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Query: gi|6319256|ref|NP_009339.1| NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources; Gdh3p (YAL062W) [Saccharomyces cerevisiae], from S.cerevisiae

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MTSEPEFQQAYDEIVSSVEDSKIFEKFPQYKKVLPIVSVPERIIQFRVTWENDNGEQEVAQGYRVQFNSAKGPYKGGLRFHPSVNLSILKFLGFEQIFKNALTGLDMGGGKGGLCVDLKGKSDNEIRRICYAFMRELSRHIGKDTDVPAGDIGVGGREIGYLFGAYRSYKNSWEGVLTGKGLNWGGSLIRPEATGFGLVYYTQAMIDYATNGKESFEGKRVTISGSGNVAQYAALKVIELGGIVVSLSDSKGCIISETGITSEQIHDIASAKIRFKSLEEIVDEYSTFSESKMKYVAGARPWTHVSNVDIALPCATQNEVSGDEAKALVASGVKFVAEGANMGSTPEAISVFETARSTATNAKDAVWFGPPKAANLGGVAVSGLEMAQNSQKVTWTAERVDQELKKIMINCFNDCIQAAQEYSTEKNTNTLPSLVKGANIASFVMVADAMLDQGDVFLast
1 -109.000[E] COG0334 Glutamate dehydrogenase/leucine dehydrogenase  ali follow..  27  1MTENNNLVTSTQGIIKEA-----LHKLGFDEGMYDLIKEPLRMLQVRIPVRMDDGTVKTFTGYRAQHNDAVGPTKGGVRFHPDVDEEEVKALSMWMTLKCGIVNLPYGGGKGGIVCDPRQMSIHEVERLSRGYVRAISQFVGPNKDIPAPDVFTNSQIMAWMMDEYSALDKNSPGFITGKPIVLGGSHGRDRSTALGVVIAIEQAAKR---RNMQIEGAKVVIQGFGNAGSFLAKFLYDLGAKIVGISDAYGALHDPNGLDIDYLLDRRDSFGTVTNL---------------FEETISNKELFELDCDILVPAAISNQITEDNAHDIKASIV---VEAANGPTTPEATRILT---------ERGILLVPDVLASAGGVTVSYFEWVQNNQGYYWSEEEVNEKLREKLEAAFDTIYELSQNRK--------IDMRLAAYIIGIKRTAEAARYRGW.. 413
2 -97.300[E] KOG2250 Glutamate/leucine/phenylalanine/valine dehydrogenases  ali follow..  23  61.EDDPNFFKMVEGFFDRGASISEEQKRNRVRGILRIIKPCNHVLSLSFPIRRDDGSWEVIEGYRAQHSQHRTPCKGGIRYSTDVSVDEVKALASLMTYKCAVVDVPFGGAKAGVKINPKNYTENELEKITRRFTMELAKFIGPGVDVPAPDMNTGEREMSWIADTYASTIGHAHACVTGKPISQGGIHGRISATGRGVFHGIENFINQASYMTPGFRDKTFVVQGFGNVGLHSMRYLHRFGAKCIAVGESDGSIWNPDGIDPKELEDFKLQHGSILGFPK---------------AKPYEGSILEVDCDILIPAATEKQLTKSNAPRVKAKII---AEGANGPTTPEADKIFL---------ERNILVIPDLYLNAGGVTVSYFEWLKNLNHVSYGRLTFKYERDSNYHLLLSVQESLERKFGKHMKYNLGLDLRTAAYVNAIEKVFKVYSEAGVTF 557
3 -19.900[E] COG2902 NAD-specific glutamate dehydrogenase  ali follow..  14  697..EEKKRVKKLAEIHKAIEAALSGVPNLDEDRTLRRYVN-DATLRTNYFQKNADGTPRDLLAFKFDHLRFGKVARGGLRWSDRGQRTEVLGLVKAQQVKNAV--IVPVGAKGGFFPKNRDEVFNAGREAYKTYIRTLLSITDNIVDVVAADKGTAT------FSDTANGLAHEAGFWLDDAFASGGSAGKMGITARGAWETVKRHFREMDT---DIQTTPFTVAGVGDMSGDVFGMLLSEKIRLIAAFDHRDIFIDPDPDTDKSFAERKRLFELSRSEKSVTLTPEAVAAIGLDKSVATPFEIMTAGIGTYIKAAVENDPIRVNATELRAKVI---GEGANLGITQKG-----------AYALAGGRCNSDAIDNSAGVNSSDVEVNIKLASAVNSGRLTMPKRNQLLASMTPDVAQLVLRNNYQQSLAISLTRLGLANREELGRLMGALEATGQL. 1231
4 -7.430[C] COG0281 Malic enzyme  ali follow..  16  69...................................................................................VISNGTAVLGLGNIGALAGKPVMEG-KFAGINVFDIEVNEHDPDKLVD-IIASLEPTFG---GVNLEDIKAPECFYIEQKLRERMNIPVFHDDQHG--------------TA---IISAAAIINSLRIVGKKIEDVRLVASGAGAASIACLNLLLSLGMK-ITVCDSKGVVYGRDDKMDQTKKEYAIEDNGWRKLADAIP-----------------------NADIFLGCSAAGALTQDMVKSMAAHPIILAL--AN-P-NPEITPPEAKAVRPDAIVCTGRSDYPNQVNNV-GALDVGATTINEEMKRAAVYAIADLALEEQNEVVTSAYGGEGATFGADYVIPRPFDPRLIVRIAP--AVAKAAMESGV.. 405
5 -7.000[C] KOG1257 NADP+-dependent malic enzyme  ali follow..  10  130.............................PKGLFISISDRGHVRSIVDNWPENHVKAVVVTGERILGLGDLGVYGMGI---PVGKLCLYTACAGIRPDRCLPVCIDVGTDNIALLKDPKRDRTQQYDDLIDEFMKAITDRYGRNTLIQFEDFGNHN-----FLRKYREKYCTFNDDIQGT-----------------AAVALAGLLAAQKVISKPISEHKILFLGAGEAALGIANLIVMSMVE-IWMFDKYGLLVKGRKAKIDSYQEPFTHSAPESIPDTFEDAVNILK-----------------PSTIIGVAGAGRLFTPDVIRAMASINERPVIFALSNPTSPFGPVKLTDGRVFTPGQGNNVYIFPGVAL---AVILCNTRHIS----------------DSVFLEAAKALTSQLTDEELAQGRPPLANIQEVSINIAI-KVTEYLYANKM.. 539
