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Query: gi|41629666|ref|NP_009345.2| Multistep regulator of cAMP-PKA signaling; inhibits PKA downstream of Gpa2p and Cyr1p, thereby increasing cAMP dependency; inhibits Ras activity through direct interactions with Ira1p/2p; regulated by G-alpha protein Gpa2p; homolog of Gpb1p; Gpb2p (YAL056W) [Saccharomyces cerevisiae], from S.cerevisiae

Results of FFAS03 search in CSGID
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MEISSSPWNDGGYSPYERNRVAVSPFSSALEGEERIETSRSLGDHCFEPLPYVTNYLSIFALFGKEIFGDKGNVSSRNEYLLKKYYSLKKPFVLRHNGHALKNPDMPLQRNDILQTNFMVDKFLNRTVRSVNFNNFKIISDMQSKSGRGTKSGTNQNQSADAIQNICLPSIPSALPYFQYYRKLLTVNTKEWDILKLHSLWVPKLRKDFKDFSLYGDKNSLKPIDSHYDEDNTMKKNLFFERSPSRQTLDGKGCASKGYDISSGNMIIPSLFSEDKLPALTYHCSVELNGNIYIFGGLMPCYSYEEDAPMLNDFFVDGIKNLPPPLLPQVINNPSMVNNPHLYVASIPSCRFSKPKMGGYIPPPLLCVQGSKLTDRHIFFYGGFEIRTETRGDENGKYHLKKRLYVNNTGYILDIMSFKFTKIDIIVQPSKYNAYPTMSSRFGHLQISIDNPNRRASVHSSSMNEIHKMGSASMKQGSSITSGRLEKAAVLSSLPHNTVHTVIIFGGYRQTGDDRYEAMNDLWKIEIPVIRRGKKGYCKFSETANAILLTPSEKDKSDWPEERAFSAFSVHGTSLMDRSSLDMRLLNNLKNHFVLKPSYISQDRVVSPKPVFPMMVHGTHQDLFNSGSAAQESPKAGASASSASAASFDPDMDDNLENYIINPGRKSSSIPMTAIGRQRLILSQEKPVGKTVVLHGGSNGLNVLDDMWLMDLECETWTPIETFAKADSSEDGDEKLDSVNVGLVGHRMESIGRICVCIGGMVQEDVDQFYSENDDEPPRKRKVDTLPLGGNFLNTIDLSTQFWEEHKITLSKKAADEDRQDSENEDTNSNIVVGVGGTSLQCDKSIILIGGLISRRSNVKEIYLHGTITKSIFPSVNPSALast
1 -27.000IDP04233 putative lipoprotein [Clostridium perfringens ATCC 13124] CPF_0722 [Clostridium perfringens ATCC 13124]  ali follow..  12  5..........................................................................................................................................................................................................................................................................................WKYGVLLALPLVLAGCGNKPS-----------------------------------EGSNKNKEITSIKWTVD---GALEAQKTAGLLYGKTKDYIVVGGGANFPEEPVAKGGAK-------KLYPDIYVLKNENGDLKQVDHTTLDYE----------------------------------------------------------IGYGSSITTEEGIYYVGGSPNKE-----EGNNVSLITTDEKGKIG-------------------KHIGDLPFTFSDGFAVKKDKDIYLGLGKQDGKASNKVYKFNVETGKTEE---------------------------------------------------------------------KEIPGEPTRNQAVAQLLGDDIYVFSGGDK-IAYTDGYKYSIKDNSWTQVADVKIGSEEISL----------LGANSVKLNEDEMLVIGGFNKAVYDDAVKNLNTLKDESLAEFKKFAWNTKVLIYNSKNNEWK--------------------SIGDVPFNAPCGEALILDGDNIFSINGEIKPGIRTNKIYSGELIYK.......... 383
2 -21.400IDP90191 gene: CPXV193 CDS; CPXV193 protein AAM13632.1 [Cowpox virus (Brighton Red)]  ali follow..  11  1...............MHNSSELIAVINGFRNSGRFCDINIVINDERINALSGASEYFSIL--SSDFIDSNDYEVNLSHNDLIDYIYGIP--------SLTNDNVKYILSTADFLQIGSAITKYILKNLCSRN-YIYADKYNNKKIESASFNTILRNILRLINDENFKYLTEESMIKILS--DMLNIKN--EDFAPLILIKWLESTQQPYSHRLVSSIYECITFLNNIAFLDESFPRYHSIELISIGISNSHDKISINCYNRKKNTWEMIS-----SRRYRCSFAVAVLDNIIYMMGGY----------------------------------DQSPYRSSKVIAYNTCTNSWIY--DIPELKYPRSNCGGVAD-DEYIYCIGGIR---------------DQDSSLISSIDRWKPSKPYWQTYAKMREP------------------------------------------------------------KCDMGVAMLNGLIYVIGGIVKGDDALESLSEDGWM------------------------------KHQRLPIKMSNMSTIVHA---------------------------------------------------------------------------------------------------------------------GKIYISGGYNNSSPSNLVLSYNPIYDEWTKLS----------------SLNIPRINPALWSAHNKLYVGGGISNDQTTT------------------------SETYDKEKDCWT-------------------LDNGHVLPRNYIMYKCEPIKHKYPLEKIQYTN-DFLKCLESFI-------DS..... 563
