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Query: PF01128.19; ISPD_ECOLI/8-229; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, from PfamA32U

Results of FFAS03 search in SCOP207
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst VCAVVPAAGFGRRMQTECPKQYLSIGNQTILEHSVHALLAHPRVKRVVIAISPGDSRFAQLPLANHPQITVVDGGDERADSVLAGLKAAGDAQWVLVHDAARPCLHQDDLARLLALSETSRTGGILAAPVRDTMKRAEPGKNAIAHTVDRNGLWHALTPQFFPRELLHDCLTRALNEGATITDEASALEYCGFHPQLVEGRADNIKVTRPEDLALAEFYLTRLast
1 -115.000d1i52a_ c.68.1.13 (A:) 4-diphosphocytidyl-2C-methyl-D-erythritol (CDP-me) synthase (IspD, YgbP) {Escherichia coli [TaxId: 562]}  ali model 3D-neighbors follow..  100  4VCAVVPAAGFGRRMQTECPKQYLSIGNQTILEHSVHALLAHPRVKRVVIAISPGDSRFAQLPLANHPQITVVDGGDERADSVLAGLKAAGDAQWVLVHDAARPCLHQDDLARLLALSETSRTGGILAAPVRDTMKRAEPGKNAIAHTVDRNGLWHALTPQFFPRELLHDCLTRALNEGATITDEASALEYCGFHPQLVEGRADNIKVTRPEDLALAEFYLTR 225
2 -99.100d2yc3a1 c.68.1.13 (A:76-300) 4-diphosphocytidyl-2C-methyl-D-erythritol (CDP-me) synthase (IspD, YgbP) {Thale cress (Arabidopsis thaliana), chloroplast [TaxId: 3702]}  ali model 3D-neighbors follow..  31  4VSVILLAGGQGKRMKMSMPKQYIPLLGQPIALYSFFTFSRMPEVKEIVVVCDPFFRDIFEEYEESDVDLSFAIPGKERQDSVYSGLQEIDNSELVCIHDSARPLVNTEDVEKVLKDGSAV-GAAVLGVPAKATIKEVNS-DSLVVKTLDRKTLWEMQTPQVIKPELLKKGFELVKSEGLEVTDDVSIVEYLKHPVYVSQGSYTNIKVTTPDDLLLAERILSE 225
3 -98.700d2xwla1 c.68.1.0 (A:2-219) automated matches {Mycobacterium smegmatis [TaxId: 1772]}  ali model 3D-neighbors follow..  36  2TVAVVPAAGSGERLRAGRPKAFVTLGGTPLLEHALSGLRASGVIDRIVIAVPPALTDESKLVFGG-EDSVIVSGGVDRTESVALALEAAGDAEFVLVHDAARALTPPALIARVVAALKEGHSAVVPGLAPADTIKAVDA-NGAVLGTPERAGLRAVQTPQGFHADVLRRAYARATAGG--VTDDASLVEQLGTPVQIVDGDPLAFKITTPLDLVLAEAVLA. 218
4 -98.500d4myba_ c.68.1.0 (A:) automated matches {Francisella tularensis [TaxId: 263]}  ali model 3D-neighbors follow..  35  3KYVIIPAAGIGTRMQLDIPKQYYKLNGKTILDNTLVKFIDNPLFDKIFVAIAASDNFWNNSLYYNHDKIVVCNGGETRFNSVYNALNVIDNDDWVFVHDAARPCVSIDSIIDLYEQTKSSHQAGILAVRAYETVKQVT--KNIVVKTLARDNIWLAQTPQLSRLGQLEKAFDFCYSNNLKVTDEASALEMFGINPIVVECSKKNIKITTKDDLEYANWQL.. 227
5 -96.700d5ddta_ c.68.1.0 (A:) automated matches {Bacillus subtilis [TaxId: 224308]}  ali model 3D-neighbors follow..  34  3YDVVIPAAGQGKRMKAGRNKLFIELKGDPVIIHTLRVFDSHRQCDKIILVINEQEREHFQQLLSDYTSIELVAGGDERQHSVYKGLKAVKQEKIVLVHDGARPFIKHEQIDELIAEAEQT-GAAILAVPVKDTIKRVQ--DLQVSETIERSSLWAVQTPQAFRLSLLMKAHAEAERKGFLGTDDASLVEQMGGSVRVVEGSYTNIKLTTPDDLTSAEAIMES 225
