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Query: PF01128.19; ISPD_ECOLI/8-229; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, from PfamA32U

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst VCAVVPAAGFGRRMQTECPKQYLSIGNQTILEHSVHALLAHPRVKRVVIAISPGDSRFAQLPLANHPQITVVDGGDERADSVLAGLKAAGDAQWVLVHDAARPCLHQDDLARLLALSETSRTGGILAAPVRDTMKRAEPGKNAIAHTVDRNGLWHALTPQFFPRELLHDCLTRALNEGATITDEASALEYCGFHPQLVEGRADNIKVTRPEDLALAEFYLTRLast
1 -103.000[I] COG1211 4-diphosphocytidyl-2-methyl-D-erithritol synthase  ali follow..  53  12IVAVVPAAGIGSRMQMDKPKQYLHIHGKTILEHTLSVLLGYPLIEKIILAVAANDPYISTCPLLTHPKIQLVEGGSSRADSVLNGLNAVKEDFWVMVHDAARPCLTHQDLDKLVQVEDQN--GAILAIPATDTIKRALH-NQQIHYTEDRSQLWLAQTPQFFPIATLAQALEQALAQGLQVTDEASAMEFAGFRPHLVAGRSDNIKVTRPEDFALAEFYLSR 236
2 -25.400[H] COG2266 GTP:adenosylcobinamide-phosphate guanylyltransferase  ali follow..  15  1MLTLLMCGGKGTRLGRG-EKPLFEVCGMKLIDHSLLQYKDFD-----VIAITSPHTPATESYLAEKGVEVYRAAGKGYIEDYSEACRELAINEPVIVASADIVYIRDIAFDIVDAYMKTIKPALTVVME-----------------------------GEPVGVNIIDSLLINTWQEEEIYSIEKDSV----------------VNVNTVADVERAERLWTT 171
3 -20.600[M] COG1207 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains)  ali follow..  17  6LNIVILAAGKGTRMYSKMPKVLHEIGGETMLGRVIDTAAALNPQNICVVVGHGKEQ--VLDTVKRDVVWVEQTEQLGTGHAVKTALPHLAAEGRTLVLYGDVPLIDVETLETLLEA--AGNEVGLLTDVPADP-RIIRDSSGSVTAIVEEKDADAAQKALVLPNAKLEAWLNSLSSNNYYLTDLIAKAVADGIKIHPVRSSHLAAGVNNKLQLAELERIFQT 240
4 -20.400[M] COG1083 CMP-N-acetylneuraminic acid synthetase  ali follow..  10  7RIAIIPARAGSKGIKD---KNLQLVGGVSLVGRAILAAQESGMFDQIVVTSDGENILKEATKYGAKRPESLAQSDTRTIDAILHCLETLNISGTAALLQPTSPLRNALDIRNAMEIFLGGKYKSVVSACECEHSFTLEGTEVQPIHELTDFESPRQKLPKSYRANIYINDIQSLFEEKRFFIAPMRFY---------LMPTYRSIDIDSTLDLQLAESLISK 226
5 -19.900[M] COG1212 CMP-2-keto-3-deoxyoctulosonic acid synthetase  ali follow..  14  4FTVIIPARYASTRLPG---KPLAEIAGKPMIAHVFEKAMQSG-AKRVIVATDHEQVATVARGFGAEVCMT--QSGTERLAEVVEKLGI-AEDEIIVNIQGDEPLIPPAIVRQVAENLAKYQVKASLAVNITDPEELFNPNAVKVLTDHAGYVLYFSRAPYAYRAGFIKQQWQPSVLEQIESLEQLRVLWY-GEKIHVELREVPPVGVDTAEDLEKVRSILEK 258
