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Query: PF15664.5; E2RC46_CANLF/29-168; Transmembrane protein 252 family, from PfamA32U

Results of PSI-BLAST search in nr85s
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# E-value Template Links and tools%idFirst SSGSIFNCRGNLILAYMLLPLGFVILLSGIFWSTYRQASKSKGVFTHVLRRHLSHGALPLATVDRPDFYPPAYEESLDAEKQPCPTEGEVSDIPPPLYTEPGLEFEDAADAHPEAPPSYEESVAGGVPAATPLQDAERQSLast
1 1.000e-42UniRef50_UPI0006B16AAF transmembrane protein 252 isoform X1 n=2 Tax=Bifurcata TaxID=1329961 RepID=UPI0006B16AAF  ali  36  51NRNEIIRCKDKI----FLLQKGFFFLIAGISWSTYHEASKHNSLFHSIIHGIPRLQESHITTIDRPDFYPPSYDDSTALGKQTFSPKSYAYNIPPPLYTESRFEFIEETGDQEQQPPSYEVSVQQRPTGNDPT....... 186
2 5.000e-42UniRef50_I3MCE9 Transmembrane protein 252 n=3 Tax=Marmotini TaxID=337730 RepID=I3MCE9_ICTTR  ali  71  64...................................RQASGNKGVFSHVLRRQLAHQDLPLATVDRPDFYPPAYEESLDAEKHTCPADPEALDIPPPLYTETGFELQGENGAHPEAPPSYQASVADLVSAATS-EDAERPS 167
3 7.000e-41UniRef50_UPI000CE63FEE LOW QUALITY PROTEIN: transmembrane protein 252 n=1 Tax=Chrysemys picta bellii TaxID=8478 RepID=UPI000CE63FEE  ali  42  37TGSSLCRCGNNXXXXXXXXXXXXXXXXXXXXXXTYHEVRKNKNLF-YILQRNPSHRETHINTIDRPDFYPPCYEDSTDPGKQTFPREEELYNIPPPLYTESSMEFIDETSLQEEQPPSYEMSVQQQQPTTEHDSNTE... 179
4 9.000e-41UniRef50_U3K6V6 Transmembrane protein 252 n=60 Tax=Neognathae TaxID=8825 RepID=U3K6V6_FICAL  ali  38  30TNSSMCRCGNNKLVFYCLLALGLCLLVTGIFWSTFHEVLKYRAL--GIFIRNPSHRELHVCTIDRPDFYPPSYEDSIDPEKLSTLKQQEFINIPPPPYSESSAEFASETNEQ-EQPPPYTLSVEQQQTADQDPN...... 167
5 1.000e-39UniRef50_L5K5S3 Uncharacterized protein n=4 Tax=Boreoeutheria TaxID=1437010 RepID=L5K5S3_PTEAL  ali  65  29SLGSNFNCRGNXXXXXXXXXXXXXXXXXXXXXNTYRQASESKGLFSHVLRQHLAHGAVALATVDRPDFYPPAYEENLDGEKQTCPAEGEALDVPPPVYTEMVFEFVDENNDHREAPPSYD-SIDDSCDSNL-ISGAERQS 166
6 2.000e-38UniRef50_Q8C353 Transmembrane protein 252 n=23 Tax=Theria TaxID=722675 RepID=TM252_MOUSE  ali  51  3NRTGLILCALSLLTGFLMICLGGFFISNSIFHSQXRQANENKEMFNHVLRQHLAFQDLPLATVDRPDFYPPAYEESLDVEKQACPAGRELLGFPPPLYTETNLEFEHLEDPQPEAPPPYQEIIADA-GAPAKAQDAEEPS 166
7 1.000e-37UniRef50_Q8N6L7 Transmembrane protein 252 n=69 Tax=Eutheria TaxID=9347 RepID=TM252_HUMAN  ali  69  62.................................NYRQVTESKGVLRHMLRQHLAHGALPVATVDRPDFYPPAYEESLEVEKQSCPAEREASGIPPPLYTETGLEFQDGNDSHPEAPPSYRESIAGLVVTAIS-EDAQRR. 166
8 4.000e-36UniRef50_A0A060YS25 Uncharacterized protein (Fragment) n=2 Tax=Oncorhynchus mykiss TaxID=8022 RepID=A0A060YS25_ONCMY  ali  30  96SLHNVYNSSLCYILAYVLIAFGLCCLLSGVFWTICHGMKRKR----QRSRSHHIAAHIHVYTVDRPSFHLPSYEESQHNHTSATAADGLRFNLAPPLYTQDISEAPDDTFNHEE-PPAYSEMAMQLHREPQGLPQQPEHS 238
