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Query: gi|6319258|ref|NP_009341.1| NAD-dependent (R,R)-butanediol dehydrogenase, catalyzes oxidation of (R,R)-2,3-butanediol to (3R)-acetoin, oxidation of meso-butanediol to (3S)-acetoin, and reduction of acetoin; enhances use of 2,3-butanediol as an aerobic carbon source; Bdh1p (YAL060W) [Saccharomyces cerevisiae], from S.cerevisiae

Results of FFAS03 search in H.sapiens
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MRALAYFKKGDIHFTNDIPRPEIQTDDEVIIDVSWCGICGSDLHEYLDGPIFMPKDGECHKLSNAALPLAMGHEMSGIVSKVGPKVTKVKVGDHVVVDAASSCADLHCWPHSKFYNSKPCDACQRGSENLCTHAGFVGLGVISGGFAEQVVVSQHHIIPVPKEIPLDVAALVEPLSVTWHAVKISGFKKGSSALVLGAGPIGLCTILVLKGMGASKIVVSEIAERRIEMAKKLGVEVFNPSKHGHKSIEILRGLTKSHDGFDYSYDCSGIQVTFETSLKALTFKGTATNIAVWGPKPVPFQPMDVTLQEKVMTGSIGYVVEAFEEVVRAIHNGDIAMEDCKQLITGKQRIEDGWEKGFQELMDHKESNVKILLTPNNHGEMKLast
1 -85.600sp|Q00796|DHSO_HUMAN Sorbitol dehydrogenase OS=Homo sapiens GN=SORD PE=1 SV=4  ali follow..  25  9NLSLVVHGPGDLRL-ENYPIPE-PGPNEVLLRMHSVGICGSDVHYWEYGRI---------GNFIVKKPMVLGHEASGTVEKVGSSVKHLKPGDRVAIEPGAPREN--------------DEFCKMGRYNLSPSIFFCATPPDDGNLCRFYKHNAAFCYKLPDNVTFEEGALIEPLSVGIHACRRGGVTLGHKVLVCGAGPIGMVTLLVAKAMGAAQVVVTDLSATRLSKAKEIGADLVLQISKESPQEIARKVEGQLGCKPEVTIECTGAEASIQAGIYATRSGGNLVLVGL-GSEMTTVPLLHAAIREVDIKGVFRYC-NTWPVAISMLASKSV---NVKPLVTHRFPLEK-ALEAFETFKKGLG--LKIMLKCDPSDQN. 356
2 -55.800sp|P28332|ADH6_HUMAN Alcohol dehydrogenase 6 OS=Homo sapiens GN=ADH6 PE=2 SV=2  ali follow..  18  10CKAAILWKPGAPFSIEEVEVAP-PKAKEVRIKVVATGLCGTEMKVLGSKHLDLL------------YPTILGHEGAGIVESIGEGVSTVKPGDKVITLFLPQCGE--------------CTSCLNSEGNFCIQFKQSKTQLMSSTFCEYTVIKEISVAKIDAVAPLEKVCLI--FSTGFGAANTAKVTPGSTCAVFGLGGVGLSVVMGCKAAGAARIIGVDVNKEKFKKAQELGATECLNPQDLKKPIQEVLFDMTDA-GIDFCFEAIGNLDVLAAALASCNESYGVCVVVGVLPASVQLKISQLFFSGRSLKGSVWKSRQHIPKLVADYMAEKLN---LDPLITHTLNLDK-INEAVELMKTGK................. 367
3 -54.500sp|P11766|ADHX_HUMAN Alcohol dehydrogenase class-3 OS=Homo sapiens GN=ADH5 PE=1 SV=4  ali follow..  20  8CKAAVAWEAGKPLSIEEIEVAP-PKAHEVRIKIIATAVCHTDAYTLSGADPEGC------------FPVILGHEGAGIVESVGEGVTKLKAGDTVIPLYIPQCGE--------------CKFCLNPKTNLCQKIRVTQGKGL-STFSEYTVVADISVAKIDPLAPLDKVCLL--ISTGYGAANTAKLEPGSVCAVFGLGGVGLAVIMGCKVAGASRIIGVDINKDKFARAKEFGATECINPQDFSKPIQEVLIEMTDG-GVDYSFECIGNVKVMRAALEACHKGWGVSVVVGVAASGEEIATRPFLVTGRTWKGTAWKSVESVPKLVSEYMSKKIK---VDEFVTHNLSFDE-INKAFELMHSGK--SIRTVVK........ 373
