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Query: gi|15922991|ref|NP_370525.1| chromosomal replication initiation protein (SAV0001) [Staphylococcus aureus subsp. aureus Mu50], from S.aureus

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MSEKEIWEKVLEIAQEKLSAVSYSTFLKDTELYTIKDGEAIVLSSIPFNANWLNQQYAEIIQAILFDVVGYEVKPHFITTEELANYSNNETATPKETTKPSTETTEDNHVLGREQFNAHNTFDTFVIGPGNRFPHAASLAVAEAPAKAYNPLFIYGGVGLGKTHLMHAIGHHVLDNNPDAKVIYTSSEKFTNEFIKSIRDNEGEAFRERYRNIDVLLIDDIQFIQNKVQTQEEFFYTFNELHQNNKQIVISSDRPPKEIAQLEDRLRSRFEWGLIVDITPPDYETRMAILQKKIEEEKLDIPPEALNYIANQIQSNIRELEGALTRLLAYSQLLGKPITTELTAEALKDIIQAPKSKKITIQDIQKIVGQYYNVRIEDFSAKKRTKSIAYPRQIAMYLSRELTDFSLPKIGEEFGGRDHTTVIHAHEKISKDLKEDPIFKQEVENLEKEIRNVLast
1 -122.000[L] COG0593 ATPase involved in DNA replication initiation  ali follow..  37  1MNLSNLWQSCLLQLQDQVSASDLSTWLRPLQADVVADNHIVLYASNMFVKGWVETHYLAQIQQICQTLAQNPELRISLKEGVKPAPKIVESTPNTSLRSESAVDFQAESSASESHLNTKHLFDNFVEGKSNQLARAVGQKLAQAPGESANPFFLYGGTGLGKTHLLHAIGNGILADKPNARVLYIHANNFMQHMVKAVRDNKMDQFKKFYRSLDALLVDDIQFFAEKEKTQEEFFHIFNSLFETGRQIILTSDRYPKEIEKIEERLKSRFGWGLTTAIEPPDLETRVAILLKKAEEHNMNLPEEVAFFIAQRLRTNVRELEGALNRVKAMQDFKGGDIDIDFVRDTLKDILA-LQERLVTIENIQKVVAEYYRIKVSDLKSKSRARSVTRPRQIAMALAKELTNRSLPEIGRAFD-RDHTTVLNACREVPKFREQDNSIQEDWANLIRTLSA. 454
2 -23.400[L] COG1484 DNA replication protein  ali follow..  20  80......................................................................................................................QLGFKEFRTEGKPQCTKEYVADYEQIKDCRKNSIALLGQPGSGKTHLLTAAANELMRTC-YVPVIYFPFVEGFTDLKNDFALLE--AKLNRMKQADVLFIDDL---NGKPRQLEQMYSVLNYRYLNHKPILLSSELTIEGLVRVDEALGTKI--DYLVIIKGAAYELNHRLEGVR................................................................................................................................................................ 266
3 -15.100[L] COG2255 Holliday junction resolvasome, helicase subunit  ali follow..  13  9.....................................................................................................SAAVINDEESIDRAIRPK-LLTEYV-GQPHVREQEIFIQAAKQRGDALDHVLIFGPPGLGKTTLANIIANEMGVNLRTTSGPVLEKAGDLAAMLTNLEPH------------DVLFIDEIHRL--SPVVEEILY----PAMEDYQLDIMIGEGPAARSIKLDSPLRDRFG--IVQRLEFYQVADLEHIVSRSAKCLGLELTPEGAHQLARRSRGTPRITNRLLRRVRDFAEVRADGAINGEVAMKALDMLNVDAEGFDFMDRKLDNLAAAIGEERETIEDVLEPYLIQQGFIQRTPRGRIATNHAYKHFG.......................................... 329
4 -13.200[L] KOG0990 Replication factor C, subunit RFC5  ali follow..  13  5...............................................................................TSAMDIDVDEIQPRKPINKGKDVVGFGPPPQSKATPWVEKYRPQSLVAAH-RDIIDTIDRLTNEN---KLPHLLLYGPPGTGKTSTILAVARKLYGPKYRNMILELNASD--DRGIDVVRQ-QIQDFASTQSSVKLVLLDEADAMT--KDAQFALRRVIEK-YTKSTRFALIGNHVNKIIPALQSRC-TRF------RFAPLDGVHMSQRLKHVIEAERLVVSDCGLAALVRLSNGDMRKALNILQSTHMASKEITEEESKQITEEDVYLCTGNPLPKDI--EQISHWLLNKPFDECYKDVSEIKTRKGLAIVDIVKEITLFIFKIKMPSAVR-------VQLINDLADIEYRLSFGCNDKLQLGAIISTFTHA 360
