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Query: PF02558.16; Q9K9R6_BACHD/6-154; Ketopantoate reductase PanE/ApbA, from PfamA32U

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst VAVIGSGSIGLLLYAYLKLANWPALLVTNRPEQADHLNKEGLTFVAKSGEHQPISVTATPLSSFSAEEAEVGFITVKSFAVKALLPQLQRKKWDGLVFFQNGMTHLEILRQIPARAICCGIVEIGAKRESDVRVQHTGDGAIWIGDMVGLast
1 -56.500[H] COG1893 Ketopantoate reductase  ali follow..  100  6VAVIGSGSIGLLLYAYLKLANWPALLVTNRPEQADHLNKEGLTFVAKSGEHQPISVTATPLSSFSAEEAEVGFITVKSFAVKALLPQLQRKKWDGLVFFQNGMTHLEILRQIPARAICCGIVEIGAKRESDVRVQHTGDGAIWIGDMVG 154
2 -15.500[S] COG4408 Uncharacterized protein conserved in bacteria  ali follow..  13  4LLMIGTGPVAIQLANICYLKSDYIDMVGRASTSEKSKREKQFEVKIQNEAHQHLE-RLYKDVKNVKGEYETVVMACTADAYYDTLQQLSLESVKHVILISPTFGSQMIVEQFMSKF................................. 135
3 -14.600[EH] COG0059 Ketol-acid reductoisomerase  ali follow..  10  40IVIVGCGAQGLNQGLNMRDSGLDISYALRKRASFQRATENGFKVGTY---------------EELIPTADLVVNLTPDKQHSKVVADVMPMKKDSAFGYSHGFNIVEVGEEIRKD.................................. 146
4 -14.500[C] COG0240 Glycerol-3-phosphate dehydrogenase  ali follow..  14  5IGYLGMGIWGFCLASLLANKGYPVVAWSRNPDLIKQLQEERRH-PLAPNVVISPNLSFTTDMKEAIHNAFMIVEGVTSAGIRPVAEQLKQILSVPFVITSKGINTGLLLSEIMLEVLGDSVTPYLGYLSGPSIAKEVLNG......... 147
5 -14.400[R] COG2085 Predicted dinucleotide-binding enzymes  ali follow..  14  8IAILGAGRVGSSLARSAVAAGYEVKVAGSGAVDKIALTAEIL------------PGAVPSTADQAVKDADIVFLAVPLHKFRSVNPAT--LEGKIVIDTMNHWTSEIIAEFFAGSTMVKSFNHIGYHEIEQDAIKSFGFVPLNIGALE. 180
6 -12.500[E] KOG2380 Prephenate dehydrogenase (NADP+)  ali follow..  17  55IAIIGFGNYGQFLAETLISQGHILFAHSR-SDHSSAARRLGV-------------SYFTDLHDLCERHPDVVLLCTSILSIENILKTLPRLRRNTLFV................................................... 140
7 -12.400[C] KOG2711 Glycerol-3-phosphate dehydrogenase/dihydroxyacetone 3-phosphate reductase  ali follow..  12  27VGIIGSGNWGTAIAKICGENAKKIQHEGKECNLTEVFNTTHENVKYLKGIKCPSNVFANPDIRDVGSRSDILVWVLPHQFVVRICNQLKGCKDAVAISCIKGVSVTKDRVRLFSDIIEENTGMYCGVLSGANIASEVAQEK........ 186
8 -12.400[G] KOG2653 6-phosphogluconate dehydrogenase  ali follow..  14  5FGLIGLAVMGQNLILNAADHGFTVCAYNRTQSKVDHFLANEAKGKSIIGATSIEDFISKLKRPRK-----VMLLVKAGAPVDALINQIVPLLEKGDIIIDGGNSHFPDSNRRYEELKKKGILFVGSGVSGGEEGARYGPSLMPGGS... 145
9 -12.300[S] COG5495 Uncharacterized conserved protein  ali follow..  13  14IAILSTGRVG----VALERADQVVVCSAVSHASRQWVQF-------------RLPETSVASPPEVASSAELLLLAVPDCEFAGLMSGVAVTSPGTIVAHTSWANGVGILAQLGKDGCIPLAIH.......................... 123
10 -12.300[G] COG1023 Predicted 6-phosphogluconate dehydrogenase  ali follow..  16  3LGMIGLGRMGANIVRRLAKGGHDCVVYDHDPDAVKAMAGED----------RTTGVASLRELSQRLSAPRVVWVMVPAGNTTAVIEELANTLEAGDIVIDGGNTYYRDDLRHEKLLFKKGIHLLDCGTSGGVWGRERGYCLMIGGD... 139
11 -12.200[CR] KOG2614 Kynurenine 3-monooxygenase and related flavoprotein monooxygenases  ali follow..  11  9IIIVGAGISGLATALGLHRLGIRSIVL----ESSEQLRATGFALSYFNAWKAMEALGISQHIRSLGDRFQGWVVRPISAGDPPKEMLFPESEEYEVRCVQRKLLLDALAGELPQGTIRFSSKLVHIELSGHYKMVHLSDGTILKTKVDG 158
12 -11.700[R] COG1712 Predicted dinucleotide-utilizing enzyme  ali follow..  13  4IGIVGCGFIGGQICRAIDGGEVSAELYDSSESKALELAAS-------------TCKPSYMKIEELIRGVDLIIESASQNAVRFIVPQALKAGCDVMILSVGALADEELRDTL..................................... 107
