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Query: gi|6319260|ref|NP_009343.1|(removed signalp:1-19) Calnexin; integral membrane ER chaperone involved in folding and quality control of glycoproteins; chaperone activity is inhibited by Mpd1p, with which Cne1p interacts; 24% identical to mammalian calnexin; Ca+ binding not yet shown in yeast; Cne1p (YAL058W) [Saccharomyces cerevisiae], from S.cerevisiae

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst TSLLSNVTLAEDSFWEHFQAYTNTKHLNQEWITSEAVNNEGSKIYGAQWRLSQGRLQGSAWDKGIAVRTGNAAAMIGHLLETPINVSETDTLVVQYEIKLDNSLTCGGAFIKLMSGFMNVEALKHYAPDTEGVELVFGPDYCAPEINGVQFAINKVDKITHESKLRYLQEMPLSKLTDTSQSHLYTLIIDESAQSFQILIDGKTVMVREHIEDKKKVNFEPPITPPLMIPDVSVAKPHDWDDRIRIPDPEAVKLSDRDERDPLMIPHPDGTEPPEWNSSIPEYILDPNAQKPSWWKELEHGEWIPPMIKNPLCTAERGCGQQIPGLINNAKYKGPGELNEIINPNYMGEWHPPEIENPLYYEEQHPLRIENVISGVILEFWSGSPNMLISNIYVGKNVTEAQIIGNKTWLMRDRAFRGSDGPTERKFMNSRLGNLQTTFHNERESPNPFDRIIDRILEQPLKFVLTAAVVLLTTSVLCCVVFTLast
1 -113.000[O] KOG0675 Calnexin  ali follow..  29  49IKYKTPQPIGEVYFAETFD-----SGRLAGWVLSKAKKDDEISIYDGRWEIEELKENQVPGDRGLVLKSRAKHHAISAVLAKPFI-FADKPLIVQYEVNFQDGIDCGGAYIKLLAD--TDDLILENFYDKTSYIIMFGPDKCGE-DYKLHFIFRHKHPKTGVFEEKHAKPPDVKKFFTDRKTHLYTLVMNPDD-TFEVLVDQTVVNKGSLLEDV-----VPPIKPPKEIEDPNDKKPEEWDERAKIPDPSAVKPEDWDESEPAQIEDSSVVKPAGWLDDEPKFIPDPNAEKPDDWNEDTDGEWEAPQILNPACR--IGCGEWKPPMIDNPKYKGVWRPPLVDNPNYQGIWSPRKIPNPDYFEDDHPFL-LTSFSALGLELWSMTSDIYFDNFIICSEKEVADHWAADGWRWKIMIANANKPGVLKQLMAAAEGHP................................................ 470
2 -109.000[O] KOG0674 Calreticulin  ali follow..  26  10LLATVGFISAEVYLKENFDN----ENWEDTWIYSKHPGK-----EFGKFVLTPGTFYNDEADKGIQTSQDARFYAASRKFDGF--SNEDKPLVVQFSVKHEQNIDCGGGYVKLFDC----SLDQTDMHGESPYEIMFGPDICGPGTKKVHVIFSYKGKNHLISKDIRCK--------DDVYTHFYTLIVRPDN-TYEVLIDNEKVESGNLEDDW-------DFLAPKKIKDPTATKPEDWDDRATIPDPDDKKPEDWDK---------------------PEHIPDPDATKPEDWDDEMDGEWEPPMIDNP-------------------EFKGEWQPKQLDNPNYKGAWEHPEIANPEYVPDDKLYL-RKEICTLGFDLWQVKSGTIFDNVLITDDVELAAKAAAEVKNTQAGEKKMKEAQDEVQRKKDEEEAKKASDKDDEDEDD.................................... 385
3 -5.720[R] KOG0231 Junctional membrane complex protein Junctophilin and related MORN repeat proteins  ali follow..  281...................DATTTETYVGEWKNDKRSQRSDGLKYEGEWA------SNRRHGYGCMTFPDGTKE--EGKYKQNILVGGKRKNLIASKIREKVDRAVEAAKAEIAASRTSHSRAKAEAALTAAQKAQEEARIARITAKEFSPSFQHRENGLEYQRPKRQTSCDDIEVLSTGTPLQQ---------------ESPELYRKGTTPSDLTPDDSPLQSFPTSPAATPPPAPAARNKVAHFSRQVSVDEERGGDIQMLLEGRAGDCARSSWGEEQAGGSRGVRSGALRGGLLVDDFRTRGSGRKQPGNPKPRERRTESPPVFTWTSHHGSRLLELQEEKLSNYRMEMKPLLRMETHPQKRRYSKGGACRGLGDDHRPEDRGFGVQR--AQNKENFRPASSAEPAVQKLASLRLGGAEPRLLRWDLTFSPPQKSLPVALESDEENGDELKSSTGSAPILVVMVILLNIGVAILFINFFI 748
4 -5.350[R] COG3271 Predicted double-glycine peptidase  ali follow..  23................................................................AILIAIGIPAGASEIKVKCVVPENGTTMLLQVPVRQSTNYSCGASCFQAVVSYWGGKDMGEGQFIELVNTTLGETDRKGTTPSGIVEGAEKMGLRAEIRENLTLDDNEDQTWEMNASSH-YMVVIGIDSKNVYFE-SRGYIPHDEFVERWH............................................................................................................................................................................................................................................................................ 197