6 -93.300d4kt7a1 c.68.1.0 (A:1-230) automated matches {Anaerococcus prevotii [TaxId: 525919]}  ali model 3D-neighbors follow..  26  7ISAIITAAGSGLRMRSKINKPYIEVGGRKVLEITLDTVSRVKEIDEIILVIRKDDEDIIKDILEKYGNIRYVYGSTTRELSTFEGLKALDQSELVLTHDGVRPFASEELFLKTINALRKN-KAVITATKSKDTVKIIDD-DMYVDFTPNRDYVYNIQTPQAFDKKLIYAMYEKYLASEFKVTDDSQLFEFFDEKVKVVHGEYSNIKITTQEDIIFANAYLQR 230
7 -91.000d1vpaa1 c.68.1.13 (A:1-219) 4-diphosphocytidyl-2C-methyl-D-erythritol (CDP-me) synthase (IspD, YgbP) {Thermotoga maritima [TaxId: 2336]}  ali model 3D-neighbors follow..  29  3.VAILLAAGKGERMSENVPKQFLEIEGRMLFEYPLSTFLKSEAIDGVVIVTRREWFEVVEKRVFHEKVLGIVEGGDTRSQSVRSALEFLESPSYVLVHDSARPFLRKKHVSEVLRRARET-GAATLALKNSDALVRVEND---RIEYIPRKGVYRILTPQAFSYEILKKAHENGGE----WADDTEPVQKLGVKIALVEGDPLCFKVTFKEDLELARIIARE 217
8 -91.000d1w55a1 c.68.1.13 (A:3-207) IspD/IspF bifunctional enzyme, CDP-me synthase domain {Campylobacter jejuni [TaxId: 197]}  ali model 3D-neighbors follow..  25  2MSLIMLAAGNSTRFNTKVKKQFLRLGNDPLWLYATKNLSSFYPFKKIVVTSSNITYMK-----KFTKNYEFIEGGDTRAESLKKALELI-DSEFVMVSDVARVLVSKNLFDRLIENLDKA-DCITPALKVADTTLFDN-------EALQREKIKLIQTPQISKTKLLKKALD----QNLEFTDDSTAIAAMGGKIWFVEGEENARKLTFKEDLKKLDLPTP. 204
9 -87.800d2vsha_ c.68.1.0 (A:) automated matches {Pneumococcus (Streptococcus pneumoniae) [TaxId: 1313]}  ali model 3D-neighbors follow..  23  3IYAGILAGGTGTRMGSNLPKQFLELGDRPILIHTIEKFVLEPSIEKIVVGVHGDWVSHAEDLVDKYERIIITKGGADRNTSIKNIIEAIDPEDIVVTHDSVRPFITLRMIQDNIQLAQN-HDAVDTVVEAVDTIVESTNG-QFITDIPNRAHLYQGQTPQTFRCKDFMDLYGSLSDEEEILTDACKIFVIKGKDVALAKGEYSNLKITTVTDLKIAKSMIE. 234
10 -24.700d1hm9a2 c.68.1.5 (A:2-251) N-acetylglucosamine 1-phosphate uridyltransferase GlmU, N-terminal domain {Pneumococcus (Streptococcus pneumoniae) [TaxId: 1313]}  ali model 3D-neighbors follow..  17  2NFAIILAAGKGTRMKSDLPKVLHKVAGISMLEHVFRSVGAIQPEKTVTVVGHKAEL--VEEVLAGQTEFVTQSEQLGTGHAVMMTEPILEGLS-TLVIAGDTPLITGESLKNLIDFHINHKNVATILTAETDN-RIVRNDNAEVLRIVEQKDATDFEKQYVFDNERLFEALKNINTNNYYITDVIGIFRETGEKVGAYKDFDESLGVNDRVALATAESVMRR 240
11 -24.600d1h7ea_ c.68.1.13 (A:) CMP:2-keto-3-deoxy-manno-octonic acid (CMP-KDO)synthetase {Escherichia coli, KpsU [TaxId: 562]}  ali model 3D-neighbors follow..  17  3AVIVIPARYGSSRLPG---KPLLDIVGKPMIQHVYERALQVAGVAEVWVATDDPRVEQAVQAFGGKAIMT--ESGTDRLVEVMHKV----EADIYINLQGDEPMIRPRDVETLLQGMRDDPALPVTLCHAISAAEAAEPSTVKVVVNTRQDALYFSRSPYAYRRDVLQNQLPESMPEQAESLEQLRLMNA-GINIRTFEVAATGPGVDTPACLEKVRALMAQ 239
