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Query: gi|6319258|ref|NP_009341.1| NAD-dependent (R,R)-butanediol dehydrogenase, catalyzes oxidation of (R,R)-2,3-butanediol to (3R)-acetoin, oxidation of meso-butanediol to (3S)-acetoin, and reduction of acetoin; enhances use of 2,3-butanediol as an aerobic carbon source; Bdh1p (YAL060W) [Saccharomyces cerevisiae], from S.cerevisiae

Results of FFAS03 search in PDB1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MRALAYFKKGDIHFTNDIPRPEIQTDDEVIIDVSWCGICGSDLHEYLDGPIFMPKDGECHKLSNAALPLAMGHEMSGIVSKVGPKVTKVKVGDHVVVDAASSCADLHCWPHSKFYNSKPCDACQRGSENLCTHAGFVGLGVISGGFAEQVVVSQHHIIPVPKEIPLDVAALVEPLSVTWHAVKISGFKKGSSALVLGAGPIGLCTILVLKGMGASKIVVSEIAERRIEMAKKLGVEVFNPSKHGHKSIEILRGLTKSHDGFDYSYDCSGIQVTFETSLKALTFKGTATNIAVWGPKPVPFQPMDVTLQEKVMTGSIGYVVEAFEEVVRAIHNGDIAMEDCKQLITGKQRIEDGWEKGFQELMDHKESNVKILLTPNNHGEMKLast
1 -89.6005vm2_A mol:protein length:347 Alcohol dehydrogenase  ali model follow..  25  3NSKAILQVPGTMKI-ISAEIPV-PKEDEVLIKVEYVGICGSDVHGFESGPFI--------PPKDPNQEIGLGHECAGTVVAVGSRVRKFKPGDRVNIEPGVPCGH--------------CRYCLEGKYNICPDVDFMATQPYRGALTHYLCHPESFTYKLPDNMDTMEGTLVEPAAVGMHAAMLADVKPGKKIIILGAGCIGLMTLQACKCLGATEIAVVDVLEKRLAMAEQLGATVVINGAK-EDTIARCQQFTED-MGADIVFETAGSAVTVKQAPYLVMRGGKIMIVGT-VPGASAINF-LKINREVTIQTVFRYA-NRYPVTIEAISSGRF---DVKSMVTHIYDYRD-VQQAFEESVNNKRDIIKGVIKISD..... 347
2 -86.7003m6i_A mol:protein length:363 L-arabinitol 4-dehydrogenase  ali model follow..  25  9NIGVFTNPQHDLWILESVQKGEELKEGEVTVAVRSTGICGSDVHFWKHGCI---------GPMIVECDHVLGHESAGEVIAVHPSVKSIKVGDRVAIEPQVICNA--------------CEPCLTGRYNGCERVDFLSTPPVPGLLRRYVNHPAVWCHKIGN-MSYENGAMLEPLSVALAGLQRAGVRLGDPVLICGAGPIGLITMLCAKAAGACPLVITDIDEGRLKFAKEICPEVVTHKVERLSAEESAKKIVEGGIEPAVALECTGVESSIAAAIWAVKFGGKVFVIGV-GKNEIQIPFMRASVREVDLQFQYRYC-NTWPRAIRLVENGLV---DLTRLVTHRFPLED-ALKAFETASDPKTGAIKVQIQSLE..... 363
3 -86.5002dq4_A mol:protein length:343 L-threonine 3-dehydrogenase  ali model follow..  29  1MRALAKLAPEEGLTLVDRPVPE-PGPGEILVRVEAASICGTDLHIWKWDAW---------ARGRIRPPLVTGHEFSGVVEAVGPGVRRPQVGDHVSLESHIVCHA--------------CPACRTGNYHVCLNTQILGVDR-DGGFAEYVVVPAENAWVNPKDLPFEVAAILEPFGNAVHTVYAGSGVSGKSVLITGAGPIGLMAAMVVRASGAGPILVSDPNPYRLAFARPYADRLVNPLE--EDLLEVVRRVT--GSGVEVLLEFSGNEAAIHQGLMALIPGGEARILGIPSDPIRFDLAGELVMRGITAFGIAGRRWQTWMQGTALVYSGRV---DLSPLLTHRLPLSR-YREAFGLLASGQ--AVKVILDPKA..... 343
4 -85.7003qe3_A mol:protein length:355 Sorbitol dehydrogenase  ali model follow..  24  7NLSLVVHGPGDLRL-ENYPIPE-PGPNEVLLKMHSVGICGSDVHYWQHGRI---------GDFVVKKPMVLGHEASGTVVKVGSLVRHLQPGDRVAIQPGAPRQT--------------DEFCKIGRYNLSPTIFFCATPPDDGNLCRFYKHNANFCYKLPDNVTFEEGALIEPLSVGIHACRRAGVTLGNKVLVCGAGPIGLVNLLAAKAMGAAQVVVTDLSASRLSKAKEVGADFILEISNESPEEIAKKVEGLLGSKPEVTIECTGVETSIQAGIYATHSGGTLVLVGL-GSEMTSVPLVHAATREVDIKGVFRYC-NTWPMAISMLASKSV---NVKPLVTHRFPLEK-ALEAFETSKKGLG--LKVMIKCDPSDQ.. 353
5 -85.6003gfb_A mol:protein length:350 L-threonine 3-dehydrogenase  ali model follow..  28  5MQAIMKTKPAYGAELVEVDVPK-PGPGEVLIKVLATSICGTDLHIYEWNEW---------AQSRIKPPQIMGHEVAGEVVEVGPGVEDLQVGDYISVETHIVCGK--------------CYACKHNRYHVCQNTKIFGVD-MDGVFAHYAIVPAKNAWKNPKDMPPEYAALQEPLGNAVDTVLAGPI-AGRSTLITGAGPLGLLGIAVAKASGAYPVIVSEPSEFRRKLAKKVGADYVVNPFE-EDPVKFVMDITDG-AGVEVFLEFSGAPKALEQGLKAVTPGGRVSLLGLFPREVTIDFNNLIIFKALEVHGITRHLWETWYTVSSLIQSGKL---NLDPIITHKYKGFDKFEEAFELMRAGK--TGKVVFFPHKG.... 350