5 -5.140[U] COG3701 Type IV secretory pathway, TrbF components  ali follow..  12  68............................................................................................VTPYVIEVDQS----GQVRAVGEAATPYRPADAQIAHHLARFVTLSIDPIVVRQNWLDAYDYTTDKGAAVLNDYASKNDPFARIGKESVTVQITSVVRASDTSFNVRWTEQRFVNGAPAGTERSTVLQTPRTEQRLRKNPLGIYVNGLSWSRELDSSEGAKP..................................................................................................................................................................................................................................... 234
6 -5.110[J] COG2174 Ribosomal protein L34E  ali follow..  12  4..................................................................VLIHKGATYKTRSNRRRKVRTPSGKLVNRRVKKHSKKHRCHNAILGSIARMRPAEFSRQKVSARRV-NRPYGATTCGRCVREK-FLGNEERIVMEKTGAA............................................................................................................................................................................................................................................................................................................................. 107
7 -4.970[J] KOG1790 60s ribosomal protein L34  ali follow..  13  5..................................................................LVYRSRHSYATKSNQHRIVKTPGGKLTYQTTNKRASGPKCPGKRIQGIPHLRPAEYKRSRLANERTVNRAYGGVLSGVAVRE--FLVEEQKIVKKVLKLQKAKEKTAPK.................................................................................................................................................................................................................................................................................................................... 119
8 -4.710[S] KOG1032 Uncharacterized conserved protein, contains GRAM domain  ali follow..  195...................................................................QRNKDFHETFKSVP------KDDRLLDDFNCGLNREL--GKLYI-------------------TETHLCFNSNVLGWIAK---VLIAFEDVTFMEKTSAAGLFPSAISIETKMGKTLFNGFISRD-AAFGLMKEDAINSIDEENNDKDANDNDTNENDDENISTNETTPNSTSSSPDKEKEKAYKLRADSSYQYDGPIYHHSTSFPAEPMANNEFVLKELPFDCAPG--NSEQNEFLLDFLRGQEGSQITTIPNFTSIDGSSMT--------LKREYSYEKALHFPAGPKSTTCYVAEVIKRKDPDTYYEVISSIRTPNVPSGGSFSTKTVSFWVEWTGSSW-IKGMVENGCKNGQLEAAQLMERILSKFIKNNVEECQI.................................... 587
9 -4.540[U] KOG4173 Alpha-SNAP protein  ali follow..  91.....................................................................................FDALDDYEHHYHTLHGNVCSCKRAFLDAHILEWHDSLFQILSERQDMYQCLV--EGCTSRDRKDHMVRMHLYPADFRFDKPKKSRSPASAEAPGDSGERSE......................................................................................................................................................................................................................................................................................................... 200
10 -4.500[S] COG4893 Uncharacterized protein conserved in bacteria  ali follow..  10  11...............................................................GVALAADTGRIIIRNDLAACVDMRVEKPVAINANFKLRKPIACG-RYASSVNERESRLFLQQNLKKSDTKTLPLATEPALVKDGNIEITVGCARPR.................................................................................................................................................................................................................................................................................................................................... 125

FFAS is supported by the NIH grant R01-GM087218-01
1 3 6 9 0 4   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Zhang Q, Zmasek CM, Dishaw LJ, Mueller MG, Ye Y, Litman GW, Godzik A. Novel genes dramatically alter regulatory network topology in amphioxus. Genome Biol.2008 Aug 4;9(8):R123.