13 -11.600[G] COG0362 6-phosphogluconate dehydrogenase  ali follow..  13  7IGVIGLAVMGQNLILNMNDHGFKVVAYNRTTSKVDEFLQGAAKGTNIIGAYSLEDLAAKLEKPRK-----VMLMVRAGDVVDQFIEALLPHLEEGDIIIDGGNSNYPDTNRRVKALAEKGIRFIGSGVSGGEEGARHGPSIMPGGN... 147
14 -11.500[E] COG0345 Pyrroline-5-carboxylate reductase  ali follow..  11  6IGFIGAGKMGSALMQGTIKAGENIGASDVYEPFLKDLQAK-------------LGIRVSTDNAVIVRESDILILAVKPQTLSSVLSNLKNESEKLVISIAAGVPLSTYEDALLEGTRVVRVMPNIAATVSEAAS............... 132
15 -11.300[I] COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases  ali follow..  13  4IGFIGLGIMGAPMAGHLLDAGYKVIASDHRSKPLADLVAKG--------------LKTVSGHAAVAKAADIIITMVPDTPQVADVNGVASGLTRGKLVIDMSSISPIETKVFAGKINELGCDYLDAPVSGGEVGAKAASLTIMVG.... 138
16 -11.200[HC] COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases  ali follow..  30  5VAIIGAGPAGLLLGQLLQRSGIDAVILETRSRRAGVLEQGTVDTLNEAG.................................................................................................... 60
17 -11.000[R] COG4007 Predicted dehydrogenase related to H2-forming N5,N10-methylenetetrahydromethanopterin dehydrogenase  ali follow..  14  25EKYGGEAPYGG-MAIEFAEAGHDVVLAEPARDMLDDAHWKVVE---------DAGVTVTDNDAEAASEAEIAVLFTPGKKTFEIAKNITNHLPEGAVIANTCTVSPVVLYYV..................................... 129
18 -10.900[M] COG0677 UDP-N-acetyl-D-mannosaminuronate dehydrogenase  ali follow..  15  18IGIVGLGYVGLPLMLRYNAIGFDVLGIDIDDVKVDKLNAGQCYIEHIPQAKIAKARAEATTDFSRVSECDALILCVPTSFVINTTDALKPLRVGQVVSLESGTTEEELLPRVQEGGLVVGRLVYSPEREDPGNPNFE............ 175
19 -10.900[P] COG0569 K+ transport systems, NAD-binding component  ali follow..  20  3IIILGAGQVGTTLAENLVSEDNDITLVDNESPQLQTLQEK-HDLRVVQGSPSSPKV----LRDAGAADADLMVAVTASDEINMVACQMGY........................................................... 87
20 -10.800[E] COG0287 Prephenate dehydrogenase  ali follow..  15  10IALIGIGLIGSSIARDVRELGRHVVISTRSEDTLKRAEELALG-------------DYTVSAAEAVKDADLVIVSVPVGASESVAQQIAPYLKPSAIVTDVGSTKASVIAQMAP................................... 113
21 -10.600[M] COG1004 Predicted UDP-glucose 6-dehydrogenase  ali follow..  13  3VTVFGIGYVGLVQATVLAEVGHDVLCIDIDANKVADLKKGRIAIFEPKENYEAGRLQFSTDAQAGVAHGVIQFIAVGTKYVLDVASTIGTYMDSPKVIIDKSTVPVGTADKV..................................... 130
22 -10.600[H] COG1232 Protoporphyrinogen oxidase  ali follow..  22  12TLVIGAGPAGLTTAYTLAKAGRGVTVLEMDETYSRTVDYKGFKFD........................................................................................................ 60
23 -10.500[Q] COG5310 Homospermidine synthase  ali follow..  13  20VVMIGFGSIGRGTLPLIERHFKRMTVLDPRDTDRKLLDERGIAFVQEAVTENNYK-KLLTPLLTNGGGQGFCVNLSVDTGSVDLMR----------LCRKLGVLYIDTVVE...................................... 123
24 -10.400[R] COG3380 Predicted NAD/FAD-dependent oxidoreductase  ali follow..  22  5IAIIGTGIAGLSAAHALRSAGQTVQLFDKGHGSGGRMASK............................................................................................................. 44
25 -10.400[I] KOG2304 3-hydroxyacyl-CoA dehydrogenase  ali follow..  13  25VTIIGAGLMGSGIAQVSANAKLNVTVVDSNQSALEKAKKKHADDAAAQTSSVLDRIKMSTNVSDSVKDADLVIEAIVE---RKLFAEVEVAAKPTTLITTNSLRLADIGLNLKDKSRFGGL............................ 164
