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Query: PF00208.21; DHE3_ORYSJ/176-408; Glutamate/Leucine/Phenylalanine/Valine dehydrogenase, from PfamA32U

Results of FFAS03 search in SCOP207
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst GGSLGRDAATGRGVMYATEALLTEYSESISGSTFVIQGLGNVGSWAAKLIHQKGGKIVAVGDVTGAIRNKSGIDIPALLKHRSEGGSLEDFYGAEVMDAAELLVHECDVLVPCALGGVLNRENAAEVKARFIIEGANHPTDTEADEILAKKGVIVLPDIYANSGGVVVSYFEWVQNIQGFMWDEEKVNRELQKYMKNAFQNIKDMCKSQNCNLRMGAFTLGVNRVAKATLLRGLast
1 -93.800d1gtma1 c.2.1.7 (A:181-419) Glutamate dehydrogenase {Pyrococcus furiosus [TaxId: 2261]}  ali model 3D-neighbors follow..  43  1GGSLGRIEATARGASYTIREAAKVLGDTLKGKTIAIQGYGNAGYYLAKIMSEDFGKVVAVSDSKGGIYNPDGLNADEVLKWKNEHGSVKDFPGATNITNEELLELEVDVLAPAAIEEVITKKNADNIKAKIVAEVANGPVTPEADEILFEKGILQIPDFLCNAGGVTVSYFEWVQNITGYYWTIEEVRERLDKKMTKAFYDVYNIAKEKNIHMRDAAYVVAVQRVYQAMLDRG 235
2 -89.400d1bgva1 c.2.1.7 (A:195-449) Glutamate dehydrogenase {Clostridium symbiosum [TaxId: 1512]}  ali model 3D-neighbors follow..  30  6GGSLVRPEATGYGSVYYVEAVMKHENDTLVGKTVALAGFGNVAWGAAKKLAELGAKAVTLSGPDGYIYDPEGITTEEKINYMLEMRASADKFGVQFFPGEKPWGQKVDIIMPCATQNDVDLEQAKKINVKYYIEVANMPTTNEALRFLQQPNMVVAPSKAVNAGGVLVSGFEMSQNSERLSWTAEEVDSKLHQVMTDIHDGSAAAAERYGLNLVAGANIVGFQKIADAMMAQG 252
3 -79.500d1hwxa4 c.2.1.7 (A:209-501) Glutamate dehydrogenase {Cow (Bos taurus) [TaxId: 9913]}  ali model 3D-neighbors follow..  33  2....GRISATGRGVFHGIENFIENASPGFGDKTFAVQGFGNVGLHSMRYLHRFGAKCVAVGESDGSIWNPDGIDPKELEDFKLQHGTILGFPKAK-IYEGSILEVDCDILIPAASEKQLTKSNAPRVKAKIIAEGANGPTTPQADKIFLERNIMVIPDLYLNAGGVTVSYFQILKNLNHVSYGRLTFKYERDSNYHLLMSVQESLERKFGLDLRTAAYVNAIEKVFRVYNEAG 289
4 -65.600d1c1da1 c.2.1.7 (A:149-349) Phenylalanine dehydrogenase {Rhodococcus sp., M4 [TaxId: 1831]}  ali model 3D-neighbors follow..  26  2......AFTTAVGVFEAMKATVAHRGGSLDGLTVLVQGLGAVGGSLASLAAEAGAQLLVADTDTERVAHAVALGHTAV-------------------ALEDVLSTPCDVFAPCAMGGVITTEVARTLDCSVVAGAANNVIDEAASDILHARGILYAPDFVANAGGAIHLVGREVLG-----WSESVVHERAVA-IGDTLNQVFEISDNDGVTPDEAARTLAGRRAREA..... 200
5 -65.000d3vpxa2 c.2.1.0 (A:145-363) automated matches {Sporosarcina psychrophila [TaxId: 1476]}  ali model 3D-neighbors follow..  25  1....NPSPVTAYGIYYGMKAAAKEADDSLAGKTVAVQGVGNVAYALCEYLHEEGAKLIITDINEEAVQRAVDAF------------------GATAVGINEIYSQEADIFAPCALGAIINDETIPQLKAKVIAGSANNQLKTRHGDLIHEMGIVYAPDYVINSGGVINVADELDG------YNRERALKRVEG-IYDVIGKIFAISKRDNIPTYVAADRMAEERIARVANTRS 207
6 -14.800d1li4a1 c.2.1.4 (A:190-352) S-adenosylhomocystein hydrolase {Human (Homo sapiens) [TaxId: 9606]}  ali model 3D-neighbors follow..  11  5........GCRESL---IDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVI-------------------ITEIDPINALQAAMEGYEVTTMDEACQEGNIFVTTTGCIDIILGRHFEQMKDDIVCNIGHFDVEIDVKWL...................................................................................... 122
7 -12.800d1vl6a1 c.2.1.7 (A:155-376) Malate oxidoreductase (malic enzyme) {Thermotoga maritima [TaxId: 2336]}  ali model 3D-neighbors follow..  15  3.......QGTAVVVSAAFLNALKLTEKKIEEVKVVVNGIGAAGYNIVKFLLDLGVKNVVAVDRKGILNPETCLNEYHLEIARITNPERLSGDLETALEGA-------DFFIGVSRGNILKPEWIKKMSRKPVIFALANPVPEEAGAFIVATGRSDHPNQVNNL-GAVEKRSKITKNM--------SAVEAIARSCEPEPERIIPEAFDMKVHLNVYTAVK............. 219
8 -11.900d1j4aa1 c.2.1.4 (A:104-300) D-lactate dehydrogenase {Lactobacillus helveticus [TaxId: 1587]}  ali model 3D-neighbors follow..  13  37........................IGREVRDQVVGVVGTGHIGQVFMQIMEGFGAKVITYDIFRNPELEKKGYYVDSLDDLYKQADVIS-----------------LHVPDVPANVHMINDESIAKMKDVVIVNVSRGPLVDTDARGLDSGKI----------FGYAMDVYEGEVGIFNEDWEGKEFPDARLADLIARPNVLVT............................. 192