6 -85.4006dkh_A mol:protein length:346 L-idonate 5-dehydrogenase (NAD(P)(+))  ali model follow..  24  8TQSCVVAGKKTVAV-TEQTID--WNNNGTLVQITRGGICGSDLHYYQEGKV---------GNFMIKAPMVLGHEVIGKV--IHSDSSELHEGQTVAINPSKPCGH--------------CKYCIEHNENQCTDMRFFGSPHVDGGFTRYKMVETSQCVPYPAKADEKVMAFAEPLAVAIHAAHQAGELQGKRVFISGVGPIGCLIVSAVKTLGAAEIVCADVSPRSLSLGKEMGADVLVNPQNDD-----MDHWKAEKGYFDVSFEVSGHPSSVNTCLEVTRARGVMVQVGM-GGAMAEFPMMTLIGKEISLRGSFRFT-SEFNTAVSWLANGVI---NPLPLLSAEYPFTD-LEEALRFAGD-KTQAAKVQLV........ 345
7 -85.3001pl6_A mol:protein length:356 Sorbitol dehydrogenase  ali model follow..  25  8NLSLVVHGPGDLRL-ENYPIPE-PGPNEVLLRMHSVGICGSDVHYWEYGRI---------GNFIVKKPMVLGHEASGTVEKVGSSVKHLKPGDRVAIEPGAPREN--------------DEFCKMGRYNLSPSIFFCATPPDDGNLCRFYKHNAAFCYKLPDNVTFEEGALIEPLSVGIHACRRGGVTLGHKVLVCGAGPIGMVTLLVAKAMGAAQVVVTDLSATRLSKAKEIGADLVLQISKESPQEIARKVEGQLGCKPEVTIECTGAEASIQAGIYATRSGGTLVLVGL-GSEMTTVPLLHAAIREVDIKGVFRYC-NTWPVAISMLASKSV---NVKPLVTHRFPLEK-ALEAFETFKKGLG--LKIMLKCDPSDQN. 355
8 -84.6002d8a_A mol:protein length:348 Probable L-threonine 3-dehydrogenase  ali model follow..  30  5MVAIMKTKPGYGAELVEVDVPK-PGPGEVLIKVLATSICGTDLHIYEWNEW---------AQSRIKPPQIMGHEVAGEVVEIGPGVEGIEVGDYVSVETHIVCGK--------------CYACRRGQYHVCQNTKIFGVDT-DGVFAEYAVVPAQNIWKNPKSIPPEYATLQEPLGNAVDTVLAGPI-SGKSVLITGAGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVINPFE-EDVVKEVMDITDG-NGVDVFLEFSGAPKALEQGLQAVTPAGRVSLLGLYPGKVTIDFNNLIIFKALTIYGITRHLWETWYTVSRLLQSGKL---NLDPIITHKYKGFDKYEEAFELMRAGKT--GKVVFMLK...... 348
9 -84.4004a2c_A mol:protein length:346 GALACTITOL-1-PHOSPHATE 5-DEHYDROGENASE  ali model follow..  22  1MKSVVNDTDGIVRV-AESVIPEIKHQDEVRVKIASSGLCGSDLPRIFKNGA-------------HYYPITLGHEFSGYIDAVGSGVDDLHPGDAVACVPLLPCFT--------------CPECLKGFYSQCAKYDFIGSR-RDGGFAEYIVVKRKNVFALPTDMPIEDGAFIEPITVGLHAFHLAQGCENKNVIIIGAGTIGLLAIQCAVALGAKSVTAIDISSEKLALAKSFGAMQTFNSSE-MSAPQMQSVLREL-RFNQLILETAGVPQTVELAVEIAGPHAQLALVGTLHQDLTSATFGKILRKELTVIGSWMWPGQEWETASRLLTERKL---SLEPLIAHRGSFES-FAQAVRDIAR-NAMPGKVLLIP....... 346
10 -83.0005kia_A mol:protein length:351 L-threonine 3-dehydrogenase  ali model follow..  25  3MKALAKLERGPGLTLTRVKKPEV-GHNDVLIKIRRTAICGTDIHIWKWDDW---------AQKTIPVPMHVGHEYVGEIVEMGQEVRGFSIGDRVSGEGHITCGF--------------CRNCRAGRRHLCRNTVGVGVNR-EGAFAEYLAIPAFNAFKIPPEISDDLAAIFDPFGNATHTALSFNL-VGEDVLITGAGPIGVMAVAIAKHVGARNVVITDINDYRLDLARRMGATRAVNVSR-ESLRDVMADLHMT-EGFDVGLEMSGVPSAFTSLLESMNHGGKVALLGI-PPAQTAIDWNQVIFKGLEIKGIYGREMETWYKMVAMLQSG-----DLSPIITHRFAVDD-YEKGFAAMLSGES--GKVILDWAAA.... 345
11 -82.4004oh1_A mol:protein length:351 L-iditol 2-dehydrogenase  ali model follow..  28  10IRDFEKNTMGTVDM-MEAPMPE-PKDEEIRIKVVYASICGSDTHILTGNL------GEMESTTRSMLPMSFGHELSGVIDKVGSTAEGFKVGQKVVANYAKYCGC--------------CENCREGKVNLCSNMGYR-----MNGFSEYAVYHMSQIFPIPDDADLKDYALVEPLTVALSSAEQAKISYGKSVAIMGAGGLGMMLVQLARLAGASTITVFDIVPEKLELALENGADYALNSAE-EGVAERAIELAGG--RYDCVLEGTGATAAAKLGLQLLARDGDAVYFAMYGKDPI---QSDLYWDQKHIHGMIQGA-WQFPKSIRMIPR------DFSKIIQKEHTLTN-YKQAFEDLYSKK--YAKIVIKMDE..... 351
12 -81.2004ilk_A mol:protein length:359 Starvation sensing protein rspB  ali model follow..  24  15MKSILIEKPNQLSI-IEREIPT-PSAGEVRVKVKLAGICGSDSHIYRGHNPF------------AKYPRVIGHEFFGVIDAVGEGVESARVGERVAVDPVVSCGH--------------CYPCSIGKPNVCTTLAVLGVHA-DGGFSEYAVVPAKNAWKIPEAVADQYAVMIEPFTIAANVTGHGQPTENDTVLVYGAGPIGLTIVQVLKGVNVKNVIVADRIDERLEKAKESGADWAINNSQT----PLGESFAEKGIKPTLIIDAACHPSILKEAVTLASPAARIVLMGF-SSEPSEVIQQGITGKELSIFSSRLNA-NKFPVVIDWLSKGLI---KPEKLITHTFDFQH-VADAISLFELDQKHCCKVLLTFSE..... 353