5 -13.100[L] KOG2028 ATPase related to the helicase subunit of the Holliday junction resolvase  ali follow..  14  71...............................................................................KRPNPKTQIHVAADDSNKRHKLSSSSHRQHQPLSERMRPR-TLDDVV-GQDHLLSPSSLLRSAVESNRLPS-IVFWGPPGTGKTSIAKSLINSSKDPSLYRFVSLSAVTSGVKDVRDAVESAKRLNLEGRKRT--VLFMDEVHRF---NKSQQDTF--LPVIEDGSILFIGATTENPS---HLITPLLSRCRVLTLNPLKPNHVETRAVDDSERGLPNSVEVDDSVIEFLANNCDGDARVALNALEISATMAT-TDAVVSIDDAKEALQ-------CKHLAYDKAGEQHYNLISALHKSMRGGDANAAIYWLARMPLYIARRLIRFASEDIG.......................................... 395
6 -12.900[R] COG2607 Predicted ATPase (AAA+ superfamily)  ali follow..  15  60.............................................................................................................................LAGVGRQTELLVRNTEQFIVGRPANNVLMSGARGTGKSSLVKALLHEY--ADKGLRLIEVDKSDLIGYLLTLLKECPEK----------IVFCDDLSFESGDETYKALVYATSNRRHENAGTTGMRGEIHQKEAVEEKISLSDRF--GLWLSFYPFDQNDYLAAVQNWLEDFGVPYDETALQWAQTRGSRSGRSAWQFACDWAGRLPKQRA..................................................................................................................... 286
7 -12.600[O] COG1222 ATP-dependent 26S proteasome regulatory subunit  ali follow..  14  185.......................................................................................................................................................VLMYGPPGTGKTLMARACASKT-----NATFLKLAGPQLVQMYIGDGARLVRDAFALAKERKPIIFIDEIDAIGAKQRTMLELLNQLDGFSSSEEVKIIAATNRVDILDPALLR--GRLD----IEFPLPNTLGRKRILQIHARKMSVRDDVNFDELARSTEGFNGAQCKAVCVEAGMAARKEKTEISQNDFMDGIQEVLSRKKSKLL.............................................................................................. 398
8 -12.400[R] COG1223 Predicted ATPase (AAA+ superfamily)  ali follow..  17  88.........................................................................................................ESDPRVIETEIVRDITLDDVVGQEEAKRKAKVILEYLRNPKWAPKNVLFYGPPGTGKTMMAKALSNEA-----KTPFLSVKSTKLIGEHVGDGARRVHELYERARQLAPIVFLDEFDAIALDSEIVNALLTELDGTNSNEGICTIAATNRV---ELLDASIRSRFEEEIEFRL--PSYEERLEILRRNLEEFPVPVKARLELVAAASEGFSGRDLVEKVIKLHKAIAEGKDKIETEDLLTAAEKVKMPSRQPPKQMF........................................................................................... 351
9 -12.400[O] KOG0728 26S proteasome regulatory complex, ATPase RPT6  ali follow..  19  185.......................................................................................................................................................VLLYGPPGTGKTLLARAVAHHT-----ECTFIRVSGSELVQKFIGEGSRMVRELFVMAREHAPIIFMDEIDSIGSSQRTMLELLNQLDGFEATKNIKVIMATNRIDILDPALLR--GRID----IEFPPPNEEARLDILKIHSRKMNLTRGINLRKIAELMPGASGAEVKGVCTEAGMYARERRVHVTQEDFEMAVAKVMQKDSEKNM.............................................................................................. 398