9 -11.800d1ebua1 c.2.1.3 (A:2-150,A:341-359) Homoserine dehydrogenase {Baker`s yeast (Saccharomyces cerevisiae) [TaxId: 4932]}  ali model 3D-neighbors follow..  11  1...........................STKVVNVAVIGAGVVGSAFLDQLLAMTYNLVLLAEAERSLISKDFSPLNVGSDWKAALAASTTKTLPLDDLIAHLKTPKPVILVDNTSSAYIAGFYTKFVENGISIATPNKKAFSSDLATWKPTNGFVYHEATVGAGLXAAVTAA............................................................. 156
10 -11.400d1l7da1 c.2.1.4 (A:144-326) Nicotinamide nucleotide transhydrogenase dI component {Rhodospirillum rubrum [TaxId: 1085]}  ali model 3D-neighbors follow..  12  26...........................TVPPARVLVFGVGVAGLQAIATAKRLGAVVMATDVRAATKEQVESLGGKFITVDDEAMKTAETAGGYAKEMGEEFRKKQAEAVLKELVKTDI-------AITTALIPGKPAPVLITEEMVTKMKPGSVIIDLAVEAGG.................................................................... 156
11 -11.200d1t2da1 c.2.1.5 (A:1-150) Lactate dehydrogenase {Malaria parasite (Plasmodium falciparum) [TaxId: 5833]}  ali model 3D-neighbors follow..  18  2.............................PKAKIVLVGSGMIGGVMATLIVQKNLGDVVLFDIVKNMPHGKALDTSHTNVMAYSNCKVSGSNTYDDLAGADVVIVTAGF--PGKSDKEWNRDDLLPLNNKIMIEIGGHKNCPNAFIIVVTNPVDVMVQLLHQHSGV................................................................... 141
12 -11.000d1qp8a1 c.2.1.4 (A:83-263) Putative formate dehydrogenase {Pyrobaculum aerophilum [TaxId: 13773]}  ali model 3D-neighbors follow..  16  39...........................LIQGEKVAVLGLGEIGTRVGKILAALGAQVRGFSRTPKEGPWRFTNSLEEALREARAAVCALPLNKHTRVKYQHLALMAEDVFVNVGRAEVLDRDGLRILKERPQFIFAGRNDFAKDAEFFSLPNVVATPWV.......................................................................... 179
13 -10.900d1saya1 c.2.1.4 (A:136-303) L-alanine dehydrogenase {Phormidium lapideum [TaxId: 32060]}  ali model 3D-neighbors follow..  22  19..........GRGVLLGGVP-------GVKPGKVVILGGGVVGTEAAKMAVGLGAQVQIFDINVERLSYLETLFGSRVELLYSNSAEIETAVA------------EADLLIGAVL-----------------VPGRRAPILVPASLVEQMRTGSVIVDVAVDQGG.................................................................... 137
14 -10.700d1mx3a1 c.2.1.4 (A:126-318) Transcription corepressor CtbP {Human (Homo sapiens), Ctbp1 [TaxId: 9606]}  ali model 3D-neighbors follow..  19  44.........................AARIRGETLGIIGLGRVGQAVALRAKAFGFNVLFYDPYSDGVERALGLQRVSTLQDLLFHSDCVTLHCGLNEHNHHLINDF--FLVNTARGGLVDEKAAQALKEGRIRGAASEPFSFSQGPLKDAPNLICTPHA.......................................................................... 191
15 -10.200d1edza1 c.2.1.7 (A:149-319) Methylenetetrahydrofolate dehydrogenase/cyclohydrolase {Baker`s yeast (Saccharomyces cerevisiae) [TaxId: 4932]}  ali model 3D-neighbors follow..  15  1.......PCTPLAIVKILEFLLLPEGNRLYGKKCIVINRSEVGRPLAALLANDGATVYSVDVNNIQKFTRG--------ESLKLNKHHVEDLGEYSEDLLKKCSLDSDVVITGVPSENY------KFPTEYIKEGANFACTKNFSDDVKEKASLYVP-----TGKVTIAML.............................................................. 155
16 -10.100d5dzsa2 c.2.1.0 (A:101-269) automated matches {Peptoclostridium difficile [TaxId: 272563]}  ali model 3D-neighbors follow..  15  3...............FGLDSMFKMANIDVQGKVAVILGTGGASKAALTYFIDSGIEKLYVST-------------------RKKDDKKLLNSKAILIDYEELKHIKGDIILNATPVGMYPNVGISPVNFDILIDLIYNPGETEFLRIGNSMGKKTC-------DGLYMLVGQAIKSQE---WQDTKIDNSILDVIYNELKL................................ 166
