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Query: gi|6319250|ref|NP_009333.1| Putative permease, member of the allantoate transporter subfamily of the major facilitator superfamily; mutation confers resistance to ethionine sulfoxide; Seo1p (YAL067C) [Saccharomyces cerevisiae], from S.cerevisiae

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MYSIVKEIIVDPYKRLKWGFIPVKRQVEDLPDDLNSTEIVTISNSIQSHETAENFITTTSEKDQLHFETSSYSEHKDNVNVTRSYEYRDEADRPWWRFFDEQEYRINEKERSHNKWYSWFKQGTSFKEKKLLIKLDVLLAFYSCIAYWVKYLDTVNINNAYVSGMKEDLGFQGNDLVHTQVMYTVGNIIFQLPFLIYLNKLPLNYVLPSLDLCWSLLTVGAAYVNSVPHLKAIRFFIGAFEAPSYLAYQYLFGSFYKHDEMVRRSAFYYLGQYIGILSAGGIQSAVYSSLNGVNGLEGWRWNFIIDAIVSVVVGLIGFYSLPGDPYNCYSIFLTDDEIRLARKRLKENQTGKSDFETKVFDIKLWKTIFSDWKIYILTLWNIFCWNDSNVSSGAYLLWLKSLKRYSIPKLNQLSMITPGLGMVYLMLTGIIADKLHSRWFAIIFTQVFNIIGNSILAAWDVAEGAKWFAFMLQCFGWAMAPVLYSWQNDICRRDAQTRAITLVTMNIMAQSSTAWISVLVWKTEEAPRYLKGFTFTACSAFCLSIWTFVVLYFYKRDERNNAKKNGIVLYNSKHGVEKPTSKDVETLSVSDEKLast
1 -98.200[G] KOG2533 Permease of the major facilitator superfamily  ali follow..  13  2.......................................................ASEWPETSRASSVEENPKLNIPEIVESVSDSKPSLKNQFSTTVIDSSDLNVFNDGAETTVKEQEFTSSELRRLQKLRLKMDLRIIPCLWILYFLSCCLRFTVSLSFTMNTAQGHSLSAHYLALGLALFYVGYIIFEVPSNLMMAFIEPRIWVSRIQLTIGVVGACHAVLGNAQSYVALRFFLGVAESGLWPGLAYYMSRWYRGKHLGKRIGWYYTAAQIAAAAVSLVSAGFQK-MDGARGLYGYQWMFLIWGVVAIAQALSIPWWLPAVASKERIGFLTPADKSLHSRYIAEMNVG------KRWQWSDLLKSCLDLRVWPFILMY-FGIVGVGNGIFNYCTLIIEEINFSGIDISLLNAPIWLADALGIVTVMPLYDRFHKKFSFFTGSCLIIIAGLAVANYAPRAWSRYGGLLMIGFGLGPTVPICMAWCSASMAKGDVGVASSLALVTGLGN-LGSVVTTYALYSGGDPTFRKSNDVCIALIGVSIIACGIEFLLDKTGFGQFNASFNNHDHEVEDEQEMTDIKPALP....... 561
2 -45.100[G] COG2271 Sugar phosphate permease  ali follow..  12  12........................................................................................................................ARLPAAEIDPTYRRLRWQIFLGIFFGYAAYYLVRKNFALAMP--YLVEQGFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRVFLPAGLILAAAVMLFMGFVSSIAVMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGGIVSVWNCAHNVGGGIPPLLFLLGMAWFND------WHAALYMPAFCAILVALFAFAMMRDTPQSCG--LPPIEEYKNDYPDDYNEKAEQELTAKQI----FMQYVLPNKLLWYIAIANVFVYLLRYGILDWSPTYLKEVKHFALDKSSWAYFLYEYAGIPGTLLCGWMSDKVGNRGATGVFFMTLVTIATIVYWMNPAGNPTVDMICMIVIGFLIYGPVMLIGLHALELAPKKAAGTAAGFTGLFGYLGGSVAASAIV-TVDFFGWDGGFMVMIGGSILAVILLIVVMIGEKRRHEQLLQERNGG......................... 452
3 -39.000[G] KOG4686 Predicted sugar transporter  ali follow..  3.......................................................................................REDEERIVDNEEVSRPTEEDQVVSRAGRRDNELSLPSGGCCMPSSTSHRFMALVFMCLLGFGSYFCYDAPG-ALQNYFKKDLNLTSAQFTLIYSIYSWPNVVLCFVGGFLIDRLFGIIIYMMILLVGQLIFACGGILDAFWMMILGRFIFGIGAESLAVAQNSYAVLWFKGKELNMVFGLQLSVARFGSTVNFWVMQPIYEYV-------SNFYKGHTALGVVLLLATLTCVMSMTCALILG------------WMDKRAERILQRNNNPAGQIPKLTDVFSFKPPFWMVSIICVAYYVAIFPFIALGQNFFVDRFGLSPAEANTVDSLVYLIAAVSSPVFGFIIDKLGRNVTWVFTATLTTIGAHALLTFTQLTPYVGMIIMGLSYSMLAAS----LWPLVALIIPEYQLGTAYGFCQSIQNLGLAVITIVAIVDHSGGEHMWLQLFFMGWLTIALISTGVIWAYNNKNRGNLNMTPQQRAQFVSAENYQNFE............ 478