10 -12.200[O] KOG0739 AAA+-type ATPase  ali follow..  18  163.......................................................................................................................................................ILLFGPPGTGKSYLAKAVATEA----NNSTFFSVSSSDLMSKWLGESEKLVKNLFEARQHKPSIIFIDEVDSLCGSRNENEEFLVQMQGVGNNNDGTVLGATNIPWV---LDSAIRRRFEKRIYIPL--PEEAARAQMFRLHLGSTPHNLTDANIHELA-------RKTEG-------YSGADISIIVRDSLMQPVRKVQSATHFKKVC............................................................................................. 359
11 -11.800[DL] KOG2035 Replication factor C, subunit RFC3  ali follow..  13  7......................................................................................................................KYRPKDLLGKDGVDYHIEQANHLKFLSADCMPHLLFCGPSGAGKKTRIKCLLRELSPSNKKLEIQTVSSNYHIEMTPSDVGIYDRVVVQDLVKEMKVVVLCEADSLT--RDAQHGLRRTMEK-YANNCKIVLSCESLSRIIEPLQSRC-------IIINVPAPTDEDVTKVLRKVIERESFLLPENVLQKIVEKSEGNLRR---AILMTEALRMENESGVAESVVIPVPEWEIYIQETARLILQKQSSDMLLKVRERLYELLSRCIPPTVIF-KKLLEHLLPKCPPQIAREVVSEAAKFEH--------RLVLGQKAIFHLEGFVAAFMDIYLT. 348
12 -11.700[O] KOG0741 AAA+-type ATPase  ali follow..  16  256.......................................................................................................................................................ILLYGPPGCGKTLLARQIGKMLNARE----PKVVNGPEILNKYVGESEANIRKLFADAEEGLHIIIFDEIDAICKQDTVVNQLLSKIDGVEQLNNILVIGMTNRPDLIDEALLR--GRLE--VKMEIGLPDEKGRLQILHARMRGHQLLSADVDIKELAVETKNFSAELEGLVRAAQSTAKAESLQVTRGDFLASLENDIKPAFGTNQEWGDPVTRVLDDGELLVQQLEGPPHSGKTALAAKIAEESNFPFIKICSPDKMIGFSETAKCQAMKKIFDDAYKSQLSCVVVDDIERLLDY.... 611
13 -11.700[O] KOG0733 Nuclear AAA ATPase (VCP subfamily)  ali follow..  17  529.......................................................................................................................................................VLLWGPPGCGKTLLAKAVANES-----KANFISIRGPELLNKYVGESERAVRQVFLRARASSPVIFFDELDAMVPRRDDSLTLLTELDGLSDRSGVYVIAATNRPDIIDPAMLR--GRLD----LLVDLPDAHERVEILKTLTKQTPLHEEVNLDVLGRDERCSNFADLA-ALVREAAVTALRSAVFADIASNEPEITQHSALEPIRVTNADFELAFKNI-SVSDRDRQKYQRLAK.................................................................. 768
14 -11.600[L] KOG0991 Replication factor C, subunit RFC2  ali follow..  11  1..............................................................................MEVEAVCGGAGEVEAQDSDPAPAFSKAPGSAGHYELPWVEKYRPVKLIVGN-EDTVSRLEVFAREG---NVPNIIIAGPPGTGKTTSILCLARALLGPALKDAMLELNASN-VRNKIKMFAQQKVTLPKGRHK---IIILDEADSMT--DGAQQALRRTMEI-YSKTTRFALACNASDKIIEPIQSRCAV-------LRYTKLTDAQILTRLMNVIEKERVPYTDDGLEAIIFTAQGDMRQALNNLQSTFSGFGFINSENVFKVCDEPHPLLVKE-------IQHCVNANIDEAYKILAHLWHLGYS-----PEDIIGNIFRVCKTFQMAEYLK-------LEFIKEIGYTHMKIAEGVNSLLQMAGLLARLCQK 347
