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Query: gi|15923009|ref|NP_370543.1| two-component sensor histidine kinase (SAV0019) [Staphylococcus aureus subsp. aureus Mu50], from S.aureus

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MKWLKQLQSLHTKLVIVYVLLIIIGMQIIGLYFTNNLEKELLDNFKKNITQYAKQLEISIEKVYDEKGSVNAQKDIQNLLSEYANRQEIGEIRFIDKDQIIIATTKQSNRSLINQKANDSSVQKALSLGQSNDHLILKDYGGGKDRVWVYNIPVKVDKKVIGNIYIESKINDVYNQLNNINQIFIVGTAISLLITVILGFFIARTITKPITDMRNQTVEMSRGNYTQRVKIYGNDEIGELALAFNNLSKRVQEAQANTESEKRRLDSVITHMSDGIIATDRRGRIRIVNDMALKMLGMAKEDIIGYYMLSVLSLEDEFKLEEIQENNDSFLLDLNEEEGLIARVNFSTIVQETGFVTGYIAVLHDVTEQQQVERERREFVANVSHELRTPLTSMNSYIEALEEGAWKDEELAPQFLSVTREETERMIRLVNDLLQLSKMDNESDQINKEIIDFNMFINKIINRHEMSAKDTTFIRDIPKKTIFTEFDPDKMTQVFDNVITNAMKYSRGDKRVEFHVKQNPLYNRMTIRIKDNGIGIPINKVDKIFDRFYRVDKARTRKMGGTGLGLAISKEIVEAHNGRIWANSVEGQGTSIFITLPCEVIEDGDWDELast
1 -140.000[T] COG5002 Signal transduction histidine kinase  ali follow..  45  1MNKVGFFRSIQFKITLIYVLLIIIAMQIIGVYFVNQVEKSLISSYEQSLNQRIDNLSYYIEQEYKSDNDSTIKDDVSRILNDFTKSDEVREISFVDKSYEVVGSSKPYGEEVAGK-QTTDLIFKRIFSTKQSYLRK-YYDPKSKIRVLISAKPVMTNQEVVGAIYVVASMEDVFNQMKTINTILASGTGLALVLTALLGIFLARTITHPLSDMRKQAMELAKGNFSRKVKKYGHDEIGQLATTFNHLTRELEDAQAMTEGERRKLASVIAYMTDGVIATNRNGAIILLNSPALELLNVSRETALEMPITSLLGLQENYTFEDLVEQQDSMLLEIRDDELTVLRVNFSVIQREHGKIDGLIAVIYDVTEQEKMDQERREFVANVSHELRTPLTTMRSYLEALAEGAWENKDIAPRFLMVTQNETERMIRLVNDLLQLSKFDSKDYQFNREWIQIVRFMSLIIDRFEMTKEQHEFIRNLPDRDLYVEIDQDKITQVLDNIISNALKYSPEGGHVTFSIDVNEEEELLYISVKDEGIGIPKKDVEKVFDRFYRVDKARTRKLGGTGLGLAIAKEMVQAHGGDIWADSIEGKGTTITFTLPYKEEQEDDWDE 610
2 -74.900[T] COG5000 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation  ali follow..  18  67.RHGKAASRLHVRIVAMFALVAAIPAIMVAIIASITLDDAYVQENARNLQGTTLSMAYDLDA--SRSLYGLDRTGFLDLLNKEAVGRSLAHAALIKPDGSFVMSAQTDADFAMPE-PPEGSVSSATDGK-------PVLIEPRTRNIMGAIVKLREIEGLYLYTIRLVDRQIVRSNTDEYRNPYLSLTLIIILSAIWTGIAVADRLVRPIRQLIGAADEVATGNLDVAVPVRSSDDVASLGDTFNKMLLELKSQRNEILSAKDLIEAVLAGVTAGVIGVDPYGIVTIVNRSAESMLAISASAALGQNLSAIL--PHVGRVFEIGRQSGKPVYREQAGTERTFNVQITIEADDGSEEKSYVVTVDDITDLVQAQRSSADVARRIAHEIKNPLTPIQLSAERIKKVITEDREVFDQCTDTIIRQVEDIGRMVDEFSAFARMPK----PEMKAIDLRESLREASFLVEVSRADITFERIFGNEPLKGTFDSRLLAQAFGNVIKNAAEAIDGLEQKDIRIQAGRQNGAIRIDVIDNGKGLPRENRQRLLEPYM------TTREKGTGLGLAIVKKIVEDHGGRLELHDAPGRGAMISIILPLAAVTPLRGEG 723