4 -53.100sp|P08319|ADH4_HUMAN Alcohol dehydrogenase 4 OS=Homo sapiens GN=ADH4 PE=1 SV=5  ali follow..  21  10CKAAIAWEAGKPLCIEEVEVAP-PKAHEVRIQIIATSLCHTDATVIDSKFEGLA------------FPVIVGHEAAGIVESIGPGVTNVKPGDKVIPLYAPLCRK--------------CKFCLSPLTNLCGKISNLKSPASDSTFSQYTVVSDINLAKIDDDANLERVCLL--FSTGYGAANNAKVTPGSTCAVFGLGGVGLSAVMGCKAAGASRIIGIDINSEKFVKAKALGATDCLNPRDHKPIQEVIIELTKG--GVDFALDCAGGSETMKAALDCTTAGGSCTFIGVAAGSKGLTIFPEELIIGRTINGTFWKSVDSIPKLVTDYKNKKFN---LDALVTHTLPFDK-ISEAFDLMNQGK--SVRTIL......... 378
5 -52.600sp|P00326|ADH1G_HUMAN Alcohol dehydrogenase 1C OS=Homo sapiens GN=ADH1C PE=1 SV=2  ali follow..  22  10CKAAVLWELKKPFSIEEVEVAP-PKAHEVRIKMVAAGICRSDEHVVS-------------GNLVTPLPVILGHEAAGIVESVGEGVTTVKPGDKVIPLFTPQCGK--------------CRICKNPESNYCLKNDLGNPRGT-STFSQYTVVDENAVAKIDAASPLEKVCLI--FSTGYGSAKVAKVTPGSTCAVFGLGGVGLSVVMGCKAAGAARIIAVDINKDKFAKAKELGATECINPQDYKKPIQEVLKEMTDG-GVDFSFEVIGRLDTMMASLLCHEACGTSVIVGVPPDSQNLSINPMLLLTGRTWKGAIFKSKESVPKLVADFMAKKFS---LDALITNILPFEK-INEGFDLLRSGK--SIRTVLT........ 374
6 -52.500sp|P07327|ADH1A_HUMAN Alcohol dehydrogenase 1A OS=Homo sapiens GN=ADH1A PE=1 SV=2  ali follow..  22  10CKAAVLWELKKPFSIEEVEVAP-PKAHEVRIKMVAVGICGTDDHVVS-------------GTMVTPLPVILGHEAAGIVESVGEGVTTVKPGDKVIPLAIPQCGK--------------CRICKNPESNYCLKNDVSNPQGT-STFSQYTVVDENAVAKIDAASPLEKVCLI--FSTGYGSANVAKVTPGSTCAVFGLGGVGLSAIMGCKAAGAARIIAVDINKDKFAKAKELGATECINPQDYKKPIQEVLKEMTDG-GVDFSFEVIGRLDTMMASLLCCEACGTSVIVGVPPDSQNLSMNPMLLLTGRTWKGAIFKSKECVPKLVADFMAKKFS---LDALITHVLPFEK-INEGFDLLHSGK--SIRTIL......... 373
7 -51.800sp|P00325|ADH1B_HUMAN Alcohol dehydrogenase 1B OS=Homo sapiens GN=ADH1B PE=1 SV=2  ali follow..  22  10CKAAVLWEVKKPFSIEDVEVAP-PKAYEVRIKMVAVGICRTDDHVVS-------------GNLVTPLPVILGHEAAGIVESVGEGVTTVKPGDKVIPLFTPQCGK--------------CRVCKNPESNYCLKNDLGNPRGT-STFSQYTVVDENAVAKIDAASPLEKVCLI--FSTGYGSANVAKVTPGSTCAVFGLGGVGLSAVMGCKAAGAARIIAVDINKDKFAKAKELGATECINPQDYKKPIQEVLKEMTDG-GVDFSFEVIGRLDTMMASLLCCEACGTSVIVGVPPASQNLSINPMLLLTGRTWKGAVFKSKEGIPKLVADFMAKKFS---LDALITHVLPFEK-INEGFDLLHSGK--SIRTVLT........ 374
