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Query: PF07728.14; Q82S33_NITEU/475-632; AAA domain (dynein-related subfamily), from PfamA32U

Results of FFAS03 search in PfamA32U
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst NLILQGPPGTGKTWLAKRLAFALMGQKDDSKVRAVQFHPNLSYEDFVRGWRPTGEGKLSLADGVFMEAIKAASKDPSSKFVVVIEEINRGNPAQIFGELLTLLEAGKRTPNEALELCYPDADGKRRPVHIPENLYVVGTMNIADRSLALVDLALRRRFLast
1 -103.000PF07728.14; Q82S33_NITEU/475-632; AAA domain (dynein-related subfamily)  ali  100  1NLILQGPPGTGKTWLAKRLAFALMGQKDDSKVRAVQFHPNLSYEDFVRGWRPTGEGKLSLADGVFMEAIKAASKDPSSKFVVVIEEINRGNPAQIFGELLTLLEAGKRTPNEALELCYPDADGKRRPVHIPENLYVVGTMNIADRSLALVDLALRRRF 158
2 -18.000PF07726.11; Q87G66_VIBPA/36-166; ATPase family associated with various cellular activities (AAA)  ali follow..  23  1HILVEGPPGLAKTRAVKSLSDCV-----EGDFHRIQFTPDLLPADLTTDIFRPETGEFTFQSGPIFN-------------LILADEINRAP-AKVQAAMLEAMAEKQ--------------TAGRHTYALPELFLVMATQNPIEEGTYPLPEAQLDRF 129
3 -14.200PF07724.14; Q7PAG5_RICSI/595-759; AAA domain (Cdc48 subfamily)  ali follow..  23  5SFLFLGPTGVGKTELTKALAGFLFDDRNA-RIDMSEYMEKHAISRLIGA--PPGYIGYD-QGGVLTEAVRRRPYQ-----VILFDEVEKAH-PDIFNIMLQILDEGRLTDSQGITVDF-------------KNTIIVLTSNLGAEILV.......... 131
4 -14.100PF03266.15; NTPTH_METAC/3-167; NTPase  ali follow..  13  1RIAVTGSPGVGKSTVVAKTAEKLAEKPHREGFSIRDLATGKTGILSHVKGSGPRLGKYHVNLDDLERIGANAVRNALACDLVVIDEIGPMELQSFVSAVEEVLESDKP-----VLAVLHHSSRHPLAQRFRKGFEVL-TVDKGNRDELPEKIT..... 165
5 -13.900PF05496.12; RUVB_BACAN/21-179; Holliday junction DNA helicase RuvB P-loop domain  ali follow..  25  35HVLLYGPPGLGKTTLANIIANEMGVNVRTTSGPAIE-----------------------------PGDLAAVLTSLQPGDVLFIDEIHRLH-RSIEEVLYPAME------DFCLDIVIGKGPSARSVRLDLPPFTLVG----ATTRAGALSAPLRDRF 153
6 -12.800PF01078.21; Q8EJV7_SHEON/193-396; Magnesium chelatase, subunit ChlI  ali follow..  21  24NLLMLGPPGTGKTMLASRMMALLPALNYEEALEVAAIHHTCSSISLVGGGSIPKPGEISLAHR-----------------VLFLDEVAEFP-RKVLDCLREPMETGE-----------VVISRAAAKLTFLSRFQLIAAMNPS............... 159
7 -12.600PF00004.29; LON_BRECH/351-493; ATPase family associated with various cellular activities (AAA)  ali follow..  26  1.LCLVGPPGVGKTSLARSVARALGREFVRISLGGVR-------EAEIRGHRRTYVGAL---PGRIIQGMKQAGTINPVFLLDEIDKLASDFRGDPASALLEVLDPNQNDKFSDHYIEETYD----------TNVMFITTANSLD.............. 125
8 -12.500PF01695.17; Y4IQ_SINFN/60-238; IstB-like ATP binding protein  ali follow..  20  50NILLFGPPGGGKSHLAAAIGLALIENGWR-----VLFTRTTDLVQKLQVARRELQL-------------ESAIAKLDKFDLLILDDLAYVTKDQAETSVLFLISARYERRSIMITANQPFGEWNR-------------VFPDPAMTLAAVDRLVHH.. 175
