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Query: PF02737.18; Q2YR99_BRUA2/5-183; 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain, from PfamA32U

Results of FFAS03 search in SCOP207
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst TVGIIGAGQMGSGIAHVCALAGYNVLLHDAAPDRLEKGIATINGNMARQVASGKLQEEQRADAMKLIRPANSMEDLAGVDLAIEAATEDETIKRKIFAQLCPVLNPEAILATNTSSISITRLASTTDRPERFIGIHFMNPVPVMKLVELVRGIATEEDTFRKSNDFVTALGKTVTVAEDLast
1 -89.200d1wdka3 c.2.1.6 (A:311-496) Fatty oxidation complex alpha subunit, middle domain {Pseudomonas fragi [TaxId: 296]}  ali model 3D-neighbors follow..  35  6QAAVLGAGIMGGGIAYQSASKGTPILMKDINEHGIEQGLAEAAKLLVGRVDKGRMTPAKMAEVLNGIRPTLSYGDFGNVDLVVEAVVENPKVKQAVLAEVENHVREDAILASNTSTISISLLAKALKRPENFVGMHFFNPVHMMPLVEVIRGEKSSDLAVATTVAYAKKMGKNPIVVND 184
2 -84.700d1f0ya2 c.2.1.6 (A:12-203) Short chain L-3-hydroxyacyl CoA dehydrogenase {Human (Homo sapiens) [TaxId: 9606]}  ali model 3D-neighbors follow..  36  6HVTVIGGGLMGAGIAQVAAATGHTVVLVDQTEDILAKSKKGIEESLRKVAKKKKAGDEFVEKTLSTIATSTDAASVHSTDLVVEAIVENLKVKNELFKRLDKFAAEHTIFASNTSSLQITSIANATTRQDRFAGLHFFNPVPVMKLVEVIKTPMTSQKTFESLVDFSKALGKHPVSCKD 190
3 -82.500d4j0ea1 c.2.1.0 (A:1-198) automated matches {Nematode (Caenorhabditis elegans) [TaxId: 6239]}  ali model 3D-neighbors follow..  39  13NVAIVGSGQMGSGIAQVTASSGFNVMLADVNKKALDRAMKAISQSVTHLSKKQKGTDKEKSDTMSRIKTCNNVSTVADADLIIEAAIENIDLKRGIFAQIEQSCKKDSILTTNTSSFLLEDVAKGLQDKTRFGGLHFFNPVPVMKLLEVIRSDDTSDETYATLIKFGTAVGKTTVACKD 196
4 -78.600d4e12a1 c.2.1.0 (A:1-189) automated matches {Acinetobacter baylyi [TaxId: 202950]}  ali model 3D-neighbors follow..  26  6NVTVLGTGVLGSQIAFQTAFHGFAVTAYDINTDALDAAKKRFEGLAAVYEKEAGAADGAAQKALGGIRYSDDLAQVKDADLVIEAVPESLDLKRDIYTKLGELAPAKTIFATNSSTLLPSDLVGYTGRGDKFLALHFANHVWVNNTAEVMGTTKTDPEVYQQVVEFASAIGMVPIELK. 185
5 -42.000d3daga1 c.2.1.6 (A:1-242) 5,10-methenyltetrahydromethanopterin hydrogenase, HMD {Methanocaldococcus jannaschii [TaxId: 2190]}  ali model 3D-neighbors follow..  11  62VSDPCFAEEPGLVIDEFDPKEVMEAHLSGNPESIMPKIREVVKAKAKELPKPPKACIHLVHPEDVGLKVTSDDEAVEGADIVITWLPKG-NKQPDIIKKFADAIPEGAIVTHACTIPTTKFAKIFKDLGREDLNITSYHPGPEMKGQVYIAEGYASEEAVNKLYEIGKIARGKAFKM.. 241
6 -16.000d2f1ka2 c.2.1.6 (A:1-165) Prephenate dehydrogenase TyrA {Synechocystis sp. PCC 6803 [TaxId: 1148]}  ali model 3D-neighbors follow..  15  2KIGVVGLGLIGASLAGDLRRRGHYLIGVSRQQSTCEKAVER--------------------------EAGQDLSLLQTAKIIFLCTP--IQLILPTLEKLIPHLSPTAIV-TDVASVKTAIAEPASQLWSGFIGGHLFVNAPYV----LTPTEYTDPEQLACLRSVLEPLGVKIYLC.. 165
7 -15.700d3fr7a1 c.2.1.0 (A:86-307) automated matches {Oryza sativa [TaxId: 39947]}  ali model 3D-neighbors follow..  14  42QIGVIGWGSQGPAQAQNLRDSLAEAKSDIVVKIGLRKGSKSFDEARAAGFTEESGTLGDIW------------ETVSGSDLVLLLISD--AAQADNYEKIFSHMKPNSIL-GLSHGFLLGHLQSAGLDFPKNISVIAVCPKGMGPSVRFAVHQDVDGRATDVALGWSVALGSPFTF... 219
8 -14.500d2i76a2 c.2.1.6 (A:2-154) Hypothetical protein TM1727 {Thermotoga maritima [TaxId: 2336]}  ali model 3D-neighbors follow..  9  1VLNFVGTGTLTRFFLECLKDRYEIGYILSRSIDRARNLAEVYGG-----------------------KAATLEKHPELNGVVFVIVPDR-----YIKTVANHLNLGDAVLVHCSGFLSSEIFKKSGRASIHPNFSFSSLEKALEMKDQIVFGLEGDERGLPIVKKIAEEISGKYFVIPS 151