26 -10.400[E] COG1748 Saccharopine dehydrogenase and related proteins  ali follow..  12  5VLIIGAGGVAQVVAHKCAQNSDDIHIASRTVDKCRKIVES---VREKKSLKTEVKLEAHALD---ALDVEATKALIVSTGSQIVINVGSAFVNMSVLCMDTGVAYMDTAIHEEPNKICETPPWYGNYEWKAAECKEKGITAILVGFDPG 154
27 -10.300[R] COG2910 Putative NADH-flavin reductase  ali follow..  12  4IALIGAGNAGSRILKELSDRGHQVTAIARNPEKIA--ALPNVVAKKGD-------VFDQAALSELLKGHDAVISSVTASDPATLIEAVRASGVQRYLVV.................................................. 96
28 -10.300[I] KOG1298 Squalene monooxygenase  ali follow..  11  48VIIVGAGVGGSALAYALAKDGRRVHVIERDPGGRLMLSKLGL-QDCLEDIDAQKATGLAVYKDGKEADAPFPVDNNNFSYEPSARSFHNGRFVQQLRRKAFSLSNVRLEEGTVKSLLEEKGVVKGVTYKNKEGEETTALAPLTVVC-DG 207
29 -10.200[S] COG1255 Uncharacterized protein conserved in archaea  ali follow..  10  17VIEVGIGF-YTRIAKRLKELGFDVLAIDINKDAVVNAKNSGLNAEVDD---------IFNPNISLYMGAKAIYSIRPTPEMMNYILKISKAVKVPAYIV.................................................. 105
30 -10.200[Q] COG4569 Acetaldehyde dehydrogenase (acetylating)  ali follow..  18  6VAIIGSGNIGTDLMIKILRHGQHLEMAVMVGIDPQ---SDGLARARRMGVATTHEGVIGLMNMPEFADIDIVFDATSAGAHVKNDAALREAKPDIRL.................................................... 99
31 -10.100[R] KOG1336 Monodehydroascorbate/ferredoxin reductase  ali follow..  17  165AVVIGGGYIGMECAASLVINKINVTMVFPEAHCMARLRAKGVKFIKGTVLTSFEKVTAVNLKDGSHLPADLVVVGIGIRPNTSLFEGQ--------TIEKGGIKVNSRMQSSDSSVYAIG............................. 295
32 -10.100[G] KOG1203 Predicted dehydrogenase  ali follow..  13  125ILVAGAGGVGRRIVDILRKRGLPVKALVRNEEKARKMLGPEIDLIVAD-------TKENTLVPEKFKGVRKVINAVSV....................................................................... 197
33 -10.100[C] KOG3851 Sulfide:quinone oxidoreductase/flavo-binding protein  ali follow..  12  46VLVVGGGTGGCAMAAKLSSGSDKVVVLEPEDKHMADVLPTKAKWVKEKALEFDPDNNTVSTSGGKTIKYDFLIIATGLQLNYGKIPGLVEALETSIYSPKYVDHVYECLRRTNKGNAIFTFPNCPIKCAGA.................. 206
34 -9.990[H] COG1635 Flavoprotein involved in thiazole biosynthesis  ali follow..  25  28VALVGGGPANLVAAKYLAEAGVKVALYEQKLSLGGGMWAGGMMF......................................................................................................... 71
35 -9.910[I] COG1250 3-hydroxyacyl-CoA dehydrogenase  ali follow..  11  5VGIIGAGQMGCGIAHVSAAAGYKVQLYDIAADRIEAVSSGKMSDEDRKRALSLIKG---SGDINDLAQADLVIEAVTE---RKIYGQVCPVMRPDAILATNSLSITRLASATDRPERFMGI............................ 138
36 -9.680[E] KOG3124 Pyrroline-5-carboxylate reductase  ali follow..  16  3VGFIGAGQLAYALARGFTAAG--------------ILSAHKIIASSPEMNLPTVSVNLTRSNKETVKHSDVLFLAVKPHIIPFILDEIGADARHIVVSCAAGVTISSVEKKLMAFQPAPKVI-----RCMTNTPVVVQEGATVY..... 135
37 -9.670[R] COG1832 Predicted CoA-binding protein  ali follow..  11  19IAVVGLSDTSHMVSKAMQDAGYEIIPVNPTIDEA-------------------LGVKAVSSLKEIDGPIDIVNVFRRSEQLPGVAEEFLET-DAPVFWAQQGLVNEEAYQMLKEKGR................................ 119
38 -9.650[O] KOG2018 Predicted dinucleotide-utilizing enzyme involved in molybdopterin and thiamine biosynthesis  ali follow..  12  129VIVVGCGGVGSWVINMLARSG-KIRIVDFDQVSLSSLNRHSIATLQDVGTPKTLAIKPDSADDLLSGNPDFVIDAIDNIQTKVDLLSYCYNHKLPVIA................................................... 247
39 -9.610[H] COG1179 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1  ali follow..  16  38VCVIGIGGVGSWAVEALARTG-ELTLIDMDDVCVTNINRQIHAMTGTIGKSKIEVITPDNQHLYLNKSFDYVLDAIDSLKAKASLLAYCRSNKIKVIT................................................... 156