12 -21.800d2y6pa_ c.68.1.0 (A:) automated matches {Aquifex aeolicus [TaxId: 63363]}  ali model 3D-neighbors follow..  15  2RAVIIPARLGSTRLKE---KPLKNLLGKPLIRWVVEGLVKT--GERVILATDSERVKEVVEDLCEVFLTP--PSGSDRVLYVVRDL----DVDLIINYQGDEPFVYEEDIKLIFRELEKGE--RVVTLARKDKEAYERPEDVKVVLDREGYALYFSRSPYGFRKETLMEAMPPSKLEQIEGLEQLRLLEN-GIKIKVLITENYYHGVDTEEDLKIVEEKLK. 231
13 -21.300d1qwja_ c.68.1.13 (A:) CMP acylneuraminate synthetase {Mouse (Mus musculus) [TaxId: 10090]}  ali model 3D-neighbors follow..  11  4LAALVLARGGSKGIPL---KNIKRLAGVPLIGWVLRAALDAGVFQSVWVSTDHDEIENVAKQFGAQRSSETSKDSSTSLDAIVEFLNYHNEVDIVGNIQATSPCLHPTDLQKVAEMIREEGYDSVFSVVRRHEIQKGVREVTEPLNLNPAKRPRRQDWDGELENGSFYFAKRHLIEMGYLQGGKMAYYEM---------RAEHSVDIDVDIDWPIAEQRVLR 222
14 -20.800d2dpwa1 c.68.1.19 (A:1-231) Uncharacterized protein TTHA0179 {Thermus thermophilus [TaxId: 274]}  ali model 3D-neighbors follow..  14  3PSAIVLAGGKEAWAEGVGSKALVPYRGRPMVEWVLEALYAAG--LSPVYVGENPGLV--------PAPALTLPDRGGLLENLEQALEHVEGRVLVATGD---PHLTEEAVRFVLDKAPEAA--LVYPIVPKEAVEARFPRTKLREGTFTGGNLLLLDKSLFRKALPLARRVVALRKRPLALAREARAQRILGVEARALVTPYPEVDVDREEDLV........ 231
15 -19.500d1e5ka_ c.68.1.8 (A:) Molybdenum cofactor biosynthesis protein MobA {Escherichia coli [TaxId: 562]}  ali model 3D-neighbors follow..  18  4ITGVVLAGGKARRMGGV-DKGLLELNGKPLWQHVADALM--TQLSHVVVNANRHQEIYQASGLKVIEDSLADYPGP--LAGMLSVMQQE-AGEWFLFCPCDTPYIPPDLAARLNHQRKDAPV----------VWVHDGERDHPTIALVNRAIEPLLLEYLQAGERRVMVFMRLAGGHAVDFSDHKDAF----------------VNVNTPEELARWQ..... 188
16 -19.100d1ezia_ c.68.1.13 (A:) CMP acylneuraminate synthetase {Neisseria meningitidis [TaxId: 487]}  ali model 3D-neighbors follow..  13  5NIAVILARQNSKGLPL---KNLRKMNGISLLGHTINAAISSKCFDRIIVSTDGGLIAEEAKNFGVERPAELASDTASSISGVIHALETIGSNGTVTLLQPTSPLRTGAHIREAFSLFDEKIKGSVVSACPMETLLQINNGEYAPMRHLSDLEQPRQQLPQAFRPNIYINDTASLIANNCFFIAPTKLY---------IMSHQDSIDIDTELDLQQAENILN. 224
17 -16.000d2e8ba_ c.68.1.8 (A:) Molybdenum cofactor biosynthesis protein MobA {Aquifex aeolicus [TaxId: 224324]}  ali model 3D-neighbors follow..  15  12NTCYVLAGGKSKRFGED--KLLYEIKGKKVIERVYETAK--SVFKEVYIVAKDRE----KFSFLNAPVVLDEFEESASIIGLYTALKHA-KEENVFVLSGDLPLMKKETVLYVLENFKEHTLVGVYSKKLLEKIEEIKKGDYRIWALLKDVGYNEVEIPE.............................................................. 173