13 -81.0003fpc_A mol:protein length:352 NADP-dependent alcohol dehydrogenase  ali model follow..  23  1MKGFAMLSIGKVGW-IEKEKPAP-GPFDAIVRPLAVAPCTSDIHTVFEGAI------------GERHNMILGHEAVGEVVEVGSEVKDFKPGDRVVVPAITPDWR--------------TSEVQRGYHQHSGGMLAGWKNVKDGVFGEFFHVNDANLAHLPKEIPLEAAVMIDMMTTGFHGAELANIKLGDTVCVIGIGPVGLMSVAGANHLGAGRIFAVGSRKHCCDIALEYGATDIINYKN-GDIVEQILKATDG-KGVDKVVIAGGDVHTFAQAVKMIKPGSDIGNVNYLGEGDIPRSEWGVGMGHKHIHGGLCPGRLRMERLIDLVFYKRV---DPSKLVTHVFRGFDNIEKAFMLMKDKPKDLIKPVVILA...... 352
14 -80.4001e3j_A mol:protein length:352 NADP(H)-DEPENDENT KETOSE REDUCTASE  ali model follow..  28  5NLSAVLYKQNDLRL-EQRPIPE-PKEDEVLLQMAYVGICGSDVHYYEHGRI---------ADFIVKDPMVIGHEASGTVVKVGKNVKHLKKGDRVAVEPGVPCRR--------------CQFCKEGKYNLCPDLTFCATPPDDGNLARYYVHAADFCHKLPDNVSLEEGALLEPLSVGVHACRRAGVQLGTTVLVIGAGPIGLVSVLAAKAYGA-FVVCTARSPRRLEVAKNCGADVTLVVDAKEEESSIIERIRSAGDLPNVTIDCSGNEKCITIGINITRTGGTLMLVGM-GSQMVTVPLVNACAREIDIKSVFRYC-NDYPIALEMVASGRC---NVKQLVTHSFKLEQ-TVDAFEAARKKADNTIKVMISCRQ..... 351
15 -80.4001jqb_A mol:protein length:351 NADP-dependent Alcohol Dehydrogenase  ali model follow..  21  1MKGFAMLGINKLGW-IEKERPVA-GSYDAIVRPLAVSPCTSDIHTVFEGAL------------GDRKNMILGHEAVGEVVEVGSEVKDFKPGDRVIVPCTTPDWR--------------SLEVQAGFQQHSNGMLAGWKNFKDGVFGEYFHVNDMNLAILPKDMPLENAVMIDMMTTGFHGAELADIEMGSSVVVIGIGAVGLMGIAGAKLRGAGRIIGVGSRPICVEAAKFYGATDILNYKN-GHIEDQVMKLTNGK-GVDRVIMAGGGSETLSQAVKMVKPGGIISNINYHGSGLIPRVEWGCGMAHKTIKGGLCPGRLRAERLRDMVVYNRV---DLSKLVTHVYHGFDHIEEALLLMKDKPKDLIKAVVI........ 350
16 -80.4001kev_A mol:protein length:351 NADP-DEPENDENT ALCOHOL DEHYDROGENASE  ali model follow..  21  1MKGFAMLGINKLGW-IEKERPVA-GSYDAIVRPLAVSPCTSDIHTVFEGAL------------GDRKNMILGHEAVGEVVEVGSEVKDFKPGDRVIVPCTTPDWR--------------SLEVQAGFQQHSNGMLAGWKNFKDGVFGEYFHVNDMNLAILPKDMPLENAVMIDMMTTGFHGAELADIQMGSSVVVIGIGAVGLMGIAGAKLRGAGRIIGVGSRPICVEAAKFYGATDILNYKN-GHIVDQVMKLTNG-KGVDRVIMAGGGSETLSQAVSMVKPGGIISNINYHGSGLIPRVEWGCGMAHKTIKGGLCPGRLRAEMLRDMVVYNRV---DLSKLVTHVYHGFDHIEEALLLMKDKPKDLIKAVVI........ 350
17 -80.0003fsr_A mol:protein length:352 NADP-dependent alcohol dehydrogenase  ali model follow..  23  1MKGFAMLSIGKVGW-IEKEKPA-PGPFDAIVRPLAVAPCTSDIHTVFEGAI------------GERHNMILGHEAVGEVVEVGSEVKDFKPGDRVVVPAITPDWR--------------TSEVQRGYHQHSGGMLAGWKNVKDGVFGEFFHVNDMNLAHLPKEIPLEAAVMIDMMTTGFHGAELADIQMGSSVVVIGIGAVGLMGIAGAKLRGAGRIIGVGSRPICVEAAKFYGATDILNYKN-GHIVDQVMKLTNG-KGVDRVIMAGGGSETLSQAVSMVKPGGIISNINYHGSGLIPRVEWGCGMAHKTIKGGLCPGRLRMERLIDLVFYKRV---DPSKLVTHVFRGFDNIEKAFMLMKDKPKDLIKPVVILA...... 352
18 -80.0003fpl_A mol:protein length:351 NADP-dependent alcohol dehydrogenase  ali model follow..  21  1MKGFAMLGINKLGW-IEKERPVA-GSYDAIVRPLAVSPCTSDIHTVFEGAL------------GDRKNMILGHEAVGEVVEVGSEVKDFKPGDRVIVPCTTPDWR--------------SLEVQAGFQQHSNGMLAGWKNFKDGVFGEYFHVNDANLAILPKDMPLENAVMIDMMTTGFHGAELADIELGATVAVLGIGPVGLMAVAGAKLRGAGRIIAVGSRPVCVDAAKYYGATDIVNYKD-GPIESQIMNLTEGK-GVDAAIIAGGNADIMATAVKIVKPGGTIANVNYFGEGPVPRLEWGCGMAHKTIKGGLCPGRLRAEMLRDMVVYNRV---DLSKLVTHVYHGFDHIEEALLLMKDKPKDLIKAVVI........ 350