9 -14.400d2pv7a2 c.2.1.6 (A:92-243) Prephenate dehydrogenase TyrA {Haemophilus influenzae [TaxId: 727]}  ali model 3D-neighbors follow..  17  11KIVIVGGGKLGGLFARYLRASGYPISILDREDWAVAE------------------------------------SILANADVVIVSVP--INLTLETIERLKPYLTENMLLADLTSVKREPLAKMLEVHTGAVLGLHMFGAIASMAKQVVVRCDGRFPERYEWLLEQIQIWGAKIYQT.. 152
10 -14.100d2v6ba1 c.2.1.0 (A:22-164) automated matches {Deinococcus radiodurans [TaxId: 1299]}  ali model 3D-neighbors follow..  20  3.VGVVGTGFVGSTAAFALVLRGSELVLVDRDEDRAQAEAEDI--------------AHAAPVSHGTRVWHGGHSELADAQVVIDLLEKNADIFRELVPQITRAAPDAVLLVTSNPVDLLTDLATQLAPGQPVIGS............................................ 138
11 -13.800d3g0oa1 c.2.1.0 (A:6-169) automated matches {Salmonella typhimurium [TaxId: 602]}  ali model 3D-neighbors follow..  19  3HVGIVGLGSMGMGAARSCLRAGLSTWGADLNPQACAN-----------LLAEGACGAAASAREFA-----------GVVDALVILVVNAAQVRQVLFGEAHLMKPGSAVMVSSTIS---SADAQEIAAALTALNLNMLDAPVSGGAVKAAQGEMTSEAAFTRLKPVLDAVASNVYRISD 164
12 -13.700d2ahra2 c.2.1.6 (A:1-152) Pyrroline-5-carboxylate reductase ProC {Streptococcus pyogenes [TaxId: 1314]}  ali model 3D-neighbors follow..  19  2KIGIIGVGKMASAIIKGLKQTPHELIISGSSLERSK----------------------EIAEQLALPYAMSHQDLIDQVDLVI------LGIKPQLFETVLKPLHFKQPIISMAAGISLQRLATFVGQDLPLLRIMPNMNAQILQSTALTGNALVSQELQARVRDLTDSFGSTFDI... 150
13 -13.700d3nepx1 c.2.1.0 (X:22-163) automated matches {Salinibacter ruber [TaxId: 309807]}  ali model 3D-neighbors follow..  14  3.VTVIGAGNVGATVAECVARQDVEVVMVDIKDGMPQGKALDMRESSP------------IHGFDTRVTGTNDYGPTEDSDVCIDLLAKNTEIVGGVTEQFVEGSPDSTIIVANPLDVMTYVAYEASGFPNRVMGM............................................ 142
14 -13.300d1llda1 c.2.1.5 (A:7-149) Lactate dehydrogenase {Bifidobacterium longum, strain am101-2 [TaxId: 216816]}  ali model 3D-neighbors follow..  18  3KLAVIGAGAVGSTLAFAAAQRGIEIVLEDIAKERVEAEVLDMQHGSSFYPT-------------VSIDGSDDPEICRDADMVVELVGATVNILKAIMPNLVKVAPNAIYMLITNPVDIATHVAQKLTGENQIFGS............................................ 142
15 -13.300d1txga2 c.2.1.6 (A:1-180) Glycerol-3- phosphate dehydrogenase {Archaeoglobus fulgidus [TaxId: 2234]}  ali model 3D-neighbors follow..  14  2IVSILGAGAMGSALSVPLVDNGNEVRIWGTEFD---------TEILKSISAGREHPRLGVKLNGVEIFWPEQLEKLENAEVVLLGVSTD----LPVMSRILPYLKDQYIVLISKGLIDFDNKHDLRERTVAITGPAIAR--------EVAKRMPTTVVFSSPSESSANKMKEI...... 168
16 -13.200d1z82a1 c.2.1.0 (A:2-166) automated matches {Thermotoga maritima [TaxId: 243274]}  ali model 3D-neighbors follow..  13  3RFFVLGAGSWGTVFAQMLHENGEEVILWARRKEIVDLINVSHTSPYVEESK---------------VRATNDLEEIKKEDILVIAIPV-----QYIREHLLRLPVKPSMVLNLSKGIEIKTGKRVSEIVEEILGCPYAVLSGPSHAEEVAKKLPTAVTLAGENSKELQKR......... 154
17 -13.200d1hyea1 c.2.1.5 (A:1-145) MJ0490, lactate/malate dehydrogenase {Methanococcus jannaschii [TaxId: 2190]}  ali model 3D-neighbors follow..  18  3.VTIIGAGRVGSATALLLAKEPFDLVLIGREHS--------INKLEGLREDIYDALAGTRSDANIYVESDENLRIIDESDVVIDLAKTNAKIVGKYAKKIAEICDTKIFVITNPVDVMTYKALVDSKFENQVFG............................................. 145
18 -13.100d4ypoa1 c.2.1.0 (A:1-180) automated matches {Mycobacterium tuberculosis [TaxId: 1773]}  ali model 3D-neighbors follow..  13  16KVGVIGYGSQGHAHSLSLRDSGVQVRVGLKQG-----------------------SRSRPKVEEQGLDVDTPAEVAKWADVVMVLAPDTAQAEIFAGDIEPNLKPGDALFFGHGLNVDVAVAMVAPKGPGHLVRRQFVDGKGVPCLVAVEQD--PRGDGLALALSYAKAIGGTRA.... 174