6 -19.400[M] COG1861 Spore coat polysaccharide biosynthesis protein F, CMP-KDO synthetase homolog  ali follow..  11  4ILFIIQARMGSTRLPG---KVLRPLGSNRLLDILVHRVRQSKDRDNLVIATSDKETDDILEAHCIKQGFRVFRGSEERVLDRFVKVIEAVKPSVIIRLTGDNPFVDPELLDVMIQAHFDQGSGICGEVVNANLLIDISRIQALEDQYQEHVTLYIRNHPALYRVQFLEAPERFRAPQ--------------------------RLTIDTKEDYESIKALYQK 211
7 -18.900[R] COG2068 Uncharacterized MobA-related protein  ali follow..  19  11VGIVLLAAGRSSRMGGP-NKLLALFDGKPLVRRTAERALGSKASGTIVVTGHQRERVRAALSGLDVTFADNPDFANGLSTSLKAGIAYLPEDAGAMIVLGDMPGVVSGDLDRLIDAFRKAGGNSVVRASHQGK------------------------NPVLLPRALFPAIAHLEGDTGAR-----HLVEAEGLDVVDVEGEGASVDVDTREALEGAGGVLQD 206
8 -18.400[H] COG0746 Molybdopterin-guanine dinucleotide biosynthesis protein A  ali follow..  13  3HVNVLLAGGASRRFGEP--KAFVKWKGRMLYECAKEALGE----QTVIISRPEFIDRFQENGENEVYQDAEPFQGMGPLAGIYTAFKKT-DGDLYTVLSCDTPLIQRRTMLELKRLMIAGADAVVPISDGQ-------------------------VQPAIYHKRIMPVLYDQLSEKRLRISDLLGRISVCYVQAENIGANPAEFNINTRDDFSCLEEKSNS 195
9 -17.400[M] COG1213 Predicted sugar nucleotidyltransferases  ali follow..  15  1MEAVILAAGFGSRLGREIPKALLKIGKRPLIYYTVQTLMENG-IRDVVVVTGHKGYVLREYLSQFDLNFKFVHNSLYKKYSLYLAMDHVSKGFYILNSD----LFHPGIFRELHSSTKENGEEEMKVKIEDGVVKRISKQLNPSEADGEYIGIARVEENIIDDLYNHVSRVMERKGRRVFYEEAFQSMMDDGIAVYYETTKGLPIEIDTPADLMKARYEI.. 235
10 -15.700[M] COG1209 dTDP-glucose pyrophosphorylase  ali follow..  14  4RKGIILAGGSGTRLYMAVSKQLLPIYDKPMIYYPLSTLMLAG-IRDILIISTPQDTPRFQQLLGDGSQWGLNLQYKVQPSAFIIGEEFIGGDDCALVLGD---IFYGHDLPKLMEAAVNKESGATVFAYHVNDPERYGDKNGTAISLEEKPL--YFYDNDVVQ---MAKNLKPSARGELEITD-RIYLEQGRLSVAMMGRGYAWLDTGTHQSLIEASNFIAT 242
11 -15.300[M] COG4750 CTP:phosphocholine cytidylyltransferase involved in choline phosphorylation for cell surface LPS epitopes  ali follow..  11  1MKAIILAAGLGTRLRENTPKALVQVNQKPLIEYQIEFLKEKG-INDIIIIVGYLKEQF--DYLKEKYGVRLVFNDKYADYNNFYSLYLVKENSYVIDADNY---------NMFRNDLTRSTYFSVYREDCTNEWFLVYGDDYKVQDIIVDSKAGRILSGVSFWDAPTAEKIVSFIDKAYVSGEFVDNIKELDVYVEELEGNS--YEIDSVQDYRKLEEILKN 227
12 -14.000[M] COG1210 UDP-glucose pyrophosphorylase  ali follow..  16  8..AVIPAAGLGTRFTKAQPKEMLPIVDKPAIQYIVEEAAESG-IEDILIITGRNKRSIEDHFDRSAELEFNLREKGKTEHAVLCAEHFIGDEPFAVLLGDDIMVSETPALRQLMDVYDVYGTEVVGVQSVL-NTSGSQGHVYEVNDLVEKPSPEEAPSSSIFS---VLKTIGRGAGNEIQLTD-REVCRKEPIHARLLEGNRYDI................. 256
