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Query: PF11059.8; Q6LS16_PHOPR/28-325; Protein of unknown function (DUF2860 topsan), from PfamA32U

Results of FFAS03 search in PfamA32U
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst GFSGDISLLTGFSNTKSQFNTDIESTPSLESSGESDTKALIAPLGAIQYTFASDKQIFIGTSRSDLALGRFHIEAGYRQRFEGNGMVSLSYVPGIIGTKTWEDPFLVNENRTETDTKIKGFRFQYKNILGSNFSMETSVGQQEIDSEKSGQKQNLSETEIASLDREGNIIYLEGAYRQPIAPGRLLRGALNYTRFDADGDAMSYDTYGAQLSIIQMLPSSSLALTFGYKNAQYEAENPVFDEKQKDDLWSVFLAYEYNEPFGWTDWGLVSLIGYNTTDSNINFYNEDTLMATVGINYKLast
1 -111.000PF11059.8; Q6LS16_PHOPR/28-325; Protein of unknown function (DUF2860 topsan)  ali  100  1GFSGDISLLTGFSNTKSQFNTDIESTPSLESSGESDTKALIAPLGAIQYTFASDKQIFIGTSRSDLALGRFHIEAGYRQRFEGNGMVSLSYVPGIIGTKTWEDPFLVNENRTETDTKIKGFRFQYKNILGSNFSMETSVGQQEIDSEKSGQKQNLSETEIASLDREGNIIYLEGAYRQPIAPGRLLRGALNYTRFDADGDAMSYDTYGAQLSIIQMLPSSSLALTFGYKNAQYEAENPVFDEKQKDDLWSVFLAYEYNEPFGWTDWGLVSLIGYNTTDSNINFYNEDTLMATVGINYK 298
2 -67.300PF04575.13; A6VQE8_ACTSZ/196-486; Protein of unknown function (DUF560 topsan)  ali follow..  11  1.WQFNVNAGYMREENVNNVSDSLYIAFKKGDSMLPQKAHGIQFYVGFERDFNLMYSHYLHIENLTYGKAYWDNNDYTDITNRTYLGYRHKSAKTAWSVLPF---YERQWYATHRYKKATGVRGELNHWLNRNWQISTALEYGKEQYH-------------RNALLDGNNKLASATLVWLRTPRQYFYFGGDYSFQRAQARHYGYDLKTARIGWGQEWEGISTRLGFAVSKREYKADHFYFSKPREDDIYNINASLWKRDWHLW-GITPKLRFNWKKQRSNFDLYSYIDRSITVSVEKT 290
3 -24.500PF10082.9; Q1QI05_NITHX/173-566; Putative beta-barrel porin 2  ali follow..  9  11GVKSAVELWGGYDTNPPVPTNVDRPDFTGRVDGRLDVTHDTRINSELRLRIGTDNPGSPNIQAGLERYPLYATTGGTAGIEHDFNRLQLSLNGTADRTTYQNSRLTDGTSNDDRDFNQYGAVARASYELLPGVKPFGEVEADTRVHD--------TRFDRNGFQRDSNGGYAKVGSSFELTRLLTGEASIGYAARSYADPRLNVLTRTYTFEVDHDFRWLTAIGRFTYGTRDYQGSS------RSDEIYSLSGDLVYKL----REFQIKAQVRRDILASNISGASSASTVVMLGVRLQ 393
4 -19.900PF16946.5; B8K3G3_9VIBR/48-336; OMPG-porin 1 family  ali follow..  10  19.FHGTLGSNVEVERLIRDDGVNEGKVKYTIAQGSFRHDDLP----GWDFGFYSGREELFTGNLKHA-----------DYNRGVNSIQEIYVNRSYNHEKGNIGWGLKLAGESIDQRTTPGGKVFGSYQLTDRLGMHGYALYHVEYKRGTG---------------EFPYWEVEPGFSYKINDNTGAWLNFRYQEGQWKAKDETETEWIIKPGIWHNFGKLSASLWGEFGSFEKSVDST--AHAWTEDYSKLGVSANYPLS---KSWRMFGEASYKASGPQRDEFDGYIPLFILGVNYS 288
5 -18.800PF09381.10; D1AL54_SEBTE/71-353; Outer membrane protein G (OmpG)  ali follow..  11  4.WHGTFGILQETENVEGSGDKDGLYEPSVYFDLRKGKWSFGMTNYNENHDFDYSDW-------RGNYLNRLELRAHYQFTDNDKYAVGLGAALRNYQWF-----HKDGTSPTTTNNRWLNIQPDWRYNFTSNLSYEGWLGLYS------------MFNDAQENGYSDKELETESGLKYKFNDFISVRLNYYLDRGWNLGGPTENSFNNQQIRGYVPMKTTTITPYFRQGFIN-KSWNAGANQANNEIDTRLGLRIDQQLP---AGFAVSLEYAYEMRNAPGQKSFSKFHYTGVGLSY. 283