9 7.000e-36UniRef50_A0A1S3NP76 transmembrane protein 252 n=4 Tax=Salmoninae TaxID=504568 RepID=A0A1S3NP76_SALSA  ali  30  31SRHNAYNSSLRYILDYFLIACGLWCLLTGVFWTICHGMKRKRQ--HQRSRRHHTAAHIHVYTVDRPSFHLPSYEESQQNHVLGLSEDGLRFNLAPPLYTQDISEAPDHTFNHEE-PPAYSEMAMQPHREPQELPQQPEHS 180
10 3.000e-35UniRef50_A0A2K6SYB6 Transmembrane protein 252 n=22 Tax=Theria TaxID=722675 RepID=A0A2K6SYB6_SAIBB  ali  66  31..SSIFSCQEXXXXXXXXXXXXXXXXXXXXXXXNYRQVIESKGVFRHVLGQHLAHGALPLATVDRPDFYPPAYEESLEGEKQSCPAEREASGIPPPPYTETGLEFQDGNYSYPEAPPSYREFIAGLVVTATS-EDAQRRD 167
11 7.000e-34UniRef50_UPI0007401F3C transmembrane protein 252 n=1 Tax=Lepisosteus oculatus TaxID=7918 RepID=UPI0007401F3C  ali  38  58..........KLTFSCVCFTCGFLLLLAGCSWNICHGM-KNKRFLTRVAC--HQHTRVCICTVDRPHFYPPSYEESV--ERSPGLAVGSLCNIAPPLYTESSSEVVDETYSQEE-PPSYKETL................. 171
12 1.000e-32UniRef50_K7EEQ0 Uncharacterized protein n=2 Tax=Mammalia TaxID=40674 RepID=K7EEQ0_ORNAN  ali  52  29STGSLLRCRGXXXXXXXXXXXXXXXXXXXXXXXTYHQATQSKNMFSDVFRQHLGPRATHIQTVDRSDFYLPSYEDSIDPEKQVCSAQEEHSNIPPP-YTESCLELLEETDPYKDNPPPYEAS.................. 149
13 2.000e-30UniRef50_A0A1L8HY66 Uncharacterized protein n=3 Tax=Xenopus TaxID=262014 RepID=A0A1L8HY66_XENLA  ali  33  31SSSYVCNCQSEXXXXXXXXXXXXXXXXXXXXXXTYHEAN-HKNLFHSMIRRIHSQQEVHVETIDRPDFYPPSYESVINEIRLQPESSCELLNIPPPLYTESAVDIADEVYTCNDSPPSYQASV---QLSNTETNSEREPD 172
14 2.000e-30UniRef50_A0A2I0UCF6 Uncharacterized protein n=2 Tax=Neognathae TaxID=8825 RepID=A0A2I0UCF6_LIMLA  ali  40  30TSSSTCRCGNNEXXXXXXXXXXXXXXXXXXXXNTCHEVVKYRGPFSA-FIRNPSRRELCVSTIDRPDFYPPSYEDSTDPEKQTFPKQQEAINIPPPPYSESGAEFISKTNEQ-EQPPPYRLSVG................ 158
15 4.000e-30UniRef50_A0A091UUW9 Transmembrane protein 252 (Fragment) n=10 Tax=Neognathae TaxID=8825 RepID=A0A091UUW9_NIPNI  ali  41  18TSSSTCRCGNNEXXXXXXXXXXXXXXXXXXXXXTFHEVLKYRG-FSSIFIRNPSHRDLRISTIDRPDFYPPSYEHSTDPEKQTFPKQQEVINIPPPPYSESNAEFISETNEQ-EQPPLY..................... 141
16 1.000e-29UniRef50_G1T6T2 Uncharacterized protein n=5 Tax=Euarchontoglires TaxID=314146 RepID=G1T6T2_RABIT  ali  71  34..................................YRQANGSKGVFSRVLGEHLAQGALPLATVDRPDFYPPAYEESPDAEKPSCPAQGEAWHDPPPRYTETSLEFQDENDAQPEAPPAYEE................... 120
17 4.000e-29UniRef50_A0A091F113 Transmembrane protein 252 (Fragment) n=2 Tax=Corvus brachyrhynchos TaxID=85066 RepID=A0A091F113_CORBR  ali  37  18TDSSMCRCGKNKXXXXXXXXXXXXXXXXXXXXXTFHEALKYRAL--GIFIRNPSHRELHVCTIDRPDFSPPSYEDSIDHEKLVSPKQQEFINIPPPPYSESSAEFVSETNEQ-EQPPPY..................... 140