4 -33.900[P] COG2223 Nitrate/nitrite transporter  ali follow..  2.......................................................................................................SHLSAPERATGAVITEWRPEDPAFWQQRGHRVASRNLWISVPCLLLAFCVWMLFSAVAVNLPKVGFNFTTDQLFMLTALPSVSGALLRVPYSFMVPLFGGRRWTAFSTGILIVPCVWLGFAVQFSTFIIISLLCGFAGAN-FASSMANISFFFPKQKQGGALGLNGGLGNMGVSVMQLVAPLVVSLSI---AAFGSHGVEQPDGSQLYLANAAWIWVPFLAIFTLAA------------------WFGMNELATSKASLKEQLPVLKRGHLWIMSLLYLATFGSFIGFSAGFAMLSKTQ--FPDVQILHYAFFGPFIGALARSAGGAISDRLGGTRVTLINFVLMAIFSGLLFLTLPTGGVGGSFIAFYGGSTFQMISVIFRKLTMDRVKAATDTAAALGFISAIGAIGGFFIPKAFSSLALTGSPVGAMKVFLIFYIACVVITWAVYGRHSKNKK.................................. 465
5 -28.300[G] COG2814 Arabinose efflux permease  ali follow..  12  28..........................................................................................................................................GVFAMSVCAFALIASE--LPVSLLTPMARDLQVTEGMTGQGIAISGAFAVLTSLFISALAGSLNRKTLLLGLTLAMGVSGAIVALAPNYAIYMLGRALIGVVVGGFWSMSAATAIRMVPKRDVPRALAIVNGGNALATVVAAPMGAYLSTVI-------GWRGAFLCLVPVSLIALAWQWKTLPSMPAAARA--------------------------PGIGQVFKVFTLFKHPGVVVGMLASSLLFMGQFGLFTYVRPFLETVTNVHGATISLFLLVLGAAGFIGTVLIGRVLQRSFYQT-MIVIPVLMALTALALIAFGSSVAIVLVLLALWGLTGTSAPVGWWAWIAKVFPKDAEAGGGLFVAVVQMSIALGSTVGGILFDHS-------GYRTTFVASAVLLAICAVLTVVTARQSASHG............................... 409
6 -28.200[G] KOG2532 Permease of the major facilitator superfamily  ali follow..  11  12...................................................................................................................................................VICMDDIVEDFHMFHNSTETHWFERSTEKSLLFSGVAIGGLIGLVPSVPQISSIGLRNTQTISGFISGLGSFLFPLAVSVG-SFLCRVLQGIGAAVLFTAVGVVPGVWAPKSEANTFMSILACAFQLSNVICMPVSGLLCES--------GWRSIYYISGAITFVLYTVFWFTYTDDPKLHR--NVSQKELRKISTGKVEKIKEPVP----------YFAVSTDPTVIISWISLFGGNMGFYVLCIYGPTYLREVLKFDVKETGFLTALPFILSAIAKFSAGRISDKLTSERARFVFFASIFQIGLVAGLVVMAFTTNRVIAQIAFNFAIVSSGLNIMGVVKFADLPKNLIFVNLPICQFAGSFREILYKIETLKVRCLQHVHYTLTVMSFTAYASQFLSPTLVSIICPNYTNEQ............................... 412
7 -26.500[R] KOG0255 Synaptic vesicle transporter SVOP and related transporters (major facilitator superfamily)  ali follow..  4.....................................TSTYRHTIVVDLLEYLGIVSNLETLQSAREDETRKPENTDKKECKPDYDIECGPNRSCSESSTDSDSSGSQIEKNDPFRVDWNGPSDPENPQNWPLLKKSLVVFQIMLLTCVTYMGSSIYTPG-QEYIQEEFHVGHVVATLNLSLYVLGYGLGPIPLS--TARYGRLNLYMVTLFFFMIFQVGCATVHNIGGLIVMRFISGILCSPSLATGGGTVADIISPEMVPLVLGMWSAGAVAAPVLAPLLGAAMVDAK-------NWRFIFWLLMWLSAATFILLAFFF---PETQHHNILYRRALKLRKETGDDRYYTEQDKLDREVDARTLKMIIKEPAILAFDLYIAVAYGCFYLFFEAFPIVFVGIYHFSLVEVGLAYMGFCVGCVLAYGLFGILNMRIEAFLIVAMCVCWCLPLSLFLFGWTARVHLPVISEVFFVLAVFNIFQATFAYLATCYPKYVASVFAGNGFCRASFACAFPLFGRAMYDNLATKNYPVAWGSSL-VGFLTLGLAIIPFILYKYGPSLRTRSS............................ 544