15 -11.600[LO] COG1474 Cdc6-related protein, AAA superfamily ATPase  ali follow..  12  33...................................................................................................................LRPSYTPDL-LLHRNEQINSLATILVSALRGETPSNVLIYGKTGTGKTYVGKELERVSEDKSLFCSVVYINCEVIDTNLARHFEEMKFKEAIDARDQVIIIILDEIDKLIKKGDDVLYNLSRINTDLRKAKVSMIGVSNDLKFTEFLDPRVKSSLGEEELI-FPPYDAEQISDILKQRAKMA--VLGEMVIPLCAAFAAQEHGDARRAL----------------DLLRVS-GEIAERENQPQVLEEHVRRAQEKIEIDRVVEVV-----RTLPTQSKLVLYSIILLRSRGREGKNVTTG-----EMYNVYRQLCHHIDVDILTQRRVTDLMSELDML 366
16 -11.600[O] KOG0727 26S proteasome regulatory complex, ATPase RPT3  ali follow..  15  192.......................................................................................................................................................VLLYGPPGTGKTMLAKAVANHT-----TAAFIRVVGSEFVQKYLGEGPRMVRDVFRLAKENAPIIFIDEVDAIATAQRILMELLNQMDGFDQTVNVKVIMATNRADTLDPALLR--GRLD----IEFPLPDRRQKRLVFQVCTSKMNLSDEVDLEDYVSRPDKISAAEIAAICQEAGMHARKNRYVILPKDFEKGYRANVKKPDTD................................................................................................ 403
17 -11.600[O] KOG0651 26S proteasome regulatory complex, ATPase RPT4  ali follow..  16  187.......................................................................................................................................................CLLFGPPGTGKTLLARAVASQL-----DCNFLKVVSSAIVDKYIGESARMIREMFNYARDHQPIVFMDEIDAIGGRQRTLMELLNQLDGFDSLGKVKVIMATNRPDTLDPALLR--GRLD----IEIGLPNEQSRLEILKIHSNKITKHGEIDFEAVVKLSDGFSAADLRNVCTEAGMFARAEREFVIDEDFMKAVRKVGDAKRLE................................................................................................ 398
18 -11.500[LD] KOG2227 Pre-initiation complex, subunit CDC6, AAA+ superfamily ATPase  ali follow..  11  126.............................................................................................................................ILCREDEQIRIFEFVKGCIDQQKAGSLYICGCPGTGKSLSMEKVVQQVGDWSPPVDTLSVNCTSLSKKILGEIKPGKSQKQESSSSRMMLIIADEMDYLITKD--RGVLYDLFMLTTLPFSRCILIGVANAIDLADFLPKLKSLNCKPMVITFRAYSKDQILRILQERLRVLSYVFQPKALELCARKVAAASGDMRKALCVCRSALEILEIETRGSTGPE---SQGPTPDDSVVRMDHMAAALSKTFKSPVVETI-----QSLPQHQQIIICAAAKAFRGSKKDA---------GELNKLYLEICKSWMISPAGITEFTNMCTVLNDQ 465
19 -11.500[O] KOG0652 26S proteasome regulatory complex, ATPase RPT5  ali follow..  16  208.......................................................................................................................................................VLLYGPPGTGKTLMARACAAQT-----NATFLKLAGPQLVQMFIGDGAKLVRDAFQLAKEKAPIIFIDEIDAIGTKQRTMLELLNQLDGFSSDERIKVIAATNRADILDPALMR--GRLD----IEFPHPTEEARARILQIHSRKMNVHPDVNFEELARSTDDFNGAQLKAVCVEAGMLARRDATEVNHEDFNEGIIQVQAKKKAS................................................................................................ 419