19 -13.100d1hyha1 c.2.1.5 (A:21-166) L-2-hydroxyisocapronate dehydrogenase, L-HICDH {Lactobacillus confusus [TaxId: 1583]}  ali model 3D-neighbors follow..  19  3KIGIIGLGNVGAAVAHGLIAQGVDYVFIDANEAKVKADQIDFQDAMANLEAHGNIV-------------INDWAALADADVVIAELKFTSSMVQSVGTNLKESGFHGVLVISNPVDVITALFQHVTGFPHKVIG............................................. 145
20 -13.100d2g5ca2 c.2.1.6 (A:30-200) Prephenate dehydrogenase TyrA {Aquifex aeolicus [TaxId: 63363]}  ali model 3D-neighbors follow..  17  3NVLIVGVGFMGGSFAKSLRRSGFKIYGYDINPESISKAVDL--------------------GIIDEGTTSIAKVEDFSPDFVMLSSP--VRTFREIAKKLSYILSEDATVTDQGSVKGKLVYDLENILGKRFVGGH---PIA--KKVILTPTKKTDKKRLKLVKRVWEDVGGVVEYM.. 171
21 -13.100d1t2da1 c.2.1.5 (A:1-150) Lactate dehydrogenase {Malaria parasite (Plasmodium falciparum) [TaxId: 5833]}  ali model 3D-neighbors follow..  17  5KIVLVGSGMIGGVMATLIVQKNLDVVLFDIVKNMPHGKALDTSHTNVMAYSN------------CKVSGSNTYDDLAGADVVIDLLPLNNKIMIEIGGHIKKNCPNAFIIVTNPVDVMVQLLHQHSGVPNKIIGL............................................ 149
22 -13.000d4ajjc1 c.2.1.0 (C:1-159) automated matches {Norway rat (Rattus norvegicus) [TaxId: 10116]}  ali model 3D-neighbors follow..  15  21KITVVGVGAVGMACAISILMKDLELALVDVIEDKLKGEMMDLQHGSLFLKT-------------PKIVSSKDYSVTANSKLVINLVQRNVNIFKFIIPNVVKYSPQCKLLVSNPVDILTYVAWKISGFPNRVIG............................................. 159
23 -13.000d1xc2a3 c.2.1.6 (A:1-152) Pyrroline-5-carboxylate reductase ProC {Neisseria meningitidis, serogroup B [TaxId: 487]}  ali model 3D-neighbors follow..  14  2NVYFLGGGNMAAAVAGGLVKQG-RIYIANRGAEKRERLEKELG-----------------------VETSATLPELHSDDVLILAV------PQDMEAACKNIRTNGALVLSVAAGLSVGTLSRYLGGTRRIVRVMPNTPGKILGVSGMYAEAEVSETDRRIADRIMKSVGLTVWL... 151
24 -13.000d1bg6a2 c.2.1.6 (A:4-187) N-(1-D-carboxylethyl)-L-norvaline dehydrogenase {Arthrobacter, strain 1c [TaxId: 1663]}  ali model 3D-neighbors follow..  15  3TYAVLGLGNGGHAFAAYLALKGQSVLAWDIDAQRIKEIQDRGAIIAEGPGLAGTAHPDLLTSDIG--------LAVKDADVILIVVPAI--HHASIAANIASYISEGQLIILNPGAT.............................................................. 109
25 -12.700d3fefa1 c.2.1.0 (A:7-171) automated matches {Bacillus subtilis [TaxId: 1423]}  ali model 3D-neighbors follow..  14  5KIAYIGGGSQGWARSLMSDLS--TVALYDLDFEAAQ--------------KNEVIGNHSGNGRWRYEAVSTLKKALSAADIVIISI-VHLPERCGIYQSVGDTVGPGGIIRGLRAVPIFAEIARAIRDPESWV-INYTNPMSVC................................... 150
26 -12.700d2uyya1 c.2.1.0 (A:262-429) automated matches {Human (Homo sapiens) [TaxId: 9606]}  ali model 3D-neighbors follow..  16  8KIGFLGLGLMGSGIVSNLLKMGHTVTVWNRTAEKCDL-----------FIQEGARLGRTPAEV------------VSTCDITFACVSDPKAAKDLVLGPLQGIRPGKCYVDMSTVDADTVTELAQVIVSR---GGRFLELSNDGMLVILAAG---DRGLYEDCSSCFQAMGKTSFFLGE 168
27 -12.600d5je8a1 c.2.1.0 (A:1-163) automated matches {Bacillus cereus [TaxId: 226900]}  ali model 3D-neighbors follow..  16  3KIGFIGLGNMGLPMSKNLVKSGYTVYGVDLNKEAEAS-----------FEKEGGIIGLSISKL------------AETCDVVFTSLPSPRAVEAVYFGAFENGHSNVVFIDTSTVSPQLNKQLEEAAKEK---KVDFLAPVS--TLTFMVGG---SKDVYEKTESIMGVLGANIFHVSE 163