9 -12.100PF00910.22; A7M6L1_9SECO/473-576; RNA helicase  ali follow..  15  1.VYAYGESRTGKTLVVDKLITDFQNHFGLGKDTVYSRNPIDQYWSGYRR-----------------------------QPIVSIDDFGAVTCDPSMEAQMIPLVSSAPLPLTMAAIEEKGMMFDSKFIFCSSNL........................ 104
10 -11.800PF04665.12; Q6TUP8_YMTV5/6-246; Poxvirus A32 protein  ali follow..  10  15RIALVGGSGSGKTAYLLSLFNTFVEKYRHIFLFTPVYNSEYDHVNRVTTYEELDYSLITTKQKIEKYVKKQGNDKTTEMFLLILDDMDKQIRSSCLLDFLN------HGRHLNTSIILLCQTYKHVPVNGRTSITHFCCCNVSDSDIENM........ 165
11 -11.500PF01443.18; RDRP_TMV/829-1085; Viral (Superfamily 1) RNA helicase  ali follow..  16  1.VLVDGVPGCGKTKEILSRV--------NFDEDLILVPGKQAAEMIRRRANSSGIIVATKDN-VDSFMMNFGKSTRCQFKRLFIDEGLMLHT----GCVNFLVAMSL-----------------------CEIAYVYGDTQQIP.............. 110
12 -11.500PF01591.18; F262_BOVIN/27-250; 6-phosphofructo-2-kinase  ali follow..  17  16.IVMIGLPARGKTYVSKKLTRYLTKVFNLGVYRRQAVKSYKSYDFFRHDNEEAMKIRKQCALVALKDVKAYLTEESGQ--IAVFDATN--NFAEENSFKVFFVE...................................................... 130
13 -11.100PF05673.13; Q0K6N5_CUPNH/29-287; Protein of unknown function (DUF815 topsan)  ali follow..  20  60NVLLTGARGTGKSSLIKACLNAF----VRDGLRLVEVDKDDLGD---------------------LGDIVELVAQRPERFVIFCDDLSFEEGESGYKSLKSALDGSVAAQ--------------------SDNVLIYATSN................. 155
14 -11.000PF02702.17; B8ET99_METSB/24-233; Osmosensitive K+ channel His kinase sensor domain  ali follow..  20  6KVFFGAVPGVGKTYEMLTAAHARKAEGVDVVIGVVESHGRPETEALIRGLEIVPLRQIAYKGRTIGEVDLDAI--KRRPQLVLMDELAHTNAPKRYLDVEELLNA---GIDVYTTLNVQHLESLNDVVKIPDSI-----LDRADE-IELIDLDLIQRL 171
15 -10.800PF13481.6; B2JV40_PARP8/220-401; AAA domain  ali follow..  15  34..AVWGASAAAKSFLVLDLAAALTECREPVPVLLVSLEGNNGLPRRYLAWEKHNGRPVPLDPRDTDDLCEAIETCGITGGVVFIDPFALANSSADMGRAGAALNTLRERTGCTVIAVHHTGKKQE................................. 182
16 -10.700PF13671.6; B2JHT3_PARP8/20-178; AAA domain  ali follow..  22  2.VFICGHAGTGKTTLAKRLIGPLMKATDKDTLYGVYSAAAIGALTGDPNDRDSPLFLQHFRDPEYRGLFDTAAENLRLGIGVIAV......................................................................... 92
17 -10.700PF05621.11; B7J739_ACIF2/21-211; Bacterial TniB protein  ali follow..  14  38.LLIVGDSNNGKTTVIRRFQKLHGEGVNEDAVIVSEAPPSADEKGLYIWTPYRATDSASKLRYQVVHLMRDCHVR-----ILVIDEFHS------------LLTGTVTKQREVMNAIKLLCNELAIP------IVGVGIREA--VRVLHTDPQHASRF 179
