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Query: gi|6319258|ref|NP_009341.1| NAD-dependent (R,R)-butanediol dehydrogenase, catalyzes oxidation of (R,R)-2,3-butanediol to (3R)-acetoin, oxidation of meso-butanediol to (3S)-acetoin, and reduction of acetoin; enhances use of 2,3-butanediol as an aerobic carbon source; Bdh1p (YAL060W) [Saccharomyces cerevisiae], from S.cerevisiae

Results of FFAS03 search in CSGID
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MRALAYFKKGDIHFTNDIPRPEIQTDDEVIIDVSWCGICGSDLHEYLDGPIFMPKDGECHKLSNAALPLAMGHEMSGIVSKVGPKVTKVKVGDHVVVDAASSCADLHCWPHSKFYNSKPCDACQRGSENLCTHAGFVGLGVISGGFAEQVVVSQHHIIPVPKEIPLDVAALVEPLSVTWHAVKISGFKKGSSALVLGAGPIGLCTILVLKGMGASKIVVSEIAERRIEMAKKLGVEVFNPSKHGHKSIEILRGLTKSHDGFDYSYDCSGIQVTFETSLKALTFKGTATNIAVWGPKPVPFQPMDVTLQEKVMTGSIGYVVEAFEEVVRAIHNGDIAMEDCKQLITGKQRIEDGWEKGFQELMDHKESNVKILLTPNNHGEMKLast
1 -78.500IDP00931 gene: ybdR; putative dehydrogenase STM0615 [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]  ali follow..  23  1MKALTYHGPHHVKV-ENVPDPGIEQPDDIILRVTATAICGSDLHLYRGK------------IPQVKHGDIFGHEFMGEVVETGHDVKNIRKGDRVVIPFVIACGD--------------CFFCRLQQYSACENTNDGHGAGVPGGQAEYVRVPKGGPFKVPPLLSDDKALFLDILPTAWQAAKNAQIQQGFSVAVFGAGPVGLLTIACARLLGAEQIFVVDHHAWRLRFAEERYGAIPINFDDENDPAEKIIEQTAGHRGVDAVIDAVGFEAALRQCIAAVRRGGVVSVPGVYAGFIHGFLFGDAFDKGLTFKMGQTHVHAWLGELLPLIEKGLL---KPEEIVTHYMPFEEA-ARGYEIFEKREEECRKVILVPGATSAQA 395
2 -77.700IDP02503 gene: gutB; putative zinc-binding dehydrogenase [Yersinia pestis CO92] YPO2502 [Yersinia pestis CO92]  ali follow..  24  61MSAVVCHGPQDYRL-EHVPTPV-PKAKELVIKVKGCGICAGDCKCKNGAKMFWG------ETPWVKPPVVPGHEFYGHIVALGEGTSKYKLGERVIAEQIVPCWD--------------CRYCNSGSYWMCETHNIYGFDVAEGGMAEYMRFSENAVHKIPESLSHEDAVLIEPMACAIHTVARGDIQLDDVVVLAGAGPLGLCMVPVARLKTPKKLIVIDTIEERLALAKAFGADVVINPLK-EDADKIVKSLTGG-YGCDVYIEATGAPIGVTQGLQMIRKLGRFVEFSVFGQETTVDWSIIGDRKELDIRGAHLA-PYSYEIATDLFERGLV---TSKGIVTHSYSLDD-WEKAFELADSTN--SIKVILVP....... 408
3 -77.600IDP04681 gene: adhB; alcohol dehydrogenase, zinc-containing [Bacillus anthracis str. `Ames Ancestor`] GBAA3131 [Bacillus anthracis str. `Ames Ancestor`]  ali follow..  25  1MKAVTYQGPNQVQV-KQVDDAKLEKKDDIIVKITSTAICGSDLHLY-------------QGNMPLPQGYIIGHEPMGIVEEVGPDVTKVKKGDRVVIPFNVACGH--------------CFYCQHEMESQCDNSNPHYDSGHPGGQVEYLKVPFGTPFVIPESCELEDESLLDVLPTAYWSVINAGVKPGDTVIVLGCGPVGLMTQKFAWMHGAKRVIAVDYLDYRINYAKKINNVEVFEFTKFPDMGEHLKEI--THGGADVVIDCVGMDGPIQIATKAVRKYGTVQMTGVYGGNYNAFPLGAFWVRNINLKMGQAPVIHFMPELFEKITNKEF---DPKEIITHKIPLEE-ASYGYQIFNNREDDCIKVILKP....... 377
4 -56.900IDP90877 oxidoreductase, zinc-binding dehydrogenase family [Campylobacter jejuni subsp. jejuni NCTC 11168] Cj1548c [Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819]  ali follow..  24  13SKGYAMLSKDAKFTPFEFSRHA-IGDNDILIKILYAGICHSDIHTARSE-------------GEATYPCVPGHEIAGEVIAVGKNVSKFKVGDYAGVGCMVSCGE--------------CDACKRSQEQFCENGKTIFTYNTYGGYSNNIVVSEKFAVCVPKDAPMEKVA---PLLCAYSPLKFSNIKEGSSVAVAGFGGLGMMAVKYAVKMGA-KVSVFARNENKKADALAMGVSSFYTSCDKNAV----------KERFDLIISTIPTPYNPAIYLDLLKFGGEMAIVGLPPHAPSISVITFVHKAGKKVYGSLIGGIAETQEMLDFSLKHGIYP------ETELITPQE-IDKAYENLTSGKAKFRYVIDMTKE..... 358