8 -26.100[R] KOG2563 Permease of the major facilitator superfamily  ali follow..  2............................................................................................GADDGAISADKVDIRLQPLNKNGAQDETDEEAADQIQLRVYKQRWIVLLAVALLNNTNTMSWIGYA-PSGNYVNSFYGE--SSAAWLSMVYMMCTIPVGMFAMWAGRELRTAVLIAGWANGIGAVIRVISSLLRFPICMTGQGIAAIAYPFIMFLPTKVAGSWFPDTQRAIATSIGVMSNPLGVLMANLISPAIVKSPEHVIWL-----NIFTCVPSLIAMLIATFGVNRSEPKIPPTFSASKPQMDF---------------------VSGMKSCFSSKQYIILLIVMGGGIGM-FNCLYTVMLELLCPSGYSNFFSGVCAALMIVGGVFGAAASSIFVDRTKLYEETLKIALGAAVIFGLIFLQLGYSVILGVTCLLFGVLGLATYPIGLELASECT---PVSEATSTGLIVLSGQIQSVIYVFIMKNFARP---KDNTMSIMIFSLLATLLVLTLVVLFKPVYKRLEAERGNRATADKAKELSNQNKDRITLQAESA. 500
9 -25.500[P] COG2807 Cyanate permease  ali follow..  2.............................................................................................................................TCSTSLSGKNRIVLIAGILMIATTLRVTFTGAAPL-LDTIRSAYSLTTAQTGLLTTLPLLAFALISPLAAPVARRFGMERSLFAALLLICAGIAIRSLPSPY-LLFGGTAVIGGGIALGNVLLPGLIKRDF-PHSVARLTGAYSLTMGAAAALGSAMVVPLALNGFG------WQGALLMLMCFPLLALFLWLPQWRSQQHANLS----------------------------TSRALHTRGIWRSPLAWQVTLF-LGINSLVYYVIIGWLPAILISHGYSEAQAGSLHGLLQLATAAPGLLIPLFLHHVKDQRGIAAFVALMCAVGAVGLCF--MPAHAITWTLLFGFGSGATMILGLTFIGLRASSAHQAAALS-GMAQSVGYLLAACGPPLMGKIHDA-NWSVPLMGVAILSLLMAIFGLCA........................................... 386
10 -24.200[U] KOG3764 Vesicular amine transporter  ali follow..  12  80...........................................................................................................................SYYDNSTMVTGNATRDLTLHQTATQHMVTNASAVP-SDCPSEDKDLLNENVQVGLLFASKATVQLITNPFIGLLTNRIGYPIPIFAGFCIMFVSTIMFAFSSSYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDERGNVMGIALGGLAMGVLVGPPFGSVLYEFV-------GKTAPFLVLAALVLLDGAIQLFVLQPSRVQPES------------------------------KGTPLTTLLKDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRW-LCALLGMIIVGVSILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLHVSVYGSVYAIADVMGYAIGPSAGGAIAKA--------GFPWLMTIIGIIDILFAPLCFFLRSPPAKEEKMAILMDHNCPIKTKMYTQNNIQSYPIGEDE 509