6 -6.960[C] COG4074 H2-forming N5,N10-methylenetetrahydromethanopterin dehydrogenase  ali follow..  1...............................................................................................................................................................................MIDMKLAILGGCYRTHAASGITNFSRACEVAEMVGKPEIAMTHSTILKELAGVDEVVVADPVFDNQFTVIDDFAYEDVIEAHKEDPEKIMPQIREKVNEVAK-KPPEGAIHFTHPEDLGFEITTDDREAVADADFIMTWFPKGDMQPGIIDKFIDDI-AIVTHACTIPTTK-FYKIFEEKHGDLVTKPETLNVTPGAVPEMKGQVYIAEG----------ASEEAINTLFELGQKARGNAYRLPAEL................................... 250
7 -6.940[R] COG1712 Predicted dinucleotide-utilizing enzyme  ali follow..  13  2..........................................................................................................................................................................................................................LKIGIVGCGFIGGQICRAIDGGSAELYALCDSS-----------------------------ESKALELAASLKTCKPSYMKIEELIRGVDLIIESASQNAVRFIVPQALKAG-CDVMILSVGALADEELRDTLFGLAKEKLYFPSGAVVGIDGLNSA................................................................................. 134
8 -6.870[V] KOG1515 Arylacetamide deacetylase  ali follow..  13  151.............................................................................YRYAPSSSGGNSRKLPVMLQFH--------GGG-GSNDSVANDFFCRRMAKHCDIIVLAVGYRLAPENRYPAA-CEDGFKVLKWLGKQANLAECNKSMGNSR-----RPGGEVKKSEVNKHIVDAFGASLVEPWLANHADPSRCVLLG-ANIADYVARKAIEVGQNLDPV----------------------KVVAQVLMYPFFIGSVPTQSEIKQANSYFYDKPMCILAWKLFLPEEEFNPLVPGRSPPLKFMPPTLTIVAEHDWMRDRAIAY------SEELRKVNVDA---PVLEYKDAVHEFATLLLRTPQAQACAEDIAIWAKKYISLRGHE........................................... 457
9 -6.750[H] COG0373 Glutamyl-tRNA reductase  ali follow..  12  8................................................................INHNTASVELREKVAFGPEKLSLALNQLSTSSHVKGGVI---------------STCNRTEIYCDVRS-KNKVIEWLSQFHQVSLDELKEEQAAIRHLM----RVACGLDSLVLGEPQILGAKRVRTETEGGSAVSVAYAACTLAKHIFESLADATVLLVGAGETIELVAKHLAGHHCKRMIVANRTAQQFGADVIALNEIPDYLAQADIVISSTASPLPIIGKGMVESALKARRHQPML---VDIAVPRDIEPQVGKNDAYLYSVDDLQSIVDEQRKVEAIQAEAIVSEESATFMSWMRSLQAVDSIRDYRKQANEAREELLNKSLQALAAGGDPEKLLIELSNKLTNKLIH........................................ 388
10 -6.430[H] KOG1370 S-adenosylhomocysteine hydrolase  ali follow..  1.................................MSDKLPYKVAAWGRKALDIAENKMPGLMRIWERYSASK-PLNG---------ARIPGCLHRTVETAVLMSLITLGTEVQWSSCNIFSTQDHAAAAIAKAGILPRLACLEGRNRR----VPVTGDLTNLIHSEYSQLLLSFRGISTTIGVHNLYKMMVNGILKVPAIDVNDSATKSKQATDVMIAGKVAVVAGYGDKGKSCAQALRGFRASVI-ITKTD--------------------------------PIKALQAAMEGYEVTTMDEACQEGDVFVTTTGCVDIILGQHFEQTKDDTIVCNTGYFDVEMDVKWLNKNTVEKVNVK-GRGIILLAEGRLVNFTSQVMAQIKLWTHPDKYPVGVHFLPKKLDESVAEAHLGKLNMKLTKLTEKQAQYLGMSCYCPF.................. 406

FFAS is supported by the NIH grant R01-GM087218-01
1 3 6 9 0 4   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Zhang Q, Zmasek CM, Dishaw LJ, Mueller MG, Ye Y, Litman GW, Godzik A. Novel genes dramatically alter regulatory network topology in amphioxus. Genome Biol.2008 Aug 4;9(8):R123.