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Query: PF09984.9; B7VK74_VIBTL/31-175; Uncharacterised signal transduction histidine kinase domain (DUF2222 topsan), from PfamA32U

Results of FFAS03 search in PfamA32U
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
    .   10    .   20    .   30    .   40    .   50    .   60    .   70    .   80    .   90    .  100    .  110    .  120    .  130    .  140    .
# Score Template Links and tools%idFirst FNRYQDLEGQVVNTGTSIIEPLAIASESGMKLESRESVRQLISYAHRKNSKLVRSIAVFDERHELFVTSNFHPDFESLTYPKDKPIPHLSSSNLLDNTLILRTPIIAEGQYINSANGQSQANQAIGYIAIELDLSSLRLQQYQEVLast
1 -63.700PF09984.9; B7VK74_VIBTL/31-175; Uncharacterised signal transduction histidine kinase domain (DUF2222 topsan)  ali  100  1FNRYQDLEGQVVNTGTSIIEPLAIASESGMKLESRESVRQLISYAHRKNSKLVRSIAVFDERHELFVTSNFHPDFESLTYPKDKPIPHLSSSNLLDNTLILRTPIIAEGQYINSANGQSQANQAIGYIAIELDLSSLRLQQYQEV 145
2 -32.300PF10144.9; SMP_YERPE/1-162; Bacterial virulence factor haemolysin  ali follow..  11  36.SHQLARSEQVEELAQTLAKQVAFSLSPIMDSGDSQKVDAILQQL--TQSSRILDASVYQIDGTLVASAGENVKVRDRLALDG-------KRPGSYFNHQIVEMIAGN-------------SGPSGFLRMTLDTHVLATESKQ.. 159
3 -24.600PF17152.4; F9ZZV9_METMM/42-151; Periplasmic sensor domain  ali follow..  16  2.......HRALLVNAKSTANMIGFNASAALVFEDGPSATDVLKAL--RNSPNVIAAQLYTVRGEPIARYSADSSDIDLPRLLSEPDKQRNQSHWKWLTHTLIQPIFHQ-------------TEVVGYLAL............... 109
4 -16.600PF14827.6; A9B1A1_HERA2/45-312; Double sensory domain of two-component sensor kinase  ali follow..  8  13.TNTGVGLETIEAQILDNLRLIVTSPATAFSKNDVDQVEQIINNAFNY---KPSRLIALNADGQVLVDVLSTELAKDLAVLRGQVDDYGDKYASLLTMFFVVAPVKGS------------SEQVVGAIIYAEPLERIVNEELPPR 146
5 -15.100PF17149.4; Q9KMV7_VIBCH/45-151; Periplasmic sensor domain found in signal transduction proteins  ali follow..  14  1..DYNREFNNVQARHDEIQTIHAELLASSLWNYDLVVLTQRLEGLV--NLPNVDYMKITSGDYHFSAGE-----------------------PVTSMALNSEIALEYT-------NPDTQVTENIGTLYVESDAQGIYNY..... 106
6 -12.700PF09308.10; F7YS51_VIBA7/41-278; LuxQ, periplasmic  ali follow..  11  18.SLIQNLFNFRLSLLQINQDSSAKNAGLAIRKGDNDSIDQFFFGVDQEVANTPDIRFISDSDSLMWEDGNAVNMSRKVALSNNWHMIKSPSQLGYAYLMVRRTPVIDSQ-----------SGEVIGFLHLATVLNN......... 154
7 -11.500PF16736.5; Q65G91_BACLD/33-148; Single Cache-like  ali follow..  9  4...DAKLSSHIEKEAALVASLANGENM------KSSEQGAILEKASRELD---SRVSLIDTKGQVLFHFGGRAEKEALESDLNGEGGGFRINPDDESVYRYVQPL-------------KDDGNVNGYILISTP............ 116
8 -10.600PF17154.4; Q6CYZ0_PECAS/36-155; Gammaproteobacterial periplasmic sensor domain  ali follow..  7  1....HQRREDYAKQLESIAYSVRQPLTDAVLQGEVQRAGNILDSLLPVAF--LSRADVLLPDDFQTLHANFPEERPVPD-----------IARVFKLPIRISIPLYSPPQ--------TQYSAPLAHLVLQADSYRMYQFIVST. 120
9 -8.570PF06018.14; Q834K5_ENTFA/3-183; CodY GAF-like domain  ali follow..  8  1.........TLLEKTRQVNELLQKNNLFDVQAEPYNKMAMILGDILESN------AYIISSSGDLLGYTEKLDVNNARIKNMFKEKKFPQGYTEAPFGLTTIVPLYGA-------------GKRLGTIILARVEKSFNEDDLVLA 146
10 -8.430PF16448.5; D3S9W2_THISK/23-144; LapD/MoxY periplasmic domain  ali follow..  13  7.SARDYLAQQLLTKNIDNAASLALSLS---LPKDDTTVELQIASQFDTGH--YRHIRLVDPGGELMIERRNPEPPQG-------------------------VP-LLAFNVRPGIAHVSDGWSSFGTLIVESQTNYAYES..... 120
FFAS is supported by the NIH grant R01-GM087218-01
1 4 8 0 6 6   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Pawlowski K, Pio F, Chu Z, Reed JC, Godzik A. PAAD - a new protein domain associated with apoptosis, cancer and autoimmune diseases. Trends Biochem Sci. 2001 Feb;26(2):85-7.