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Query: gi|6319278|ref|NP_009361.1| Cytochrome c heme lyase (holocytochrome c synthase), attaches heme to apo-cytochrome c (Cyc1p or Cyc7p) in the mitochondrial intermembrane space; human ortholog may have a role in microphthalmia with linear skin defects (MLS); Cyc3p (YAL039C) [Saccharomyces cerevisiae], from S.cerevisiae

Results of FFAS03 search in H.sapiens
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MGWFWADQKTTGKDIGGAAVSSMSGCPVMHESSSSSPPSSECPVMQGDNDRINPLNNMPELAASKQPGQKMDLPVDRTISSIPKSPDSNEFWEYPSPQQMYNAMVRKGKIGGSGEVAEDAVESMVQVHNFLNEGCWQEVLEWEKPHTDESHVQPKLLKFMGKPGVLSPRARWMHLCGLLFPSHFSQELPFDRHDWIVLRGERKAEQQPPTFKEVRYVLDFYGGPDDENGMPTFHVDVRPALDSLDNAKDRMTRFLDRMISGPSSSSSAPLast
1 -81.900sp|P53701|CCHL_HUMAN Cytochrome c-type heme lyase OS=Homo sapiens GN=HCCS PE=1 SV=1  ali follow..  33  1MGL--PSAPAVAVQASNASASPPSGCPMHEGKMKGCPVNTEPSTAAENKENLDPSNLMPPPNQTPAPDQPFALSTVREESSIPRAD-SEKKWVYPSEQMFWNAMLKKGWKWKDEDISQKDMYNIIRIHNQNNEQAWKEILKWEALHAAECPCGPSLIRFGGKAKEYSPRARIRSWMGY--------ELPFDRHDWIINRCG----------TEVRYVIDYYDGGEVNKDYQFTILDVRPALDSLSAVWDRMKVAWWRWTS......... 268
2 -7.210sp|Q9NRZ9|HELLS_HUMAN Lymphoid-specific helicase OS=Homo sapiens GN=HELLS PE=1 SV=1  ali   15  8...............................................................................................ERQKLVRNIYKRKGTLQIHPVVITSFEIAMRDRNALQHCYWKYLIEGHRIKNMKCRLIRELKRFNADNKLLTP-SELWSLLNFLLPDVFDDLKSFE--SWFDITSLSETAEDIIAKEREQNVLH------------MLHQILTPFL............................ 148
3 -7.120sp|Q5JTJ3|CA031_HUMAN Uncharacterized protein C1orf31 OS=Homo sapiens GN=C1orf31 PE=2 SV=1  ali follow..  9  6......................................PLLSPSRGFLLCKTGWHSNRLLGDCGPHTPVSTALSFIAVGMAAPSMKERQVCWG--ARDEYWKCLDENLEDASQCKKLRSSFESSCP-------QQW--IKYFDKRRDYLKFKE-KFEAGQFEPSETTAKS................................................................................................... 125
4 -7.010sp|Q9NRZ9|HELLS_HUMAN Lymphoid-specific helicase OS=Homo sapiens GN=HELLS PE=1 SV=1  ali   15  130..............................................................................LSTLPNWMAEFKRFT-PDRQKLVRNIYKRKGTLQIHPVVITSFEIAMRDRNALQHCYWKYLIEGHRIKNMKCRLIRELKRFNADNKLLTP-SELWSLLNFLLPDVFDDLKSFE--SWFDITSLSETAEDIIAKEREQNVLH------------MLHQILTPFL............................ 298
5 -6.940sp|Q6IQ55|TTBK2_HUMAN Tau-tubulin kinase 2 OS=Homo sapiens GN=TTBK2 PE=1 SV=2  ali   12  2...........................................................................EKRLTLEPK----------PDTDKFLETCLEKMQKDTSAG-KESILPALLHKPCVPAVSRTDHIWHYDEEYLPDASKPASANTPEQADGGGS---------GFIAVNLSSCKQEIDSKEWVI-----------DKEQDLQ---DFRTNEAVGHKTTGSPSDEEPE............................. 134
6 -6.580sp|P40238|TPOR_HUMAN(removed signalp:1-21) Thrombopoietin receptor OS=Homo sapiens GN=MPL PE=1 SV=1  ali   11  9...IWENCEEEEKTNPGLQTPQFSRCHFKSRNDSIIHILVEVTTAPGTVHSYLGSPFWIHQAVRLPTPNLHWREISSGHLEL--------EWQHPSSETCYQLRYTGEGHQDWKVLEPPLLQLRARLNGPTYQGPWSS---WSD............................................................................................................................. 158
7 -6.550sp|P33402|GCYA2_HUMAN Guanylate cyclase soluble subunit alpha-2 OS=Homo sapiens GN=GUCY1A2 PE=1 SV=1  ali   12  9.....ESFSSLGSDYLETSPEEEGECPLSCWNGSRSPPGPLEPSPAAAAAAAAPAPTPAASAAAAAATAGARRVQRRRRVNLDSLGESISRLTAPSPQTIQQTLKRT-------------------EHQVIGYRDAEKNFHADHSNKEEIEDVSGILQCTANILGLKFEE-IQKRFGEEFFNIC-----FHENERVLRAVGGTLQDFFNGFDALLEHIRTSFGKQATLESPSFYFHPHHIVGFA......................... 249
8 -6.370sp|O60502|NCOAT_HUMAN Bifunctional protein NCOAT OS=Homo sapiens GN=MGEA5 PE=1 SV=2  ali   7  3...............KEEEKKQPDEEPMDMVVEKQEETDHKNDNQILSEIVEAKMAEELKPMDTDKESIAESKSPEMSMQEDCISDIAPMQTDEQTNKEQFVPGPNEKPLYTAEPVTLEDLQLLADLFQMLREFQWEKIEEWRSRAAKFEEMCGLVMGMFTRLSNCANRTILYDMYSYVWDIKSIMSMVKSFVQWLGCRSHSSAQFLIGDQEEFQRLLDLFFQPPPLTPTSKVYT-IRPYFPKDEASVYKI.................. 281
9 -6.370sp|Q9H082|RB33B_HUMAN Ras-related protein Rab-33B OS=Homo sapiens GN=RAB33B PE=1 SV=1  ali follow..  12  59.................................................................PDRTEATIGVDFRERAVEIDGER-QLWDTAGQERFRKSMVQHYYR---------NVHAVVFVYDMTNMASFHSLPSWIEECKQHLLANDIPRILVGNKCDLRSAIQVPTDLAQKFADTHS.................................................................................... 171
10 -6.350sp|Q92918|M4K1_HUMAN Mitogen-activated protein kinase kinase kinase kinase 1 OS=Homo sapiens GN=MAP4K1 PE=1 SV=1  ali   13  118.....GQLSPGVLVRCASGPPPNSPRPGPPPSTSSPHLTAHSEPSLWNPPSRELDKPPLLPPKKEKMKRKGCALLVKLFNGCPLRIHSTAAWTHPSTKDQHLLLAEEGIFILNRNDQEATLEMLFP-----SRTTWVYSIN-------------VLMSLSGKTPHL....................................................................................................... 262
FFAS is supported by the NIH grant R01-GM087218-01
1 4 8 3 1 6   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Li W, Jaroszewski L, Godzik A. Sequence clustering strategies improve remote homology recognitions while reducing search times. Protein Eng. 2002 Aug;15(8):643-9.