6 -16.800PF06316.11; Q9LA63_9CAUD/1-199; Enterobacterial Ail/Lom protein  ali follow..  10  35........................................................................................................YLQTHTDMPGSDDLNGINVKYRYEFTDTLGLITSFSYAN---AEGEQKTHYNDTRWHEDSVRNRWFSVMAGPSVRVNEWFSAYALAGVSYARVSSFAGDYVTLTSDEG------------------KKQEHLTRSDSGRRSHTALTYSAGVQINPT---ENIVVDLAYEASGRG------DWRTEAFIVGTGYR 198
7 -14.900PF06178.13; Q8ZQ33_SALTY/16-230; Oligogalacturonate-specific porin protein (KdgM)  ali follow..  11  59...............................................................................................................SDLVANAIELGVSYNYKVTDNFVLQPGFIFESGP--------------------DTSIYKPYLRGQYNFDSGVYMAGRYRYDYARKTANYSDDEKTRFDTYIGYVFDELKLEYNFTWMDSDQIKFD------NKKTNYEHNVALAWKLN---KSFTPYVEVGNVAVRNN---TDERQTRYRVGLQYH 214
8 -14.600PF11854.8; A1S4W3_SHEAM/64-698; Putative outer membrane beta-barrel porin, MtrB/PioB  ali follow..  9  298....SVRASYDFRDRDNKTPEYLYPLVTTDSIYRGEYYNKGYLKLGAKYRFSRQWDLDTLYRYDHNSYSELSRDS------VFENHVEATVRGQIMAGWRVSLKGEVSARRGDSYQTSSNTQMPNQSAMRQELRLMTDHYFADVSLQFNVHSGNEDYSESELGLGEVQYTGFGMNAGYPLTEHLLLNGFLGMDWRDTTENRDEHTSASLGLKWQNLMDN-KLSLGLDYGYSDGNSDTEVSLGLSSATRHNVSAYANYQLS---DAMSLRIDWLYENYSDM----DYQAHYLGFSFSYQ 634
9 -12.900PF10677.9; C6XUB1_PEDHD/25-222; Protein of unknown function (DUF2490 topsan)  ali follow..  9  1....................................................................................................................NSGWFLFLNSTKFNDKWGMHLDVQLRSADE------------------DGLRNFLFRPGVTYYINKKSNATVGYLLDQTGPVGHVLTEHRIWEQYILMHKIKSVAVQHRFRLEQRFIEAAGDDIFSQRLRYFLRGIIPLTETKETFTKGPFAALQNELFFNVQHKAKLNFDQNRAYGAIGYR 173
10 -12.700PF07396.11; Q7MX84_PORGI/78-408; Phosphate-selective porin O and P  ali follow..  9  32SAHGELNRHLSFDWRQRLNRAAD-------GTSFADNLSNAIDIAGVDWHPNDKVSFFFGRQYARFGGIEYDMN---------------------------VEIYQYSDLVDYMTCYTSGVNFAWNFHPEQQLQLQVLNAYNNRFADRYHVTPDVATATSYHQAQERNMWYFTAGNLFNPGKRINGYLDLTYSIEGLDKTLTDVKYYALVSKWNFRIDQVNLFLKGMYENGYAPAQY---ESSHTRHSYGYMGGVEY------TNFRLFVTYIGRHYRYS-ATETESTNALRAGLIYQ 330
11 -12.600PF03922.14; Q98A70_RHILO/45-230; OmpW family  ali follow..  12  33......................................................................................................................................................................SNTVTPELDISYFFTDNIAAELILGTTYANIDGKVGKVWLLPPTLTLQYHFTDFGIGAGVNYTIFYHQQVGSADDLKVKNT-AALQVGFDYMVD---QHWGVNFDVKKLFLKPDFDVAKLDPWVIGAGLTYR 185