3 -20.400IDP90209 gene: m140R; m140R MYXV_gp144 [Myxoma virus (strain Lausanne)]  ali follow..  11  24................................DVTLVTDDDVSIHAHK-LSASSTYFYMFSHDFIEKDRNVINVCVEYRALLINFYSGTLRLTDDTVDCILVAADYLQILEASELAENFILARLR-AENCLHYYEFSKRYNRRHIFNVVITTIIHNIVSVLRQPNFKTIELCDLQNILS--DDLNVID--EDVCAVVLVTWLMSVKNLLLKTPCIRNKRYVQSLAKLDHSPRPPTQGCILSIGGRKYYDDITSSPVELYSPVDDVWTTVSYLPT----HRQFFSVAVLDFVVYVVGGLQDSVSV-----------------------------------ASVSSYDVKTNEWKECP---PLKSPRHGCGLVVLRDK-LIVIGGKGRNSYL-----------------KDVDYWRPTYATWRKLCSLREA------------------------------------------------------------RTNVGAAVVRNKVYTIGGIRSVEDTVECLQNNKWV------------------------------AKKSLPEPKACLAVAPYKHFIYAAGGYAINGRGTVVTKTNTLYMYNVELDDWFYLPMM----------------------------------------------------------------ELSRNDASLCVLGKDLYVVGGFVGSGYTNSVEKYNHKTNNWERII----------------PCKSPKYGHCSVVLNHECPWK.......................................................................................................................... 550
4 -20.400IDP90219 gene: m008L; m008L, m8 MYXV_gp011 [Myxoma virus (strain Lausanne)]  ali follow..  10  3......................SYPLYKLFLKGKLCDVEIVAEGKSIR-LSAYSKYFNLFNGNFLEKNVDVIDLEADYKTVVIYYYTES--------ELHKGNTESIFSLVHYLQIKPLIKYEFNSIVNEENCIRLFKFAELYD-LSELKRRARWLMPSLVMNEKDRLREMS--------LDDLSLMLVQIRNTVDRSIAWIVRERRRHAVHLATCLGDVPGTASSRAVYKHYMSELRIRVTEFQPAYHNSMKGRVTALDPETGKSVVLSTW--WPEERWECFTAVCMNDVLYFAGGKLDA-----------------------------------VPTRQVLSYDVKANTWSRQP---NLSEFRSDAAAYAIGGC-IYIIGGYDANDRPT----------------NTTLYWRPGYDRWYRGPTLVEA------------------------------------------------------------VAETSAVCYKNEIWVLGGRIHRDGVPQKLSGGTWT------------------------------KVNELSVPKASVTAIVYK---------------------------------------------------------------------------------------------------------------------ERLYCVGGVDRYAPTNEVIRYRDDTNEWEYVG----------------STKIERGGAVGCVYNDELYVFGGTDTFTS-ERYNGVIWKRANDVSCHFATMNAAYATYLEL.................................................................................. 515
5 -20.300IDP90201 gene: CPXV215 CDS; CPXV215 Protein AAM13653.1 [Cowpox virus (Brighton Red)]  ali follow..  1MDIENDIRNRRIIRNISNLLDD----------DVIITIRDGEEIKAHK-LAAGSTYFKTMFTTPMIARDLVTRVNLQMKNIVQYLYNRH---------ISSMNVIDVLKCADYLLIDDLVASYIKDYTNHDT-YHKLYEMIHIPIVKYIKRMLMSNIPTLITTDAFKKTVFEILFDIISTNDNVYLYR--EGYKVTILLKWLQNLDKKSRLLLYSNKTINMYPSCIQFLIDNKQNRNIIPRQLCLVCHDTKYNVCNPCILVYNINTMEYSVISTIPNH-IINYASAIVDNEIIIAGGYNFNNPSLNKVYKIN---ENKIHVELPPMIKNRCRFSLAVIDDTIYAYTMGDDKWKLLP---DMPIALSSYGMCVL-DQYIYIIGGSTLYIDYTSVHANSIDMEEDTDTSNKVIRYDTVNNIWETLP-----------NFWTGTIKPGVVSHEDDIYVVCDIKDEKNVKTCIFRYNTNTYNGWELVTTTESRLSALHTILHDNTIMMLHCYESYMLDTFNVYTREWN.................................................................................................................................................................................................................................................................................................................................................................... 538
