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Query: PF09899.9; V4J3D1_9GAMM/276-1132; Putative amidoligase enzyme (DUF2126 topsan), from PfamA32U

Results of FFAS03 search in PfamA32U
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst DKCDVTFYFHNRVKRIHEDARVTKPYTEEQWNAIESLGHAIDAELADNDVRLTMGGEPTFVSIDDMEGAEWNIAALGPTKKLLAEDLLLRLKRQFAPGGMLHIGQGKWYPGEQLPRWALACYWRKDGEPVWRDEGLLGNERETYEQGPDEAKRFVTTLARKLGVRPEYAQPAHEDVFYYLWKEARLPVNVDPFDNKLKDPIERARVARVFSQGLERIVGYALPLRWTGLTPGGGWVSGRWSLRDGNLFLIPGDSPMGFRLPLEALPYVPDAELDTHPQRDPFEPVYSAQAPAADALDRDRGRGRFVHEVQSDQPRQAVQEQGTDPDAMARLHGRQASIDDRRQPLSAQWTLPDDYPAELVRTALCIEAREGRLYCFMPPLTHLEHWLDLVANLEASAAETGLRIIIEGYEPPRDFRLTKLAVTPDPGVIEVNVHPASSWDDLVRDTSILYEEARLTRLGTEKFMLDGRHTGTGGGNHVTLGGPTPADSPLLRRPDLIQSLITYWQHHPSLSYLFSGTFIGPTSQAPRVDEARDDSLYELAIAFQQMPKGQIKQPWIVDRVLRNLLVDVTGNTHRTEFCIDKLYSPDSASGRQGLVEFRAFEMPPHARMSLAQMLLLRALVARFWQQPYAHEPVRWGTELHDRFLLPHFVRQDFGDVICDLQRAGYAFESAWFEPFFEFRFPHYGDLITGNGIRMELRGAIEPWHVLGEEVTAQGTSRFVDSSVERMQVKVNGMTGARHALTCNGRRVPLHPTGRRGEFVAGVRFKAWNPPSGLHPTIASHNPLVFDVVDLWNCSSLGGCTYYVSHPGGRAEQRFPVNSYEAESRRIARFRLMGHTPGDIDPPPEEPAGEHPYTLDLRLast
1 -222.000PF09899.9; V4J3D1_9GAMM/276-1132; Putative amidoligase enzyme (DUF2126 topsan)  ali  100  1DKCDVTFYFHNRVKRIHEDARVTKPYTEEQWNAIESLGHAIDAELADNDVRLTMGGEPTFVSIDDMEGAEWNIAALGPTKKLLAEDLLLRLKRQFAPGGMLHIGQGKWYPGEQLPRWALACYWRKDGEPVWRDEGLLGNERETYEQGPDEAKRFVTTLARKLGVRPEYAQPAHEDVFYYLWKEARLPVNVDPFDNKLKDPIERARVARVFSQGLERIVGYALPLRWTGLTPGGGWVSGRWSLRDGNLFLIPGDSPMGFRLPLEALPYVPDAELDTHPQRDPFEPVYSAQAPAADALDRDRGRGRFVHEVQSDQPRQAVQEQGTDPDAMARLHGRQASIDDRRQPLSAQWTLPDDYPAELVRTALCIEAREGRLYCFMPPLTHLEHWLDLVANLEASAAETGLRIIIEGYEPPRDFRLTKLAVTPDPGVIEVNVHPASSWDDLVRDTSILYEEARLTRLGTEKFMLDGRHTGTGGGNHVTLGGPTPADSPLLRRPDLIQSLITYWQHHPSLSYLFSGTFIGPTSQAPRVDEARDDSLYELAIAFQQMPKGQIKQPWIVDRVLRNLLVDVTGNTHRTEFCIDKLYSPDSASGRQGLVEFRAFEMPPHARMSLAQMLLLRALVARFWQQPYAHEPVRWGTELHDRFLLPHFVRQDFGDVICDLQRAGYAFESAWFEPFFEFRFPHYGDLITGNGIRMELRGAIEPWHVLGEEVTAQGTSRFVDSSVERMQVKVNGMTGARHALTCNGRRVPLHPTGRRGEFVAGVRFKAWNPPSGLHPTIASHNPLVFDVVDLWNCSSLGGCTYYVSHPGGRAEQRFPVNSYEAESRRIARFRLMGHTPGDIDPPPEEPAGEHPYTLDLR 857
2 -6.960PF04107.13; GCS2_MYCTU/20-297; Glutamate-cysteine ligase family 2(GCS2)  ali follow..  14  33..........................................................................................................................................................................................................................................................................................................................................................................RVHKELLRNTVEIVSGICECTQDLRDTLGPARQIVRDRGMELFCAGTHPFARWS-------------AQKLTDAPRYAELIKRTQWWGRQMLIWGV------------------HVHVGIRSAHKVMPIMT-NYYPHLLALSASSP----WWGGEDTGYASNRQQLPTAGLPFHFQRWAEFEGFVYDQKKTGIIDHM--------------------DEIRWDIRPSPHLGTLEVRICDGVSNLRELGALVALTHCLIVDLDRRLDAGE------------TLPTMPPWHVQENKWRAARYGL................................................................................................................................................................................................ 278