8 -51.100sp|P40394|ADH7_HUMAN Alcohol dehydrogenase class 4 mu/sigma chain OS=Homo sapiens GN=ADH7 PE=1 SV=2  ali follow..  22  22CKAAVLWEQKQPFSIEEIEVAP-PKTKEVRIKILATGICRTDDHVIK-------------GTMVSKFPVIVGHEATGIVESIGEGVTTVKPGDKVIPLFLPQCRE--------------CNACRNPDGNLCIRSDITGRGVLASTFTEYTVVDESSVAKIDDAAPPEKVCLI--FSTGYGAAKTGKVKPGSTCVVFGLGGVGLSVIMGCKSAGASRIIGIDLNKDKFEKAMAVGATECISPKDSTKPISEVLSEMTGN-NVGYTFEVIGHLETMIDALASCMNYGTSVVVGVPPSAKMLTYDPMLLFTGRTWKGCVLKSRDDVPKLVTEFLAKKF---DLDQLITHVLPFKK-ISEGFELLNSGQ--SIRTVL......... 384
9 -44.800sp|Q08257|QOR_HUMAN Quinone oxidoreductase OS=Homo sapiens GN=CRYZ PE=1 SV=1  ali follow..  21  8MRAVRVFGPEVLKLRSDIAVPI-PKDHQVLIKVHACGVNPVETYIRSGTYSRKP-----------LLPYTPGSDVAGVIEAVGDNASAFKKGDRV-----------------------------------------FTSSTISGGYAEYALAADHTVYKLPEKLDFKQGAIGIPYFTAYRALHSACVKAGESVLVHGAGGVGLAACQIARAYGL-KILGTAGTEEGQKIVLQNGAHEVFN--REVNYIDKIKKYVGEK-GIDIIIEMLA-NVNLSKDLSLLSHGGRVIVVGSRGT--IEINPRDTMAKESSIIGVTLFSQQYAAALQAGMEIGWL-----KPVIGSQYPLEKV-AEAHENIIHGSGATGKMILL........ 328
10 -40.100sp|Q53FA7|QORX_HUMAN Quinone oxidoreductase PIG3 OS=Homo sapiens GN=TP53I3 PE=1 SV=2  ali follow..  18  1MLAVHFDGGPENLYVKEVAKPS-PGEGEVLLKVAASALNRADLMQRQGQYDPPP-----------GASNILGLEASGHVAELGPGCQGWKIGDTAMA-------------------------------------------LPGGGQAQYVTVPEGLLMPIPEGLTLTQAAIPEAWLTAFQLLLVGNVQAGDYVLI-GLSGVGTAAIQLTRMAGA-IPLVTAGSQKKLQMAEKLGAAAGFN--KKEDFSEATLKFTKGA-GVNLILDCIGGS-YWEKNVNCLALDGRWVLYGLMGGGDINGPFSKLLFKRGSLITSLLRSTEQILPHFSTEGPQRL-----LPVLDRIYPVTEIQEA--HKYMEANKNIGKIVLELPQ..... 332
11 -39.300sp|Q9BV79|MECR_HUMAN Trans-2-enoyl-CoA reductase, mitochondrial OS=Homo sapiens GN=MECR PE=1 SV=1  ali follow..  19  43VRALVYGDPAKVVELKNLELAA-VRGSDVRVKMLAAPINPSDINMIQGNYGLLP-----------ELPAVGGNEGVAQVVAVGSNVTGLKPGDWV-----------------------------------------IPANAGLGTWRTEAVFSEEALIQVPSDIPLQSAATLNPCTAYRMLMDFEQLQPGDSVIQNASSGVGQAVIQIAAALGLRTINVVPDIQKLSDRLKSLGAEHVIT-EEELRRPEMKNFFKDMP-QPRLALNCVG-GKSSTELLRQLARGGTMVTYGGMAKQPVVASVSLLIFKDLKLRGFWDQFKELILTLCDLIRRGQL-----TAPACSQVPLQD-YQSALEASMKPFISS-KQILT........ 372
12 -37.200sp|Q99536|VAT1_HUMAN Synaptic vesicle membrane protein VAT-1 homolog OS=Homo sapiens GN=VAT1 PE=1 SV=2  ali follow..  18  48LRCLVLTGFGGYDKVKLQSRPAAPGPGQLTLRLRACGLNFADLMARQGLYDRLP-----------PLPVTPGMEGAGVVIAVGEGVSDRKAGDRVMV-------------------------------------------NRSGMWQEEVTVPSVQTFLIPEAMTFEEAALLVNYITAYMVLDFGNLQPGHSVLVHMAGGVGMAAVQLCRTVEN-VTVFGTASASKHEALKENGVTHPID-YHTTDYVDEIKKIS--PKGVDIVMDPLGGS-DTAKGYNLLKPMGKVVTYGMAN-NQFSVTALQLLQANRAVCGFHELVSGVVARLLALYNQGHI-----KPHIDSVWPFEKV-ADAMKQMQEKKN---KVLLVPGPEKE.. 392