3 -65.800[T] COG0642 Signal transduction histidine kinase  ali follow..  18  2........KLFQRIFATFCAVIVCAIFVAS-FSFWLVQNTLAENQFNQRRTIETTLMGSIISAFRARGDAGAREILTEWKDS---PVSSGVYVIQGDEKKDILHRYIDSYTI--------ERARLFAAGHPHSNLVHIEYDRFGEEYLFFTKD-----WDKLQARRLPSPLLIPGLPLAPIWHELIILSFIIIVGLLMAYILAGNIAKPIRILGNGMDRVANGELETRISQQRDDELSHLAIQFDKMVEKLE----------------------------------------------------------------------------------------------------------------------KLVAKERHLLHHVSHEMRSPLARMQAIVGLIQAQ----PQKQEQYLKRLEGELTRMDTLAGELLTLSRLETSNMALEKESLKLLPFLGNLVEDNQSIAQKNGQTVTLSPENTTILANESYLYRAFDNVIRNAVNYSPEGSTILINIGQDH--KHWIIDVTDNGPGVDEMQLPHIFTAFYRADSSANK--PGTGLGLALTQHIIEQHCGKIIAENIKPNGLRMRFILPKKKTGSKTEKS 466
4 -56.900[T] COG3290 Signal transduction histidine kinase regulating citrate/malate metabolism  ali follow..  17  16........KLSTTVILMVSAVLFSVLLVVHLIYFSQISDMTRDGLANKALAVARTLADS-PEIRQGLQKKPQESGIQAIAEAVRKRNDLLFIVVTDMQSLRYSHPEAQ---RIGQPFKGDDILKALNG----EENVAINRGFLAQALRVFTPIYDENHKQIGVVAIGLELSRVTQQINDSRWSIIWSVLFGMLVGLIGTCILVKVLKKILFGL-------------------EPYEISTLF---------------------EQRQAMLQSIKEGVVAVDDRGEVTLINDAAQELLNYRKSQDDEKLSTLSHSWSQVVDVSEVLRDGTPRRDEEITIKDRLLLINTVPVR-SNGVIIGAISTFRDKTEVRKLMQRLDDALRERSHEFMNKLHVILGLLHL---------KSYKQLEDYILKTANNYQEEIGSLLGKIK---------------SPVIAGFLISKINRATDLGHTLILNSESSGSEDQVATLITTLGNLIENALEALGPEPGGEISVTLHYRHGWLHCEVNDDGPGIAPDKIDHIFDKGV------STKGSERGVGLALVKQQVENLGGSIAVESEPGIFTQFFVQIPWDGERSNR... 543
5 -54.700[T] COG3852 Signal transduction histidine kinase, nitrogen specific  ali follow..  18  3..................................................................................................................................................................................................................................................................SGIQPDAGQILNSLINSVLVVDDALAIHYANPAAQQLLAQSSRKLFGTPLPELLSYFSNIDLMRESLAAGQGFTDNEVTLVIDSRSHILSLTAQRLPDDFILLEMAPMDNQRRLSQEQLDLVRGLAHEIKNPLGGLRGAAQLLSKAL--PDPALTEYTKVIIEQADRLRNLVDRLLGPQH------PGMHITESIHKVAERVVALVSMELPDNRLIRDYDPSLPELPHDPEQIEQVLLNIVRNALQLGPEGGEITLRTRTERYRLAARIDVEDNGPGIPPHLQDTLFYPMV------SGREGGTGLGLSIARNLIDQHAGKIEFTSWPG-HTEFSVYLPIRK........ 349
6 -50.500[T] COG4192 Signal transduction histidine kinase regulating phosphoglycerate transport system  ali follow..  16  253...........................................................................................RNVLRLEGDFQQSLRDRVVLTQKLESTSEQLQIQLDQQHTAIADLVANADA----------------------LFVQVKGQTAQLVQEGNRVLLICFGLSIGLSLLLMYFVHKRIVGRLHRLSESLDAIIHNDLSHPITVDGKDEIGALSEQLILYGKK------VEEMERTNALSLINNTQASLITCDRYGQIESANPSAMATLRLESLAQPLTLWSCFAKHVQLRLYLRRYSQGLHDITDVTDQEHANRLLEQRVKEKTQSLREKNRELQAEVEERQRAEAHLKQTMTSLAHELNQPLSAMSAYLFSARL-EEAPQAQLATSLDHIENLTERMGKIVNSLRHFAR--KNSSDESLQPVRLNSVVEQALVLVQTKAKRQQIKLINTPDDLMVMADALSLEQVLINLIVNGCDASTTFAQPWVKLALGTEQGMQRIAVIDSGQGFEHEVVDKLFTPFT------TTKEVGLGLGLSICQSLVEKMQGRIALASNLEKGAMVILELQQDEKYRT.... 787
