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Query: PF00389.30; Q9KCG9_BACHD/20-325; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain, from PfamA32U

Results of FFAS03 search in SCOP207
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst ILVSDAMSEQGLSPLLNDPRVECVQQNVADADDLHEYDALLVRSATTVTEELMEKMSSLKIIARAGVGVDNIDIDAATKHGIVVVNAPDGNTISTAEHTFAMICSLLRKIPQANASIKAGEWKRKAFQGTELRGKTLGIIGFGRIGSQIAKRAKAFEMTPYVFDPFLTKARAEKLGVTVASLDDVLQVADIITVHTPLTKETKGLLGMKNIGKTKKGVFLINCARGGIIDEEALKHYLREGHIAGAALDVFEEEPVADEELLAFDNVIATPHIAASTKEAQLNVAEQVSQEVLHFLEGNPVSNSINLast
1 -86.800d1ygya1 c.2.1.4 (A:99-282) Phosphoglycerate dehydrogenase {Mycobacterium tuberculosis [TaxId: 1773]}  ali model 3D-neighbors follow..  45  1..........................................................................................NIHSAAEHALALLLAASRQIPAADASLREHTWKRSSFSGTEIFGKTVGVVGLGRIGQLVAQRIAAFGAYVVAYDPYVSPARAAQLGIELLSLDDLLARADFISVHLPKTPETAGLIDKEALAKTKPGVIIVNAARGGLVDEAALADAITGGHVRAAGLDVFATEPCTDSPLFELAQVVVTPHLG................................ 184
2 -82.000d1gdha1 c.2.1.4 (A:101-291) D-glycerate dehydrogenase {Hyphomicrobium methylovorum [TaxId: 84]}  ali model 3D-neighbors follow..  31  2...........................................................................................TVATAEIAMLLLLGSARRAGEGEKMIRTRSWEPLELVGEKLDNKTLGIYGFGSIGQALAKRAQGFDMDIDYFDTHRSSDEASYQATFHDSLDSLLSVSQFFSLNAPSTPETRYFFNKATIKSLPQGAIVVNTARGDLVDNELVVAALEAGRLAYAGFDVFAGEPNINEGYYDLPNTFLFPHIGSA.............................. 191
3 -78.600d1sc6a1 c.2.1.4 (A:108-295) Phosphoglycerate dehydrogenase {Escherichia coli [TaxId: 562]}  ali model 3D-neighbors follow..  39  1..........................................................................................NTRSVAELVIGELLLLLRGVPEANAKAHRGVGNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIE--NKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALADALASKHLAGAAIDVFPTEPPFTSPLAEFDNVLLTPHIGG............................... 188
4 -76.600d1mx3a1 c.2.1.4 (A:126-318) Transcription corepressor CtbP {Human (Homo sapiens), Ctbp1 [TaxId: 9606]}  ali model 3D-neighbors follow..  37  1............................................................................................EETADSTLCHILNLYRRATWLHQALREGTRVQSVSGAARIRGETLGIIGLGRVGQAVALRAKAFGFNVLFYDPYLSDGVERALGLQRVTLQDLLFHSDCVTLHCGLNEHNHHLINDFTVKQMRQGAFLVNTARGGLVDEKALAQALKEGRIRGAALDVHESEPFSQGPLKDAPNLICTPHAA................................ 192
5 -75.700d2naca1 c.2.1.4 (A:148-335) Formate dehydrogenase {Pseudomonas sp., strain 101 [TaxId: 306]}  ali model 3D-neighbors follow..  28  1............................................................................................ISVAEHVVMMILSLVRNYLPSHEWARKGGWNIADCVAYDLEAMHVGTVAAGRIGLAVLRRLAPFDVHLHYTDRHRLPESVEK--TWHATREDMYPVCDVVTLNCPLHPETEHMINDETLKLFKRGAYIVNTARGKLCDRDAVARALESGRLAGYAGDVWFPQPPKDHPWRTMPYNGMTPHISG............................... 188
6 -69.400d1j4aa1 c.2.1.4 (A:104-300) D-lactate dehydrogenase {Lactobacillus helveticus [TaxId: 1587]}  ali model 3D-neighbors follow..  29  3.............................................................................................AIAEHAAIQAARILRQDKAMDEKVARHDLRWAPTIGREVRDQVVGVVGTGHIGQVFMQIMEGFGAKVITYDIFRNPE-LEKKGYYVDSLDDLYKQADVISLHVPDVPANVHMINDESIAKMKQDVVIVNVSRGPLVDTDAVIRGLDSGKIFGYAMDVYEGEVARLADLIARPNVLVTPKTA................................ 196
