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Query: gi|6319278|ref|NP_009361.1| Cytochrome c heme lyase (holocytochrome c synthase), attaches heme to apo-cytochrome c (Cyc1p or Cyc7p) in the mitochondrial intermembrane space; human ortholog may have a role in microphthalmia with linear skin defects (MLS); Cyc3p (YAL039C) [Saccharomyces cerevisiae], from S.cerevisiae

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MGWFWADQKTTGKDIGGAAVSSMSGCPVMHESSSSSPPSSECPVMQGDNDRINPLNNMPELAASKQPGQKMDLPVDRTISSIPKSPDSNEFWEYPSPQQMYNAMVRKGKIGGSGEVAEDAVESMVQVHNFLNEGCWQEVLEWEKPHTDESHVQPKLLKFMGKPGVLSPRARWMHLCGLLFPSHFSQELPFDRHDWIVLRGERKAEQQPPTFKEVRYVLDFYGGPDDENGMPTFHVDVRPALDSLDNAKDRMTRFLDRMISGPSSSSSAPLast
1 -77.500[CO] KOG3996 Holocytochrome c synthase/heme-lyase  ali follow..  36  135....AGVSEVLTGVDSKQQSYVPEGCPVATPKRGWFNWFGNNDDQKQEAYEVDKSNMMYNIPQTAVDDQVVGLETTRTTSSIPKVD--GKNWEYPSPQQMYNAMWRKGY-----RDSGENVPIMVQVHNFLNEGAWSEIKAWEREA--GENTEPKLLRFEGNANKRTPRALWYMMLGRINPNRWSGEGPFDRHDWYVQRKD---------NSIVRYVIDYYEAPDSADGKPVFSLDVRPAVDSFESVALRWKHWRAMRQMQQQ...... 377
2 -6.860[S] COG2840 Uncharacterized protein conserved in bacteria  ali follow..  12  18..........................................PLKRHTDVHWQPTRNLKTPQRIDTLQLDNFLTTGFLDIL---PLNEPLEFRREGLQQGVIDKLRSGK----------PQQASLNLLRQPVETCRKMLFRFILEAQKEGLRNVLIIHGKGREAK-SHANIVRSYV----------------ARWL---------------TEFEDVQAYCSALPHHGGGGACYVALRKTVQAKQDNWERHAK................ 184
3 -6.680[L] KOG0981 DNA topoisomerase I  ali follow..  7  53.....ESDEDDIPIRKRRASSKKNMSNSSSKKRAKVMGNGGLKNGKKTAVVKEEEDFNEIAKPSPKHKRVSKANGSKNGAKSAVKKEESDTDDSVPLRAVSTVSLTPYKSELPSGASTTQNRSPNDEEDEDEDYKWWT-QKWTTLEHNGVIFAPPYLIYDGNPVNLPPEAEVAGFYAAMLETDHAKNPVFQDNDFVCDECNFNHNIKEFSKCDFTQMFHHFEQKREEKKSMP..................................... 299
4 -6.000[BK] COG5259 RSC chromatin remodeling complex subunit RSC8  ali follow..  14  1...........................................MSDTEKDKDVPMVDSHEATEEPPTTSTNTPSFPHLAQEQAKEESATLGAEVAHKKINYEQEAQKLEEKALRFLAKQTHPVIIPSFA-----SW---FDISKIHEIEKRSNPDF--FNDSSRFKTPKAY----------------------------------------KDTRFIINTYRLSPYE----LTITAVRRNVAMDVASIVKIHAFLEKW........... 163
5 -5.850[K] KOG3786 RNA polymerase II assessory factor Cdc73p  ali follow..  10  338.....SSIKQGHHAVQKAPDAPPGRPPLAKPIQLLTSSTATSSGSSAAQNGSKRTSRSPIIIVPSAMNTMINLYNVRDI--------QNFSYVPVDQRR--DLAIQRQKNGVTSKNSKKKQKLVIDNAEKLANDDWDRVIAWQ---------------FKGWKWNGNPTDIFTHIPAFHF----QDKPVAQVMQWNVHKIPVSATKRHMDKARFS---QVWETIEN------FVRKNKPHLTARLGL...................... 574
6 -5.630[R] KOG3840 Uncharaterized conserved protein, contains BTB/POZ domain  ali follow..  13  20.....SATSSSSQAGPSASTSTARKSSLVGGRGSASSSGHTSPSPSESPARNAGCSSSGESNPDRSLTTPPLAPALKHSAKDGHYRGQRSMSLGGPAHEMLMSQLGGRQGNTVDCSPGEGDKVCLLVDQ---------------------------TRFLVSQRLLTPDT----MLGRMFSMRASCGDPNERDEFEVAD---------MTSSCFRAILDYYQSGTMRCPSSVSVSELREACDYLL........................ 229
7 -5.480[S] COG3236 Uncharacterized protein conserved in bacteria  ali follow..  12  1.........................................................MPVRAQRIQHVMQDTIDDYGDFSNFAAWPIKVDGKTWPTSEHYFQAQKFLDEKYREEIRRVSSPMVAARMGRDRSRKNWESVKE-------QVMRKALRAKFEQHAE-------LRALLLATAPAKLVEHTENDAY-WGDGGHGKGKNRLGYLLMELREQL................................................... 156
8 -5.440[G] COG5020 Mannosyltransferase  ali follow..  11  37.................VSEPASVDGTMGNFLPFSKMDLATKRDRPFYSNCVNTQDYLLNPSYIKQNASFVMLTRNGELEDVIKTEHFNQWFHYP---VFLN----------DQPFEEDFKAKVRDVFGTIDEISWNFPSDVKDTFEFYNAIEDQGDRSILYGNLESYHKMCRFYSGLFY-----KHPLVQKYEWY------RLEPDVEFFCDITY--DPFLEMLRTNKKYGFTIIIPELYWTVPNLFRHTKSFISQ............ 264
9 -5.440[G] KOG4472 Glycolipid 2-alpha-mannosyltransferase (alpha-1,2-mannosyltransferase)  ali follow..  11  37.................VSEPASVDGTMGNFLPFSKMDLATKRDRPFYSNCVNTQDYLLNPSYIKQNASFVMLTRNGELEDVIKTEHFNQWFHYP---VFLN----------DQPFEEDFKAKVRDVFGTIDEISWNFPSDVKDTFEFYNAIEDQGDRSILYGNLESYHKMCRFYSGLFY-----KHPLVQKYEWY------RLEPDVEFFCDITY--DPFLEMLRTNKKYGFTIIIPELYWTVPNLFRHTKSFISQ............ 264
10 -5.400[O] COG3555 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases  ali follow..  11  50..............................................................................VPNRPYLAPQTFPELQVLVDN-WQAIRSEALHLHDAGNIKRSEQYDDIGFNSFFKSGWKRLKWYDEAHPSAGQLCPQTTALLRQ-AELPPGSKLVRHRDPYLRFHLGLFTP-ERYHWRDGEAETFIHYAENATEHNRIIL---------------FCDIRPLTQGWATAFNRW.................. 234
FFAS is supported by the NIH grant R01-GM087218-01
1 4 8 3 1 9   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Ye Y, Godzik A. Multiple flexible structure alignment using partial order graphs. Bioinformatics. 2005 Mar 3;