6 -19.000IDP90215 gene: m006L; m006L, m6 MYXV_gp009 [Myxoma virus (strain Lausanne)]  ali follow..  2......................ERTLVSFLDSGTMSDITLVAGETSFTALSVHSDYFRLFNGSFEVPDTITLDTDDGVLRTVLRYYTGYSNI----RDRTVEDLQSIIVLADYLGITKLVKDYMVSRVDPTNCVSAFQFAETYH-IEDLKRNLNTFLPELLLNSRGAFTKLDT--------DEAVVVLRASYEIVDRRFVWVRKGPKRIERIKTLSAAIGDDVEQDDVYDVYARYVEEVKDIPRNPIVTIDRRRYIRAFNPETSWNT--RIAHVDRIEVDDRFTAVCIDNVLYCLGGTLKHI-----------------------------------PTSDVLGYDLLTGDCTPMP---SMRQCRRNASACGVNGC-VYAIGGIDEEDRLI----------------PDVEYWTPEEDEEWYFG-----------RYLYPNVEAAVACYKN-------------------------------------------------ELWVAGGTCGLYPAVNRLTEDGWV------------------------------EMAPLPTPRSGASMVVYK---------------------------------------------------------------------------------------------------------------------GRLYCVGGRTNEHTTNHVYRYDDDRGAWERVE----------------NMTESRRNPICCVYNNALYVFGGRTNSA--ETYNGWKWHR-------------NDVSLYTGCTNTAC............................................................................ 503
7 -18.700IDP90196 gene: CPXV204 CDS; CPXV204 protein AAM13643.1 [Cowpox virus (Brighton Red)]  ali follow..  11  3................................SITITVGNLTIRSNLQTLVNKSSYFDILKCGNSTNNITLCDFQEDAIYRVMQFNNDIIEIESTKDVESMIWHAKQLGVESLLKE----QNYLLKILRIYN-YRITNINALSYIYNNVRNFILDNILLIYKDPDFIYLPKYIIIDLLS--DHLNVFN--EDNVVKIIYTYISSDIYKDISDILPVIRWNYLSPEGNVDKTIVHKKRCYCGIVTVNYNRDKGLMIISKHGSELETEFSFSIKTD----IVDKFETVYLNKKIYIIGGVKQKGE----------------------------------STNQVLSVDLSTKRLTIEP---SLNDKRIGAAATVVNGR-IYVIGGRDGSNYL-----------------NTVESWKPMDNKWRYET-----------PINYKRSSASAVSVNN-------------------------------------------------TIFVTGGLFINDSNSMIVINNMEKLDIYKDKQ---------------------WSIIEMPIARVYHGIDSTF---------------------------------------------------------------------------------------------------------------------GMLYLAGGLSVTEKSNEISCYNPRTNKWFDIS----------------YNIYKRSISSLCKLNNVFYVFSKDIGY.................................................................................................................... 475
8 -18.500IDP90171 gene: CPXV013 CDS; CPXV013 protein AAM13460.1 [Cowpox virus (Brighton Red)]  ali follow..  10  17..............................................DKKLLCSYSFFKNRFEFDDTTDINLTSYDNHDKKLIMFINTNE--------DIDEDNVQDMLVLADSLNITKAIDEFIKERLDAINCLDIITYAAFYEDLKLAAINTTATNFTHVVKDDTFISLPFDIISSIFENDDLDTKS--EDEAMDALCIWM-MVKENISKLIRVDELLSKKYILNELGCENLPPSVPRKSSSGVLYAVGISPDDDTMYNRVENEWKIVSDIPF----KAINCMIAAIGDIVYIMCGKQTYNF----------------------------------TTTNVYSYNTKTNIWKKEP---STVYPRANAGLAVVND-YIYLIGGTAEPHSDTDTDSARFT--NNRYYNPTIERRSPEDGKWRVLKMT------------------------------------------------------------MPVAGICSATSIGDNIYIIINSYKGVIYRCDTKILRWRKCIKLKS-----------------------------SYTANSAIIAYNGGIYCINRFKNIEYRDDTKSYN-------------------------------------------------------------------------YIEKLTIHRYRYRYNYSLAVLGDELFMIGGVDITNATHDVDVYNHKTNRWISLK----------------QNKLHSLERQFVTFVRK.............................................................................................................................. 523
9 -18.500IDP90115 kelch-like protein [Monkeypox virus] MPXV_ZAI1979_005_024 [Monkeypox virus]  ali follow..  14  50................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................TIVGNTDRQFYDANVLHNCLYIIGGMINNRHVYSVSRVDLKTKKWKTVT----------------NMSSLKSEVSTCVNDGKLYVIGGLEFS-----------------------ISTGIAEYLKHGTSKWK---------------------RLPNLITPRYSGASVFVNDDIYVMGGVYTTMRNM..................... 176