13 -12.900[J] KOG1461 Translation initiation factor 2B, epsilon subunit (eIF-2Bepsilon/GCD6)  ali follow..  12  25LQAILLADSFATKLLLERPNVLLPLVNIPMIDYTLAWLESAG-IEEVFVFCSMQVIDYLNNSDWYSHKDFTVAGDALRYIYEQQIETSQIQGDFVLVNGCIVSNMPLTQLIQEHRDRKKKDEKAIMTMVIRQS-LITDHQLFIAVNPLTKQLLYYDEDNICFDKSLLDRNPSVLLCSDMQDCYSLEVLSLFVDNFDYQHMRCDFVEGVLADDIIGYKIFTH. 261
14 -12.500[GMO] KOG1460 GDP-mannose pyrophosphorylase  ali follow..  15  9VVAVIMVGGKGTRFRLNIPKPLFPIAGQPMVHHPISACKRIPNLAQIYLVGFYEEREFALYVSAISNELKV-HGSAGGLYHFRNLIMEDSPSHIFLLNCDV---CCSFPLPKMLEAHRGYGGIGTLLVASQFGELVADPVTNELLHYTEKPETFVSDRINCGVYVFTPEIFNAIGDVSTQRKDRATLKRVSSFEALQPATRIPTDFVRLDQDI......... 239
15 -11.300[MJ] COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)  ali follow..  14  1MRAVLMAGGSGTRLRCDLPKPMVPILNRPIAEHIINLLKRHH-ITEVIATLQDGGDFGVQMTYAVEEDQPLGTAG-----CVKNIAELLDETFLVISGDS----ITDFDLGEAIAFHKQKQSKATLILTRVPNPIEFGDEAGKIKRFLEKPSTSEIFSDTV--TYILEPEVLEYLPSNTECDFSKDLFPLLDEPMYGYVAEGYWCDVGHLDAYREAQYDG.. 232
16 -10.900[M] COG0836 Mannose-1-phosphate guanylyltransferase  ali follow..  11  8ITPVLLAGGAGSRLRDQLPKQFQPLVGLSTYQQTLKRVGDKSLYSEPLVIT-----------------------NEDFRFFARRQAEEIDLPATVVLEPARR--SAAAMAAAAVLAERREPGCLVLALAADHVVLDVDKFSEAVKLGAK-----AADQGNIVVFGLVPTEPRTSYG-------------KPGDAIDGEKDLSTVDAFVEKPDVTTAISYLEK 194
17 -9.550[M] KOG2388 UDP-N-acetylglucosamine pyrophosphorylase  ali follow..  11  129AAFVLVAGGLGERLGYNGIKVALPRTGTCFLQHYIESILALQEASNFIIMTSDDTHSRTLDLLEL------------------NSYFGMKPTQVHLLKQEKVACLDDNDARLALDPHNKYSIQIQMDFSSMLVAATQLLCLKVFIQFLMEIHNSLMTSLVQAIPASLGVSATKQYHVNSLAVPRKAKEAIGGISKLTHVDGRSMVINVEYNQL......... 338
18 -9.310[J] KOG1462 Translation initiation factor 2B, gamma subunit (eIF-2Bgamma/GCD1)  ali follow..  13  39FQAVVFA-GFGNSLSDALPKALLPIGNKPMLHYPLYWLEAAG-FTSAILICMEEAEAHINAWLRSGRIHVEAPTILDDSKSSADALRAVSHNDFVCLS----DSIVGLPPIYGLDKFRLDNPSALAVYEHITSQSKEIDAKQLIGIEEKTSRLLYAKSSADVGSDFTFRMSLLWKHPRVTLNTNLSDAHIFVFKHWVIDLIREKESISSIRGDLIPYLVKCQ 284
FFAS is supported by the NIH grant R01-GM087218-01
1 4 6 8 3 2   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Grynberg M, Erlandsen H, Godzik A. HEPN: a common domain in bacterial drug resistance and human neurodegenerative proteins. Trends Biochem Sci. 2003 May;28(5):224-6. Review.