7 -48.800[T] COG4191 Signal transduction histidine kinase regulating C4-dicarboxylate transport system  ali follow..  14  28...............LVFAAVALVLLAAGLLLARDYGRSQALAGLAGQSRIDASLKASLLRAVVELSPDRPSLDRINRKLEALATSAEAAVIYLIDRSGVAVAASNEPTSFVGNDYAFRDYFRLAVRDGMAE---HFAMGTVSNRPGLYISRRVDGPGGPLGVIVAKLEFDGVEADWQASGKPAYVTDRRGIVLITSLPSWRFMTT--------------------KPIAEDRLAPIRESLQFGDAPLLPLPFRKIEARPDGSSTLDALLPGDSTAAFLRVETMVPSTNWRLEQLSPLKAPLAAGAREAQLLTLAALVPLLALAALLLRVAMRSAEERLARNALEASVEERTRDLRMARDRLETEIADHRQTTEKLQQVAAGVAHEINQPVATIRAYADNART-HRGQTVTAAENMESIAELTERVGAITDELRRFAR----KGHFAAGPTAMKEVVEGALMLLRSRFAGRMDAIDLPPDGLQALGNRIRLEQVLINLLQNALEAIGDSEDGAIQVRCEEAAGGIALTVADNGPGIAADVREELFTPFN------TSKEDGLGLGLAISKEIVSDYGGTIEVESGPS-GTTFAVNLKKA......... 621
8 -46.400[T] COG2205 Osmosensitive K+ channel histidine kinase  ali follow..  21  479.........................................................................................................................................................................................LLTFGVMLIVGIVVGNLTAGVRYQAKIARYREQRARHLYEMSRSLSRALTPEDIAKTSRHFLSSSFQAKTSLLLPQEEGHLQPIMPDDGGILSVDDAIAHWSFNQGAPAGAGTDTLPGVPYQLLPLTAAQQTYGVLAIEPANLRQLMV--PEQQRLLQTFTSLIANALERLH-LARSAELAKLDAEREQLRNSLLAALSHDLRTPLTVLFGQAEILTLDLAAEGSRHAPQANQIRQQVLSTTRLVNNLLDMARIQSGGFNLRKEWQSLEEIIGSALYMLETTLSQHQIRVELPDEMVLINCDASLLERVFINLLENAHKYAGHAALLGIRAEVQ--GEWLNVDVWDNGPGVTIGQENLIFDKFSRGNKESAIP--GVGLGLAICRAIIDVHGGRIWVEKRQEGGASFRFVLPLEKVPEIDADN 894
9 -45.800[T] KOG0787 Dehydrogenase kinase  ali follow..  12  3........................................................................................................................................................................................................VLGKTLQEKVNLL--AQYPQTGLSLKQLVYFGKNPTPGTLFRAGLFLRDELPIRLARRIQDLQNLSPMLRSMKR----------ISSVKAAYGRSMEEIIELKGVELPKCLPKHARYHNAPKWRSSLMDSEILHNPSLANTHLDSSKGRYFETDF--SDQDNGVDCNWPESLLKFNSNFAYLLNTIRTRHDNVAVEIALDIQEKTNQIDNSIQIFLDRFYMSRIGIRMLLGQYIALVSEPPRENYVGVTRANIYQIIEGAAENAKYICRLAYGLFEAPDPSLEMMYVESHLNHAVFEILKNSLRATVEFHGVDIKVIVAKGQEDITIKISDEGGGISRRNIPLVWSYMFTVSANSTTPMAGFGFGLPLARLYTRYFGGDLELISMEGYGTDVYIHLNRLCESAEPLQ. 425
10 -30.400[T] COG3850 Signal transduction histidine kinase, nitrate/nitrite-specific  ali follow..  11  1...MTVKRPVSASLAKAFFYIVLLSILSTGSALL----------TLTSSLRDAEAI----------------------------NIAGSLRMQSYRLGYDLQSRSPQINAHRQLFQHALNSPVLQNLNAWYVPQAVKTRYERLHANWLEMNSRLQDGDIAWYQTNINNYVNQIDLFVLALQHYALAGGIGIFTLVFFTLRRIRQQVVRPLNQLVTASQRIEHGQFAPLLDTSLPNELGLLAKTFSQMSSELHKLYRSLEASVEEKTHDLHEAHRRLEVLYQCSQALNTSQIDVHCFRHILQIVREHDAAWYLEQSPDLPMQMLPVTMQDTVYGELHWQSPNVNASTPLLNSVSTMLGRGLYFNQAQKHFQQLLLMERATIARELHDLAQVLSYLRIQLTLLKRAIPEDNAGAQSIMADFSRALNDAYRQLRELLT-------TFRLTLQQADLPSALHEMLEDLQSQTP--KLTLDCRLPTLALDAQMQHLLQIVREAVLNAIKHA-NASEIAVSCVTAP-DGDHTVYIRDNGIGIGEPHEP------------------AGHYGLNIMRERAERLGGTLNFSQPSGGGTLVSISFRSSNKEESQ... 564