11 -23.500[P] KOG0252 Inorganic phosphate transporter  ali follow..  11  2............................................................................................................................AKKGKEVLNALDFTAIVIAGMGFFTDAYDLFSISLVTKDSSKKPGTLPPNVAAAVNGVAFCGTLAGQLFFGWLGDKLGRKKVYGITLMLMVLCSLGSGLSFGHSALCFFRFWLGFGIGGDYPLSATIMSEYANKKTRGAFIAAVFAMQGFGILAGGIVSLIVSSTFDHAFKAPVWRIVLMF-GAIPALLTYYWRMKMPETAR-----YTRNTKQAASDMSKVLQVDLIAEEEAQSNSNSSNPNFTFGGLHLLGTTTTWFLLDIAYYSSNLFQKDIYTAIGWVFTVSKAQTLIALCGTVPGYWFTVAFIDILGRFFIQLMGFIFMTIFMFALAIPYRENRIGFLIMYSLTMFFANFGPNATTFVVPAEIFPARLRSTCHGISAASGK-AGAIVGAFGFLTDAGYPPGIGVRNSLLMLACVNFLGIVFTLLVPESKGKSLEEISREDEEQSGGDTVVEMTVANSGRKVP.. 541
12 -19.600[G] KOG0569 Permease of the major facilitator superfamily  ali follow..  11  4....................................................................................................................................LSIHILSIALCLSSGFQQGYIASVLNQPYAQGHPISDSTLHLLWSLLNVCFPIATIFGQFLAGWMCSQFKHTALIASFLYIPGLCAAAKWCFPAFELLFVGRIIWSLANGVNTVNATVWIVECAPPQIRGRMAAMQEFFMALGSLLTQAVGVPFSTD-------ELWPYNFLPNCAVVV-VSMVMFSWVAESPQ-----FIKYNDVDRARKALAQYHGVSEDDPSVESEIRICEQSIGKYCAWVGVMVKIAYVFTGARSLRGYSTFILYTLSFTYSQATWLSFATGLLRLPFTLVPVFLVDRLGRRPLIIVSMLVSFVSILVMININGELKYATFIGLTVLLLVNTCGIGSVSRFYAAELVPRNLLLSSVSTLTMFEALTKIGVEFAFYPTANV----IGAQSLLLFLIPTGVFTVMCYLMC--ETSRMTVNEVLNNVAAKKKMDVV.............. 491
13 -18.900[R] KOG0253 Synaptic vesicle transporter SV2 (major facilitator superfamily)  ali follow..  21.....................................................................................................................................KFQIYVLAYAGMGWVAEAMEMMLLS-FVGPAVQSLWNLSARQESLITSVVFAGMLIGAYSWGIVSDKHGRRKGFIITAVVTFVAGFLSAFSPNYMWLIILRCLVGLGLGGGPVLASWYLE-FIPAPSRGTWMVVFSAFWTVGTIFEASLAWLVMPRL-------GWRWLLAFSSVPSSLL-LLFYRWTSESPR-----YLRKAEALAILEKIARMNKTQKIVLKADKEPGFSLLALLSPTL-LLLWVVFFGNAFAYYGVVLLTTELNNSHNRCYPTEKQLRFIASFAEFPGLLISAAMVDRLGRKAS-MASMLFTCCIFLLPLLSHQSPFITTVLLFGGRICISAAFTVVYIYAPEIY--PTAVRTTGVGVGSSVGRIGGILCPLVAVGLVHG----CHQTIAVLLFEVVILVSGICVCLFPFETSGRDLTDSISASKEPPSAS................ 499
14 -17.400[S] KOG3097 Predicted membrane protein  ali follow..  2..........................................................................................TGFTNAGFENDEPVKPKAGFEPDTASLREKVVLNPGEKWRILKNI--SIISIAFMVQFTAFQGTANLQSSINA--KDGLG------TVSLSAIYAALVVSCI-PTLIIRKLTVKWTLVCSMLCYAPYIAFQLFPRFYT-LVPAGILVGMGAAPMWASKATYLTQV-VDAIIVRFFGFFFLAWQSAELWGNLISSLVLSSGAHGGGSS------TTVSEEDLQFCGANFCTTGSGGHGNLERPPEDEIFEISRYGEKRKGSNSAAELSGLQLLSATFRQMKKPNLQLLIPITVFIGMEQAFIGADFTQAYVAC-ALGVNKIGFVMICFGVVNALCSILFGSVMKYIG-RTPIIVLGAVVHFTLITVELFWRPNPDNPIIFYAMSGGDAVWQTQINGLYGLLFRRNKEAAFSNYRLWESAGFVIAYAYATTLCTQMK-------LYILLAVLTLGCIGYVIVEILYRKKQRKLKKQEKLEAAEKEKEAAAAAAAAALAAAEAGAD 517