7 -65.600d1qp8a1 c.2.1.4 (A:83-263) Putative formate dehydrogenase {Pyrobaculum aerophilum [TaxId: 13773]}  ali model 3D-neighbors follow..  23  1...........................................................................................ADAVAEFALALLLAPYKRIIQYGEKMKRGDYGRD-VEIPLIQGEKVAVLGLGEIGTRVGKILAALGAQVRGFSRTPKEGP----WRFTNSLEEALREARAAVCALPLNKHTRGLVKYQHLALMAEDAVFVNVGRAEVLDRDGVLRILKERPQFIFASDVWWGRNDKDAEFFSLPNVVATPWVAG............................... 181
8 -48.900d1sc6a2 c.23.12.1 (A:7-107,A:296-326) Phosphoglycerate dehydrogenase {Escherichia coli [TaxId: 562]}  ali model 3D-neighbors follow..  19  7FLLVEGVHQKALESLRAAGYTNIELDDEQLKESIRDAHFIGLRSRTHLTEDVINAAEKLVAIGAFAIGTNQVDLDAAAKRGIPVFNAPFSXSTQEAQENIGLEVAG-KLIKYSDNGSTLSAVN....................................................................................................................................................................................... 133
9 -48.700d1ygya2 c.23.12.1 (A:3-98,A:283-316) Phosphoglycerate dehydrogenase {Mycobacterium tuberculosis [TaxId: 1773]}  ali model 3D-neighbors follow..  33  5VLIADKLAPSTVAALGDQVEVRWGPDRDKLLAAVPEADALLVRSATTVDAEVLAAAPKLKIVARAGVGLDNVDVDAATARGVLVVNAPTSXASAEAQDRAGTDVAESVRLALAGEFVPDAVNV....................................................................................................................................................................................... 130
10 -42.600d1mx3a2 c.23.12.1 (A:28-125,A:319-352) Transcription corepressor CtbP {Human (Homo sapiens), Ctbp1 [TaxId: 9606]}  ali model 3D-neighbors follow..  26  3VALLDGRDCTVEMPILKDVATVAFSTQEIHEKVLNEAVGALMYHTITLTREDLEKFKALRIIVRIGSGFDNIDIKSAGDLGIAVCNVPAASVXYSEQASIEMREEAAREIRRAITGRIPDSLKNCV.................................................................................................................................................................................... 132
11 -39.600d1gdha2 c.23.12.1 (A:2-100,A:292-321) D-glycerate dehydrogenase {Hyphomicrobium methylovorum [TaxId: 84]}  ali model 3D-neighbors follow..  23  4ILITWPLPEAAMARARESYDVIAKITIDEMIETAKSVDALLITLNEKCRKEVIDRIENIKCISTYSIGFDHIDLDACKARGIKVGNAPHGXATQAREQANDLIDALFGGADMSYALA............................................................................................................................................................................................. 130
12 -36.200d2naca2 c.23.12.1 (A:1-147,A:336-374) Formate dehydrogenase {Pseudomonas sp., strain 101 [TaxId: 306]}  ali model 3D-neighbors follow..  20  48QLLGSVSGELGLRKYLESNGHTLVVPDSVFERELVDADVVISQPFWYLTPERIAKAKNLKLALTAGIGSDHVDLQSAIDRNVTVAEVTYCNSXTTLTAQARYAAGT-REILECFFEGRPIRDEYLIVQGGALA............................................................................................................................................................................. 187
13 -35.300d1j4aa2 c.23.12.1 (A:2-103,A:301-332) D-lactate dehydrogenase {Lactobacillus helveticus [TaxId: 1587]}  ali model 3D-neighbors follow..  16  36..........................TPETVALAKGADGVVVYQQLDYIAETLQALADITKMSLRNVGVDNIDMAKAKELGFQITNVPVYSXYTTHAVRNMVVKAFDNNLELVEGKEAETPVK....................................................................................................................................................................................... 134