20 -11.400[O] KOG0737 AAA+-type ATPase  ali follow..  16  408....................................................................................................................EIGVTFAD--IGSLDETKESLQELVMRRPGGLLKPILLFGPPGTGKTMMAKAIANEA-----GASFINVSMSTITSKWFGEDEKNVRALFTLAAKVSPIIFVDEVDSMLGQRKIKNEFMTHWDGLMSNAGDLVLAATNRPFD---LDEAIIRRFERRIMVGL--PSVESREKILRTLLSKEKTE--QELAQMTDGYSGSDLKNFTAAYRPVRELIKQECLKDQERRKREEAEK--NSEEGSEAKEEVSEERGITLRPLSMEDMKVAKSQVAASFAAEGA.......................................................... 699
21 -11.300[L] COG0470 ATPase involved in DNA replication  ali follow..  14  2......................................................................................................STSTEKRSKENLPWVEKYRPETLVYGQ-NEVITTVRKFVDEG---KLPHLLFYGPPGTGKTSTIVALAREIYGKNYSNMVLELNASD---DVVRNQIKDFASTRQIFSKGFKLIILDEADAMT--NAAQNALRRVIER-YTKNTRFCVLANYAHKLTPALLSRC-TRF------RFQPLPQEAIERRIANVLVHEKLKLSPNAEKALIELSNGDMRR---VLNVLQSCKATLDNPDEDEISDDVIYECCGAPRPSDL--KAVLKSILEDDWGTAHYTLNKVRSAKGLALIDLIEGIVKILEDYELQNEETR------VHLLTKLADIEYSISKGGNDQIQGSAVIGAIKAS 330
22 -11.300[O] KOG0726 26S proteasome regulatory complex, ATPase RPT2  ali follow..  15  221.......................................................................................................................................................VILYGPPGTGKTLLAKAVANQT-----SATFLRVVGSELIQKYLGDGPKLVRELFRVAEEHAPIVFIDEIDAVGTKQRTMLELLNQLDGFDSRGDVKVIMATNRIETLDPALIR--GRID----IEFPLPDEKTKRRIFTIHTSRMTLAEDVNLSELIMAKDDLSGADIKAICTEAGLMARERRMKVTNEDFKKSKESVLYRKKEGTPE............................................................................................. 435
23 -11.300[H] COG1239 Mg-chelatase subunit ChlI  ali follow..  10  58.............................................................................................................................VVGYDDTVIPQLVNALLARQN-----FILLGLRGQAKSRILRAITELLLPRADRYVEKLATPDVTVADLIGDVDPIKAARLGTSLGD-GIFAVNELADLSPKNILQEGDVQIKGYPIRLELDVMLVFSANPEDYTAIVTPLKDRI--GSEIRTHYPDVQLGMDITAQEAVEEGVVVPPFIAELIED-IAFQAREDGRIDKLSGVSQRLPISLMELACANAERRSLVSGDAPVVRVTDVYAGLPA---------ITGKMELEYEGELKGADNVAKDLIRKAAGAAYARSYGSADTRELEKWFDQGNVFRFPQGGDASAALKATGEVPGL 431
24 -11.100[O] KOG0730 AAA+-type ATPase  ali follow..  12  550.......................................................................................................................................................VLFYGPPGCGKTLLAKAIANEC-----QANFISVKGPELLTMWFGESEANVREIFDKARQSAPVLFFDELDSIATQRGNSAQLLTEMDGMNAKKTVFIIGATNRPDII---DSALLRPGRLDQLIYIPLPDEDSRLNIFKACLRKSPVALAKYTQGFSGADITEICQRAC-AIRENIEKDIENERRRSQNPEAMEEDM--VDDEVSEIRAAHFEESMKYA-SVSDADIRKYQAFAQRGFGSEFRFDVGRTTGVAAADPFATSA....................................... 833