15 -16.500[R] KOG0254 Predicted transporter (major facilitator superfamily)  ali follow..  40...........................................................................................................................................LITFCHGIALGWLSPMLPKLLSPQETPLSFYIDVNEASWLGAVISIGGISGNFSFSYLMNRFGRKV----------SIYALAVPHTSIEWLYVARVFAGLTGGGMFVVLPIFIGEIADNSIRGRLCSFFTLTMNTGIMVGFVVSSHI-----------AYHVIPCAVVGLPV-LYVLLATRYPEPPQ----QLIRWKREEEAEKSLLAIQQQNNDTDDNGLSMSDFLTKRSLKALATGLVLMVANIFTGTFAFNNYMSNIFDAVHTQL-DPNTNTIIIGAVQILGTLASIYLVDRYGRKILLIVSCAGSGIGTSAFVDLSAFSAWLPVTLMAFIIFIANVGVISVTMVVLVEILPQKIRAVATSFCLGCLSFFAFASLKTFPLMMFH-----GLAATMWFCAAVSVICLFYVVVCLEETKGRSMYD............................ 472
16 -16.000[G] COG0738 Fucose permease  ali follow..  6.......................................................................................................................PTNNPLHTETSSQKNYGFALTSLTLLFFMSGFIT--CLNDILIPHLKNVFQLNYTQSMLIQFCFFGAYFIVSLPAGQLVKRISYKIVVGLIVAAIGCALFIAASYRVYALFLGALFVLASGVTILQVAANPYVTILGKPETAASRLTLTQAFNSLGTTVAPVFGAVLI-----LSAATDATVNAEADAVRFPYLLLALAFTV-------------------LAIIFAILKPPDVQEDEPALSDKKEGSAWQYRHLVLGAIGIFVYVGAEVSVGSFLVNFLSDPTGLSETDAAHHVAYFWGGAMVGRFIGSAAMRYIDDG---ALAFNAFVAIILLFITVATTGHIAMWSVLAIGLFNSIMFPTIFSLALHGLG----SHTSQGSGILCLAIVGGAIVPLIQGALADA----IGIHLAFLMPIICYAYIAFYGLIGSKS.................................... 412
17 -15.800[GEPR] COG0477 Permeases of the major facilitator superfamily  ali follow..  11  20.................................................................................................................................TAIEFFDYYIYAAAAVLVFNTFFHSDDPLSNDLLSL---------------STLALAFFARPIGSALF-DKIGRKKTLVASLVLMGGSTVVIGLLPNYAQLCVCRVGQGIGLGGEWGGAALVATENAPEGKRAWYGTFPQLGAPIGLFVANGTFFLVSYLLGHNALVEAWRIPFVS----SILLVAVGLYV---------------------RLTLHESHVFVEAEQKGKKLNAPVSVVFTKLKPMVIGTFIMVATYSLFYIMTAFAQAYSRTLGIPANTFTGLLLISAIVFGIFISISGFYADKIGRRKWLIWVTIAIGVLGLAMPLFLENGTPVSVFAFLVIGMAIMTFGPMAALLPELFPTEVRYSGASLALASIIGATIAAMISLKINASFGV--------MGVGIYLAINALMTFLALLASKETKNVDLTE............................ 437
18 -15.300[S] KOG3098 Uncharacterized conserved protein  ali follow..  28..................................................................................DSGFFDQEPTNLSGIENCAKAREMRQGTESASTIYLILYSAFMIILFNF---SKFPKFYAVTNVILGQKMPKSFVLESVIHSIHER-AIGKYAGYYGQAVMYIIYMIGCLFSPSILNEIGAKYILICSAICFASFPLGFFFVNSY--YYFSQMLLGFGYALYYQGHGGYLTSHSTRKTIESNINIAWCVGCICLLLSSGILATVTHMTLDSREIMQNLKNSTEFEPVERRFSDLEIKLLFGVFLGASV---IVNFISCPGKDVTNCIQETKKKGTFMEGFKQTCSALTSKSMLQLFPLFTVLGTSSSFWLSIFTTAMNFTAANSNLTAAIYPLSVGVGEIGTALFITQMSRRFKDLQPTMLIGAIFSILGFGLVHVSHSYLVISVIGVIVGIGDCCLNSCRSVICALAMPDRRAQAFSISKLYQALGSCVLFFASPIIPLYVY-------TIGVSIHLIIANVFFNITARRTQTMEKDMQ............................... 519