28 -12.600d3k96a1 c.2.1.0 (A:3-180) automated matches {Coxiella burnetii [TaxId: 227377]}  ali model 3D-neighbors follow..  13  5PIAILGAGSWGTALALVLARKGQKVRLWSYESDHVDE------------MQAEGVNNRYLPNYPETLKAYCDLKALEGVTDILIVVPSFA---HEVITRMKPLIDAKTRIAWGTKGLAKGSRLLHEVVATELGQVPMAVISGPSLATEVAANLPTAVSLASNNSQFSKDLIER...... 166
29 -12.300d4m1qa1 c.2.1.0 (A:3-144) automated matches {Bacillus selenitireducens [TaxId: 439292]}  ali model 3D-neighbors follow..  17  5RVVIIGTGAVGSSYAFSMINQNVEMVLIDLDKRKTEGDAMDLNHGIPFGAPTKVWAGDYGDCKSADIVVITAGAAQKPGETRLDLVEKNANIFKGIVDQVMGSGFNGIFIATNPVDVLAYATWKFSGLPERVIG............................................. 142
30 -12.200d1u8xx1 c.2.1.5 (X:3-169) Maltose-6`-phosphate glucosidase GlvA {Bacillus subtilis [TaxId: 1423]}  ali model 3D-neighbors follow..  8  5SIVIAGGGSTFTPLDHLEEFPIRKLKLYDNDKERQDRIAGACDVFIREKAPDIEFA-----------ATTDPEEAFTDVDFVMAHIMRSIGGVLEILDYMEKYSPDAWMLNYSNPAAIVAEATRRLRPNSKILN............................................. 167
31 -12.200d4dlla1 c.2.1.0 (A:29-190) automated matches {Polaromonas sp. [TaxId: 296591]}  ali model 3D-neighbors follow..  20  5KITFLGTGSMGLPMARRLCEAGYALQVWNRTPARAAS-----------LAALGATIHEQARAA------------ARDADIVVSMLENGAVVQDVLFAQAAAMKPGSLFLDMASITPREARDHAARLGAL---GIAHLDPVS--TLVIMAGG---KPADFERSLPLLKVFGRA...... 158
32 -11.800d1x0va1 c.2.1.0 (A:2-193) automated matches {Human (Homo sapiens) [TaxId: 9606]}  ali model 3D-neighbors follow..  14  4KVCIVGSGNWGSAIAKIVGGNAAQLAQFDPRVTMWVFEEDIGGKKLTEIINTQHENVKYLPGHKPNVVAVPDVVQAEDADILIFVVPHQF---GKICDQLKGHLKANATGISLIKGVDEGP--NGLKLISEVIGERLGIPMSVLMASEVADEKFCETTIGCKDPAQGQLLKEL...... 179
33 -11.800d1kjqa2 c.30.1.1 (A:2-112) Glycinamide ribonucleotide transformylase PurT, N-domain {Escherichia coli [TaxId: 562]}  ali model 3D-neighbors follow..  15  13RVMLLGSGELGKEVAIECQRLGVEVIAVDRYADA----------------PAMHVAHRSHVINMLDGDALRRVVELEKPHYIV------PEIEAIATDMLIQLEEEGLNVVPCARATKLTM.......................................................... 111
34 -11.700d2gf2a1 c.2.1.0 (A:41-201) automated matches {Human (Homo sapiens) [TaxId: 9606]}  ali model 3D-neighbors follow..  19  2.VGFIGLGNMGNPMAKNLMKHGYPLIIYDVFPDACKEFQDA-----------------------GEQVVSSPADVAEKADRIITMLPTSINAIEAYSGALKKVKKGSLLIDSSTIDPAVSKELAKEVEKM---GAVFMDPVS--NLTFMVGG---VEDEFAAAQELLGCMGSNVVYC.. 159
35 -11.600d4gwga1 c.2.1.0 (A:1-176) automated matches {Human (Homo sapiens) [TaxId: 9606]}  ali model 3D-neighbors follow..  15  4DIALIGLAVMGQNLILNMNDHGFVVCAFNRTVSKVDD-----------------LANEAKGTKVVGAQSLKEMVSKLKKPRRIILLVKAGQAVDDFIEKLVPLLDTGDIIIDGGNSEYRDTTRRCRDLKAK--GILFVG........................................ 124
36 -11.500d3ws7a1 c.2.1.0 (A:1-161) automated matches {Pyrobaculum calidifontis [TaxId: 410359]}  ali model 3D-neighbors follow..  20  2RVGFIGLGIMGGPMATHLLKAGFLAAVYNRTREKTKP-----------FAEAGVYVAESPADL------------AKRVDVVIVMVSDAPDVEQVLFGPVEGARPGLIVVDMSTNSPDWARKFAERLAQY---GIEFLDPVT--TLTIMVGG---KEELFHRLLPIFKAMGRDIVYM.. 160
37 -11.300d1s6ya1 c.2.1.5 (A:4-172) 6-phospho-beta-glucosidase {Bacillus stearothermophilus [TaxId: 1422]}  ali model 3D-neighbors follow..  12  3KIATIGGGSSYTPIKRYHELPVGELWLVDIPEG---------KEKLEIVGALAKRMVEKAGVPIEIHLTLDRRRALDGADFVTTQFLRTIPVILDIIRDMEELCPDAWLINFTNPAGMVTEAVLRYTKQEKVVGL............................................ 168