14 -34.600d1dxya2 c.23.12.1 (A:1-100,A:300-330) D-2-hydroxyisocaproate dehydrogenase {Lactobacillus casei [TaxId: 1582]}  ali model 3D-neighbors follow..  16  5AYGARVDEIQYFKQWAKDTGNTLEYHTEFLDENAKGFDGINSLQTTPYAAGVFEKAYGIKFLTIRNVGTDNIDMTAMKQYGIRLSNVPAYXTETAVHNMVYFSLQHLVDFLTKGETSTEVT......................................................................................................................................................................................... 131
15 -32.700d1qp8a2 c.23.12.1 (A:1-82,A:264-302) Putative formate dehydrogenase {Pyrobaculum aerophilum [TaxId: 13773]}  ali model 3D-neighbors follow..  21  3LYVNFELPPEAEEELRKYFKIVR-------GGDLGNVEAALVS---RITAEELAKMPRLKFIQVVTAGLDHLPWESIPP-HVTVAGNAGSNXGYGNERVWRQMVMEA--------------------------VRNLITYATGGRPRNIAKREDYIG..................................................................................................................................................... 122
16 -30.500d1li4a1 c.2.1.4 (A:190-352) S-adenosylhomocystein hydrolase {Human (Homo sapiens) [TaxId: 9606]}  ali model 3D-neighbors follow..  16  2..........................................................................................NLYGCRESLIDGIK---------------------RATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVIITEI-INALQAAMEGYEVTTMDEACQEGNIFVT----TTGCIDIILGRHFEQMKDDAIVCNIGHFVEIDVKWLNENAVEKVNIKPQVDRYRLKNGRRIILLAEGRLV---NLGCAM............................. 162
17 -21.800d1kjqa2 c.30.1.1 (A:2-112) Glycinamide ribonucleotide transformylase PurT, N-domain {Escherichia coli [TaxId: 562]}  ali model 3D-neighbors follow..  16  1.............................................................................................................................TLLGTALAATRVMLLGSGELGKEVAIECQRLGVEVIAVDRYADAPAMHVAHINMLDGDALRRVVELEKPHY-IVPEIEAIATDMLIQLEEEGLNVVPCARATKLTM........................................................................... 111
18 -12.600d4ypoa1 c.2.1.0 (A:1-180) automated matches {Mycobacterium tuberculosis [TaxId: 1773]}  ali model 3D-neighbors follow..  16  12...................................................................................................................................IQGRKVGVIGYGSQGHAHSLSLRDSGVQVRVGQGSRSRPKVEEQGLDVDTPAEVAKWADVVMVLAP-DTAQAEIFAGDIEPNLKPGDALFFGHGLNVHFGLIKPPADVA.................................................................. 121
19 -10.900d2cvza2 c.2.1.6 (A:2-157) Hydroxyisobutyrate dehydrogenase {Thermus thermophilus [TaxId: 274]}  ali model 3D-neighbors follow..  18  1......................................................................................................................................EKVAFIGLGAMGYPMAGHLARRFPTLVWNRTFEKALRHQEEFGSEAVPLERVAEARVIFTCLPTTREVYEVAEA--YPYLREGTYWVDATSGEPEASRRLAERLREKGVTYLDAPV........................................................ 115