11 -27.300[T] COG4251 Bacteriophytochrome (light-regulated signal transduction histidine kinase)  ali follow..  10  127.....................................................GTARKMVDRIREADSVESLISRTTRLVKATLGYD---RVMIYDGAGKVVSEAKQPEESFLGQYFPASDIPQQARA-LDLSYAHLRSVSPIHCEYL-MSISVIVDGALWGLIAFSMHLQVLKQKRRLDTINHAHAALDRFLRLAAHHANIEELLVDSFQDFADLMPCWVGNNWHGHGATPPHDAIPRLARFVASASEGRVWATHALSQAIPEAEI-YAGTAAGMLAIVKSDYLLFFRKEIVQNLGNPEKSYETGPMGDRLTPRKSFAIWKETVRLQAQP--------SEADREIAEAARIALVEVAFHHSELMAGERERAEVRQRMLNEELNHRVKNVLAIIKSLVGNPS----QEGKTLQEYVTALKGRIQALSFAHDQIIRGEGGGA-----------LRDLLEAELSPHRSPETTVKLE----PQITLDSRAFSVMALVLHELATNAAKYGQNGGQLHVRWDVNE-NRDCEISWRETLLTTLPAPSRA-----------------GFGTAL-ISRSIPYDLGGRSTIRYLPN-GLEAEILLPFRHVSSVS... 708
12 -27.200[S] COG5385 Uncharacterized protein conserved in bacteria  ali follow..  1.............................................................................................................................................................................................................................................................................................................................................................................MPVTLSALDLGALLCSRICHDIISPVGAINNGLELLEEGSADEDA-----MALIKSSARNASAR----LQFARIAFGAA----GSAGVQIDTGDAQNVATEYFRNEKPEFTWEGARVLL---PKNKVKLLLNMLLIGNGAIPRGGSLAVRLEGGDTDPRFVITVKGRMLRVPPKFLELHSGAAP------EEPIDAHSVQPYYTLLLAEEAGMKISIHATAEDIV.................. 203
13 -25.200[T] COG4564 Signal transduction histidine kinase  ali follow..  12  1............................................................................................................................................................................................MAILTITAFITWQSANLVQSSIATFEKNMLKAKETELLNLTDEDAMEKVRAILTSLDYGRDGYFFVYDYNGNNVVHPRQLFRPGHNWLNLTDPDGDRVIANLIAKAKEGGGLHRYKWEKPSSHEMADKLSFYLDDVYAQTAAANADFRANIRTTFLIVSLIAVPAVMLVFATCMLLNLRERRMADTKLKELLARELHDISQNLVGVRYAIDLASRQVRTGSGGAPQAIEKA---SDALNGAIKEVRRLSH--------DLRPRILDDL--GLTVALKALCERTGIETRFKADSLQETIKPEPLYRVVQEALTNVERHSGAT---RVDIRLKGAHGKVTMTIADNGNGFAVRGL----------------KDPLSGLGLRNMQERMAHFGGVLLVETS-ADGTQLTARLPKSATERRLEPE 437