38 -11.200d2cvza2 c.2.1.6 (A:2-157) Hydroxyisobutyrate dehydrogenase {Thermus thermophilus [TaxId: 274]}  ali model 3D-neighbors follow..  14  2KVAFIGLGAMGYPMAGHLARRFPTLVWNRTFEKALRHQEEFG-------------------------SEAVPLERVAEARVIFTCLPTTREVYEVAEALYPYLREGTYWVDATSGEPEASRRLAERLREK---GVTYLDPVS--TLTVMLGGPEEAVERVRPFLAYAKKV......... 151
39 -11.200d2g1ua_ c.2.1.0 (A:) automated matches {Thermotoga maritima [TaxId: 2336]}  ali model 3D-neighbors follow..  14  7.IVIFGCGRLGSLIANLASSSGHSVVVVDKNEYAFHR----LNSEFSGFTVVGDAAEFEKECGMEKADMVFAFTNDDSTNFFISMNARYMFNVENVIARVYDIFEENGIKTICPAVLMIEKVKEFIIGS.................................................. 137
40 -11.200d5bsea1 c.2.1.0 (A:3-169) automated matches {Medicago truncatula [TaxId: 3880]}  ali model 3D-neighbors follow..  13  10TLGFIGAGKMAESIAKGAVRSGVRIKTAIHSNPARRT----------------------AFESIGITVLSSNDDVVRDSNVVVFSV--KPQLLKDVVLKLKPLLTKDKLLVSVAAGIKMKDLQEWAGHERFIRVMPNTAATVGEAASVMSLGGAATEEDANLISQLFGSIGKIWKA... 165
41 -11.200d3u95a1 c.2.1.0 (A:1-191) automated matches {Thermotoga neapolitana [TaxId: 309803]}  ali model 3D-neighbors follow..  17  2KISIVGAGSVRFALQLVLSREDTHIYLMDVHERRLNASYILARKYVEELNSPVKVV-----------KTESLDEAIEGADFIINTAYPDVKLALEIAEKMKKMA-PKAYLMQTANPVFEITQAVRRWTGANIIGF............................................ 180
42 -11.000d1ojta2 c.3.1.5 (A:276-400) Dihydrolipoamide dehydrogenase {Neisseria meningitidis [TaxId: 487]}  ali model 3D-neighbors follow..  16  28KLLIIGGGIIGLEMGTVYSTLGSRLDVVEMMDGLMQGADRDLVKVWQKQNEYRFDNEPKEDGVYVTFEGANAPKEPQRYDAVLVAA............................................................................................. 123
43 -10.900d1nhpa2 c.3.1.5 (A:120-242) NADH peroxidase {Enterococcus faecalis [TaxId: 1351]}  ali model 3D-neighbors follow..  17  32NVVVIGSGYIGIEAAEAFAKAGKKVTVIDILDRPLGVYLDKEFTDVLTEEMEANNITIATGETVERYEGDGRVQKVVDADLVVVAV............................................................................................. 123
44 -10.900d1evya2 c.2.1.6 (A:9-197) Glycerol-3- phosphate dehydrogenase {Trypanosome (Leishmania mexicana) [TaxId: 5665]}  ali model 3D-neighbors follow..  11  9KAVVFGSGAFGTALAMVLSKKCREVCVWHMNEEEVRL-----------NEKRENVLFLKGVQLASNITFTSDVEKYNGAEIILFVIPTQF---RGFFEKSGGNLEKQVPVLVCTKGIERSTLKFPAEIIGEFLPSPLLSVLAGPSFAEVATGVFTCVSIASADINVARRLQRI...... 176
45 -10.800d2cula1 c.3.1.7 (A:2-231) GidA-related protein TTHA1897 {Thermus thermophilus [TaxId: 274]}  ali model 3D-neighbors follow..  17  4QVLIVGAGFSGAETAFWLAQKGVRVGLLTQSLDAVMMPFPPGSLLERAYDPKDERVWAFHARAKYLLEGLRPLHLFQAT--ATGLLLEGNRVVGVRTWEGPPARGEKVVLAVGS................................................................. 122
46 -10.800d1ryia1 c.3.1.2 (A:1-218,A:307-364) Glycine oxidase ThiO {Bacillus sp. [TaxId: 1409]}  ali model 3D-neighbors follow..  16  6EAVVIGGGIIGSAIAYYLAKENKNTALFESGTGRTTSAAAGMLGAHAECEERDAFFDFAMHSQRLYKGLGEELYALSGVDFKLAFSEEDVLYSKEEVLEKEPYASGDASFIQDDVHVEPYFVCKAYVKAAKMLGAEIFEHTPVLHVIKTPSGDVWANHVVVASGVWSGMFFK....... 211
47 -10.800d1i36a2 c.2.1.6 (A:1-152) Conserved hypothetical protein MTH1747 {Methanobacterium thermoautotrophicum [TaxId: 145262]}  ali model 3D-neighbors follow..  18  2RVGFIGFGEVAQTLASRLRSRGVEVVTSLEGR-----------------------SPSTIERARTVGVTETSEEDVYSCPVVISAVTPGVALGA---ARRAGRHVRGIYVDINNISPETVRMASSLIEKGGFVDAAIMGSVRRKGADIRIIASGRDAEEFMKLNRYGLNI......... 145