40 -9.540[H] KOG4254 Phytoene desaturase  ali follow..  31  16AVVIGGGHNGLTAAAYLARGGLSVAVLERRHV..................................................................................................................... 47
41 -9.480[H] COG0499 S-adenosylhomocysteine hydrolase  ali follow..  11  261VLVCGYGDVGKGCAEAFDGQGARVKVTEADPINALQALMDGYSVVTVDEAIEDADIDIISFEQMLKMKDHALLGNIGHFDNEIDMHSLLHRDGRSIIVLSEG............................................... 388
42 -9.460[C] COG0644 Dehydrogenases (flavoproteins)  ali follow..  25  7VVVAGAGTAGAYASYLLAKAGLKVALLESKS...................................................................................................................... 37
43 -9.410[E] COG0665 Glycine/D-amino acid oxidases (deaminating)  ali follow..  26  3VVILGSGVVGVASAWYLNQAGHEVTVIDREPGAALETS............................................................................................................... 40
44 -9.350[S] COG3349 Uncharacterized conserved protein  ali follow..  31  3VAIAGAGLAGLSCAKYLTDAGHTPIVLERRDV..................................................................................................................... 34
45 -9.200[R] COG2344 AT-rich DNA-binding protein  ali follow..  17  88VILIGVGNLGTAFLHYNFTKNNNTKISMAFDINESKIGTGGVPVYNLDDLEQHVK------------DESVAILTVPAVAAQSITDRLVALGIKGILNF.................................................. 176
46 -9.200[H] KOG2337 Ubiquitin activating E1 enzyme-like protein  ali follow..  11  338CLLLGAGTLGCGVARNLLSWG-HVTFVDYSTVSYSNPVRQSLFTFEDCKRKLPKAECAAQR-ENLISTHDAIFLLTDTRESRWLPTVISTAMDKLLINSALGFDSWLVMR....................................... 486
47 -9.190[E] KOG3923 D-aspartate oxidase  ali follow..  26  20VAVVGEGVIGLSTATAILDLAEKRNIPAPE....................................................................................................................... 49
48 -9.180[R] COG1064 Zn-dependent alcohol dehydrogenases  ali follow..  17  177VAIVGLGGLGHMGVKLAHAMGAEVTVLSQTLSKKEDGLKLGAD--------HYYATKDPETFTKLAGSFDLIICTVAAIDWNAYLNLLKVDGELVLVGIPENPVPVHAFSLVPARRSISGSM-IGSIKETQEMLDFCGEHGIV...... 311
49 -9.180[E] COG3075 Anaerobic glycerol-3-phosphate dehydrogenase  ali follow..  25  5TIIMGGGLAGLLCGLQLQKHGLRCAIVTRGQ...................................................................................................................... 35
50 -9.080[H] COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2  ali follow..  17  144VGVIGCGGTGSAIAMLLPKMG-NIALFDKDIVEDTNLNRL-----------------------HGARQPDADAMSPKVEVVAKSLVELG--LGVQVRTYQAWIGEADCRDPLKACDVIFCCTDDHTGR..................... 247
51 -9.040[M] COG3967 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)  ali follow..  11  8VLITGGSAIGLELAKRLLELGNEVIICGRSEARLAEAKQQNIHTKQCDVADRSQREALYEWALKEYPNLNVLVFQAPVHLSALFTPHLMKQPEAAIVQVTSGLA............................................. 142
FFAS is supported by the NIH grant R01-GM087218-01
1 4 6 8 2 5   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Luz JG, Hassig CA, Pickle C, Godzik A., Meyer BJ, Wilson IA. XOL-1, primary determinant of sexual fate in C. elegans, is a GHMP kinase family member and a structural prototype for a class of developmental regulators. Genes Dev. 2003 Apr 15;17(8):977-90. Epub 2003 Apr 02.