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Query: PF15961.5; ZN839_HUMAN/7-805; Domain of unknown function (DUF4764 topsan), from PfamA32U

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst IQPQTARKSQLPRGNSCLVGLHIASPQLLRVQPLVRTEPQSCFLSDLCQPPAQGFVQRPLPALQVVPAKRVPAPKAPDEQGSMLTPLSASDPLAVTSLSSSSAHPFISNLHTRHTEKLKKSLKVKTRSGRVSRPPKYKAKDYKFIKTEDLADGHLSDSDDYSELCVEEDEDQRERHALFDLSSCSLRPKSFKCQTCEKSYIGKGGLARHFKLNPGHGQLDPEMVLSEKASGSTLRGCTEERTLSLTSLGLSMPADPCEGGARSCLVTESARGGLQNGQSVDVEETLPSEPENGALLRSERYQGPRRRACSETLAESRTAVLQQRRAAQLPGGPAAAGEQRASPSKARLKEFLQQCDREDLVELALPQLAQVVTVYEFLLMKVEKDHLAKPFFPAIYKEFEELHKMVKKMCQDYLSSSGLCSQETLEINNDKVAESLGITEFLRKKEIHPDNLGPKHLSRDMDGEQLEGASSEKREREAAEEGLASVKRPRREALSNDTTESLAANSRGREKPRPLHALAAGFSPPVNVTVSPRSEESHTTTVSGGNGSVFQAGPQLQALANLEARRGSIGAALSSRDVSGLPVYAQSGEPRRLTQAQVAAFPGENALEHSSDQDTWDSLRSPGFCSPLSSGGGAESLPPGGPGHAEAGHLGKVCDFHLNHQQPSPTSVLPTEVAAPPLEKILSVDSVAVDCAYRTVPKPGPQPGPHGSLLTEGCLRSLSGDLNRFPCGMEVHSGQRELESVVAVGEAMAFEISNGSHELLSQGQKQIFIQTSDGLILSPPGTIVSQEEDIVTVTDAEGRLast
1 -18.800[R] KOG2350 Zn-finger protein joined to JAZF1 (predicted suppressor)  ali follow..  8  409............................................................................................................................................................................................QELNCPWCGLDCLRLYALLKHLKL--CHARFNFTYQPAGSGARIDVTINDAYDGSYAGSPYDLAGPSGSSFARTCGPVRRTSVTSLMVCRPRRQKTCLDEFLELDEDEISNQRSYITGHNRL---------------------------HHTETCLPVHPKELDIDSEGEEFSDVN-EGEKELMKLWNLHVMR--HGFVGDCQLPIACEMFLDAKGT-KNLYRNFILHMCSLFDYGL-IAAETVYKTVQKLQ-----GLLSKYAAGQELMQRQREEQLKYWLDVGMHKKQEDPKTLKSPQKPAPPADQASTSSASTSGSGSGSSSMQPPKRMPAHLKRGSAASSPGVQSKGTENGTNGSNSSSSNSKNVAKKSADQPLSTLANTRERRSEYGQKRNVSGSRLAATPASKRKLSSKDVEQAADAPEVLTHSDNAVDVGIIDDECGGFGAVGVMNGVASPVANNSEMDTEAEVEAEPTATKAITIHCQQPVTTPVAAAATANERLPGVAPHRRGPRRADRREEELVASAPGYRCRPSMRGADAGAAAAAAAAPTHPHPHRPPP.................................................. 950
2 -11.200[U] KOG1091 Ypt/Rab-specific GTPase-activating protein GYP6  ali follow..  11  290...............................................................................................................................................................................................................................................................................................................................................TGLTPVLEACSAFYRILAVVDSSGVLRVLFGRLQDLLLVWDEIILADNSARTDEDSRNQNFRIFDSMILYLRSLSTENATCC----PENIDLNK--IQKAKLLQALVLDTDMLTSPRSPLIIAPESYWEKKWRVLHKAEEEENKICLEKQTPPTQKKKRWLNVTKLFRAVIDLSHHKLGIGERKANSSPVTQSLLEDSSEQLNVDCHVTVNKENIHPQETEENIMEFHSADEESIVSGSSPSEESSFVSLDPTSPVRCSTKIENDSVSSAGSNLLPDEDDKSIVSISEENSSVSSDPISPAIDSNYSGKYLDCCTGSENDKDQQTSVNSPLSVSPHRRNEYPVTLSSEETSHRKASDATKTNDVKIKKNQIGCYSESHPQALSSGDSSQNLRKTLKNLGQSMLKHIEAIELVFQ-LVPAGLIGNLAKEKGQVTATTA----LRKLSNLLSE............. 839
3 -11.200[KD] COG5189 Putative transcriptional repressor regulating G2/M transition  ali follow..  17  581...................................................................................................................DDPARRLYVMDHEE--QKP--FK-KTYKHRLHGHQNQKLHENPDGTFSVIDPDSTDSFGDGMGSA------KDKPYRCEVCGKRYKNLNGLKYH-RGHSTH....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 683
4 -10.400[A] KOG3408 U1-like Zn-finger-containing protein, probabl erole in RNA processing/splicing  ali follow..  20  2................................................................................................................................GRVARKRKHHSNGNHALYGRDLDQIHNDLTESEKFDKLPIDPDLPGLG-------------QHYCIECARYFDSSQALLVHKK-GKVH....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 80
5 -10.400[R] COG5112 U1-like Zn-finger-containing protein  ali follow..  20  2................................................................................................................................GRVARKRKHHSNGNHALYGRDLDQIHNDLTESEKFDKLPIDPDLPGLG-------------QHYCIECARYFDSSQALLVHKK-GKVH....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 80
