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Query: gi|6319257|ref|NP_009340.1| Putative medium-chain alcohol dehydrogenase with similarity to BDH1; transcription induced by constitutively active PDR1 and PDR3; BDH2 is an essential gene; Bdh2p (YAL061W) [Saccharomyces cerevisiae], from S.cerevisiae

Results of FFAS03 search in CSGID
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MRALAYFGKGNIRFTNHLKEPHIVAPDELVIDIEWCGICGTDLHEYTDGPIFFPEDGHTHEISHNPLPQAMGHEMAGTVLEVGPGVKNLKVGDKVVVEPTGTCRDRYRWPLSPNVDKEWCAACKKGYYNICSYLGLCGAGVQSGGFAERVVMNESHCYKVPDFVPLDVAALIQPLAVCWHAIRVCEFKAGSTALIIGAGPIGLGTILALNAAGCKDIVVSEPAKVRRELAEKMGARVYDPTAHAAKESIDYLRSIADGGDGFDYTFDCSGLEVTLNAAIQCLTFRGTAVNLAMWGHHKIQFSPMDITLHERKYTGSMCYTHHDFEAVIEALEEGRIDIDRARHMITGRVNIEDGLDGAIMKLINEKESTIKIILTPNNHGELNREADNEKKEISELSSRKDQERLRESINEAKLRHTLast
1 -78.800IDP02503 gene: gutB; putative zinc-binding dehydrogenase [Yersinia pestis CO92] YPO2502 [Yersinia pestis CO92]  ali follow..  25  61MSAVVCHGPQDYRLEH-VPTPV-PKAKELVIKVKGCGICAGDCKCKNGAKMF------WGETPWVKPPVVPGHEFYGHIVALGEGTESYKLGERVIAEQIVPCWD--------------CRYCNSGSYWMCETHNIYGFDVAEGGMAEYMRFSENAVHKIPESLSHEDAVLIEPMACAIHTVARGDIQLDDVVVLAGAGPLGLCMVPVARLKTPKKLIVIDTIEERLALAKAFGADVV---INPLKEDADKIVKSLTGGYGCDVYIEATGAPIGVTQGLQMIRKLGRFVEFSVFGQETTVDWSIIGDRKELDIRGAHLAP-YSYEIATDLFERGLVTS---KGIVTHSYSLDD-WEKAFELA--DSTNSIKVILVP......................................... 408
2 -78.300IDP04681 gene: adhB; alcohol dehydrogenase, zinc-containing [Bacillus anthracis str. `Ames Ancestor`] GBAA3131 [Bacillus anthracis str. `Ames Ancestor`]  ali follow..  20  1MKAVTYQGPNQVQVKQ-VDDAKLEKKDDIIVKITSTAICGSDLHLYQGN-------------MPLPQGYIIGHEPMGIVEEVGPDVTKVKKGDRVVIPFNVACGH--------------CFYCQHEMESQCDNSNPHYDSGHPGGQVEYLKVPFGTPFVIPESCELEDESLLDVLPTAYWSVINAGVKPGDTVIVLGCGPVGLMTQKFAWMHGAKRVIAVDYLDYRINYAKKINNVEV---FEFTKFPDMGEHLKEITHGGADVVIDCVGMDGPIQIATKAVRKYGTVQMTGVYGGNYNAFPLGAFWVRNINLKMGQAPVIHFMPELFEKITNKEFDP---KEIITHKIPLEE-ASYGYQIFNNREDDCIKVILKP......................................... 377
3 -77.400IDP00931 gene: ybdR; putative dehydrogenase STM0615 [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]  ali follow..  22  1MKALTYHGPHHVKVEN-VPDPGIEQPDDIILRVTATAICGSDLHLYRGK------------IPQVKHGDIFGHEFMGEVVETGHDVKNIRKGDRVVIPFVIACGD--------------CFFCRLQQYSACENTNDGHGAGVPGGQAEYVRVPKGGPFKVPPLLSDDKALFLDILPTAWQAAKNAQIQQGFSVAVFGAGPVGLLTIACARLLGAEQIFVVDHHAWRLRFAEERYGAIPINF-DDENDPAEKIIEQTAGHRGVDAVIDAVGFEAALRQCIAAVRRGGVVSVPGVYAGFIHGFLFGDAFDKGLTFKMGQTHVHAWLGELLPLIEKGLLKP---EEIVTHYMPFEEA-ARGYEIFEKREEECRKVILVPGATSAQAAQKQA............................. 400
4 -55.900IDP90877 oxidoreductase, zinc-binding dehydrogenase family [Campylobacter jejuni subsp. jejuni NCTC 11168] Cj1548c [Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819]  ali follow..  19  13SKGYAMLSKDAKFTPFEFSRHA-IGDNDILIKILYAGICHSDIHTARSE-------------GEATYPCVPGHEIAGEVIAVGKNVSKFKVGDYAGVGCMVSCGE--------------CDACKRSQEQFCENGKTIFTYNTYGGYSNNIVVSEKFAVCVPKDAPMEKVA---PLLCAYSPLKFSNIKEGSSVAVAGFGGLGMMAVKYAVKMGA-KVSVFARNENKKADALAMGVSSFYTSCDKNAV-----------KERFDLIISTIPTPYNPAIYLDLLKFGGEMAIVGLPPHEVSISVITFVHKAGKKVYGSLIGGIAETQEMLDFSLKHGIYP------ETELITPQE-IDKAYENLTSGKAKFRYVIDMTKE....................................... 358