48 -10.800d3tria1 c.2.1.0 (A:2-162) automated matches {Coxiella burnetii [TaxId: 777]}  ali model 3D-neighbors follow..  13  4NITFIGGGNMARNIVVGLIANGYRICVTNRSLDKLDF----------------------FKEKCGVHTTQDNRQGALNADVVVLAV-KPHQIKMVCEELKDILSETKILVISLAVGVTTPLIEKWLGKASRIVRAMPNTPSSVRAATGLFANETVDKDQKNLAESIMRAVGLVIWV... 160
49 -10.700d2hmta_ c.2.1.9 (A:) Ktn bsu222 {Bacillus subtilis [TaxId: 1423]}  ali model 3D-neighbors follow..  13  3QFAVIGLGRFGGSIVKELHRMGHEVLAVDINEEKVNAYASYATHAVIANATEENELLS---------------LGIRNFEYVIVAIGANIQ-ASTLTTLLLKELDIPNIWVKAQNYYHHKVLADRIIHPEKDMGVKIAQSLSDENVLN............................... 138
50 -10.600d1yjqa2 c.2.1.6 (A:1-167) Ketopantoate reductase PanE {Escherichia coli [TaxId: 562]}  ali model 3D-neighbors follow..  14  2KITVLGCGALGQLWLTALCKQGHEVQGWLRVPQP----------------YCSVNLVETDGSIFNESLTANDPDFLATSDLLLVTLKA-----SDAVKSLASTLPVTTPILLIHNGMGTIEELQNIQQP.................................................. 112
51 -10.600d1mo9a2 c.3.1.5 (A:193-313) NADH-dependent 2-ketopropyl coenzyme M oxidoreductase/carboxylase {Xanthobacter sp., py2 [TaxId: 35809]}  ali model 3D-neighbors follow..  8  24TVVVVGGSKTAVEYGCFFNATGRRTVMLVRTEPLKLIKDNETRAYVLDRMKEQRIEEDANGRVQAVVAMTPNGEMRIETDFVFLGL............................................................................................. 120
52 -10.600d1lvla2 c.3.1.5 (A:151-265) Dihydrolipoamide dehydrogenase {Pseudomonas putida [TaxId: 303]}  ali model 3D-neighbors follow..  13  23HLVVVGGGYIGLELGIAYRKLGAQVSVVEARERILPTYDSELTAPVAESLKKLGIA-EGYENGCLLANDGKGGQLRLEADRVLVAV............................................................................................. 114
53 -10.500d2izza1 c.2.1.0 (A:1-164) automated matches {Human (Homo sapiens) [TaxId: 9606]}  ali model 3D-neighbors follow..  14  2SVGFIGAGQLAFALAKGFTAAGVKIMASSPDMDLATV---------------------SALRKMGVKLTPHNKETVQHSDVLFLAV--KPHIIPFILDEIGADIEDRHIVVSCAAGVTISSIEKKLSAFRPAPRVIRCMTNTPVVVREYATGTHAQVEDGRLMEQLLSSVGFCTEV... 162
54 -10.500d1li4a1 c.2.1.4 (A:190-352) S-adenosylhomocystein hydrolase {Human (Homo sapiens) [TaxId: 9606]}  ali model 3D-neighbors follow..  14  26VAVVAGYGDVGKGCAQALRGFGARVIITEIDPINALQAAMEGYEVTTMDEACQEGNIFVTTTGCIDIILGRHFEQMKDDAIVCNIGHFDVEIDVKWLNEN............................................................................... 125
55 -10.300d1mv8a2 c.2.1.6 (A:1-202) GDP-mannose 6-dehydrogenase {Pseudomonas aeruginosa [TaxId: 287]}  ali model 3D-neighbors follow..  15  2RISIFGLGYVGAVCAGCLSARGHEVIGVDVSSTKIDL----INQGKSPIVEPGLEALLQQGRQTGRLSGTTDFKKVLDSDVSFICV---ETVCREIGFAIREKSERHTVVVRSTVLPGTVN.......................................................... 131
56 -10.300d1ebda2 c.3.1.5 (A:155-271) Dihydrolipoamide dehydrogenase {Bacillus stearothermophilus [TaxId: 1422]}  ali model 3D-neighbors follow..  16  24SLVVIGGGYIGIELGTAYANFGTKVTILEGAGEILSGFEKQMAAIIKKRLKKKGVE........................................................................................................................... 79