18 6.000e-29UniRef50_V8NWV7 Uncharacterized protein (Fragment) n=20 Tax=Sauria TaxID=32561 RepID=V8NWV7_OPHHA  ali  34  64...................................HEASKHNSLLHSIIHGSSRLEESHITTIDRPDFYPPSYEDTAALGKQTFSPKNYAYNIPPPLYTESRFEFIEETGAQ-QQPPSYEVSVQQRATGNDST....... 167
19 3.000e-28UniRef50_A0A094MRK9 Transmembrane protein 252 (Fragment) n=5 Tax=Neognathae TaxID=8825 RepID=A0A094MRK9_9AVES  ali  38  20TSSSTCRCGNNEXXXXXXXXXXXXXXXXXXXXXTFHEVLQYRGL-TRTFIRNPSHRELRVSTIDRPDFYPPSYEDSTDPEKQTSPKQQEDINIPPPPYNQSSAEFISETNEQ-EQPPPY..................... 143
20 9.000e-27UniRef50_UPI000BBDB5E8 transmembrane protein 252 n=1 Tax=Astyanax mexicanus TaxID=7994 RepID=UPI000BBDB5E8  ali  31  67.........................................KGVLVKWSGGRMRHTDVQVFTVDRMNF-PPSYEESQAEGTGPVPAVPLWPGLAPPIYTQSSFETLTEDYSH-EAPPTYEQAIRQNQIQNQSLNQNQ... 165
21 6.000e-26UniRef50_A0A2F0AX02 Transmembrane domain-containing protein (Fragment) n=1 Tax=Eschrichtius robustus TaxID=9764 RepID=A0A2F0AX02_ESCRO  ali  77  45.................................................................PDFYPPAYEESLDAEKQACPAEQESSGVPPPPYTETGLEFADEGDAHPEAPPSYDESVADTVEAATPLQDAQRQN 119
22 6.000e-23UniRef50_M3XHY9 Transmembrane protein 252 n=1 Tax=Latimeria chalumnae TaxID=7897 RepID=M3XHY9_LATCH  ali  40  69.......................................KKKVLFHHLARRSMPQGLVHVNTVDRPDFYPPSYEEAVHSGTHSDSENEGGYNLPPPLYTESSSEVPEEDCGIEVEPPSYETSVHQS.............. 163
23 2.000e-22UniRef50_A0A2D0R2D1 transmembrane protein 252 n=2 Tax=Characiphysae TaxID=186628 RepID=A0A2D0R2D1_ICTPU  ali  30  69.........................................KNVLLKRSVRRSRNADVQVFTVDRSDLYPPSYEESQVPTVISIPTGMQWAGPAPPVYMQTGYETSVEDFSHEE-PPTYQQAVADSQAVHLPTNSSVEP. 177
24 6.000e-22UniRef50_UPI000B8F1E27 transmembrane protein 252 n=3 Tax=Ovalentaria TaxID=1489908 RepID=UPI000B8F1E27  ali  24  68.........................................HSMKSKMFCRGRHEQRIQVFTVERPSCFPPSYEASEGSLVSSDTPYELAVRVAPPLYSQDGSEPPDCTFS-WEQPPRYSVVEGLQRGQAEEQREA.... 170
25 1.000e-20UniRef50_A0A2U9BTB7 Putative transmembrane protein 252 n=2 Tax=Percomorphaceae TaxID=1489872 RepID=A0A2U9BTB7_SCOMX  ali  23  68.............................................SKMYQRGGGEQHIHVYTVERPSSFPPSYEDSQGSRFSSDAAVDVVMSPAPPLYSRDSSEAPDCTWS-WEQPPRYSQVERIQQGRVDAEERRE... 167
26 2.000e-20UniRef50_UPI000901B39A uncharacterized protein LOC104922965 n=1 Tax=Larimichthys crocea TaxID=215358 RepID=UPI000901B39A  ali  25  1...........................................MKSKIYQRGGRDQHIQVYTIERPSCFPPSYEESQGSQVYPNAAEDVVMSLAPPLYSQDSSEAPDCTWS-WEQPPRYSQVECIQQGEVDADEQLE... 101