10 -17.600IDP90183 gene: CPXV035 CDS; CPXV035 protein AAM13482.1 [Cowpox virus (Brighton Red)]  ali follow..  12  25.....................................................YNFFKRI-----DHHLKDEAIILNGESLLDYMRWKK--------NITINNVEMILVAAVIIDVPPVVDKTMIHNINSTN-FNFSKKYRIKKLYNASMSEIINNITAVTSDPEFGKLSKDELTTILS--EDVNVNH--EDVTAMILLKWIHKNPNDVDKFMTNAMRNAISLLGLTISKSIKPVTRNGIKHNIVIIKNSDYISTITHYSPRTEYWTIVGNT------DRQFYNANVLHNCLYIIGGMINNRHV-----------------------------------YSVSRVDLKTKKWKTVT---NMSSLKSEVSTCVNDGK-LYVIGGLEFSIST-----------------GVAEYLKHDTSKWIRLP-----------NLITPRYSGASVFVND-------------------------------------------------DIYVMGGVY-TTYEKYVVLNDVECFT-----------------------KNRWIKKSPMPRHHSIVYAVEYD---------------------------------------------------------------------------------------------------------------------GDIYVITGITHET-RNYLYKYIVKEDKWIELY----------------MYFNHVGKMFVCSCGDYILIIADAKYE-----YYPKSNT-------NLFDMSTRNIEYYDMFTKDETPK---------------------CNVTRKSLPSFLSNCEKQFL................................. 511
11 -17.100IDP90188 gene: CPXV050 CDS; CPXV050 protein AAM13496.1 [Cowpox virus (Brighton Red)]  ali follow..  12  40.................................................LKKLSPYFTHLRQKYTKNKDPVTRVCLD-TSIVIYSYTGK--------YIDSHNVVNLLRASILTSVEFIIYNFILRDFRKEYCVECYMMGIEYSNLLCHTKDFIAKHFLELEDDIIDNFDYLSMKLILE--DELNVPD--EDYVVDFVIKWYMKRRNRLGNLL---------LLIKNVIRSNYLSPRGINNVKWILDCTKIFHCDKRPRKSYRYPFIEYPMNMDQIIDIFHMCTSTHVGEVVYLIGGWMNNEIH-----------------------------------NHAIALNCVSNNWIPIP---PMNSPRLYASGVPANNK-LYVVGGLP---------------------PTSVERWFHGDTSWVNMP-----------SLLKPRCNPAIASINN-------------------------------------------------VIYVIGGHSETDTEYLLPDHDQWQF-------------------------------PSTYYPHYKSCALVFGRRLFLVGRNAEFYCEYSNT-------------------------------------------------------------------------------NLIDDPIYPRDNPELIIVDNKLLLIGGFYRGSYIDTIEVYNNRTYSWNIWDGK............................................................................................................................................................. 480
12 -17.000IDP90125 kelch-like protein [Monkeypox virus] MPXV_ZAI1979_005_038 [Monkeypox virus]  ali follow..  12  40.................................................LKKLSPYFTHLRQKYTKNKDPVTRVCLD-TSIVIYSYTGK--------YIDSHNVVNLLRASILTSVEFIIYNFILRDFRKEYCIECYMMGIEYSNLLCHTKDFITKHFLELEDDIIDNFDYLSMKLILE--DELNVPD--EDYVVDFVIKWYMRRRNRLGNLLLL----------KNVIRSNYLSPRGIHNVKWILDCNKIFHCDKQPRKSYKYPFIEYPMNMDQIIDIFHMCTSTHVGEVVYLIGGWMNNEIH-----------------------------------NNAIAVNYISNNWIPIP---PMNSPRLYASGIPANNK-LYVVGGLP---------------------PTSVERWFHGDAAWVNMP-----------SLLKPRCNPAVASINN-------------------------------------------------VIYVMGGHSETDTEYLLPNHDQWQF-------------------------------PSTYYPHYKSCALVFGRRLFLVGRNAEFYCESSNT-------------------------------------------------------------------------------TLIDDPIYPRDNPELIIVDNKLLLIGGFYRGSYIDTIEVYNNRTYSWNIWN............................................................................................................................................................... 478

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Friedberg I. and Godzik A Connecting the Protein Structure Universe by Using Sparse Recurring Fragments. Structure (Camb.) (2005) Aug;13(8):1213-24