57 -10.300d1v59a2 c.3.1.5 (A:161-282) Dihydrolipoamide dehydrogenase {Baker`s yeast (Saccharomyces cerevisiae) [TaxId: 4932]}  ali model 3D-neighbors follow..  17  25RLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGLD........................................................................................................................... 80
58 -10.300d1lssa_ c.2.1.9 (A:) Ktn Mja218 {Methanococcus jannaschii [TaxId: 2190]}  ali model 3D-neighbors follow..  17  3.IIIAGIGRVGYTLAKSLSEKGHDIVLIDIDKDICKK----ASAEIDALVINGDCTKIKEDAGIEDADMYIAVTGKEEVNLMSSLLAKSYGINKTI................................................................................... 95
59 -10.200d1jaya_ c.2.1.6 (A:) Coenzyme F420H2:NADP+ oxidoreductase (FNO) {Archaeoglobus fulgidus [TaxId: 2234]}  ali model 3D-neighbors follow..  12  2RVALLGTGNLGKGLALRLATLGHEIVVGSRREEKAEAKAAEYRRIAGD----------------ASITGMKNEDAAEACDIAVLTIPWE-ILREKIVVSPLVPVSRGAKGFTYSSERSAAEIVAEVLESEKVVSA--LHTIPAARFANLDEKFDWDDESKKVVMSLISEID........ 172
60 -10.200d1e5qa1 c.2.1.3 (A:2-124,A:392-450) Saccharopine reductase {Fungus (Magnaporthe grisea) [TaxId: 148305]}  ali model 3D-neighbors follow..  19  4SVLMLGSGFVTRPTLDVLTDSGIKVTVACRTLESAKKLSAGVQH-----STPISLDVNDDAALDAEV---------AKHDLVISLI............................................................................................. 75
61 -10.100d1onfa2 c.3.1.5 (A:154-270) Glutathione reductase {Malaria parasite (Plasmodium falciparum) [TaxId: 5833]}  ali model 3D-neighbors follow..  13  24KIGIVGSGYIAVELINVIKRLGIDSYIFARGNRILRKFDESVINVLENDMKKNDVVEIKKVSDKNLSIHLSDGRIYEHFDHVIYCV............................................................................................. 117
62 -10.100d3lada2 c.3.1.5 (A:159-277) Dihydrolipoamide dehydrogenase {Azotobacter vinelandii [TaxId: 354]}  ali model 3D-neighbors follow..  23  24KLGVIGAGVIGLELGSVWARLGAEVTVLEAMDKFLPAVDEQVAKEAQKILTKQGLK........................................................................................................................... 79
63 -9.980d4jcoa1 c.2.1.5 (A:22-162) automated matches {Haloarcula marismortui [TaxId: 2238]}  ali model 3D-neighbors follow..  21  3.VSVVGAGTVGAAAGYNIALRDIEVVFVD------------IPDKEDDTVGQAADTNHGIAYDSNTRVRQGGYEDTAGSDVVVDLAGDNAPIMEDIQSSLDEHNDDYISLTSNPVDLLNRHLYEAGDRSEQVIG............................................. 142
64 -9.940d1pj5a2 c.3.1.2 (A:4-219,A:339-427) N,N-dimethylglycine oxidase {Arthrobacter globiformis [TaxId: 1665]}  ali model 3D-neighbors follow..  14  3RIVIIGAGIVGTNLADELVTRGWNITVLDQGPLNMPGGSTSHAPGLVFQTNPGGLEVATTETRLADLKRKLGYAAAWGIEGRLLSPAE-----QELYPLLDGENILGGLHVPSDGLASAARAVQLLIKRTESAGVTYRGSTTVTGIVQTADGVIPADIVVSCAGFWGAKIGAM...... 210
65 -9.930d2rcya1 c.2.1.0 (A:2-156) automated matches {Plasmodium falciparum [TaxId: 36329]}  ali model 3D-neighbors follow..  18  5KLGFMGLGQMGSALAHGIANANI--------------------------IKKENLFYYGPSKKNTTLNYMSSNEELRHCDIIVCAV--KPDIAGSVLNNIKPYLSSKLLI-SICGGLNIGKLEEMVGSENKIVWVMPNTPCLVGESFIYCSNKNVNSTDKKYVNDIFNSCGIIHEI... 153
66 -9.800d1vj0a2 c.2.1.1 (A:156-337) Hypothetical protein TM0436 {Thermotoga maritima [TaxId: 2336]}  ali model 3D-neighbors follow..  16  31TVVIQGAGPLGLFGVVIARSLGANVIVIAGSPNRLK---------LAEEIGADLTLNRRETSVEERRKAIMDITHGRGADFILEATGDSRALLEGSELLRRGGFYSVAGVAVPQDPVPFKVYEWLVLKNATFKGIWVSDTSHFVKTVSITSRNYQLLSKL................... 182