19 -79.9001y9a_A mol:protein length:360 NADP-dependent alcohol dehydrogenase  ali model follow..  21  1MKGLAMLGIGRIGW-IEKKIPEC-GPLDALVRPLALAPCTSDTHTVWAGAI------------GDRHDMILGHEAVGQIVKVGSLVKRLKVGDKVIVPAITPDWG--------------EEESQRGYPMHSGGMLGGWKNFKDGVFSEVFHVNEANLALLPRDIKPEDAVMLSDVTTGFHGAELANIKLGDTVCVIGIGPVGLMSVAGANHLGAGRIFAVGSRKHCCDIALEYGATDIINYKN-GDIVEQILKATDG-KGVDKVVIAGGDVHTFAQAVKMIKPGSDIGNVNYLGEGDIPRSEWGVGMGHKHIHGGLTPGRVRMEKLASLISTGKL---DTSKLITHRFEGLEKVEDALMLMKNKPADLIKPVVRIHYDDEDT 358
20 -79.6001bxz_A mol:protein length:352 NADP-DEPENDENT ALCOHOL DEHYDROGENASE  ali model follow..  24  1MKGFAMLSIGKVGW-IEKEKPA-PGPFDAIVRPLAVAPCTSDIHTVFEGAI------------GERHNMILGHEAVGEVVEVGSEVKDFKPGDRVVVPAITPDWR--------------TSEVQRGYHQHSGGMLAGWKNVKDGVFGEFFHVNDMNLAHLPKEIPLEAAVMIDMMTTGFHGAELADIELGATVAVLGIGPVGLMAVAGAKLRGAGRIIAVGSRPVCVDAAKYYGATDIVNYKD-GPIESQIMNLTEG-KGVDAAIIAGGNADIMATAVKIVKPGGTIANVNYFGEGPVPRLEWGCGMAHKTIKGGLCPGRLRMERLIDLVFYKRV---DPSKLVTHVFRGFDNIEKAFMLMKDKPKDLIKPVVILA...... 352
21 -79.6004cpd_A mol:protein length:347 ALCOHOL DEHYDROGENASE  ali model follow..  24  1MRAVVFENKERVAV-KEVNAPRLQHPLDALVRVHLAGICGSDLHLY-------------HGKIPVLPGSVLGHEFVGQVEAVGEGIQDLQPGDWVVGPFHIACGT--------------CPYCRRHQYNLCERGGVYGYGPLQGAQAEILRVPFSNLRKLPPNLSPERAIFADILSTAYGGLIQGQLRPGDSVAVIGAGPVGLMAIEVAQVLGASKILAIDRIPERLERAASLGAIPI--NAEQENPVRRVRSETNDE-GPDLVLEAVGGAATLSLALEMVRPGGRVSAVGVDNAPSFPFPLASGLVKDLTFRIGLANVHLYIDAVLALLASGRL---QPERIVSHYLPLEE-APRGYELF--DRKEALKVLLVVRG..... 347
22 -79.3004ej6_A mol:protein length:370 Putative zinc-binding dehydrogenase  ali model follow..  26  18MKAVRLESVGNISV-RNVGIPE-PGPDDLLVKVEACGICGTDRHLLHGE-------------FPSTPPVTLGHEFCGIVVEAGSAVRDIAPGARITGDPNISCGR--------------CPQCQAGRVNLCRNLRAIGIH-RDGGFAEYVLVPRKQAFEIPLTLDPVHGAFCEPLACCLHGVDLSGIKAGSTVAILGGGVIGLLTVQLARLAGATTVILSTRQATKRRLAEEVGATATVDPSAGDVVEAIAGPVGLVPGGVDVVIECAGVAETVKQSTRLAKAGGTVVILGVLPQGKVEIEPFDILFRELRVLGSFINP-FVHRRAADLVATGAI---EIDRMISRRISLDE-APDVISNPAAAGE--VKVLVIPSAERVAQ 363
23 -78.2003ip1_A mol:protein length:404 Alcohol dehydrogenase, zinc-containing  ali model follow..  24  31WLGSKVWRYPEVRV-EEVPEPRIEKPTEIIIKVKACGICGSDVHMAQTDEEGYILYPGL-----TGFPVTLGHEFSGVVVEAGPEAIRFEIGEPVCAEEMLWCGH--------------CRPCAEGFPNHCENLNELGFN-VDGAFAEYVKVDAKYAWSLREDRLFLAGSLVEPTSVAYNAVRGGGIRPGDNVVILGGGPIGLAAVAILKHAGASKVILSEPSEVRRNLAKELGADHVIDPTK-ENFVEAVLDYTNG-LGAKLFLEATGVPQLVWPQIEEVIWRARGINATVAADAKIPLTGEVFQVRRAQIVGSQGHSHGTFPRVISLMASG-----DMTKIISKTVSMEE-IPEYIKRLQTDKS-LVKVTMLNEG..... 398
24 -77.9001jvb_A mol:protein length:347 NAD(H)-DEPENDENT ALCOHOL DEHYDROGENASE  ali model follow..  24  1MRAVRLVEIGKPLSLQEIGVPK-PKGPQVLIKVEAAGVCHSDVHMRQGR-----GNLRIVEDLGVKLPVTLGHEIAGKIEEVGDEVVGYSKGDLVAVNPWQGEGN--------------CYYCRIGEEHLCDSPRWLGIN-FDGAYAEYVIVPHYKYMYKLRRLNAVEAALTCSGITTYRAVRKASLDPTKTLLVVGAGGLGTMAVQIAKAVSGATIIGVDVREEAVEAAKRAGADYVINASM-QDPLAEIRRITESK-GVDAVIDLNNSEKTLSVYPKALAKQGKYVMVGLFG-ADLHYHAPLITLSEIQFVGSLVGNQSDFLGIMRLAEAGKV-----KPMITKTMKLEE-ANEAIDNLENFKAIG-RQVLIP....... 347
25 -77.9002eer_A mol:protein length:347 NAD-dependent alcohol dehydrogenase  ali model follow..  23  1MRAMRLVEIGKPLKLEDIPIPK-PKGSQVLIKIEAAGVCHSDVHMRQGR-----GNLRIVEDLGVKLPVTLGHEIAGRIEEVGDEVVGYSKGDLVAVNPWEGEGN--------------CYYCRIGEEHLCDSPRWLGIN-YDGAYAEYVLVPHYKYLYKLRRLSAVEAALTCSGVTTYRAVRKASLDPSKTLVVIGAGGLGTMAIQIAKAVSGATIIGVDVREEALEAAKRAGADYVINASS-QDPVSEIRRITQGK-GADAVIDLNNSEKTLSIYPYVLAKQGKYVMVGLFG-ADLKYHAPLITLNEVQFIGSLVGNQSDFLGIMSLAEAGKV-----KPMVTKTMKLEE-ANEAIDNLENFKAVG-RQVLVP....... 347