14 -24.900[T] COG2972 Predicted signal transduction protein with a C-terminal ATPase domain  ali follow..  17  213........................................................................................VGDIMIADQGGNLVYTAHASAHVPEAAKETLKHPGYDLIKKNGKRYFISYLQSSYQNWSYYNVIPF----------------DQMFAKISFMKTVIGTCFLLFFCVVLLFGRKIANSITEPIEQLVTAMKSVQHSGIEAGVSLSTQDEAGMLNRHFTVMMKRINELMEENVEKQLIIKE---------------------------------------------------------------------------------------------------TELKALQQINPHFLYNT-------LESINWLAKA--------------------NQQKQISKMVESLGFLLRNSIHMKKDIVTIQEEADIVRHYMTIQRFRFEERKFTLDIDDEVKHCLIPKLTLQPLAENAIQYALEPFTRPCAIRIQAKKAK--GCVCITVEDNGPGMDGRILEST---------------GGRGIGLWNIRERISLTFGELRIHSEHEKGTRIVITIPCRNEV...... 576
15 -23.200[L] COG1389 DNA topoisomerase VI, subunit B  ali follow..  15  2..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................SGKHREISVAENKHILGYSNPAKAIITVVKEAVDNALDACEEAGILDIFVRISKVDDHFKIVVEDNGPGIPREQIPKVFGKLLYGSRFHEIRQGQQGIGISAAVLYAQLTTGKTVISKTPDEDRAKKVVLYINTKKNE.... 148
16 -23.200[R] COG3726 Uncharacterized membrane protein affecting hemolysin expression  ali follow..  12  1MARAKLKFRLHRTAIVLICLALLVLLMQGASYFSLSHQLARSEQVEELAQTLAKQVAFSLSPIMDSGDDNIDSQKVDAILQQLTQSSRILDASVYQIDGTLVASAGENVKV--------------------RDRLALDGKRPGSYFNHQIVEMIAGNSGPSGFLRMTLDTHVLATESKQVDNTTNL-LRLMILVALAVGIILARTLLQGRRSRWQQSPYLLTANIPVKEEDESEDDTPEALVGQAETDHKPADK.................................................................................................................................................................................................................................................................................................................................................................. 233
17 -21.800[S] COG5381 Uncharacterized protein conserved in bacteria  ali follow..  1...............................................................................................................................................................................................................................................................................................................................................................................................................................MSTDQTNVRQWGEFLDPIPPSD--EFLTLNFSLDRVNRLQRWRNYGLSADFLGDYFATFFPGNDGLSQRDTIKGSVSYIANELLENAVKYSTTDHDCPITITLHLYDHKLIFETSNISPLPTTIDYENFIKVLLEADKSALEDCEASQIGLLMINDYQAQFGWRFVPVSGSEDLIKVTVMTHLG......... 196