6 -9.640[O] KOG0717 Molecular chaperone (DnaJ superfamily)  ali follow..  10  248............................................................................................................EQKKLEAHKKQADNRKKQIAKNQELANSYLNDKEAEAARLAHLIEVSLQMAEDYDTCSDECDEEGEEL--------------PYCVVCSKSFKTVNAKLNH-ENSKQH---IRQLNELKKHMKEEDSTIFTEAEPKPDETPKGKKNKRKDRKKGNGIFDVEETEAVEAEIQEAPPVENEQPEEEEKECTPEVVKKEKKKRRADKNQNPSATVEEEAPKSTEPKSAICDKCREVFDSRTRLFAHLQE............................................................................................................................................................................................................................................................................................................................................................................................................................................................. 475
7 -9.250[R] COG5048 FOG: Zn-finger  ali follow..  20  562..................................................................................................................KRRYNIRSHIQTHLED--RP-------YSFVRNHDLIRHKKSHQE-----------------------------KAYACP-CGKKFNREDALVVHRSRMICSGG..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 635
8 -8.380[TZ] KOG2546 Abl interactor ABI-1, contains SH3 domain  ali follow..  9  3.................................................................................................................................................................................................................................................................................................................................................TETPMASENIMDEL------ASLIRTEIPNLERVADYCEDTYYRADNKKAALEATKNY-QSLASVAYQINTLAYSYMQLLELQAQQLGEMESQHIAQTVHIHKEKVARREIGVLTANKVSSRQFKIVAPINPEKPIKYVR------KPIDYSMLDEIGHGINSAQHSQVRQKHRGSSHGSVQSLLPPSVGPPPTTKPPTPPQMSRAGNTGTLGKSVSNTGTLGKSSREYRTPPVVNPPQVPSHYAPNYPIGHPKRMSTASSTMTTTTTGGGAAGNERAAGYSALPMPPSQQIATHVNLPSAGMMQSLPPPPPTTYDDRSSMPPAPPSPLTVSQHEMTEQSHIGMHTLGRNINRNHFSLNFARPGSQSPPLPPPPPPEDEHQDFGRPRTSTGPQLAPIVPEDQNLPGWVPKNFIEKVVAIYDYYADKDDELSFQ--ESSVL----YVLKKNDD--VMDGVTG. 462
9 -8.160[R] KOG2785 C2H2-type Zn-finger protein  ali follow..  11  21.......................................................................................................................................AHYKTDWHRYNLRRKVASMAP---------VTAEGFQERVRAQRAVAEEESKGSATYCTVCSKKFASFNAYENHLKSR--H-NEKNLEKGLGVDSVDKDAMNAAIQQAIKAQPSMSPKKAPPAPAKEARNVVAVGTGGRGTHDRDPSEKPPRLQWFEQQAKKLAKQQEEDSEEEEEDLDGDDWEDIDSDEELECEDTEAMDDVVEQDAEEEEAEEGPPLCSHMKNVAFFIPYLSDIKGLIKYLGEKVGVGKI------KSFYSTEAVQAHMNDKSHCKLFTDGDAALE........................................................................................................................................................................................................................................................................................................................................................................................ 342
10 -8.090[O] KOG2231 Predicted E3 ubiquitin ligase  ali follow..  10  175.......................................................................................................................................NIFTFERRCYTQAELQLHNTKGDPDNRSHR-DRDE-------------RHLRREHYFCHFCDADYNDYADLAEHFR--AEHFLCEEGKCATEQ---RNEIEYKAHVANVHGKSLNKQQAKQTRTLQVEITLGPRGRSGQTEQGITSVRTRNDEHNDYQNDLPSITQRHVSIDAGNEEQFPTLRGASTAPSVSLVRPPPPSMRNLSGTSGLARTKENFPALGGGNGGGVTGPTSSSIAA--------------------------AAQSQHPVAAVFKKPTSAAGSGSRSGPPGNGMLLHVSNRSAAVPKKAATPQVDFPALPGKGNKKNLRNLEEDMLPSGSPVPMANISAKHRSLADDYVSVASPSTFQKLQMVQKEEDEAKARQEALKKSAPKLTAAEFPSLGPSASASSSRTTAPKPSSGSPSLNWSKPANEKKQRELENRKAKVAPAPVLPSPTSKPAPKASNNNVQEQQANKKDKKQKDKKSNQENQPKTAKPKERNNNNEQKTNGAPSTPIRAPPGLKPGGPLKPPPGFVSNVTVNSVAKLPNNLTFTNSLGESYDIVPSPYTYTDPPDTEVRNQKLVDEVMSLLKTPEALNEFRLLSSKFRDGSCSGQAYYEHCQCAMLSSFYNLF---PELLAM------ISKQQELYLVHKQH.. 811
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Li W, Jaroszewski L, Godzik A. Tolerating some redundancy significantly speeds up clustering of large protein databases. Bioinformatics. 2002 Jan;18(1):77-82.