13 -36.100sp|Q8WWV3|RT4I1_HUMAN Reticulon-4-interacting protein 1, mitochondrial OS=Homo sapiens GN=RTN4IP1 PE=1 SV=2  ali follow..  21  43MPAWVIDKNEVLRFTQNMMMPIIHYPNEVIVKVHAASVNPIDVNMRSG--LNMKRDPLHVKIKGEEFPLTLGRDVSGVVMECGLDVKYFKPGDEVWAAVP---------------------------------------PWKQGTLSEFVVVSGNEVSHKPKSLTHTQAASL-PYVTAWSAINNDKNCTGKRVLILGAGGVGTFAIQVMKAWDAH--VTAVCSQDASELVRKLGADDVIDYKSGS-----VEEQLKSLKPFDFILDNVG-GSTETWAPDFLKKWSGATYVTLVTPFLLNMDRLGIADGMLQTGVTVGSSGPCLDDIAELVDAGKI-----RPVIEQTFPFSK-VPEAFLKVERGHARG-KTVIN........ 394
14 -35.500sp|O95825|QORL1_HUMAN Quinone oxidoreductase-like protein 1 OS=Homo sapiens GN=CRYZL1 PE=1 SV=2  ali follow..  16  1MKGLYFQQSSTDEEIEKEDLP-VTEDNFVKLQVKACALSQINTKLLAE-------------MKMKKDLFPVGREIAGIVLDVGSKVSFFQPDDEV--------------------------------------VGILPLDSEDPGLCEVVRVHEHYLVHKPEKVTWTEAAGS-IRDRAYTALYLSHLSPGKSVLI-GASAFGTIAIQLAHHRGA-KVISTACSLEDKQCLERFRPPIIDVSNGKVHVAESCLEETGG-LGVDIVLDAGVRLDEPAVKLQLLPHKHDIITLLGVGGHWVNLQLDPPDSHCLFLKGA-GKYLCILKDVMEKLSTGVF-----RPQLDEPIPLYEA-KVSMEAVQKNQGRK-KQVVQ........ 348
15 -35.000sp|Q8N4Q0|ZADH2_HUMAN Zinc-binding alcohol dehydrogenase domain-containing protein 2 OS=Homo sapiens GN=ZADH2 PE=1 SV=1  ali follow..  18  33MQKLVVTRLSAVTLSRDCPVPL-PGDGDLLVRNRFVGVNASDINYSAG-------------DPSVKPPFDIGFEGIGEVVALGLSASRYTVGQAVAY--------------------------------------------APGSFAEYTVVPASIATPVPSVKPEYLTLLVSGTTAYISLKELGGLSEGKKVLVTAAGGTGQFAMQLSKKAKC-HVIGTCSSDEKSAFLKSLGCDRPIN--KTEPVGTVLKQE--YPEGVDVVYESVGGA-MFDLAVDALATKGRLIVIGFISGYQTPTGLSKLLKKSASVQGFFLNHQAAMSHLLEMCVSGDLVCEGDLSPEGRFTGLESI-FRAVNYMYMGKNTG-KIVVELPHSVNSK 376
16 -34.400sp|Q9HCJ6|VAT1L_HUMAN Synaptic vesicle membrane protein VAT-1 homolog-like OS=Homo sapiens GN=VAT1L PE=1 SV=2  ali follow..  18  42MRAVVLAGFGGLNKLRLFRKAMEPQDGELKIRVKACGLNFIDLMVRQG-------------DNPPKTPLVPGFECSGIVEALGDSVKGYEIGDRVMA-------------------------------------------VNYNAWAEVVCTPVEFVYKIPDDMSFSEAAFPMNFVTAYVMLEVANLREGMSVLV-AGGGVGQAVAQLCSTVPNVTVFGTA-STFKHEAIKDSVTHLF---DRNADYVQEVKRIS--AEGVDIVLDCLCGD-NTGKGLSLLKPLGTYILYGSSN-QVEKVNPIKLYEENKVIAGF-GLIRGVVEKLIGLYNQKKI-----KPVVDSLWALEEV-KEAMQRIHDRGN---KLILDVEKTPT.. 385