18 -19.800[T] COG3920 Signal transduction histidine kinase  ali follow..  11  39..............LVVMATVITLPLILFVGYLMLRLEAEKRDDLQRETIEDVRVVSRNIDRRLQEIATSLNLLSQFPELENESLKREGLYALLATKDGQQRLNTRVPYGQPLGKIPAEANLAKAIESRR-ITVSDLFFGSTSKEWVFNITMPLPELGSAGDALILTQNASDLSRLIPTENLP-------------------------------------------------------------HWAVAIIDGTNRVVVSSAQDEAEVGKPFVNPAILSEMQAFSGNFFDGKGNLYAYAQLPGWQWKTVMWGPLAASQAALIDTWRQDLTHMAERIGEGEIVAPVDTKIKEANQVAIA---LSNASFDRSQSEERLQLLLHELVHRSKNILTLVQAMIRQLGRENKSIPEFQKEV-------DHRLRGLSIRALAEVQWQG---------LPIRKLIETHLDVFGTVVER----FRLEGDDFMLSPEAAQFGLVVHELTTNSIKYSVPPGKITVSWKALEKDGRQMLHLV--------------------------TETGGKGFGTTVIKRHAEGAGGNVTTEYRE-TGFEWSLEAPMRYFIPKRTEQ 577
19 -19.500[T] COG3851 Signal transduction histidine kinase, glucose-6-phosphate specific  ali follow..  164.................................................................................................................................................................................................................................................................ANNTWLPLGPSLVSQPINWRGRHLVWYLLLFVISLWLQLGLPDELSRFTPFCLALPILAWHYGWQGALIATLMNAIALIASQTWRDHPVDLLLSLLVQSLTGLLLGAGIQRLRELESVRRDVARELHDDIGQTITAIRTQAGIVQRLAADNAS--------VKQSGQLIEQLSLGVYDVRRLLGRLRPRQLDDLTLEQAIRSLMREMELEGRGIVSHLEWRIDESALSENQRTLFRVCQEGLNNIVKHADAS---AVTLQGWQQDERLMLVIEDDGSGLPPGSGQQ-------------------GFGLTGMRERVTALGGTLHISC--LHGTRVSVSLPQRY........ 500
20 -17.400[T] COG2770 FOG: HAMP domain  ali follow..  12  1.....MKLTLKSQAAIMATAISEAVVGLFGWSQREPIRREVMRQIKTQQTALVRESANNLRQRLDIYVQITSPEQEAAFNASIAPAAGLFDVFLATADGTVTAVSPYREGVIGINIADRDYFKQVMVVDQPTISAPL-RNRVGGEPVVTFAAPVHDEGRIIGLI-AVLPGEEASRQLNAMRDRFRWSLLALAALIGVSVWAAMLWLLRPLGRLHAAMTQLSATDLRGIRPPGASAEIEAVSTAFRKLMDEVVRQ.................................................................................................................................................................................................................................................................................................................................................................. 353
21 -16.500[NT] COG0643 Chemotaxis protein histidine kinase and related kinases  ali follow..  15  265..................................................................................................................................................................................................................................................................................................................................................................................RVAVEKVDQLINLVGELVITQSMLAQRSSELDPVNHGD----------LITSMGQLQRNARDL--------QESVMSIRMMPMEYVFSRYPRLVRDLAGKLGKQVELTLVGSSTELDKSLIERILTHLVRNSLDHKNSVGNLILSAEHQ--GGNICIEVTDDGAGLNRERILAIFAPGFSTAEQVT-DVSGRGVGMDVVKRNIQKMGGHVEIQSKQGTGTTIRILLPLT......... 508