5 -41.000IDP04685 alcohol dehydrogenase, zinc-containing [Bacillus anthracis str. `Ames Ancestor`] GBAA3438 [Bacillus anthracis str. `Ames Ancestor`]  ali follow..  19  1MKAQIIFGDSSVFQLEEVSKPK-LLPGHVLIDVKATSVNPIDTKMRSG----------AVSAVAPEFPAILHGDVAGIVIEVGEGVSKFKCGDEVYGCAGGFKET-------------------------------------GGALAEFMLADARLIAHKPNNITMEEAAAL-PLVTAWESLDRANIKSGQNVLIHGTGGVGHVAIQLAKWAGA-NVFTTASQQNKMEIAHRLGADAINYKEESVQESVQEYVQKHTNGNGFEVIFDTVG-GKNLDNSFEAAAVNGTVVTIAARSTHDLS----PLHAKGLSLHVTFMALKEILTKITKIVEEGKLRP-----LDSKSFTFDEVAQA--HEYLESNKAIGKIVLKN......................................... 333
6 -37.600IDP00076 gene: yhdH; putative oxidoreductase NT01ST4228 [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]  ali follow..  14  1MQALILQDGKTLASVQHLEESQ-LPAGDVTVDVHWSSLNYKDALAITGKGKIIR-----------HFPMIPGIDFAGTVHASE--DPRFHAGQEVLLTGW---------------------------------------ENHWGGLAERARVKGDWLVALPAGLSSRNAMIIGTAGFTAMLCDAGIRPQDGEVVVTGAGGVGSTAVALLHKLGY-QVAAVSGRESTHGYLKSLGANRILSRDEFA-------ESRPLEKQLWAGAIDTVGDK-VLAKVLAQMNYGGCVAACGLAGGFALPTTVMPFILRNVRLQGVDSVMTPPARRAEAWARLVKDLPESFYAQAATEITLAD-APKFADAIINNQVQG-RTLVKIK........................................ 324
7 -10.300IDP90674 gene: hemA; glutamyl-tRNA reductase [Campylobacter jejuni subsp. jejuni NCTC 11168] Cj0542 [Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819]  ali follow..  12  9......HKNTDIALREKLSFSNEAKKGEFLKIISTISTCNVEIVAFVKMACAEFIVKSLALLCDVDKDILLEKGAIHHLFSVASSLDSLVVGETQIA----------------------------GQLK-----DAFAFAVKNNFCGVHLSRAVHSAFKCAAKVRNETQISKNSISVASVAVAKAK--TQKKAVVIGAGEMGELAAKHLIAAGAKVIILNRDLQKAKDLCERLGVLSEYDSLENLKKYLNQ----------YEFFFSATNAPNAIITNSLIEELSYKRYFFDIAVPRDIDIN---------ENENISVFAVDDLEIVVQ-LALREQEARMAYGII------GRETSEFFRYLNDLALMPIIKAIRLQAKEYADKQLEIALKKGYLKKSDKEEARKLIHQVFKAFLHT 382
8 -9.200IDP04169 gene: hemA; glutamyl-tRNA reductase [Vibrio cholerae O1 biovar eltor str. N16961] VC2180 [Vibrio cholerae O1 biovar El Tor str. N16961]  ali follow..  11  1MSLLAIHNTASVELREKVAFGPEKLSLALVKGGVILSTCNTEIYCDVRSASKNKVIEWLSQFHQVSLDELKPSAAIRHLMRVACGLDSLVLGEPQIL----------------------------GQVK-----QAYAEARENHAVNPATEKLFQKAFSVAKRVRTETEIGGSAVSVAYAACTLAKHIFESTVLLVGAGETIELVAKHLAGHHCKRMIVANRTRERLSLAQQFGADVIA-------NEIPDYLAQ------ADIVISSTASPLPI-ESALKARRHQPMLLVDIAVPRDIEPQVG-------KLNDAYLYSVDDLQSIVD-IEQRKVEAIQAEAIV------SEESATFMSWMRSLQAVDSIRDYRKQANEAREELLNKSLQALAAGGDPEKLLIELSNKLTNKLIHT 389
9 -9.120IDP91454 gene: hemA; glutamyl-tRNA reductase [Vibrio vulnificus CMCP6] VV1_0254 [Vibrio vulnificus CMCP6]  ali follow..  12  1MSLLAIHHTASVDLREKVAFGPDKLANALVNGSVILSTCNTEVYCDVKSGARSKVIDWLSQFHQIGLEELKPSAAIRHLMRVSCGLDSLVLGEPQIL----------------------------GQVK-----QAYSDSREQQAVDASLEKLFQKTFSVAKRVRTETDIGGNAVSVAYAACTLAKHIFESTVLLVGAGETIELVAKHLHANGCSKMIVANRTRERLTLAEQFDAQVIS-------QEIPNHLAK------ADIVISSTASPLPI-ETALKQRRHQPMLLVDIAVPRDVEAQVG-------DLNDAYLYTVDDLQSIID-IEQRKVEAIQAEAIV------AEESAAFMSWLRSLQAVDSIREYRQSANEIREDLLSKALLSLESGSDPEKVLRELSNRLTNKLIHA 389
10 -8.890IDP02273 hypothetical protein GBAA3714 [Bacillus anthracis str. `Ames Ancestor`] GBAA3714 [Bacillus anthracis str. `Ames Ancestor`]  ali follow..  85.....................................................................................................................................................................................IEHLQLQGRERILEVGCAN-GKFLSLLQANGHKGQLTGFDQSEAMLSEATKTNNLIEWRLGDAGKLPFEA--------NYYDLIVARHMLEKTIQGFHKVIHPGGSLLATTNSNVTLPRIPKTTSSVTPFCLENGKEILQSVFPTVEVSVIHNALIFHHATPIVNYISSMFDWLKEEVENELLLHNGIWRD............................................. 301

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Friedberg I. and Godzik A Connecting the Protein Structure Universe by Using Sparse Recurring Fragments. Structure (Camb.) (2005) Aug;13(8):1213-24