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Query: PF03390.15; Q5WJJ9_BACSK/33-442; 2-hydroxycarboxylate transporter family, from PfamA32U

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst VGVLPFPIYIAIAAIVLAAAYFQKLPADMIGGFAIIMVAGMVLGEIGSRLPIIKSIGGPAILALFVPSAFMFFGWLNETTVNAVSNLMTTSNFLYFYIACLVAGSILGMNRVVLIQGITKMLVPLVAGTAVSMAAGVGMGLLLGYEAKHTLFFIVVPILAGGIGEGILPLSAGYSTILGIPAAELISQLIPAAIIGNIFAIIGAALLKQLGAKKPHLTGKGVLVKTKGPVMPKSIDDTKPVNFALMGAGLLVACSFYVFGHLMESSLHIPAAILMILIAAIAKVLKLIPEQLEQGAFHLYKFVSTSFTWPLMVGLGLLFIPLEDVAGIISFSYVLICATVVFAMIATGYFVGQWLNMHPVDSGIVTGCHSGLGGTGDVAILSASDRMSLMPFAQVATRLGGAGTVILATFLast
1 -110.000[C] COG3493 Na+/citrate symporter  ali follow..  31  23IFGMPLPLYAFALITLLLSHFYNAIPTDLVGGFALMFVMGAIFGEIGKRLPIFNKYGGAPVMIFLVAAYFVYAGIFTQKEIDAISNVMDKSNFLNLFIAVLITGAILSVNRKLLLKSLLGYIPTILAGIVGASLFGIVIGLCFGIPVDRIMMLYVLPIMGGGNGAGAVPLSEIYHSVTGRSREEYYSTAIAILTIANIFAIIFAALLDMIGKKYTWLSGEGELVRKASFKTEDDEKAG-QITHRETAVGMVLSTTCFLLAYVVAKKISIHYFAWMVLIVAALNASGLCSPEIKAGAKRLSDFFSKQLLWVLMVGVGVCYTDLQEIIDALTFANVVIAAIIVVGAVVGAAIGGWLIGFYPIESSITAGCMANRGGSGDLEVLSACNRMNLISYAQISSRLGGGIVLVIASI 440
2 -11.700[S] COG5505 Predicted integral membrane protein  ali follow..  10  7.........................SDDVWVLWGFIAVWAAVSIGLEQRFKWASAVS-GAIIALAGAMVFTNVGVLPVES----------DTVWSYVVPLAIPLLLFQINVRQIFKESRRLLFIFLISSVGTVLGSILAFFLLKQHIPYL----IGGMISASYIGGGVNFAAM-AAKFETPGEYVSATVVADNFMMALLFFILISIPALK-RHYAMPFEEKVKADGNSGNSAESYWKRKDISLKDIAFNAGAAFALVAVSMKVSGYFKTLGDQYLVLTSLTVLIIFLFPRFFERLNGSQE--LGTFLIYLFFVVIG-IPADLRLIVTN-APLILLFVFIIAISNLAVSLAAGKLFRVRLEEILLAV--NATVGGPTTAAAMAIAGWRELVAPIMLVGTLGYLI....... 380
3 -9.640[E] COG0786 Na+/glutamate symporter  ali follow..  14  1....................MNQIISIGALESFLIAISVLFLGHFINAKLPILTKF--EPIVGGLIVACVITALHFHGIDMEF------SLPLQNVFMLMFFSTVGLAANYTQLIKGGAKVFLFLAVASVFIIGVGVSLAAGLGLDPLLGLIAGSITLSGGGTGAA---WANTFAENYGLANTLEIA--MASATFGLIIGGIIGSPVAQKLVDKHGIESEYG-HSRFPELVTYNEYEEDKVTAKKVIEILFILLICVTGAKYLEAWVKIPDFVYALFIGVFIT--NLLEVTKLRKVDAETVDILGTVSLSLFLAMALMSLKLWNIFDLALPFLVILAIQSVVLGVFCYFVTFKVMGANYDAAVISAGCGFGLGATPTVMNMGSVKRFGPSPQAFMVVPIVGAFFIDIVN. 396
4 -9.190[P] KOG4505 Na+/H+ antiporter  ali follow..  8  8ISKPHLAYAIIGGFTSLFMLCSLIIKEKLLGEATMATATGLIFGPYVAKLFVPTSWGNTDYITEELARVLLVVEVFAAGAELPRAYMLRHWRFVMLLPVMIFGWLVSTGFMYALIPRLSFLESLAIAACITATDPVLASSIVGKGKFARRVPGHLRNMLLSGCNDGAIPFLYLAIYLIIEKPARILYECTFGCVLGAIIGVIARKMIKFSERR----------------------------GLMDRESFLVFYFVLALFCGGIGTIIGVDDLLVSFCAGAAFSWDSWFSKKTEESHVSNVIDLLLNLSFFVYVGAIMPWPQFHMPHMDLSVWRLVVLAICILIARRIPAVLLFKSFVPDIINWREALFAGHFGPIGVGALYTCLVARAELEVHSTVPEPNDAIENPEIP. 404
5 -7.980[P] KOG3826 Na+/H+ antiporter  ali follow..  10  24...TTTILIFISLYISIITLLGENFTVRSIFVIFILLVAGIFAAKISKALRL------PPLFGCLALGIIIKNITVFDQFFVFPPFVETMIRKVALVMIIVRWG--LATDIHFLYENALMPVTIGLVTAIGEIIAVTIASFILNISFVMSIFC----ILVTVSPAVTVPAMINFKEKQLGSLKRIPENILAICCVDNLFCVILFMVLSSIIFTDAPIATTGCIGGIVLGWILWRFPRSDAPHTQFARITLLGTICIAVVIGTYLIKYSCSGFLAALITSAMSAMQ---KEKLECVESTYKYIWDSFALPLLFICLGMK-FDCSTLTWEIVFLCIAVIAIGLLVRTILVMLVTLSSHINFKEQIVVALSLLPRATFQ-LAPTLLLMATPFPDMAKDAALILKAAILSVL.. 449