25 -11.100[L] COG2256 ATPase related to the helicase subunit of the Holliday junction resolvase  ali follow..  15  25........................................................................................................................TVEQYI-GQQHILGPGKPLRRALEAGHIHS-MILWGPPGTGKTTLAEVAANYA-----NAEVERVSA---VTSGVKEIRA-EKARENKLSGRRTILFVDEVHRF---NKSQQDAF--LPHIEDGTVTFIGATTENPS---ELNNALLSRARVYKLTSLNQQEILQALHQAIADTEKVAAVFADNVLDRLAELVNGDARMSLNYLELLYDMAR-GRKQIDLPLLAEVAG-------EKVSRFDNKGDIWYDLISAVHKSIRGSDPDAALYWAARMPLYIARRLLAIASEDVG.......................................... 305
26 -11.000[S] COG4916 Uncharacterized protein containing a TIR (Toll-Interleukin 1-resistance) domain  ali follow..  14  9..........................................................................................................................DVFKTVGLPPYTYVKPKHFGEVRADISQVLLIEGPSGIGKTCVVFKVFEELQWSQGRDFTYVGCRDQNAEQIIDDFLKNAAAGNALS-----VLVIDDFHLL--SQAKRMEIGSTLKRLSDRAKVILIGIPTAGVSLLSDAYDLGPRLG---SYALTRASDVEIDKLISEGEQALAVLF--EDRDVLLAESAGNFWLAQYVCNKVCAIEEVYETQDDAKILTFDILGIR----------GRLMAELTQRYLPIARTFAKGKRWRP.................................................................. 263
27 -10.500[O] COG0465 ATP-dependent Zn proteases  ali follow..  18  146....................................................................................................................QIKTSFAD-VAG-----CDEAKEEVSELVDYLREPVLMVGPPGTGKTLLAKAIAGEA-----KVPFFTISGSDFVEMFVGVGASRVRDMFEQAKKAAPIIFIDEIDAVGRQEQTLNQMLVEMDGFEGNEGIIVIAATNRPDVLDPALLR--GRFDRQVVVGL--PDVRGREQILKVHMRRVPLDTDIDASVIARGTPGFSGADLANLVNEAALFAARGNKRVSMVEFEKAKDKIMMGAERRSMVMTEAQKESTAYHEAGHAII-HDPVHKVTIIPRGRALGVTFFLPEGDESQISTLYGGRLAEEIIYGPEKVSTGASNDIKVATSI.......... 499
28 -10.400[O] KOG0729 26S proteasome regulatory complex, ATPase RPT1  ali follow..  16  212.......................................................................................................................................................VLLFGPPGTGKTLCARAVANRT-----DACFIRVIGSELVQKYVGEGARMVRELFEMRTKKACLIFFDEIDAIGGAQRTMLELINQLDGFDPRGNIKVLMATNRP---DTLDPALMRPGRLDRKIEFSLPDLEGRTHIFKIHARSMSVERDIRFELLARLCPNSTGAEIRSVCTEAGMFARARRKIATEKDFLEAVNKVIKSYAKFSATPRYM......................................................................................... 430