17 -9.780d1e5qa1 c.2.1.3 (A:2-124,A:392-450) Saccharopine reductase {Fungus (Magnaporthe grisea) [TaxId: 148305]}  ali model 3D-neighbors follow..  14  1.............................ATKSVLMLGSGFVTRPTLDVLTDSGIKVTVAC-----------RTLESAKKLSAGVQHSTPISDVNDDAALDAEVAKHDLVISLI--HATVIKSAIRQKKHVVTTSYVSPAMMELDQAAKDAGITVMNEIGXYSA..................................................................... 127
18 -9.680d1sc6a1 c.2.1.4 (A:108-295) Phosphoglycerate dehydrogenase {Escherichia coli [TaxId: 562]}  ali model 3D-neighbors follow..  15  36......................AAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFY-DIENKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLLINASRGTVVDIPAADALASKHLAGAAIDVFPTETSPLAEFDNVLLTPHI.......................................................................... 186
19 -9.610d3dona2 c.2.1.7 (A:100-269) Shikimate 5-dehydrogenase AroE {Staphylococcus epidermidis [TaxId: 176279]}  ali model 3D-neighbors follow..  14  2..........GIGYV----NGLKQIYEGIEDAYILILGAGGASKGIANELYKIVRPTLTVANRT-----------------MSRFNNWSLNINKINLSHAESHLDEFDIIINTTPAGMNGNTDSV--SHTLVSDIVYNPYKTPILIEAEQRGNPIYNGLDMFVHQGAESFKIWTNLEPDIKAMKNIVIQKLKGEL...................................... 170
20 -9.460d1dlja2 c.2.1.6 (A:1-196) UDP-glucose dehydrogenase (UDPGDH) {Streptococcus pyogenes [TaxId: 1314]}  ali model 3D-neighbors follow..  13  1...............................MKIAVAGSGYVGLSLGVLLSL-QNEVTIVDILPSKVDKINNIQDEYIEYYLKSKQLSIKATLDSKAAYKEAELV---IATPTNYNSRINYFDTQHVETATLIIKSTIPFITEMRQKFQTDRIIFSPEFLRESKAL................................................................... 149
21 -9.380d1cf2o1 c.2.1.3 (O:1-138,O:304-336) Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) {Methanothermus fervidus [TaxId: 2180]}  ali model 3D-neighbors follow..  22  2...............................KAVAINGYGTVGKRVADAIAQQDMKVIGVSKTRPDFEARMALK-YDLYVAIPERVKLFEKAGIEVAGTVDDMLDEADIVIDCTPEGI-NLKMYKEKGIKAIFQGGEKHEDIGLEESYGKDYTRVVXIVPENVDAVR.................................................................. 149
22 -9.280d1ygya1 c.2.1.4 (A:99-282) Phosphoglycerate dehydrogenase {Mycobacterium tuberculosis [TaxId: 1773]}  ali model 3D-neighbors follow..  20  36......................SFSGTEIFGKTVGVVGLGRIGQLVAQRIAAFGAYVVAYDPVSPARAAQLGIELLSLDDLLARADFISVHLPKTPETAGLIDKEALAIIVNAARGGLVDEAAADAITGGHVRAAGLDVFATEDSPLFELAQVVVTPHL.......................................................................... 183
23 -9.130d2egga2 c.2.1.7 (A:123-297) Shikimate 5-dehydrogenase AroE {Geobacillus kaustophilus [TaxId: 1462]}  ali model 3D-neighbors follow..  14  2..........GLG---YVQALEEEMNITLDGKRILVIGAGGGARGIYFSLLSTAAERID-------MANRTVEKAERLVREGDERRS-----AYFSLAEAETRLAEYDIIINTTSVGMHPRVEVQPLSLEIVSDIIYNPLETKWLKEAKARGARVQNGVGMLVYQGALAFEKWTGQWPDVNRMKQLVIEALRR........................................ 175
24 -9.090d2naca1 c.2.1.4 (A:148-335) Formate dehydrogenase {Pseudomonas sp., strain 101 [TaxId: 306]}  ali model 3D-neighbors follow..  8  38........................HAYDLEAMHVGTVAAGRIGLAVLRRLAPFDVHLHYTD-LPESVEKELNLTWHATREDMYPVCDVVTLNCPLHPETEHMINDE--YIVNTARGKLCDRDAARALESGRLAGYAFPQPAPKDHPWRTMPYNGMTP----HISG.................................................................... 188
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Plewczynski D, Tkacz A, Godzik A., Rychlewski L. A support vector machine approach to the identification of phosphorylation sites. Cell Mol Biol Lett. 2005;10(1):73-89.