12 -12.500PF07437.11; YFAZ_ECOLI/1-180; YfaZ precursor  ali follow..  13  38..............................................................................................................GFGTETTGLALSGNWTHNDDDGDVAGVGLGLNLPLGPLMATVGGKGVYTNPNYGDEGYAAAVGGGLQWKIGNSFRLFGEYYYSPDSLSSGIQSYEEANAGARYTIM----PVSIEAGYRYLNLSGKDGNRDNAVADGPY-VGVNASF......................................... 180
13 -12.500PF03349.16; Q9KT62_VIBCH/16-428; Outer membrane protein transport protein (OMPP1/FadL/TodX)  ali follow..  12  12GFQSATGLGRAFAGDAVIADNAAVMSRNPAAMALFDEMALSLGFETITTMIDVKNV---VQDTDDVGGTSVAPNIHLIVPVNEQFAWGVNAYSNFGTKTEFSDSYPASEYGGLTDVKSFNLGLAGSYRVNKEWSFGAGLDLIYGQGTMKRIAPARGTSLLNVDKADGWAVGFNLGTVYEMDENNRF--GLSYRYSKAKDDYGQEITLPLEFSGFHKIENTQFAVHYSVQWIGWSAFDKIEFRNLVQDGWHYSIGGTYYLN---SDWTLRAGYMYDTSRTSISVPDSDRQWLSAGFTYN 364
14 -11.900PF05736.11; PORF_PSEFL/1-186; OprF membrane domain  ali follow..  10  42................................................................................................................................................................DSVKHIEDGFNPGARIGYFLTDDLSLNLSYDKTNHTRSNDGTGSQKIGGSLTAQYHFDSLRPYVEGGFGHQSRGNVKADGHSGRDQSLAIAGAGVKYYFT---NNVYARAGVEADYALDN----GKWDYSALVGLGVN 181
15 -11.100PF04338.12; Q74AK7_GEOSL/122-330; Protein of unknown function, DUF481 topsan  ali follow..  11  10GNTDTKAATLSTLFQVRTKRHRFTVEAKYAYGEADSRTTVRNSLGSLKYDFFTTDKVYTYAQTL----------------------------------------LEKDSFANLNLRNTEGLGVGYQFFDDRTLNLYAEAGIS-----------YFNEDVIEGEDRQDGSGRWAAGLEWEAVPDRLKIFHRQEGYYTPSVSGVTLRA---DQGVRISLVN-DIAANLEVDY-RFNS-RPEAGKRNSDLLFIMGLTYQY......................................... 209
16 -10.800PF07239.11; C0DX39_EIKCO/30-267; Outer membrane protein OpcA  ali follow..  14  24................................................................................................................KYSGDGVTLQGRADIPLAQQHAIRAELGYRYLDSDAKANGEKVINGAKTNN-----DVYAGYLFSPSGFKNGGLRGGLGYSHGKMDDISANNLYLKAQVEYEQQLSGWSITPWTEAQEEKYTQIEFASDGRYKQNNYSLGLGVDVNKQLGESSLTFGPYYRYARKATSFTIEVPKTSRHSFGIRG. 234
17 -10.600PF11383.8; B7VSE9_VIBTL/19-333; Protein of unknown function (DUF3187 topsan)  ali follow..  9  51..VGTIEFKSSYT--ASIWAHTSAYSLDYY-----------QNQSNIAIEWQASPIWKTELDYRVVTAKDNGLDSFVMGFHDLFGIGQNGVAEDQFTMDFNHAGVHLSDFEGDDLTNALTFYNELLLHSRGPMSLSVGGSLF------------YNNVKSGRFARTSFEQGVQLNYSFITLRNFFSTVGLVHRNGDDYLVSLEGFSASWALGYEYMFARHSLLVESLNYQGWATDQPDF-----SEPSNEVVLGYRYRFNRFSLEALMTENIRNMDNSTDIGFT--------IGLRFS 314
18 -10.100PF00267.21; OMPF_ECOLI/28-362; Gram-negative porin  ali follow..  13  82GLKGSFDYGRNYGVVYDALGYTDMLPEFGGDTAYSDDFFVGRVGGVATYRNSNFFGLVDGLNFAVQYLGKNE-----------------------------------RDTARRSNGDGVGGSISYE---YEGFGIVGAYGAADRT--------NLQEAQPLGNGKKAEQWATGLKYDA-------IYLAANYGETRTNTSGFANKTQDVLLVAQYQFDF-GLRPSIAYTKSKAKDVE---GIGDVDLVNYFEVGATYYFN---KNMSTYVDYIINQIDSDNKLGVGSDDTVAVGIVYQ 334