27 3.000e-20UniRef50_UPI000643F76B transmembrane protein 252 n=1 Tax=Clupea harengus TaxID=7950 RepID=UPI000643F76B  ali  32  65..................................CHGM---RSSLYRQRRHRRRSTQVYVYTVDRPNFYPPSYEESQ-AETNTINQVC--FCMAPPLYTPTGSEMVNEAFSH-EQPPTYDQVLGQHQQSP.......... 153
28 9.000e-20UniRef50_A0A226NY37 Uncharacterized protein n=2 Tax=Odontophoridae TaxID=224313 RepID=A0A226NY37_COLVI  ali  46  4..........................................GSLSSTFVRNPSLAELRVSTIDRPGFYPPSYEDSTDPEKQTFPKEQEVINIPPPLYSENSTESVSETNE-PEQPPPYELQVSNPVDACTPTQDN.... 108
29 6.000e-18UniRef50_A0A287BDI7 Transmembrane protein 252 n=2 Tax=Boreoeutheria TaxID=1437010 RepID=A0A287BDI7_PIG  ali  72  29STGSMFSCQGXXXXXXXXXXXXXXXXXXXXXXXXXRQASESKGVFGRVLRQHRAQGAVPLATVDRPDFYPPAYEERLDAEKQACPAEPEAL................................................. 119
30 8.000e-18UniRef50_H2LI46 Uncharacterized protein n=1 Tax=Oryzias latipes TaxID=8090 RepID=H2LI46_ORYLA  ali  30  64.........................................HSMKSKLYQRRHVEQ-MHVFTVHRPSTFPPLYEESVCTPQVVVPTDGMSMSLAPPLYSQNNSEITDPSW-CWEQPPPYSQAVE................ 153
31 4.000e-17UniRef50_UPI0009B4BEB4 transmembrane protein 252 n=1 Tax=Labrus bergylta TaxID=56723 RepID=UPI0009B4BEB4  ali  25  68.........................................HSMKSKIYRRGGGERNIEVYAIERPSFFPPSYEESQYSQVTRDTPSEVVVELAPPLYSTDSSEAPDCTWS-WERPPQYSQ-----VERALQGEEEQR.. 167
32 4.000e-16UniRef50_A0A096M9W3 Uncharacterized protein n=21 Tax=Percomorphaceae TaxID=1489872 RepID=A0A096M9W3_POEFO  ali  32  68...........................................MRSKMYHRRRHDSDIQIFTVERPNSFPPPYEESMHEEVVSVDGVPVVLDVAPPLYTQDSSESPDCRWS-WEPPPRYSQVVH................ 158
33 2.000e-15UniRef50_A0A099ZWI7 Transmembrane protein 252 (Fragment) n=1 Tax=Tinamus guttatus TaxID=94827 RepID=A0A099ZWI7_TINGU  ali  38  23ASAALCRCGDERLALRCLLPLGFLLLVLGIFWNTLHEALKLRGL-----------GELRASAVGRPDCCPPSYADSIDPEKQSPPGDTAGPGLPPP............................................ 114
34 2.000e-09UniRef50_H0Z5H7 Uncharacterized protein n=1 Tax=Taeniopygia guttata TaxID=59729 RepID=H0Z5H7_TAEGU  ali  45  1................................................................RPDFYPPFYENSIDPEKLSTLKQQEFDSIPPPPYNESSAEFVSETNEQEEPSP....................... 60
35 9.000e-08UniRef50_A0A2B4S085 Uncharacterized protein n=2 Tax=Stylophora pistillata TaxID=50429 RepID=A0A2B4S085_STYPI  ali  38  160....................................................................YPPSYEEVTTNDTHDTRTQAQ--CDPPPCYTDD--EMLADANL---SPPSYETVASGTVSS........... 213
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Pawlowski K, Pio F, Chu Z, Reed JC, Godzik A. PAAD - a new protein domain associated with apoptosis, cancer and autoimmune diseases. Trends Biochem Sci. 2001 Feb;26(2):85-7.