3 -6.140PF11996.8; Q9PKM8_CHLMU/2177-3130; Protein of unknown function (DUF3491 topsan)  ali follow..  12  457.................................................................................................................................................................................................................................................................................................................................................................................................YYNRNVIPERVEDVKSLNNTVILMPPNTKRNGEHVFAIENQEGVDVKVL-LGEYEEDLMYKDVFARKITHFAVKTKYLFFTDEESLANPEDNVLFYSKLGSNTLQASQKPLTQFARQLWASYDEISVSDTSLKLEN-LMEAETIELYRQLLYDLVLKLFYVRQSEGMGA--VLITFKNFFIESMEGISAPT--LEREAKPILASDPMGLIN----AYREHLDLFLGEDKLLAILVQEFSMLQYIVSMQE-GKALGSLLTPPRYKDMNLAVLTYTVASSWEGRRASWLKAPIEYKLPLEGDLYVNQAFVIRFKGYKFQKHSVGESRIAKTVLQFRGQELFHLEKSASKLLSLSRMLFYGGDQVIRYTPLSVQQFLSLDDLWLADLKERVMNANEEGFKLISQMHDSY.................................................................. 923
4 -6.050PF17072.5; SPIKE_BRV1/1-1583; Torovirinae spike glycoprotein  ali follow..  15  512.DISTSWYFHTLAQPSGPIQQVSMPVLSEHWVTLLAQSSVYQPSMFNMGVNKSV--TAWFLSILYTRLPESRRLTLGAQLTPFIQALLSFKQATVARYNVLILMWGRKYAANQLPEWSYPLFKGGVGDSMWFRKKFLVTTKIHQTASKDVACPLSTMVPSILQVNPHTIYRSYKLGTICVLVPYSSPTDVYSSFGFFFQSALTIPTVQTTDDILPGCVGFVQPVRNSPGSSASNYTLRNYYRTTTPVTNVPEEVPLQLEIPTVSLTSYELKQSESVLLQDIEGGIVVDHNTGSIWYPGGQAYDVSFYVSVIIRYAPPKLELPSTLANFTSCLGNQQCRGEAQTFCTSMDYFEQVFNKSLTSLITALQDLHYVLKLVLPETTAVDEFSDTISLLSESFERFMSPAS-EAFDGISLPQRTGSILSSAPSLSSISSWHSYSSRTPLISNVKTPKTTFNVKLSMPKLPKASTLSTIGGLSIASLG-IELTQQQIMALEDQITILAGYTTKNSSLNTL--GQQVQDFSQTSAL------SLQQLSNGFEQITQQLDKSIYYV-ATYMSSLVNQLNELSQAVYKTQDMYITCIHSLQSGVLSCHLYQVAKNLSSGECQPILSEREISRFYSLPLVTDAMSWSIPITCSNILPTSLQYDVPTHVVTSNAGALIFDEHYCDRYAEASYLTMLYSNQTDNSSLTFHPAPRPDPCV------SASALYCYYSDECHQCVIAVGNCTNRTVTYENYTYPIMDPQCRGPIAIGADFTA-RPPLPLH-TFNVTLPNELNWTDLVLDYSFKDKVYEISKNITQLHEQILQVSNWASGQRLRDF............................ 1542
5 -5.910PF10070.9; Y443_GEOKA/26-844; Uncharacterized protein conserved in bacteria (DUF2309 topsan)  ali follow..  12  324............................................................................................................................................................................................................................................................................................................................................AWEDTYEAKLKEAVLTRQPEEPKEQAAAQLLFCIDVRSEPFRRHVEAVGPFETY--------GCAGFFGLPIQTRVLDSDDAHPSCPAIVAPRHEINETASPETAA-RDLFRFVGRTFKKIKRHLLAGLLLP--------------MSG--------PWLGLHTIARSAA--AWAGQAIHQAEMSAQQKPKTTLSLDCQGHDETTGLPIGLTKEEQVQYVKQLLLTSSFAPLVVETTNNPYASAL------DCGACGGAAGAFNARVFAALPHVRDGLAKEGIVIPDETVFVAAEHITTVDE--LRWVEVPPLSEAAEAAFRQLKQALAGVSRQANAEWSEIRPEWGLALIGRRALTKGVHLDGRVFLHSYDWREDPTGE--AGPATVGQWINLQYYASTVAPNYY----SGDKTTQTVTGGIGVMQGGSDLLAGLPWQSVAAS--FHSPLRLLVI..................................................................... 792
6 -5.340PF07520.11; Q881L8_PSESM/1-1042; Virulence factor SrfB  ali follow..  12  94..........................................................................................................................................................................................................................................................................................................................................................................................................TLGMQSSFKLLDGLWLPPVFRFLPPQRYDEGP--ARVRLIELEQPDVDGNTHRLTL--AFDTRSMASA-YLAPTRDDINAGSSFRLACHARQSRWFLDQKDWLAEIYREGNRHRPGHYLNLLSLMAKPIPEQRSSEPARVVVPEIKLAANG--ADSIDPPIQVD-----LVLDV-GNSRTCGILIENHGQSGDGMKHNYILQIRDLVNPERVYSQPFESRV------EFAQASFGKENFSVQSGRHDAFQWPTIARVGVEAGRLSGRRRGTEGSTGLSSP----RY--------------DENAYTHGWRFNNSYVQTDSEPKATAAPFSHK-------------ITKLGQAFYKLKNEDDRLPAFSPQYSRSSLMTFMLAEVLTQALLQINSPAQRTRMGHTQRPRQLSS-------TVPPGMPQVERSLLND............................. 501