18 -10.600PF02456.15; PKG1_ADEG1/61-425; Adenovirus IVa2 protein  ali follow..  13  86IGVIYGPTGSGKSHLLRALISCNMLDPIPETVIFIT-EANFDCREDGTIAPKTSTFRPEFMEMTYEEATAPEHLNIDHPDNIYVKVSKRGPVAIIMDECMDKLCSGSS-------SVLFHALPSKLFARSAHCTAFYIFVVLHNMAPRTAIGNVPT.. 253
19 -10.600PF13245.6; B1YJE6_EXIS2/332-475; AAA domain  ali follow..  22  14.MVLTGGPGTGKTTVIKGILHALQEIHDWPLEKSQVKSGE------YVLVAPTGRAAKRLSEATDVPAMQLDEDQPIAGKVLIIDESSMIDIY-LLSSLLRAVPNGMK.................................................. 129
20 -10.500PF13238.6; A0B5Y2_METTP/3-117; AAA domain  ali follow..  40  1.IALTGTPGTGKTTVSGLLPFRVVNLND.................................................................................................................................. 27
21 -10.500PF18748.1; A0A0A0YSQ1_9CAUD/11-206; P-loop Nucleotide Kinase1  ali follow..  12  20.FYVKACNGAGKSTIPSYCAERDPEAYTVSQDGRILLTVMPSYGMLAFGKSKSKGVDSLKDYDEMKKAVELSELEEFIGYTAFFEGVIPSTILHTWVEYL.......................................................... 121
22 -10.400PF01637.18; A8M939_CALMQ/15-228; ATPase domain predominantly from Archaea  ali follow..  10  23.VVIYGPEGCGKSAFLKQAVEVLGEEDESNEKLRYSEELRGLFRDIMTRIPTPFNDASALIDIAISLLYDVVRRRIRRKIALLADDVFQDKAELLVKRLLNMIEYSSVDYERIVVIVATSEGVTWGRIGRHRWAEIMAMWNMPREGFGKL........ 186
23 -10.300PF09848.9; A1A222_BIFAA/236-699; Uncharacterized conserved protein (DUF2075 topsan)  ali follow..  19  4.IFVQGVAGTGKTVLLSHLFYRIATEMDINGRINDQIASKLGLQKHFGEVALKPSQFINRFSEKTTSNRAIADKPRGKADVVLVDEAHL..................................................................... 128
24 -10.300PF13479.6; F5YIK8_TREPZ/11-202; AAA domain  ali follow..  16  4RCALFGPSGSGKTMTALRMAKGIADTMGVPFAVIVDDLDGKTVDHYIAAMNECVKAGYK---------------------VLVIDSLSH..................................................................... 88
25 -10.300PF02562.16; A0LK93_SYNFM/124-328; PhoH-like protein  ali follow..  17  22.VFGVGPAGTGKTYLAMAMAVAAMTKDLVRRI--VLVRPAVEAGEKLGFLPGDLAEKVNPYLRPLYDALHDMMDFERATGLLQRGAIEVAPLAFMRGDAFVILDEAQNTTTEQMKMFLTRLGLGSK-------AVITGDITQID.............. 159
26 -10.200PF07652.14; Q32ZD8_9FLAV/1675-1822; Flavivirus DEAD domain  ali follow..  11  7.IVLDPHPGAGKT---RKVLPEFIRQAVERRLWTLALAPTRVVAAEMAEALNGLPVRYLMCHATFTMRLLSGGRVPNYN-MFIMDEAHFTDPSSIAARGYI----STKVDMGEASAVFMTATPPGSREPFPDS......................... 146
27 -9.990PF03215.15; RAD24_YEAST/58-237; Rad17 P-loop domain  ali follow..  21  48.LLLSGPSGCSKSTVIKELSKIL-------VPKYRQNSNGTSFEHKVTEFRGDCIVNDLPQMESFSEFLKGARLVMSNLSLILIEDLPNVFHIDTRRRFQQLILQ..................................................... 150