5 -40.300IDP04685 alcohol dehydrogenase, zinc-containing [Bacillus anthracis str. `Ames Ancestor`] GBAA3438 [Bacillus anthracis str. `Ames Ancestor`]  ali follow..  20  1MKAQIIFGDSSVFQLEEVSKPK-LLPGHVLIDVKATSVNPIDTKMRSG----------AVSAVAPEFPAILHGDVAGIVIEVGEGVSKFKCGDEVYGCAGGFKET-------------------------------------GGALAEFMLADARLIAHKPNNITMEEAAAL-PLVTAWESLDRANIKSGQNVLIHGTGGVGHVAIQLAKWAGA-NVFTTASQQNKMEIAHRLGADVAINYKEESESVQEYVQKHTNGNGFEVIFDTVG-GKNLDNSFEAAAVNGTVVTIAARSTHDLS----PLHAKGLSLHVTFNDCGEILTKITKIVEEGKLRPL----LDSKSFTFDEVAQA--HEYLESNKAIGKIVLKN....... 333
6 -38.900IDP00076 gene: yhdH; putative oxidoreductase NT01ST4228 [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]  ali follow..  14  1MQALILQDGKTLASVQHLEESQ-LPAGDVTVDVHWSSLNYKDALAITGKGKIIR-----------HFPMIPGIDFAGTVHASE--DPRFHAGQEVLLTGW---------------------------------------ENHWGGLAERARVKGDWLVALPAGLSSRNAMIIGTAGFTAMLCDAGIRPQDGEVVVTGAGGVGSTAVALLHKLGY-QVAAVSGRESTHGYLKSLGANRILSRDEFAESRPL------EKQLWAGAIDTVG-DKVLAKVLAQMNYGGCVAACGLAGGFALPTTVMPFILRNVRLQGVDSVMTPPARRAEAWARLVKDLPESFYAQAATEITLAD-APKFADAIINNQVQG-RTLVKIK...... 324
7 -9.400IDP95361 set237a-001 [Yersinia pseudotuberculosis PB1/+]  ali follow..  13  34..............................................................................................................................................................................MFTLDYWIEKSRINSNTYLLDLACS-TGFSARNIVHKTGC-SAEGIDISARSIESANQLAVQGNIA-ECVHFSVGNAESVSFTDNTFTHIT-ISDKPAALVEVQRVLKQDGFLCISPFFYESEPDNELLSLVEQYIGYRPDIK-RDYSYWFNFFNQHFTLLHEELFDLPVYSDDEIEKNVN........................... 216
8 -9.320IDP95362 set237a-002 [Escherichia coli]  ali follow..  43.....................................................................................................................................................................................IKHGCINKKSHLLDLACS-TGFSSRECFKKEGA-SAEGIDISESAVMVANEKAKKLKAN-NLLKYYVADACDLPFEDNTFTHVL-IQNRLIALNETHRCLNHMGSMCISNFYYRRKISDKLINDVYNAINFRPNP-LWTLEYWHQFFSERFTLVSEENHEMESQSEDELKADIYD.......................... 219
9 -9.250IDP02273 hypothetical protein GBAA3714 [Bacillus anthracis str. `Ames Ancestor`] GBAA3714 [Bacillus anthracis str. `Ames Ancestor`]  ali follow..  85.....................................................................................................................................................................................IEHLQLQGRERILEVGCAN-GKFLSLLQANGHKGQLTGFDQSEAMLSEATKTNNLIEWRLGDAGKL---------EANYYDLIVARHMLEKTIQGFHKVIHPGGSLLATTNSNVTLPRIPKTTSSVTPFCLENGKEILQSVFPTVEVSVIHNALIFHHATPIVNYISSMFDWLKEEVENELLLHNGIWRD........... 301
10 -9.030IDP92743 hypothetical protein lpp2747 [Legionella pneumophila str. Paris] YP_125052 [Legionella pneumophila str. Paris]  ali follow..  10  27...............................................................................................................................................................................EISSKFLAKISIHSNDYLLDAGCGD-GSFTQMLANLVPDGYVLGLDRSKTMIDYANKHCRSINVR--DIGDIQEPIIYGPFDNILSFWCLHWTDLEKSLSNLYHVLKPGGKICAIFSSGKQSTLFEVLNSLQFQNLYPDVAKNYSIQCRRALDNLPFKSISFGLFENFIHGAPLFKDLPGKMYQDIVNSMVQFFDEYCKKKYGGK.. 251

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Sikora S, Godzik A. Combination of multiple alignment analysis and surface mapping paves a way for a detailed pathway reconstruction--the case of VHL (von Hippel-Lindau) protein and angiogenesis regulatory pathway. Protein Sci. 2004 Mar;13(3):786-96. Epub 2004 Feb 06.