29 -10.400[L] COG2812 DNA polymerase III, gamma/tau subunits  ali follow..  14  6...................................................................................................................LYRVWRPQKLVVGQEH----TKTLQNALVQEKFSHAYLFSGPRGTGKTSAAKIIAKAIKGITSGSIVDVMEIDAASNNGVDEIRDRDHVKFAPSEVRYKVYIIDEVHMLTTG---------AFNAL-------LKTLEEPPSHAHKIPLTIISRCQ-----DFKRISNDALVGRMKEILTHEGIEAEDEALVLVARAAEGGMRDSLSLLDQAISFA---DERVTVEDVLAITESAQKGETAEALQLVNQLLANGKDPLRFVEDLIYYYRDLMLFAAPEASQLLERAQINDSFKTLAGEINDASLFAAIEILNDCQQRMRWSSHPRVALELGVVTL... 357
30 -10.400[O] COG0464 ATPases of the AAA+ class  ali follow..  15  253.......................................................................................................................................................VLLQGPPGTGKTMLAKAVANES-----DAYFISINGPEIMSKYYGESERAIREIFEDAEKNAPIIFLDEIDSIAPKRRVVAQLLSLMDGLKARKNVIVIGATNRPEAL---DIALRRPGRFDREIELRVPDTEGRLEIFQIHTRGMPLADNVNLMDFAQITYGFVGADIAALCREAAMSAILDALQVTREDFENALKDVQPSAIREILILERVKELLKEVVEWPLKNLYGPPGTGKTLLAKAIAHESDANFITAKGSDLLSKWYGESEKRIAEVFTRARQVAPS---FLDELDSLAPI.... 597
31 -10.100[O] KOG0740 AAA+-type ATPase  ali follow..  15  395....................................................................................................................GPPVNWED-IAG---EFAKATIKEIVVWP--MLRPILLFGPPGTGKTLIGKCIASQS-----GATFFSISASSLTSKWVGEGEKMVRALFAARCQQPAVIFIDEIDSLLSQRGDGEEFLVQLDGATTSSEDLVVGATNRPQEI---DEAARRRLVKRLYIPL--PEASARKQIVINLMSKEQCCLSEEEIEQIVQQS-------DA-------FSGADMTQLCRGASLGPIRSLQ-TADIATITPDQVRPIAYIDFENAFRTVRPSVSPKDL----------------ELYENWNKTFGC..................................... 672
32 -10.100[R] COG1485 Predicted ATPase  ali follow..  14  75.......................................................................................................................................................LYFYGGVGRGKSFLMDAFFGCL----PYRRKRRVHFHAFMAEIHQRLKTLKSES-AEIAKETRVLCFDEFHVSDIADAM---LGRLLENLLNEGVVLVATSNYAPSEL----------YPQGQNRSSFLP-----IALIESSLTVLNVDGGEDY-IFFTPANEENEAKLAKLFKEMTGITDLNPGISTIAESGRAIWFDFRALCFGPRSQSDYLYLAEHYEMVFISGLEQLSPQEKAEARRLTWL-------------IDVLYDFR--VKLCATGAVDVNHIYTEGDFAEEFTRTASRMVEM 363
33 -9.910[L] KOG1514 Origin recognition complex, subunit 1, and related proteins  ali follow..  11  396.............................................................................................................................LPCRSKEMEEITAKGSISDDQCLGRCMYIHGVPGTGKTISVLSVMKNLKAE-SPYCFVEINGLKLASVIYEGLSGHRVERFAEGKKIGKILLIDELDVLVTRN--QSVLYNILDWPTKPNSKLVVLG----ANTMDLPEKLLPRISSRMRLCFGPYNHRQLQEIISTRLEGINA-FEKTAIEFASRKVAAISGDARRALEIC-----------AAEVADYRLKKSNISAKSQLVIMADVEVAIQEMFQAPHIQMKSVSKLSRIFLTAMVHELYKTGMAETSFDRVATTVHRLQKLQLNFPSDDVAFALKDNKDLPWLANYL....... 771