20 -10.300d2i76a2 c.2.1.6 (A:2-154) Hypothetical protein TM1727 {Thermotoga maritima [TaxId: 2336]}  ali model 3D-neighbors follow..  14  1.......................................................................................................................................VLNFVGTGTLTRFFLECLKD--GYILSRSIDRARNLAEVYGGKAATLEKHPELNGVVFVIVP------RYIKTVANHLNLGDAVLVHCS--GFLSSEIFKKS------GRASIHPNFSFSSLEKALEMKDQIVFGLEGDERGLPIVKKIAEEISGKYFVI........... 149
21 -10.000d3etja2 c.30.1.1 (A:1-78) N5-carboxyaminoimidazole ribonucleotide synthetase PurK (AIRC), N-domain {Escherichia coli [TaxId: 562]}  ali model 3D-neighbors follow..  18  2......................................................................................................................................KQVCVLGNGQLGRMLRQAGEPLGIAVWPVGL--------------AEPAAVPFQQSVITAEIERWPET........................................................................................................ 56
22 -9.800d4gwga1 c.2.1.0 (A:1-176) automated matches {Human (Homo sapiens) [TaxId: 9606]}  ali model 3D-neighbors follow..  14  3......................................................................................................................................ADIALIGLAVMGQNLILNMNDHGFVVCAFNDFLANEAKGTKVVGAQSLKEMVSKLKKPRRIILLVKAGQAVDDFIEVPLLDTGDIIIDGGNSEYRDTTRRCRDLKAKGILFVGSGV........................................................ 127
23 -9.410d1saya1 c.2.1.4 (A:136-303) L-alanine dehydrogenase {Phormidium lapideum [TaxId: 32060]}  ali model 3D-neighbors follow..  23  30...................................................................................................................................VKPGKVVILGGGVVGTEAAKMAVGLGAQVQIFDETLFGSRVELLYSNSAEIETAVAEADLLAVLVP-GRRAPILVPASLVEQMRTGSVIVDVAQGGCVE............................................................................ 140
24 -9.370d5je8a1 c.2.1.0 (A:1-163) automated matches {Bacillus cereus [TaxId: 226900]}  ali model 3D-neighbors follow..  17  2......................................................................................................................................KKIGFIGLGNMGLPMSKNLVKSGYTVYGVDKEAEASFEKEGGIIGLSISKLAETCDVVFTSLPSPRAVEAVYFGAEFENGHSNVVFIDTSTVSPQLNKQLEEAAKEKKVDFLAAPVSGGVIGAENRTLTF.......................................... 135
25 -9.350d4dlla1 c.2.1.0 (A:29-190) automated matches {Polaromonas sp. [TaxId: 296591]}  ali model 3D-neighbors follow..  16  4......................................................................................................................................RKITFLGTGSMGLPMARRLCEAGYALQVWNPARAASLAALGATIHEQARAAARDADIVVSMLENGAVVQDVLAQGVAAAMKPGSLFLDMASITPREARDHAARLGALGIAHLDTPVSGGTVGAEQGTLVI.......................................... 136
26 -9.020d2pv7a2 c.2.1.6 (A:92-243) Prephenate dehydrogenase TyrA {Haemophilus influenzae [TaxId: 727]}  ali model 3D-neighbors follow..  12  2..............................................................................................................................FKTINSDIHKIVIVGYGKLGGLFARYLRASGYPISILDR------------DWAVAESILANADVVIVSVPINLTLETI--ERLKPYLTENMLLADLTSVKREPLAKMLEVHTGAVLGL--------HPMFGADIASMAKVVRCDGRFPERYEWLLEQIQIWGAKIYQ............ 151
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Jaroszewski L, Rychlewski L, Godzik A. Improving the quality of twilight-zone alignments. Protein Sci. 2000 Aug;9(8):1487-96.