22 -15.800[T] COG3275 Putative regulator of cell autolysis  ali follow..  11  143................................................................................................................................................................................VTLFAEIVQMLIILVVAKPFEQSYALVSTIAAPMIIANSVGAALFMSILLDRKTIFEEYSATFSRRALNIAERSVGILAAGFNPENANARIVYEQTNVGAVSITDREKILAFVGIGDD------HHKPNTPISSQSTLDAINRNAIIYLDGKEHPYQCSLSPTCKLGSALIIPLRAGDRVIGTIKLYEP--KRKLFSTINMSMAQGIAQLLSSQILYGEYQQKQILLSRAEQAQVNPHFLAVIRREPDKARELILHLSQFFRSNLKQNVETVTLREELAHVNAYLTIEKARFSDRDVEIAIDDALLERNVPSFTLQPLVENAIKHGTSNLLEAGKVRIYSEVVE--GGMRVVVEDNAGLYQPPSED------------------YDGLGMQIVEKRLTNKFGLLQIEVAPQEYTRMSFVIPQQGT....... 557
23 -15.800[T] COG2202 FOG: PAS/PAC domain  ali follow..  13  20..........................................GRVLTEYEALITSAPTALDAIPGAVYVCDHEGWLV-GYNAEAAELWGRQPSLSAPRERFCGSQRLFLSDGSPMDHQECPMAEAIKTGVSTRNAEVIIERPDGSRALVNIRPLRDRGVIQGAINCFQDISQQKRIEAEVNEDFFENSAIGLHIV-LLGYPADEYVGRHIAEFGDILDRLSCGEKLDRYPAREDGKFVNTRCFTTDITSL-HETENAWRETEERLAATYQAATIGIAESDADGRLLRVNDAFCTMLGRSREQLLNMTFLDYTHEDDRDEEARCYARQVSGETDTYAIRKRALDVYSSTVRDRTGRFRYGVRVLLDVTEAKRMDDRRRESEQHMRDLLEA-AVEMAGRTPQIGDKWCVTWRLYRPDGTYLPHDQCPMAVTLKEDRPVRGEQAVAERPDGTRVPFIPYPTPLHDVAGKLVGAVNMLVDISDRE-KAAEYAERLASIVRFSDDAIVSKDTQGIIQTWNKGAERLFGYSAEEVIGKPI-IPPDRQGEEPGILERI-ETVRIRKDGSLIDVSLTVSPLKDARGRV............................ 641
24 -13.000[KE] COG3283 Transcriptional regulator of aromatic amino acids metabolism  ali follow..  44..................................................................................................................................................................................................................................AELEFTDFSSLMAEIRRISGVTDVRTVPWMPSEREHLALSALLEALPEPVLSLDMKSKVEMANPASCQLFAQSQERMRHHTAAQLINGFNFQRWLDG--NPQSSHNEHVVINGQNFLMEITPVHLQNENLTGAVVMLRSTIRMGQQLQ-------NLSTQDLSAFSQIIAVSAKMKH---------------VVEQARKLAMLSAPLLITGDTGTGK-----------DLFAYACHQASPRSAKPYLALNCAS--------------IPEDAVESELFGHAPEGKK-------------FFEQANGGS------LDEIGEKLLRFLNDGTFRRVGEDHEIHVDVRVICATQKNLVELVQKGL-NVLTLNLPPLRDCPQD... 376
25 -11.600[T] COG2172 Anti-sigma regulatory factor (Ser/Thr protein kinase)  ali follow..  14  3.......................................................................................................................................................................................................................................................................................................................................................................................................................................................VHQPETIEMTVPAKSEFVGVVRLTVSGIANRLGYTYD----------DIEDIKIAVAEACTNVVDHADEGGTMGLSFHLYE--DRMEIIVTDQGQSFDMDAFRESLGPIDGSKPIQDLKEG--GLGLFLINTLMD------KVEMKEDSGVVLAMTKFLQRDEVDNRVD 152