19 -9.980PF01389.17; OMP53_HAEIF/23-224; OmpA-like transmembrane domain  ali follow..  8  5TFYAGVKAGQGSFHDGINNNGAIKKGLSSSNYGYRRNTFTYGVFGGYQILNQDNFGLAAELGYDDFGRAKLREA---------------------------------GKPKAKHTNHGAYLSLKGSYEVLDGLDVYGKAGVALVRSDYKFYEDANTRDHKKGRHTARASGLFAVGAEYAVLPE--LAVRLEYQWLTRVGKYRPQDKPNTAINYNPWIGCINAGISYRFGQGE.................................................................. 202
20 -9.770PF05538.11; PORA_CAMJE/1-424; Campylobacter major outer membrane protein  ali follow..  10  230...................................................................................................................AFFYAVDAAYSTTIFDGINWTLEGAYLGNS---------LDSELDDKTHANGNLFALKGSIEV---NGWDASLGGLYYGDKEKASTVVIEDQGGYVTGGYTFNE-TVRVGADFVYGGTKTEAANHLGGGKKLEAVARVDYKYS-----PKLNFSAFYSYVNLDQGVN--SADHSTVRLQALYK 423
21 -9.590PF12600.8; K9V5V3_9CYAN/406-847; Protein of unknown function (DUF3769 topsan)  ali follow..  9  104GIFLERKFQPINTETTQLSLTPQFFA---QKAVTNPGNFASLFGFKGNFSAVLSPKSNIEATATLDSLDLSQVEENLRAGLRFRQALGDTNPHILNLEYIYRDRLYNGTLGFQRVQSSLGGVVLSPVIPLGKSGVNLTYQAGAQLIDARTDRLDLLDVGRENDRIYLGRFQANAKLFGGIPPYLRGFGELNGTSTYYTTGD-TQNTLFATVGLEGQIGHFSTGFRVSYSQGINSGLSP-FLFDRSVDNRVINLGLIQQI---YGPFRLGFQTSVNLDNGRSS-LEYSRRTYGIVLRYN 426
22 -9.540PF12099.8; R5KMA1_9BACT/7-191; Protein of unknown function (DUF3575 topsan)  ali follow..  8  31..........................................................................................................................................................................TPNIGVEASVGKKHTVQLFYGLN-KQSGGDQSSLRHWTLMPEYRYWFCQ--GQFNMGSVDLPFGVFNELEDHRYEGWYAGGGITAGYQWPLS-KHWNIEASLGVGYDYIQYDKFRCGETKLALSVLYI 184
23 -9.410PF01278.20; COLY_YERPE/30-312; Omptin family  ali follow..  10  72...........................................................................................................................................NMDDYDWMNENQSEWTDHSSHPATNVNANEYDLNVKGWLLQDENYKAGITAGYQETRFSWTATGFSMPYIGLAGQYRINDFELNALFKFNDEHYMRDLTFREKTSGSRYYGTVINAGYYVT---PNAKVFAEFTYSKYDEG---ISNKNYTVTAGLQYR 282
24 -9.290PF12094.8; G4QGK9_GLANF/10-436; Protein of unknown function (DUF3570 topsan)  ali follow..  5  58..QHILNTKLVIDS-LTGASATGAVAQPYAQTFSRPSGNGQYTTSPNELPLDDT-----------FRDTRLALSANWTQPIYRDTRINVGGNVS-----------------REYDYLSVGANVSAERDFYNKTTALFGLSYFGAGDAGEEAFEAAFEQTRIDGSDDKSTVDALFGLTQVINRRMIVQLNYSYSNSSGENRPDSRAKHSVYAQTKYAFDNAVADVSYRFATDDWD------------QSHTIDSRLRYNL----ETDYIQPHVRYYQQSADYRLGEMTAITVGLKYGHK 378