17 -21.500sp|P49327|FAS_HUMAN Fatty acid synthase OS=Homo sapiens GN=FASN PE=1 SV=3  ali   16  47.............VCSSLRHAQPTCPGAQLCTVYYASLNFRDIML----------------ATGKLSPDAIPGKWTSQDSLLGMEFSGDASGKRVMG-------------------------------------------VPAKGLATSVLLSPDFLWDVPSNWTLEEAASVPVYSTAYYALVRGRVRPGETLLISGSGGVGQAAIAIALSLGCRVFTTVGSAEKRAYLQARF-DSTSFANSRDTSFEQHVLWHTGGK-GVDLVLNSL-AEEKLQASVRCLATHGRFLEIGKFDLSQNHPLGMAIFLKNVTFHGV................................................................... 294
18 -16.400sp|Q8N8N7|PTGR2_HUMAN Prostaglandin reductase 2 OS=Homo sapiens GN=PTGR2 PE=1 SV=1  ali follow..  11  25..............MEEVYLPDNINEGQVQVRTLYLSV-----------DPYMRCRMNEDTGTDYITPWQLSQVVDGGGIGEESKHTNLTKGDFVT--------------------------------------------SFYWPWQTKVILDGNSLEKVDPQLSYFLGAIGMPGLTSLIGIQHITAGSNKTMVVSGAGACGSVAGQIGHFLGCSRVVGICGTHEKCILTSELGFDAAIN--KKDNVAEQLRESCPA--GVDVYFDNVGGN-ISDTVISQMNENSHIILCGQISQYNKD-IEAIQKERNITRERFLVLNEPGILQLSQWFKEGKLKIKE----VINGL---ENMGAAFQSMMTGGNIG-KQIVCISEE.... 348
19 -15.700sp|Q14914|PTGR1_HUMAN Prostaglandin reductase 1 OS=Homo sapiens GN=PTGR1 PE=1 SV=2  ali follow..  17  24..............LKTAELPPL-KNGEVLLEALFLTV--------------------DPYMRVAAKRLKEGDTMMGQQVAVESKNVALPKGTIVL-----------------------------------------------PGWTTHSISDGKDLEKLLTPLSLALGTVGMPGLTAYFGLEICGVKGGETVMVNAAGAVGSVVGQIAKLKGC-KVVGAVGSDEKVAYLQKLGFDVVFNYKTVESLEETLKKAS--PDGYDCYFDNVGGE-FSNTVIGQMKKFGRIAICGAISTYNRT-PPEIVIYQELRMEAVYRWQGDARQKALKDLLK----------VLEGKIQYKEYIIEGFENMPAKGDNLGKTIVK........ 328
20 -13.600sp|P49327|FAS_HUMAN Fatty acid synthase OS=Homo sapiens GN=FASN PE=1 SV=3  ali   14  2..............................................................................................................................................................................YSTAYYALVRGRVRPGETLLISGSGGVGQAAIAIALSLGCRVFTTVGSAEKRAYLQARF-DSTSFANSRDTSFEQHVLWHTGGK-GVDLVLNSL-AEEKLQASVRCLATHGRFLEIGLSQNHPLGMAIKNVTFHGVLLDAFFNESSADWREVWALVQAG-IRDGVVRPLKCTVFHGAQ-VEDAFRYMAQGKH---KVVVQVLAEEPEA 213
21 -10.300sp|Q96S19|CP013_HUMAN UPF0585 protein C16orf13 OS=Homo sapiens GN=C16orf13 PE=1 SV=2  ali follow..  5.................................................................................................................................................................AAAERNKDPILHVLRQYL-----DPAQRGVRVLEVASGS-GQHAAHFARAFPLAEWQPSDVDQRCLDSIAAQGLTNVKAPLHLDVTWGWEHWGGILPQSLDLLLCIRCTEGLFRAAGHLLKPRALLITYGPYAINGKISPQSNVDFDLMLRCRNPEWGLRDTALLEDLGKASGLLLERMVDMPANNKCL................................ 199