19 -15.100[R] KOG2816 Predicted transporter ADD1 (major facilitator superfamily)  ali follow..  1......................................................................................................................................MEVFRLGELRHLLVTVFLSGLAEYAAVCSGLDDSCSLAVYLTGVQQVTVGMGTMVMMPVIGNLSDRYGIKAMLTLPMCLSVLPPAILGYRRDTNFFYAFYVIKTLF----------DMAKNVHGTKRISMFGILAGVSSISGVCASLS-----------ARFLSIASTFQVAAISLFIGLVYMRVFLKER-----------------LQDADDDDEADSGGCRSHQEVHNGGDLKMLTEPILRDAPTKTHVFNSKYSSWKDMYFLKARFGFNKNDFAELFLLVTIIGSISLFILPTLSSTIGER--VLSTGLLMEFFNATCLSVAWSPWVPYAMTMLVPGAMFV-MPSVCGIASRQVGSSEQGKVQCISGVRAFAQVVAPFVYSPLTASENAPFYFPGFSILCIAISLMIGFLQSLLIKDHPSLPLVNITINNPSKAEA.................... 415
20 -13.100[R] KOG3762 Predicted transporter  ali follow..  2.......................................................................................................................ENHVGERTVNIFGKVFPRDAFIC--LFYLSFFASFGSL--PLLAVYFKQLGMTAAQAGFLIGSRPIVEFLSGPFWSQFASRFR-KLLLLFSLGSLVLFTLGIGLVQAFMLLLILICLCEFFSAPALPATLHSVRD-FGKIRLMASVGWGFAMFIMGIALDYSDTFRNHPCPAENTTEKNYTLCFVMCVIFMLAAMGLASKF-PGEVHGLVMDTREAEVSHVVAEKARARITQSEGGGGSENSLLLAMKALASMHILLF-FVSVVVMGGGAGLVFSFLYWHLQDIGGSPVLFGILSVVNHASEIITYFYVFKLINKYGHV--VMYLCLAVNFFRFMALSILDNPWMVLPLQILQGACLATVWSCASSYISLVAPPHAKQQYALQVGYHGIGKGLGSIIGGSVISIIGT---RTTFVIYGLICLATCAGSFGLNKLFKYEGIKYGAGNFEEEDMDIMAPQGVPMARDGKITDAFNA 601
21 -13.000[R] KOG2615 Permease of the major facilitator superfamily  ali follow..  2................................................................................................................................KRLRRGFPFWELFTVWIIVLCTALPISSL--PFLYFMIDDFNIAKKE-GFVGCSFMLGRAFTSVAWGLVADRYGRKPVILIGTASVVVFNTLFGLSLNFWMAIITRFCLGSFNGLL---IKAYAMEIFRDEYQGLALSAVSTAWGIGLIIGPAIGGFLAQPAKQYPSLFSQDSIFLAISVFAFLVTIVSSRIPETL---------HNHKFNDDESYDALKDLSDDPESNKVAERNGKSSLLNNWPLISSIIVYCVFSLHDMAYTEIFSLWANSGLGYSTADVGSVLAFSGFGLLIFQLSLYSYAERLLGPIIVTRISGSLAMVVLSCYPLIAKLSGLALTVTVTSASVAKSVLGTSAITGLFILQNKAVRQDQRGAANGIAMTAMSLAAGIIFSWSEKRQGAAFLPGNVNPNSCSCPCPCPS........................................... 439
22 -12.800[R] KOG2325 Predicted transporter/transmembrane protein  ali follow..  4...........................................................................................................PTDSPIVHDGILLEKEQLMNKDKDDRLTNWRLIITAAVVSCLNAVENSVLGIGEWPYMREDPNATAQFFGLATSASKCGHAVFALIFSIWSYKTKIPLIASRLIAIAACMIYLTIEYVKTDKLMAVYTLLGIANSGG---LRGYVTLCSSNEDRPRAFAALGLSFIFSIIVGPTIQLIFSAIPYPGYEIIP---LYSAPIWISFILTILTVFVI---------ILIEDISREKKTKLRPSESQSSFSMERWRSLYEKLKKSNLDWKLIVVCFFVRMAVSFSHSTLTIGSILYMVMFGWDGATTVRVGSITMVIFGVMSSTILLLFGKILPQHKVFLFFTIAFGAVYIITYPFEFTSNPSVTILVAGMSIPIMSTALDTVYSRILGNIDQSVAHGAAVIDDILYMITPIFTTTMFTL--------GIGPLWIVKSMAFGIIALTVLVSGQ..................................... 484