28 -9.860PF00308.18; DNAA_STRCO/317-535; Bacterial dnaA protein  ali follow..  21  37.LFIYGESGLGKTHLLHAIGHYARSLYPGTRVRYVSSEEFTN--EFINSIRDGKGDSF--------------RKRYREMDILLVDDIQESTQEEFFHTFNTLHNANKQ---------------------------IVLSSDRPPKQLVTLEDRLRNRF 155
29 -9.590PF18751.1; S5Y5G5_9CAUD/1-187; P-loop Nucleotide Kinase3  ali follow..  15  6.IYLVGQPGSGKSTLMSALTAGFDRHKIAPAPDYPVAHDVLADKTTLGVRRELFSGTDALPSSIIDKAAPWVRSQPYP---LLLAEGARLANRRFIGYEVTLVLLDHNDAEDWRKVRSKAIGKTQNPSWVKGRLKAVEVLRGHPDPIRSILKGID... 186
30 -9.570PF08433.10; O46079_DROME/1-293; Chromatin associated protein KTI12  ali follow..  13  4.VVITGLPASGKSTRARQLRDHF--VERGRKVHLISENEAVPKAGFGKNSHTGDSQKEKVVRSDLKSEASRHLN---QEDLVILDAGNRYELYCMSKVS........................................................... 101
31 -9.530PF13191.6; D0LH04_HALO1/297-485; AAA ATPase domain  ali follow..  17  27.LVIAGPPGVGKSALARGLQESPSHQHI----KFEQYRHDVPYSAVSRAFGTLIDQLLSESGERLQSWRDELHDALGNNAQVIVDVI---ELAYLLGPQRPVTPLGPAESENRFHLIFQRFLETLCTAEHPLVVFMDDLQWADAASLVLAERTL.... 178
32 -9.360PF08303.11; Q6CK12_KLULA/389-554; tRNA ligase kinase domain  ali follow..  16  2.LVTIATIGCGKSTVSLTLNEL-----------------------FPESWGLVVNDNITSNKTDYIKSALQLFKDGKQ--FVLADKNNHQFRER................................................................ 69
33 -9.210PF13177.6; A5VIC8_LACRD/13-171; DNA polymerase III, delta subunit  ali follow..  16  21.YLFVGPGGSGKMSIAQWLSLRLFDNEPDLTCAECQRILSGNHPDIVYAAPEGRQIKVDEIRRLKAEFSKSAVEGNKK--IFIIKDADKMTNGA-ANSLLKFIEEP------------------------GAGVYIFMLTTNKSAVLPTIRSRTQV.. 153
34 -9.150PF12774.7; A0A068XKX4_HYMMI/1331-1658; Hydrolytic ATP binding site of dynein motor region  ali follow..  23  39.....GPAGTGKTETSKDLAKAVA-------KQCVVFNCSDGLDKFFKGLAQSGAWA-------------------------CFDEFNRIDL-----EVLSVVAQQIHTIQMAIAQGLKQFVFEGTELQLDPTCTIFITMNPGYAGRQELPDNLKVLF 159
35 -9.040PF07931.12; Q98FG2_RHILO/59-238; Chloramphenicol phosphotransferase-like protein  ali follow..  11  4.VLLNGVGSAGKSSIARALQTITAAQMDSFLEMLPDALQDHADGFSYETVRQDGKPAVVIRAGTLRGMRHAIAAMAGQGNDLIVDDVLCNGELSDCVDLLSAFDEAREARRADRLPGLARWQYERVHAGISYDLEVDTSQSTPLECARRIQQRFQ... 180
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Pawlowski K, Pio F, Chu Z, Reed JC, Godzik A. PAAD - a new protein domain associated with apoptosis, cancer and autoimmune diseases. Trends Biochem Sci. 2001 Feb;26(2):85-7.