34 -9.870[R] KOG2383 Predicted ATPase  ali follow..  16  132.......................................................................................................................................................LYVYGDVGTGKTMVMDMFYAYV-EMKRKKRVHF---HGFMLDVHKRIHRLKQSLPKRK-EEACLLCFDEFQVTDIADAM---LKQLFENLFKNGVVVVATSNRPPEDL----------YKNGLQRANFVP-----IAVLKEYCNTVQLDSGID-KLYYLTSEADVEAVMDKLFDELAQKQNDLTRPRILKVQGRELRLNKACGTVADCTFEELLELSKNFDTIFLRNIPQFTLANRTQGRRFITL......................................................... 393
35 -9.390[R] KOG2170 ATPase of the AAA+ superfamily  ali follow..  8  70......................................................................................................................DADIANLLFGQHDVVVNSIKSHWYNENPRKPLVLSFHGYTGSGKNYVAEIIANNTFRLGLRSTFVIVATNDFPDNKLEEYQVELRNRILTTVQKCSIFIFDEA------DKLPEQLLGAIKPFLDYYSTFILLSNKGGGEIARITKEQYESGYPREQLRLEAFERELMNFSYNEKGGLQMSEL-NHLIDHFVPFLPLQREHVRSCVGAYLRKRGRGDLVSNVDFVERVLNSLQYFPESSKAFSSSGCKRVDAKTDLEMAKIRPLLSSVH.................................................................. 351
36 -9.380[L] KOG2228 Origin recognition complex, subunit 4  ali follow..  11  560..................................................................................................................................TKLYQWVRQTIVLGEG---NSVIIVGPRGSGKSVLVDILSRAAQEINEKSYVVRLNGTYQTDDTLSHPVDLGIAEDVMTTSAAVIFVLEEFDLFVQHSR-QMLLYNLFDIAQSRKAPILIIGLTTRYDCSELEKRVKSRFSHMVIPMRPPSSLSEFEQILKSVLYVSDEGGKDQIITCWNQRVDELLSDTRSHLHKLVQHHYFASRNLK-LLYVDLLFPILSMAPDRPLLADEDFANISLKVSDHKVELVKNLSLLELALLICAVRFEARDIPACNFNSAYQEY....................................... 879
37 -9.370[O] KOG0734 AAA+-type ATPase containing the peptidase M41 domain  ali follow..  20  276....................................................................................................................MKNVTFEH-VKG-----VEEAKQELQEVVEFLKNPILLVGPPGTGKTLLARAVAGEA-----DVPFYYASGSEFDEMFVGVGASRIRNLFREAKANAPVIFIDELDSVGGKRQTINQLLAEMDGFKPNEGVIIIGATNFPEALDNALIR--GRFDMQVTVPR--PDVKGRTEILKWYLNKIKFDQSVDPEIIARGTVGFSGAELENLVNQAALKAAVDGKEVTMKELEFSKDKILMGPERRSVEIDNKNKTITAYHESGHAII-AMPINKATIMPRGPTLGHVSLLPENDLAQMDVSMGGRVAEELIFGTDHITTGASSDFDNATKI.......... 627
38 -9.340[QK] COG3284 Transcriptional activator of acetoin/glycerol metabolism  ali follow..  18  324....................................................................................................................QIPPALRR-LGGDAPVI--AALQAKAAKLARTRLPILIQGETGTGKEHLARAIHEGSGLEGPFVAI-LIESELFPGAFTGASAKGRKGLIEQA--DGGTLFLDEIGDMP---ALQSRLLRVLAE-RKVRIRIVSASHRPLQTLGAFREDLYYRLN---AATLTLPALRDRPDFLLKRHGDGELILSPAALSALKAH-PGNIRELDNVIGVAAALAEVELGDLPDQLLANADTVGGNEASATLSLT---ISEAARRLGLDRSTVHRQIKRYRLKPHRH............................................................ 627
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Pawlowski K, Pio F, Chu Z, Reed JC, Godzik A. PAAD - a new protein domain associated with apoptosis, cancer and autoimmune diseases. Trends Biochem Sci. 2001 Feb;26(2):85-7.