23 -12.100[E] COG3104 Dipeptide/tripeptide permease  ali follow..  41.................................................................................................................................EFWERFGFYGMQAILTVYMVKIMGMDESASFVL-------------FGAFSALVYGFVAIGGWIGDKVIGTKR-AITLGAIVMMVGYVLLGLSTAVGPTLIYIAMGFITVGNGLFKANPSSLLAKIYPENDLDGAFTMYYMAINLGSFFSMIITPLVAIKM-------GYGMAFGVSAV-GLAITVVNFLFLKGTGSPADLMPVNKMYLVLVAVGAGLFILGCYFKEAFSMSGIERAKMLVAFILMLQGVVFFVLYFQMPTSLNFFAINNVEHHGFDVAPEQFQALNPFWIMIASPILAATYGKLGDKLAMPFKFAFGMALCALSFLVLSWGTLFAIASYAFQSIGELLVSGLGLAMVAQLV--PQRMMGFAMGLTSASAAVIAGWVASLTSTPANVHIYGEVFAQIGYVTAGIAIVTFMIAPKLTRICRGESEPLELVTQ....................... 514
24 -11.900[P] KOG3574 Acetyl-CoA transporter  ali follow..  2..................................................................SPTISHKDSSRQRRPGNFSHSLDMKSGPLPPGGWDDSHLDSAGREGDREALLGDTGTGDFLKAPQSFRAELSSILLLLFLYVLQGIPLGLAGSIPLILQSKNVSYTD--FSFVFWPFSLKLLWAPLVDAVYVKNFGRRKWLVPTQYILGLFMIYLSTQPDVIALTVAFFLFEFLAATQDIAVDGWALTMLSRENVGYASTCNSVGQTAGYFLGNVLFLALESAD-------FCNKYLRFQPQPRGIVTLSDFLFFWGTVFLITTTLVALLKKE------NEVSVVKEETQGITDTYKLLFAIIKMPAVLTFCLLILTAKIGFSAADAVTGLKLVE-EGVPKEHLALLAVPMVPLQIILLIISKYTAGPQPLNTFYKAMPLLLGLEYALLVWWTPKVEHQLLSYALHQVTVYSMYVSIMAFNAKVS--DPLIGGTYMTLLNTVSNLGGNWPSTVALWLVDPLTVKEGYYVE---SIICVFIGFGWWFFLGPKFKKLQD.............................. 537
25 -11.700[Q] KOG3626 Organic anion transporter  ali follow..  10  1...................................................................................................................................MERIYIFLGLFSFVFFLEAIG--GSYINSAVQNIERQFQMSSRTSGFMISASDFGYIPCVVFIAHFGSKGNRARWIGAGAILVSITYLMLASPNFLFPFFFSLLLLGIGRTVPWSLGVPLLDDNIKKKSLPAYFGAISSIRVLGPIC-GYMIGSFCNKFADPTWIGAWWMGFLFIGSIALFPSTMLFFFPQGKEGDGS----AVQLRDVHKEKLKKSVDEDRTITMKLKDFAKSCKKVLSTKIYMGSVLGRVCDVLAFKGYIVFLPYLENHFGIPQYLVHRYMVFGFGLGVATGYVTKKLKLNGRRAAMFVMLMSTLNVCLYSGKIFIGCESIVIFFLTVLPGSFVAGLGVVPAMLILLRSVPPETRSLSLGLQGMAVSLFGTLPSPILWGL-HPDRLRV-HLLYVVIRTVALITDVYVWKHAKNLNIMDEPVSEEKDNIRRNSIKMQAVQPDQ........ 744
26 -11.600[G] KOG4830 Predicted sugar transporter  ali follow..  5.......................................................................................................................SEEDPFTKPIGRWSVFFY-ITASCWFTYLLLFLTQIGLSPRDAA-----------------IVMLSGQVADAFATIFT-----------------GELV------DEYGLLLWQIDRFGHFKIWHAAGSLLVAISF----------SSVFGGCLPCSILHNDSLTLETFSYSMFAAIFNIGWAATQVANLGLYAIALVVFGVIKAGSKEDTET------VVIFLMGTKEPRLRIDLKETSRARIPWVYWFRKILYYQVAMVYLLTRLVLNVSQAYLAFFVIDDLQMDQSAKALVPAIIYICSFVVSVLLQEIPWNGKRLKAYYTAGGIIWIFCGAAILLLPRDISSFMYAISVFIGIANALMMVTAIQSVLVGAEVGGCAFVCGSLSFLDKMSCGLALYVL-NNNQQSVYLSVTRYGLGLVPALCSFVGVAVTFFMELEAAGSLSKPLLRDR...................... 436