26 -11.400[T] COG2114 Adenylate cyclase, family 3 (some proteins contain HAMP domain)  ali follow..  11  134...............................................................................................................LEAERLVRPVAASALARRFEDSTLEPPVSQRLRM-LLTLGIPV-----GILLLIWGYSQGIFGSDASGIMPAIAALAFASLVTGYLGNRLVVSSVVDPIRELQEAINRVRRGENDVQVDIYDGSEIGVLQAGFNEMMRGLR--------ERQRVRDLFGRYVGAEVAKRALEERPTLGGEDRKVAVLFVDVIGSTTFAVNHTPEEVVEALNEFFEHVVEVVHRNKQGDAALAIFGAPLPLSDATGHALAAARELRAELKDLQAAGHVVAGHIGGHARFEYTVI----DAVNQAARLTEIAKTTPGRTVTNASTLREANEAEQARWTLMKSVELRGRSQMTQIARPIRP..................................................................................................................................................... 480
27 -10.800[T] COG4585 Signal transduction histidine kinase  ali follow..  11  154......................................................................................................................................................................................................................................................................................................................................................EKKKDALLDEYRKMKRQLLTEEEQARQDERMLIGHEIHDSVGHKLTALVMQLEAFRLT-------AAEQDKETIESLKVLAER---------SLEETRRAVKSFKHKEVGGLQGVIRLIRKLEMESFNIHFSVKHGAFAAPLTGEQSFIYRAIQEALTNIMKHS-STREAQVLFESPG-GSVFRFEVLNAAPPNPFF---------------------QEGYGLKGMRERLEKVGGSLAIVQNER-QFIVTGSIRLFERRGSYDQG 381
28 -9.320[KT] COG3829 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains  ali follow..  12  18.............................................................................QRFARMLASVLQLEVEIVDENLYRVAGTGAYGKFLRQLSGNSRLLCHVLETKTEKVVTQSRFDPLCEREKAFLGTPVILQDRCVGVISLIAVTHEQQEHISDNLREF----------------------------------------------------SDYVRHISTIFVSKLLEDQGPGDNISKIFATMIDNMDQGVLVVDDESRVQFVNQTALKTLGVVQNNIIGKPIRFRPLTFESNFTHGHMQHIVSWD-------------KSELIIGQLHNIQGRQLFLMAFHQSHTS-------FSVANAPDEPHIEQLVGECRVMRQ---------------LKRLISRIAPSPSSVMVVGESGTGK-----------EVVARAIHKLSGRRNKPFIAINCAA------IPEQLLESELFGYVKGAFTGASANGKT-------------LIQAANTGTLFLDEDMPLMLQKLLRAIEAREILPIGASSPIQVDIRIISATNQNLAQFIAEGK-NVIPITLPPLRERQED... 450

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Friedberg I, Nika K, Tautz L, Saito K, Cerignoli F, Friedberg I, Godzik A, Mustelin T. Identification and characterization of DUSP27, a novel dual-specific protein phosphatase. FEBS Lett. 2007 May 29;581(13):2527-33. Epub 2007 Apr 30.