26 -76.3002cd9_A mol:protein length:366 GLUCOSE DEHYDROGENASE  ali model follow..  18  1MKAIIVKPPNAGVQVKDVDEKKLDSYGKIKIRTIYNGICGTDREIVNGKLTLS-------TLPKGKDFLVLGHEAIGVVEESYHGF---SQGDLVMPVNRRGCGI--------------CRNCLVGRPDFCETGEFAGIHKMDGFMREWWYDDPKYLVKIPKSIE-DIGILAQPLADIEKSIEEIGTLNCRKVLVVGTGPIGVLFTLLFRTYGLEVWMANRREPTEVEQTVIEETKTNYYNSS-----NGYDKLKDSVGKFDVIIDATGADNILGNVIPLLGRNGVLGLFGFSTSGSVPLTLQEIVHTNKTIIGLVNGQKPHFQQAVVHLASWKTLPKAAKMLITKTVSIND-EKELLKVLREKEHGEIKIRILWE...... 366
27 -74.5003wid_A mol:protein length:369 Glucose 1-dehydrogenase  ali model follow..  18  4INAIVTDAPKGGVKYTKIDMPE-PEKYEAKLKPVYIGICGTDRGEVAGALSFTYNP-------EGENFLVLGHEALLQVLDVSD-NNYIKRGDFV-VPLVRRPGK--------------CVNCRIGRQDNCSIGDPAGITGLHGFMRDVIYDDIQNLVKVNDPDLGKIAVLTEPLKNVMKAFEVFDVFIGKKMVVIGSGSEAFLYSFVGKDRGFDVTMVHDETENKMKMMDDFGVGFSNYLKDMPD-------------KIDLLVDTSGDPSTIFKFVKKVNNNGVVILFGFNGKAPNGEDIDYIVERNITIAGSVDAAKIHYVQALDSLSNWYH---RHPQTIKDIITYEAKPEE-TNIFFQKPKGEIKTVIKWPLE.... 363
28 -73.8001h2b_A mol:protein length:359 ALCOHOL DEHYDROGENASE  ali model follow..  22  16LKAARLHEYNKPLRIEDVDYPRLEGRFDVIVRIAGAGVCHTDLHLVQGM----------HELLQPKLPYTLGHENVGYIEEVAEGVEGLEKGDPVILHPAVTDGT--------------CLACRAGEDMHCENLEFPGLN-IDGGFAEFMRTSHRSVIKLPKDISREKLVEMAPLADAGITAYRATLYPGAYVAIVGVGGLGHIAVQLLKVMTPATVIALDVKEEKLKLAERLGADHVVDAR--RDPVKQVMELTRGR-GVNVAMDFVGSQATVDYTPYLLGRMGRLIIVGY--GGELRFPTIRVISSEVSFEGSLVGNYVELHELVTLALQGKVR------VEVDIHKLDE-INDVLERLEKGEVLG-RAVLIP....... 359
29 -73.6005o8h_A mol:protein length:352 Alcohol dehydrogenase  ali model follow..  24  1MKAVQYTEIGSEPVVVDIPTPT-PGPGEILLKVTAAGLCYSDIHVMDM----------PAAQYAYGLPLTLGHEGVGTVAELGEGVTGFGVGDAVAVYGPWGCGA--------------CHACARGRENYCTRAADLGITGSPGSMAEYMIVDSARLVPIGDLDPVAAAPLTDAGLTPYHAISRPLLGPGSTAVVIGVGGLGHVGIQILRAVSAARVIAVDLDDDRLALAREVGADAAVKSG--AGAADAIRELTGGQ-GATAVFDFVGAQSTIDTAQQVVAVDGHISVVGIHA-GAHAKVGFFMIPFGASVVTPFAGTRSELMEVVALARAGRLD------IHTETFTLDE-GPAAYRRLREGSIRG-RGVVVPTS..... 347
30 -73.4002dph_A mol:protein length:398 Formaldehyde dismutase  ali model follow..  18  3NKSVVYHGTRDLRV-ETVPYPKLEHNHAVILKVVSTNICGSDQHIY-------------RGRFIVPKGHVLGHEITGEVVEKGSDVELMDIGDLVSVPFNVACGR--------------CRNCKEARSDVCENNLVNPLKGWSGGQAEYVLVPYAMLLKFGDKEQAMETLISDILPTGFHGCVSAGVKPGSHVYIAGAGPVGRCAAAGARLLGAACVIVGDQNPERLKLLSDAGFETIDLRNS-APLRDQIDQILGKP-EVDCGVDAVGFEAALNSLFDVVRAGGAIGIPGIYVSGRLHLDFGKMWTKSIRIMTGMAPVTNYNRHLTEAILWDQMPY-LSKVMNIEVITLDQA-PDGYAKF--DKGSPAKFVIDPHGMLKNK 398
31 -73.2001vj0_A mol:protein length:380 alcohol dehydrogenase, zinc-containing  ali model follow..  19  12AHAMVLEKFNQPLVYKEFEISD-IPRGSILVEILSAGVCGSDVHMFRGE------------DPRVPLPIILGHEGAGRVVEVNGEKRDLKPGDLIVWNRGITCGE--------------CYWCKVSKEYLCPNRKVYGINRLRGCYSSHIVLPETDVLKVSEKDDLDVLAMAMCGATAYHAFEYPESFAGKTVVIQGAGPLGLFGVVIARSLGAENVIVIAGSPNRLKLAEEIGADLTLNRRETEERRKAIMDITHG-RGADFILEATGDSRALLEGSELLRRGGFYSVAGVAVPQPVPFKVYELVLKNATFKGIWVSDTSHFVKTVSITSRNYQ---LLSKLITHRLPLKE-ANKALELMESRE--ALKVILYPEG..... 374
32 -72.4003wle_A mol:protein length:341 (R)-specific carbonyl reductase  ali model follow..  25  12QYGFVFNKQSGLKLRNDLPVHK-PKAGQLLLKVDAVGLCHSDLHVIYEG-------------LDCGDNYVMGHEIAGTVAAVGDDVINYKVGDRVACVGPNGCGG--------------CKYCRGAIDNVCKNADWFGLG-YDGGYQQYLLVTPRNLSRIPDNVSADVAASTDAVLTPYHAIKMAQVSPTSNILLIGAGGLGGNAIQVAKAFGA-KVTVLDKKKEARDQAKKLGADAVYETLPES----------ISPGSFSACFDFVSVQATFDVCQKYVEPKGVIMPVGL-GAPNLSFNLGDLALREIRILGSFWGTTNDLDDVLKLVSEGKVKP------VVRSAKLKE-LPEYIEKLRNNAYEG-RVVFNP....... 341
