVLALMDKE----------------DLLSYIARGMADE-------------------------------------------KNAQIASNVFTNLAKH------EAGLKVLFDSHLQSEFNALLKTKDTVRMRVYDMYITVQAHSP--AFDVCKESGIFEKLISELDGRDV---VQMNCLELLTKLASISPSGLEYLDQK-----------------VTKLNNLLLEVETDPLITLIIPGIIKFFGTLAT--AHPLETTQQYPQFLEQTYSMISCGDPTLMPIAMETIGVIAHSEDGLRAVFNNQGRNKHIMKTIFGHATSSQVDLRKRALEALAPSEELCEFAKVLYKNMAAAPLEAIKQPFEELRCSALCLLRSLARYQWALQDMI--FLEYLLDRRTEFEKSGKEHKYDLIKELVH---FPPAKQIFDRPYFLRLQEYERE.. 487
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Li W, Godzik A. cd-hit: a fast program for clustering and comparing large sets of protein or nucleotide sequences. Bioinformatics. 2006 May 26;