7 -5.250PF01692.18; C_SENDO/12-215; Paramyxovirus non-structural protein C  ali follow..  18  2.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................PSFLKKILKL-QEDESRSRMLSDSSTQSYQVNQLTSEGSKGQALPTESKVRAREKSRHRRPKIIDQVRR---VESLGEKHMLETLINKIYTGPLGEELVQTLYLRAMEETPESLKILQMREDIRDQVLKMKTERWLRTLIR--KDFQKRYVHPYLMKEKVEQIIME...................................................................................................................................................................................................... 192
8 -5.190PF02689.14; HELI_EHV2/2-789; Helicase  ali follow..  13  1..............................................................................................................................................................................................................................................................................................................................................................................EEPGAGFILNMTSDSKVRAIVGRIRGLAAKTVPPPEMSWFDSQFDPEDAEFSTFLITGTAGA-----GKSTSISALYQSLNCLITGA--TAVAAQNLSN-KTYCPT-GSRHINILPRHGRNAPARDMEGIRNELCKYW---PVISDI-----------LGEFTKKKQRGQYETGAAFGALAKMGTPT--VIDELSSHILTAVV-NSSGAVPCVVCVGSPTQTDAIQSTYNHSMQKHHIQECDNILTFLMKHEAVSRYVDLNH-----NWALFINNKRCTDP----EFGHLLKTL-EYNLDISPRMVDYIDRFVVPKILSPLEYVGWTRLFVSHRE----LNQGGATAEADARLFTCPVVCEVFTDTFNEYREAVNLPGLTVTEWLQKNLCR-LSNYSQFIDQDLSAVHIETGEESTKVTYLVKYVKNSYVS............................................................ 446
9 -5.100PF04534.12; UL56_HHV2H/1-197; Herpesvirus UL56 protein  ali follow..  23  17...............................................................................................................................................................................................................................................................................................................................................................................................DSVIDAPPPYESVAGASAGQFVVIDIDTPTDSPPPYSAGTSPVGLVSPASSGDGEVCERGRSRRAAWRAARRARRRAER-RARRRSFGPGGGAHPGVGGDLPSGLPTYARPPTYAMVMAACPTEP------PGGSVGPADQ-PRVQSSRSRELYRAQRA........................................................................................................................................................................................................................................................................................................................... 194
10 -5.040PF00747.17; DNBI_EBVB9/5-1087; ssDNA binding protein  ali follow..  13  258..............................................................................................................................................................................................................................................................................................................................................ISHPDSGALMIVDSAACELAVSYAPAMLEASHETPASLNYDSWPLFADCEGPEARVAALHRYNASLAPHV--------------STQIFATNSVLYVSGVSKSTGQGKESLFNSFYMTHGLGTLQEGTWDPCRRPCFSGWGEHLVYAASF---------PNLLARYAYYLQFCQGQKSSLTPSYVAGAAASPMCS---NTLFFRLRDRFPPVMSTQRRDPYVISGASGSY-TDFLGNNQNLLERLSRLGIDAEGKLEKEPHGPRDFVKMFKDVDAAVDAEVVQFMVMQYSCNPFAQPACPIFTQLFYRSLL--TILQDISLPICMCYENDNPGLGQSPPEWLKGHYQTLGVLTAKE-AKVVHGEPTCDLPDLDAALQGRVYGRRLPVRMSKVLMLCPRNIKIKNRVVFTGENAALQTTRRENYIINGYMKFLNTYHKTLFPDTKL-SSLYLPVPSGASAEEYSDLALFVAHEESNVIDVVPGNLVTAKQRLNNAILKASLIQGLVPRTQSVPARDYPHVLGTR 869
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Schwarzenbacher R, Godzik A, Jaroszewski L. The JCSG MR pipeline: optimized alignments, multiple models and parallel searches. Acta Crystallogr D Biol Crystallogr. 2008 Jan;64(Pt 1):133-40. Epub 2007 Dec 5.