33 -72.0006FG0 Entity 1(prereleased)  ali follow..  23  1MKAVQYTEIGSEPVVVDIPTPT-PGPGEILLKVTAAGLCHSDITVMDM----------PAAQYAGGLPLTLGHEGVGTVAELGEGVTGFGVGDAVAVYGPWGCGA--------------CHACARGRENYCTRAADLGITGSPGSMAEYMIVDSARLVPIGDLDPVAAAPLTDAGLTPYHAISRPLLGPGSTAVVIGVGGLGHVGIQILRAVSAARVIAVDLDDDRLALAREVGADAAVKSG--AGAADAIRELTGGQ-GATAVFDFVGAQSTIDTAQQVVAVDGHISVVGIHA-GAHAKVGFWMIPFGASVVTPYWGTRSELMEVVALARAGRLD------IHTETFTLDE-GPAAYRRLREGSIRG-RGVVVPTS..... 347
34 -71.9002b5v_A mol:protein length:357 glucose dehydrogenase  ali model follow..  20  1MKAIAVKRGEDRPVVIEKPRPE-PESGEALVRTLRVGVDGTDHEVIAGGHGGFPE---------GEDHLVLGHEAVGVVVDPN--DTELEEGDIVVVRRPPASG--------------TNEYFERDQPDMAPDGMYFGIVGAHGYMSEFFTSPEKYLVRIPRSQA-ELGFLIEPISITEKALEHAYASDPSSAFVLGNGSLGLLTLAMLKVDDKGYENLYDRPDPTIDIIEELDATYVDSRQTPVEDVPDVYE------QMDFIYEATGFPKHAIQSVQALAPNGVGALLGVPSDWAFEVDAREMVLHNKALVGSVNSHVEHFAATVTFTKLPKW---FLEDLVTGVHPLSE-----FEAAFDDDDTTIKTAIEFST..... 356
35 -71.6005od3_A mol:protein length:352 Alcohol dehydrogenase  ali model follow..  23  1MKAVQYTEIGSEPVVVDIPTPT-PGPGEILLKVTAAGLCHSDIFVMDM----------PAAQYAGGLPLTLGHEGVGTVAELGEGVTGFGVGDAVAVYGPWGCGA--------------CHACARGRENYCTRAADLGITGSPGSMAEYMIVDSARLVPIGDLDPVAAAPLTDAGLTPYHAISRPLLGPGSTAVVIGVGGLGHVGIQILRAVSAARVIAVDLDDDRLALAREVGADAAVKSG--AGAADAIRELTGGQ-GATAVFDFVGAQSTIDTAQQVVAVDGHISVVGIHA-GAHAKVGFFMIPFGASVVTPYWGTRSELMEVVALARAGRLD------IHTETFTLDE-GPAAYRRLREGSIRG-RGVVVPTS..... 347
36 -71.5004jlw_A mol:protein length:399 Glutathione-independent formaldehyde dehydrogenase  ali model follow..  22  4NRGVVYLGPGKVEV-QNIPYPKMQIDHGVILRVVSTNICGSDQHMV-------------RGRTTAPEGLVLGHEITGEVVEIGRGVETMKIGDLVSVPFNVACGH--------------CRTCKEQHTGVCLTVNPARAGGWVGGQAEYVLVPYANLLKLPNREAAMETCLSDILPTGYHGAVTAGVGPGSTVYIAGAGPVGLAAAASARLLGAAVVIVGDVNPTRLAHAKKQGFEIADLSKD-TPLHEQIAALLGEP-EVDCAVDAVGFEAVLNSLMGITRVAGKIGIPGLYVTEALSIRFGLGWAKSHSFHTGQTPVMKYNRQLMQAIMWDRIKIADI--VGVEVITLDD-APKGYGEFDAGV--PKKFVIDPHNLFRA. 398
37 -71.3001kol_A mol:protein length:398 formaldehyde dehydrogenase  ali model follow..  19  3NRGVVYLGSGKVEV-QKIDYPKMKIEHGVILKVVSTNICGSDQHMV-------------RGRTTAQVGLVLGHEITGEVIEKGRDVENLQIGDLVSVPFNVACGR--------------CRSCKEMHTGVCLTVNPARAGDWTGGQAEYVLVPYANLLKLPDRDKAMETCLSDILPTGYHGAVTAGVGPGSTVYVAGAGPVGLAAAASARLLGAAVVIVGDLNPARLAHAKAQGFEIADLSLD-TPLHEQIAALLGEP-EVDCAVDAVGFEAVLNSLMQVTRVAGKIGIPGLYVTESLSIRFGLGWAKSHSFHTGQTPVMKYNRALMQAIMWDRINIAEV--VGVQVISLDDA-PRGYGEFDAGVP--KKFVIDPHKTFSA. 397
38 -69.9002h6e_A mol:protein length:344 D-arabinose 1-dehydrogenase  ali model follow..  24  4SKAALLKKFSEPLSIEDVNIPE-PQGEEVLIRIGGAGVCRTDLRVWKG----------VEAKQGFRLPIILGHENAGTIVEVGE-LAKVKKGDNVVVYATWGDLT--------------CRYCREGKFNICKNQIIPGQT-TNGGFSEYMLVKSSRWLVKLNSLSPVEAALADAGTTSMGAIRQASKFAEPVVIVNGIGGLAVYTIQILKALMKNTIVGISRSKKHRDFALELGADYVSEM---KDAESLINKLTDGL-GASIAIDLVGTEETTYNLGKLLAQEGAIILVGMEG-KRVSLEAFDTAVWNKKLLGSNYGSLNDLEDVVRLSESGKIK------PYIIKVPLDD-INKAFTNLDEGRVDG-RQVITP....... 344
39 -65.5004gkv_A mol:protein length:336 Alcohol dehydrogenase, propanol-preferring  ali model follow..  21  1MKAAVVTKDHHVDV-TYKTLRS-LKHGEALLKMECCGVCHTDLHVKNGD-------------FGDKTGVILGHEGIGVVAEVGPGVTSLKPGDRASVAWFYGCGH--------------CEYCNSGNETLCRSVKNAGYS-VDGGMAEECIVVADYAVKVPDGLDSAAASSITCAGVTYKAVKLSKIRPGQWIAIYGLGGLGNLALQYAKNVFNAKVIAIDVNDEQLKLATEMGADLAINSHT-EDAAKIVQEKTG---GAHAAVVTAVAKAAFNSAVDAVRAGGRVVAVGL-PPESMSLDIPRLVLDGIEVVGSLVGTRQDLTEAFQFAAEGKVVP------KVALRPLAD-INTIFTEMEEGKIRGRMVI.......... 332