18 -15.900d1fxoa_ c.68.1.6 (A:) RmlA (RfbA) {Pseudomonas aeruginosa [TaxId: 287]}  ali model 3D-neighbors follow..  15  2RKGIILAGGSGTRLHLAISKQLLPVYDKPMIYYPLSTLMLAG-IREILIISTPQDTPRFQQLLGDGSNWGLDLQYAVQPSAFLIGESFIGNDLSALVLGD---LYYGHDFHELLGSASQRQTGASVFAYHVLDPERYGDQGGKAISLEEKPL--YFYDQQVVD---IARDLKPSPRGELEITD-RAYLERGQLSVEIMGRGYAWLDTGTHDSLLEAGQFIAT 240
19 -15.500d1jyka1 c.68.1.13 (A:7-231) CTP:phosphocholine cytidylytransferase LicC {Pneumococcus (Streptococcus pneumoniae) [TaxId: 1313]}  ali model 3D-neighbors follow..  11  2..AIILAAGLGTRLRENTPKALVQVNQKPLIEYQIEFLKEKG-INDIIIIVGYLKEQF--DYLKEKYGVRLVFNDKYADYNNFYSLYLVKENSYVIDADNY---------NMFRNDLTRSTYFSVYREDCTNEWFLVYGDDYKVQDIIVDSKFWDAPTAEKIV-SFIDKAYVSGEFVDLYWDN-KDNIKELDVYVEELEGNS--YEIDSVQDYRKLEEILK. 225
20 -12.400d2cu2a2 c.68.1.20 (A:1-268) Putative mannose-1-phosphate guanylyl transferase (GDP)/mannose-6-phosphate isomerase TTHA1750 {Thermus thermophilus [TaxId: 274]}  ali model 3D-neighbors follow..  17  3TYALVMAGGRGERLREDRPKPFLPLEGKTLLEATLERLAPLVPPERTLLAVRRDQEAVARPYADGIRLLLEPLGRDTAGAVLLGVAEALKGAERLLVLPADHYVGDDEAYREALATMLEAEEGFVVALGLRPTRPETKPSYAEALEYIRKGYVWNG----AFAPATMAELFRRHLPSHHEALERLLAGASLEEVYAGLPKISIDYGVMEKAE.......... 242
21 -12.300d1tzfa1 c.68.1.13 (A:4-259) Glucose-1-phosphate cytidylyltransferase RfbF {Salmonella typhimurium [TaxId: 90371]}  ali model 3D-neighbors follow..  15  2..AVILAGGLGTRLSIVKPKPMVEIGGKPILWHIMKMYSVHG-IKDFIICCGAENRMEVHHKRVEPWNVTLVDTGDSTGGRLKRVAEYVKDDEAFLFTYG--DGVADLDIKATIDFHKAHGKATLTATFPPGRFGALDIQAGQVRSFQEKPKGDGAMINGGF-FVLNPSVIDLIDNDATTWEQEPLMTLAQQGELMAFEHPGFWQPMDTLRDKVYLEGLWEK 247
22 -9.150d2yqca_ c.68.1.0 (A:) automated matches {Yeast (Candida albicans) [TaxId: 5476]}  ali model 3D-neighbors follow..  12  102VAVLLMAGGQGTRLGSSAPKGCFNIEQKSLFQIQAEKILKIEQLAQWYIMTSGPTRNATESFFIENNYF------------------GLNSHQVIFFNQGTLPCFNLQ--------------GNKILLELKNSICQSPDGNGGLYKALKDNGILDDLNSKGIKHIHMYCVDNCLVKVADPIFIGFAIAKKFDLATKVVRKRDANES................ 290

FFAS is supported by the NIH grant R01-GM087218-01
1 4 6 8 2 5   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Luz JG, Hassig CA, Pickle C, Godzik A., Meyer BJ, Wilson IA. XOL-1, primary determinant of sexual fate in C. elegans, is a GHMP kinase family member and a structural prototype for a class of developmental regulators. Genes Dev. 2003 Apr 15;17(8):977-90. Epub 2003 Apr 02.