25 -9.260PF10626.9; Q5LEH6_BACFN/26-192; Conjugative transposon protein TraO  ali follow..  8  21...................................................................................................................................................................NGDGFGYHAGIAVSTYTKNAHHWVVGAEYLEKRYGDCLYPASQLTGEGGYYLNF-ALGLSALAGYETVNWGESDGSRLTDEDNFIYGGALTLELS-AYVTDKIVLLVNGRRVLFGGDCGKF---HTQVGVGIRF. 165
26 -9.220PF16956.5; Q3IIM9_PSEHT/1-267; Putative general bacterial porin  ali follow..  11  108................................................................................................................DTGSHNEFYTLSGGFFFNPNLLAKVTLVENKNGEDFALFDLAYNHMLNSTADDDFDYRAVAAKYFIDLQQGNFLTFEGKYESIDDKENQWV-------AETNYYFSK-ATSVFANYN---------------KQDAYSFGAQHFIN-----ENVGIKVGYGNNADDSGNDAYF-------ANMRFQ 266
27 -9.190PF13505.6; Q98N05_RHILO/16-224; Outer membrane protein beta-barrel domain  ali follow..  13  52................................................................................................................................................................NGIGGNGVFGELTAGYDYMVSDRFLLGGFIDANGGNIGPSISIGFDVGLRAGYLLN-PDTLGYVLGGYSWQHFKLDGSGFAEGLNFTQYVLGVGMETVLR---GNWTLKTEYRYAAYGDK---VEPSTHTFHIAANYR 208
28 -9.170PF07642.11; Q0BRB4_GRABC/58-438; Putative beta-barrel porin-2, OmpL-like. bbp2  ali follow..  9  4.LDAQLDGGFVINGNTPDNGVNFGQLFTDRSNQATLNQAALTLHTSKGYDFGFNLQLIYGSDVRYLPFLQANVAVHTPWLFNGGIDWKIGQYISPVGFETIDPATTPFYTHSYTFNFATGFLSVSH--VSPMVDVYFGVGKLSILALTNIGPETGSLAVGPEVANSALRFFDDIVIGYKASDKTTLTLELNYLRDEVINAES----FSTVGYYSHVFND---HWTFNARAEVFRDMDPLITSPGPGTYGDLTLGVTWKP---IAGLMLRPEVRYDRSLNGAGSFHNGQFLFAADAILQ 380
29 -9.170PF00593.24; Q8P343_XANCP/286-782; TonB dependent receptor  ali follow..  8  189....SVDLGIKSPSEMTARETPGIAVEAPVATGSIKASESVLPQIGLGYRLAEGQEVFASYAENIAAFQGGGAGGPLLVTQASFDASVGALEP------------------EKSRTLEAGYRFVRDRFEASLVGYDVTFDNRLLSLNPCASIQQGTTPACTTRFFNVSSRGGELTVIWKPTSYLQWYNSASINRSTYDDNYVQNGKRMLASEIAFNYAGWNVNLRGKYTGERFYTYT---NDQGFGGYTSFDAGAGYEQVSMLQSLKLSLNV------TNLTDKRYAPRQVFLTLDAK 497
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Lesley SA, Kuhn P, Godzik A., Deacon AM, Mathews I, Kreusch A, Spraggon G, Klock HE, McMullan D, Shin T, Vincent J, Robb A, Brinen LS, Miller MD, McPhillips TM, Miller MA, Scheibe D, Canaves JM, Guda C, Jaroszewski L, Selby TL, Elsliger MA, Wooley J, Taylor SS, Hodgson KO, Wilson IA, Schultz PG, Stevens RC. Structural genomics of the Thermotoga maritima proteome implemented in a high-throughput structure determination pipeline. Proc Natl Acad Sci U S A. 2002 Sep 3;99(18):11664-9. Epub 2002 Aug 22.