40 -65.2004eex_A mol:protein length:348 Alcohol dehydrogenase 1  ali model follow..  22  1MKAAVVRHNPDGYALVEKELRA-IKPNEALLDMEYCGVCHTDLHVAAGD-------------YGNKAGTVLGHEGIGIVKEIGADVSSLQVGDRVSVAWFFGCGH--------------CEYCVSGNETFCREVKNAGYS-VDGGMAEEAIVVADYAVKVPDGLDPIEASSITCAGVTYKAIKVSGVKPGDWQVIFGAGGLGNLAIQYAKNVFGAKVIAVDINQDKLNLAKKIGADVIINSGD-VNPVDEIKKITGGL-GVQSAIVCAVARIAFEQAVASLKPMGKMVAVAL-PNTEMTLSVPTVVFDGVEVAGSLVGTRLDLAEAFQFGAEGKVKP------IVATRKLEE-INDIIDEMKAGKIEGRMVIDFTKLE.... 342
41 -65.2005k1s_A mol:protein length:362 Oxidoreductase, zinc-binding dehydrogenase family  ali model follow..  23  12MKAVVLRSFGEAGNLETMPMPR-PGRGEVLLRVHACGVCYHDVINRRGN------------LPRTSVPAILGHEAAGEVIEVGPDTPGWKTGDRAATLQRMSCGD--------------CALCRSGRNSLCKTDNRFFGEELPGGYAQFMVAPVGGLGRVPASLPWNEAAVCCTTGTAVHTVTRGKVRAGETVLITGAGGVGLSSVQLARLDGA-RVIAVTSSEAKVQALKEAGADEVIVSRG-LDFASDVRKRTQGA-GVDVAVEIVG-SATFDQTLKSMAPGGRVVVVGNLESGMVQLNPGLVIVKELEILGAYATTQAELDEALRLTATGGV-----RQFVTDAVPLAEA-AKAHFRLENREV---RLVLVPPEA.... 356
42 -62.7005yat_A mol:protein length:350 Mitochondrial alcohol dehydrogenase isozyme III  ali model follow..  21  9QKAVIFETNGGPLEYKDIPVPK-PKSNELLINVKYSGVCHTDLHAWKGD-------------LDNKLPLVGGHEGAGVVVAYGENVTGWEIGDYAGIKWLNSCLN--------------CEYCIQGAESSCAKADLSGFT-HDGSFQQYATADATQAARIPKEADLAEVAILCAGITVYKALKTADLRIGQWVAISGAGGLGSLAVQYAKALGL-RVLGIDGGADKGEFVKSLGAEVFVDFTKTKDVVAEVQKLTNG--GPHGVINVSVSPHAINQSVQYVRTLGKVVLVGLPSGAVVNSDVFWHVLKSIEIKGSYVGNREDSAEAIDLFTRGLVKA------PIKIIGLSE-LAKVYEQMEAGAIIG-RYVVDTSK..... 350
43 -61.4004w6z_A mol:protein length:347 Alcohol dehydrogenase 1  ali model follow..  19  6QKGVIFYESHGKLEYKDIPVPK-PKANELLINVKYSGVCHTDLHAWHGD-------------LPVKLPLVGGHEGAGVVVGMGENVKGWKIGDYAGIKWLNSCMA--------------CEYCELGNESNCPHADLSGYT-HDGSFQQYATADAVQAAHIPQGTDLAQVA---PILCAYKALKSANLMAGHWVAISGAGGLGSLAVQYAKAMGY-RVLGIDGGEGKEELFRSIGGEVFIDFTKEKDIVGAVLKATDG--GAHGVINVSVSEAAIEASTRYVRANGTTVLVGMPAGAKCCSDVFNQVVKSISIVGSYVGNRADTREALDFFARGLVKS------PIKVVGLST-LPEIYEKMEKGQIVG-RYVVDTSK..... 347
44 -59.9001rjw_A mol:protein length:339 Alcohol dehydrogenase  ali model follow..  24  1MKAAVVEQFKEPLKIKEVEKPT-ISYGEVLVRIKACGVCHTDLHAAHGD-------------VKPKLPLIPGHEGVGIVEEVGPGVTHLKVGDRVGIPWLYACGH--------------CDYCLSGQETLCEHQKNAGYS-VDGGYAEYCRAAADYVVKIPDNLSFEEAA---PIFCAYKALKVTGAKPGEWVAIYGIGGLGHVAVQYAKAMGL-NVVAVDIGDEKLELAKELGADLVVNPLK-EDAAKFMKEKVG---GVHAAVVTAVSKPAFQSAYNSIRRGGACVLVGL-PPEEMPIPIFDTVLNGIKIIGSIVGTRKDLQEALQFAAEGKVKT------IIEVQPLEK-INEVFDRMLKGQINGRVVLTLEDK..... 339
45 -59.5003meq_A mol:protein length:365 Alcohol dehydrogenase, zinc-containing  ali model follow..  23  20MKAAVVRAFGKPLTIDEVPIPQ-PGPGQIQVAIQASGVCHTDLHAAEGD-------------VKPNPPFIPGHEGVGFVSAVGSGVKHVKEGDRVGIPWLYACGH--------------CRHCLGGWETLCEEQLNTGYS-VNGGFAEYVVADPNFVGHLPKNIDFNEIA---PVLCAYKGLKVTDTKPGDWVVISGIGGLGHMAVQYARAMGL-NVAAVDIDDRKLDLARRLGATVTVNAKTVADPAAYIRKETDG--GAQGVLVTAVSPKAFEQALGMVARGGTVSLNGL-PPGDFPLSIFNMVLNGVTVRGSIVGTRLDLQESLDFAADGKVKA------TIQTGKLED-INAIFDDMRQGNIEGRIVM.......... 355