67 -9.720d1l7da1 c.2.1.4 (A:144-326) Nicotinamide nucleotide transhydrogenase dI component {Rhodospirillum rubrum [TaxId: 1085]}  ali model 3D-neighbors follow..  15  31RVLVFGVGVAGLQAIATAKRLGAVVMATDVRAATKEQVESLGGKFITVDDEAMKTAEKEMGEEFRKKQAEAVLKELVKTDIAITTAIPGKPAPVLITEEMVTKMKPGSVIID................................................................... 149
68 -9.660d4h7pa1 c.2.1.0 (A:1-155) automated matches {Leishmania major [TaxId: 347515]}  ali model 3D-neighbors follow..  17  5KVAVTGAGQIGYALVPLIARGALELRLLDIEPALKALAGVEAE-----------LEDCAFPLLDKVVVTADPRVAFDGVAIAIDLLEMNARIFKEQGEAIAAVAASDCRVVANTNALILLKSAQGKLNPRHVTAM............................................ 155
69 -9.590d1xhca2 c.3.1.5 (A:104-225) NADH oxidase /nitrite reductase {Pyrococcus furiosus [TaxId: 2261]}  ali model 3D-neighbors follow..  19  34EAIIIGGGFIGLELAGNLAEAGYHVKLIHRGAMFLGLDEELSNMIKDMLEETGVKFFLNSELLEANEEGVLTNSGFIEGKVKICAI............................................................................................. 119
70 -9.590d2gf3a1 c.3.1.2 (A:1-217,A:322-385) Sarcosine oxidase {Bacillus sp., strain b0618 [TaxId: 1409]}  ali model 3D-neighbors follow..  13  5DVIVVGAGSMGMAAGYQLAKQGVKTLLVDAFDPPHTNGSHHGDTRIIRHAYGEGREALRSQELWYELEKETHHKIFTKTGVLVFGPKGESAFVAETMEAAKEHSLTNAIFEPNSGVLFSENCIRAYRELAEARGAKVLTHTRVEDFIETANGSYTADKLIVSMGAWNSKL......... 208
71 -9.480d3hhpa1 c.2.1.0 (A:1-145) automated matches {Escherichia coli K-12 [TaxId: 83333]}  ali model 3D-neighbors follow..  15  2KVAVLGAGGIGQALALLLKTQL-ELSLYDIAPVTPGVAVD--------------LSHIPTAVKIKGFSGEDATPALEGADVVLDLFNVNAGIVKNLVQQVAKTCPKACIGIITNPVNTTVAIAAEVLKKNKLFG............................................. 145
72 -9.420d1j4aa1 c.2.1.4 (A:104-300) D-lactate dehydrogenase {Lactobacillus helveticus [TaxId: 1587]}  ali model 3D-neighbors follow..  11  45VVGVVGTGHIGQVFMQIMEGFGAKVITYDIFRNPELEKKGYYVDSLDDLYKQADVISLHVDESIAKMKQDVVIVNVSRGPLV-DAVIRGLDSGKIFGYAMDVYEGEVGIFNEDWEGFPDARLADLIARPNVLVTPK........................................... 194
73 -9.310d3fi9a1 c.2.1.0 (A:2-147) automated matches {Porphyromonas gingivalis [TaxId: 431947]}  ali model 3D-neighbors follow..  16  7KLTIVGAGMIGSNMAQTAAMMRLNLCLYDPFAVGLEGVAEEI--------------RHCGFEGLNLTFTSDIKEALTDAKYIVDLLKGNAEIAAQLGKDIKSYCPDCKHVIIIFNPADITGLVT....................................................... 133
74 -9.290d3etja2 c.30.1.1 (A:1-78) N5-carboxyaminoimidazole ribonucleotide synthetase PurK (AIRC), N-domain {Escherichia coli [TaxId: 562]}  ali model 3D-neighbors follow..  20  3QVCVLGNGQLGRMLRQAGEPLGIAVWPVGLDAEP................................................................................................................................................. 36
75 -9.240d1saya1 c.2.1.4 (A:136-303) L-alanine dehydrogenase {Phormidium lapideum [TaxId: 32060]}  ali model 3D-neighbors follow..  19  34KVVILGGGVVGTEAAKMAVGLGAQVQIFDINVERLSYLETLFGSRVELLYSNSAEIETA----------------VAEADLLIGAVVPGRRAPILVPASLVEQMRTGSVIVD................................................................... 130
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Li W, Godzik A. cd-hit: a fast program for clustering and comparing large sets of protein or nucleotide sequences. Bioinformatics. 2006 May 26;