27 -10.800[H] KOG3810 Micronutrient transporters (folate transporter family)  ali follow..  33.............................................................................................................................................PTALLCAYGFFASLRPSEPFLT-LGPDKNLTEREVF-IYPVWTYSYLVLLFPVFLATDYLRYKPVVLLQGLSLIVTWFMLLYAQGLLAIQFLEFFYGIATATEIAYYSYIYSV-VDLGMYQKVTSYCRSATLVGFTVGSVLGQILVS------AGWSLFSLNVISLTCVSVAFAVAWFL----PMPQKSLFFHHIPSTCQRVNGIKVQNGGIVTDTPASNWNDFLMCYSSRPLLCWSVWWALS-TCGYFQVVNYTQGLVMPSRYAAIYNGGVEAVSTLLGAVAVFAVGYIKISWSTWGEMTLSLFSLLIAAAVYIMDTVGNIWVCYASYVVFRIIYMLL-ITIATFQIAANLSMERYALVFGVNTFIALALQTLLTLIVVDASGLGLEITTQFLIYASYFALIAVVFLASGAVSVMKKCRKLEDPQSSSQVTTS.................. 497
28 -10.800[G] COG2211 Na+/melibiose symporter and related transporters  ali follow..  16..................................................................................................................................FGKDFAIGIVYMYLMYY---YTDVVGLSVGLVGTL-----LVARIWDAINDPI-MGWIVNATRSRW---KFKP--WILIGTLTNSLVLFLLFSAHLFEGVCVTYILWGMTYTIMFWSLVPTITL--DKREREQLVPFPRFFASLAGFVTAGITLPFVSYVGGADRGFGFQMFTLVLIAFFIASTIVTLR---------------------VHEVYSSDNGVTAGRPHLTLK-TIVGLIYKNDQLSCLLGMALAYNIASNIINGFAIYYFTYVIG-DADLFPYYLSYAGAANLLTLIVFPRLVKMLSRRILWAGASVMPVLSCAGLFAM-HNAALIVAAGIFLNIGTALFWVLQVIMVADTVDYGEFKLNIVQTMVVKGGSAFAAFFIALVLGVAQSAQTLQGMQFIMIVVLFFMMTLVLYFRYYRLNGDMLRKIQIHLLDKYRKTPPFVEQPDSPAISVVATS 472
29 -9.600[S] COG3247 Uncharacterized conserved protein  ali follow..  11  1............................................................................................................................................................MTTAHNFDRPSLPHELSSKWGWFVALGVALLILGGI-GNLFLATVVSVYYVGLMMLIAGIIEIIHAFGVKTWGRLFFWLLSGLL---TAAGIVTFINPVLAAGVLTFLLAAALIGSGAFRIWLGFK----------SKPSQGWGWI-VAAGAVTLLLGLIIAIQWPVNSLFILGLFLA................................................................................................................................................................................................................................................................... 167
30 -9.280[C] COG3202 ATP/ADP translocase  ali follow..  11  20...................................................................................................................................IEQYENKKFLPLAFMMFCILLNYSTLRSIKDGFVVTDIGTESISFLKTYIVLPSAVIAMII--VKLCDILKQENVFYVITSFFLGYFALFAFVLYPYPSFASFYTIAELWGTMMLSLLFFANQITKIAEAKRFYSMFGLLANLALPVTSVVIGYFLHEKTQIV-------AEHLKFVPLFVIMITSSFLIILTYRWMNKNVLTDPRLY------DPALVKEKKTKAKLSFIESLKMIFTSKYVGYIALLIIAYGVSVNLVEGVWKSKVKELYPTKEAYTIYMGQFQFYQGWVAIAFMLIGSNILRKVSAAMITPLMMFITGAAFFSFIFFDSVIAMNLTGILASSPLTLAVMIGYIPLDKDLRVKGQAAVEVIGGRLGKSGGAIIQSTFFILFPVFGFIEATPYFASIFFIIVILWIFAVKGLNKEYQVLVNKN............................ 496

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Sikora S, Godzik A. Combination of multiple alignment analysis and surface mapping paves a way for a detailed pathway reconstruction--the case of VHL (von Hippel-Lindau) protein and angiogenesis regulatory pathway. Protein Sci. 2004 Mar;13(3):786-96. Epub 2004 Feb 06.