22 -10.200sp|Q8IXQ9|CL072_HUMAN(removed signalp:1-25) UPF0516 protein C12orf72 OS=Homo sapiens GN=C12orf72 PE=2 SV=1  ali follow..  16  76..............................................................................................................................................................................QALSRYLLDNPDVVRGKSVLDLGSG-CGATAIAAKMS-GASRILANDIDPIAGMAITLNCELNRLNPFPIQNILNLEQDKWDLVVLGDMFYDEDLADSLHQWLKKCFWTYRTRVLIGDPGRPQFSGHSIQHHLHKVV....................................................................... 212
23 -9.680sp|Q9HBK9|AS3MT_HUMAN Arsenite methyltransferase OS=Homo sapiens GN=AS3MT PE=1 SV=3  ali follow..  11  19................................................................................................................................QVLKRSADLQTNGCVTTARPVPKHIREALQNVHEEVALRYYGCGLVIP---------EHLENCWILDLGSGS-GRDCYVLSQLVGEKHVTGIDMTKGQVEVAEKYLDYHASNVTFIHGYIEKLGEAGIKNESHDIVVSVPDKQQVLQEAYRVLKHGGELYFSDVYTSLELPEEIRTHKVLWGECLGG-ALYWKELAVLAQKIGFCPPRLVTANLITIQNKELERVIGRLFKHSKTGPTKRCQVIYNGGITGHEK 284
24 -9.470sp|Q9BV86|NTM1A_HUMAN Alpha N-terminal protein methyltransferase 1A OS=Homo sapiens GN=METTL11A PE=1 SV=3  ali follow..  15  54.....................................................................................................................................................................................REGPNKTGTSCALDCGAG-IGRITKRLLLPLFR-EVDMVDITEDFLVQAKTYLGEE--GKRVRNYFCCGLQDFTPEPDSYDVILTDQHLAEFLRRCKGSLRPNGIIVIKDNMAQEGVILD---------DVDSSVCRDLDVVRRIICSAGLSLLAEERQENLPDEIYHVY............................... 218

FFAS is supported by the NIH grant R01-GM087218-01
1 3 7 7 9 2   jobs submitted since Jan 1, 2011
Comments and questions to: webmaster

Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Sikora S, Godzik A. Combination of multiple alignment analysis and surface mapping paves a way for a detailed pathway reconstruction--the case of VHL (von Hippel-Lindau) protein and angiogenesis regulatory pathway. Protein Sci. 2004 Mar;13(3):786-96. Epub 2004 Feb 06.