6 -6.900[P] KOG1650 Predicted K+/H+-antiporter  ali follow..  10  56...........................QMSVIIITSRLLYRLLKPLKQGMISAQVLAG----IILGPSLFGQSSAYMQMFLPISGITLQTLSNLGFFIHLFLLG--LRIDASIIRKAGSKAILIGTASYALPFSLGNLTVLFLKNTYLPPDVVHCISTVISLNAMTSFPVTTTVLAELNILNSDLGRLATNCSIVCEAFSWIVALVFRMFLRDGTLAS---VCRPAIIWLTERRSISIDKAGEIPFFPIIMVLLTISLTSEVLGVHAAFGAFWLGVSLPDGPPLGTGLTTKLEM--------FATSLMLPCFISISGLQTNFFIIGESHVKIIEAVILITYGCKFLGTAAASAYCNI-QIGDAFSLALLMCCQGVIEIYTCVMWKDEKVLNTECFNLLIITLLLVTGIS. 437
7 -6.780[R] COG3180 Putative ammonia monooxygenase  ali follow..  10  26................................WCLLALLSAVFAGVLEMIGIPAGLLMGPMIAGALVGMNGGTIRLPRQLFF---------------CVQVVLAMMIAASSPDLLVTFSGNWLLFLAIILSVIGVSTLCGWTITRMGILPGTTAIWGSSAGAASTMLLMADAYGADARLVAFMQYLRVVFVASTATIVSHLWVSG---------------------------VEAETATHWFAPIAGLPFFMTLAVGIASGILGKILRVPAGAFLFAIGSALNITGTLTIELPQWLLALSFAMLG-----WNIGLGFTRAILAHARRALMPT-IVSIVVLISFSGLLALLLIKVAGIDPLTAYLATS-----GGLDSIAVIAASSNVDL..................... 333
8 -6.150[P] KOG1965 Sodium/hydrogen exchanger protein  ali follow..  9  25............................SMNLFVALLCACIVLGHLLEETRWMNE----SITALIIGSCTGIVILLISGGKSSRILVFSEDLFFIYLLPPIIFNAGFQVKKKQFFRNFMTIMLFGAIGTLISFVIISFGAKHLFEKMNIGDLTIADYLAIGAIFSATDSVC-TLQVLNQDETPLLYSLVFGEGVVNDATSVVLFNAIQRFDLTNINSAI-GVAAGLLSAFVIKKLYIGRHSTDREVALMMLLAYLSYMLAELFH----LSSILTVFFCGIVMSHYT-VTDKSKVTTKHTFAAMSFLAEIFIFLYVGMDALDIEKWDVVRNSPGQSIGVSSILLGLI---LLGRAAFVFPLSFLS------NLTKSSPDEKIDLKKQVTIWWAGLMRGAVSMALAYNQFT. 406
9 -5.360[P] KOG1966 Sodium/hydrogen exchanger protein  ali follow..  10  23...YVITTWLLVASLAKILFNLMKPLSKWLPDSSLLIIVGLGLGYF--------------------------------NQTTLSGVHLDSHAFFLYLLPPIIFDAGYFMPNRALFKNFDSVLVFSVLGTLWTFAIGGSLLIMSKYQLFTMPFTTFEILVFSALISAVDPVAVIAIFEEIHVNEFLFINVFGEALFNDGVTVVLYQMFKSFALIGSEALGGAAIGIIFAIATSLATKYTQGIKILAPVFIFLLPYMAYLTAEMVS----LSSIIAIAVCGMLMKQYI-ITEAATNSVKYFTKMLAQCSETVIFMFLGLSTLTSEHHVD-----------FIFIGATLVFCLIYRAIGIIVQCFILNKFRAKKFEVVDQFILSYGGLR--------------GAIAYGLV.. 387
10 -5.270[R] KOG2140 Uncharacterized conserved protein  ali follow..  9  173VNISNISIIIQELLQENIVRGRGLLSRSVLQAQALVAIINSKFPQIGELI-LILNFKQLCLTASKFVAHLINQNVAHEVLCEMLTLLLERPTDDSVEVAIGFLGLKLTQVSPRGINAIFERLRNILHESEIDKRVQYMIEVMFA--------------VRKDGFKDHPIILEGLDLVEEDDQFTHMLPLEDDYNPEDVLNVFKMDPNFMENEEKYKAIKKDEGDTDSNTDQDAGSSEEDEEEEEEEGEEDEEGQKVTIHDKTEINLVSFRRTIYLAIQS---------SLDFEECAHKLLKMEFPE-LCNMILDCCAQQRTYEKFFGLLAGR--FCMLKKEYMESFEGIFKEQYDTIHRLETNKLRNVAKMFAHLLYTDSLPWS--LECIKLSEETTTSSSRIFVKIFFQ 588
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Rychlewski L, Zhang B, Godzik A. Functional insights from structural predictions: analysis of the Escherichia coli genome. Protein Sci. 1999 Mar;8(3):614-24.