46 -58.5004jbg_A mol:protein length:370 Alcohol dehydrogenase (Zinc)  ali model follow..  24  34MRAAAFSTPGLENLLVEAETPR-PGPGEVLIRVKYAGVNPLDYNVVAGA------------VKASPMPHIPGSEFAGVVEEAGPGVTGVSRGDPVVVYNRLYCGH--------------CRQCLTGWTQMCEVTGIIGIV-TQGGYAEYAVVPAKNAVATRADLK-EAATLPIGALTAWNMAYRASISPGEKVAVVGAGNVGIYAVQFAKLLGGEVYAISRRKAKVESILKSAGADAVLTPDE-----------AKSAAPFDVVLDPTG-SASWDLSFGVLGRGGRYVTAGALTGAEVRLDLRRLYGMQILVIGATGGRRADFNTVVRLLEAGRI-----KAFLHNVYPLAD-VRKALEELRSPER---KVLIAP....... 364
47 -58.4004z6k_A mol:protein length:346 Alcohol dehydrogenase  ali model follow..  23  1MKAAVLHEFGQSLQIEEVDIPT-PGAGEIVVKMQASGVCHTDLHAVEGD-------------VKPSPPFIPGHEGVGLITAVGEGVTHVKEGDRVGVA-YSACGH--------------CTHCLGGWETLCESQQNSGYS-VNGSFAEYVLANANYVGIIPESVDSIEIA---PVLCAYKGLKMTDTKPGDWVVISGIGGLGHMAVQYAIAMGL-NVAAVDIDDDKLAFAKKLGAKVTVNAKN-TDPAEYLQKEIG---GAHGALVTAVSAKAFDQALSMLRRGGTLVCNGL-PPGDFPVSIFDTVLNGITIRGSIVGTRLDLQESLDMAAAGKVKA------TVTAEPLEN-INDIFERMRQGKIEGRIVI.......... 334
48 -58.4003s1l_A mol:protein length:340 Zinc-containing alcohol dehydrogenase superfamily  ali model follow..  23  3MKAAVVRAFGAPLTIDEVPVPQ-PGPGQVQVKIEASGVCHTDLHAADGD-------------VKPTLPFIPGHEGVGYVSAVGSGVSRVKEGDRVGVPWLYACGY--------------CEHCLQGWETLCEKQQNTGYS-VNGGYGEYVVADPNYVGLLPDKVGFVEIA---PILCAYKGLKVTDTRPGQWVVISGIGGLGHVAVQYARAMGL-RVAAVDIDDAKLNLARRLGAEVAVNARD-TDPAAWLQKEIG---GAHGVLVTAVSPKAFSQAIGMVRRGGTIALNGL-PPGDFGTPIFDVVLKGITIRGSIVGTRSDLQESLDFAAHGDVKA------TVSTAKLDD-VNDVFGRLREGKVEGRVVL.......... 336
49 -58.0001llu_A mol:protein length:342 Alcohol Dehydrogenase  ali model follow..  21  7MKAAVVHAYGAPLRIEEVKVPL-PGPGQVLVKIEASGVCHTDLHAAEGD-------------VKPPLPFIPGHEGVGYVAAVGSGVTRVKEGDRVGIP-YTACGC--------------CEHCLTGWETLCESQQNTGYS-VNGGYAEYVLADPNYVGILPKNVEFAEIA---PILCAYKGLKQTNARPGQWVAISGIGGLGHVAVQYARAMGL-HVAAIDIDDAKLELARKLGASLTVNARQ-EDPVEAIQRDIG---GAHGVLVTAVSNSAFGQAIGMARRGGTIALVGL-PPGDFPTPIFDVVLKGLHIAGSIVGTRADLQEALDFAGEGLVKA------TIHPGKLDD-INQILDQMRAGQIEGRIVL.......... 340
50 -57.0005h83_A mol:protein length:360 heteroyohimbine synthase HYS  ali model follow..  20  15TFGFAAKDSSGFFSPFNFSRRA-TGENDVQFKVLYCGTCNYDLEMSTNK-------------GMTKYPFVIGHEIVGVVTEIGSKVQKFKVGDKVGVGGFVACEK--------------CEMCVNGVENNCSKVESTDGHFGFGGCCNIMVVNEKYAVVWPENLPLHSGVPLLCAGITTYSRRYGLDKPGLNIGIAGLGGLGHLAIRFAKAFGAKVTLISSSVKKKREALEKFGVDSFLLNSNPEEMQGA-------YGTLDGIIDTMPVAHSIVPFLALLKPLGKLIILGV-PEEPFEVPAPALLMGGKLIAGSAAGSMKETQEMIDFAAKHNIVA------DVEVIPIDY-LNTAMERIKNSDVKY-RFVIDVGNTLKS. 357
51 -56.7005h81_A mol:protein length:389 heteroyohimbine synthase THAS2  ali model follow..  20  23AYGWAAKDTSGLLSPFKFLRRT-TGEHDVQFKVLYCGLCDWDVITTKNT-------------GTTKYPFVPGHEIMGIVTEIGNKVKKFKVGDKVGVGNFISCGK--------------CERCNEGLEPYCPKVIYTDGTAFSGGYSNIMVANEYVVFRWPENLPLAAGVPILCGGIVPYSRHFGLDKPGLSIGVVGFGRIGKLAVKFAKAFGANVTVISTSISKKQEAIEKYGVDRFLISKEPEEMKAA-------ESTLDGIFDCVPSVHPLHPLLNLLKFEGTFVMLGV-AVEAYELPVSPLLMGRRKFVGSISGTMKETQEMLDFAAKHNIVSD------IELIPMDY-VNTALERIAKGNHKDAFVI.......... 374
52 -56.5005fi3_A mol:protein length:357 Tetrahydroalstonine synthase  ali model follow..  22  18AFGLAAKDSSGLFSPFNFSRRA-TGEHDVQLKVLYCGTCQYDREMSKNK-------------GFTSYPYVLGHEIVGEVTEVGSKVQKFKVGDKVGVASIITCGK--------------CEMCTNEVENYCPEAGSIDSN--YGACSNIAVINENFVIRWPENLPLDSGV---PLLCAYSPMKRYGLKPGKRIGIAGLGGLGHVALRFAKAFGAKVTVISSSLKKKREAFEKFGADSFLVSSNPEEMQGA-------AGTLDGIIDTIPGNHSLEPLLALLKPLGKLIILGA-PEMPFEVPAPSLLMGGKVMAASTAGSMKEIQEMIEFAAEHNIVA------DVEVISIDY-VNTAMERLDNSDVRYRFVIDIGNT..... 353
53 -56.4003two_A mol:protein length:348 Mannitol dehydrogenase  ali model follow..  24  5SKGFAIFSKDEHFKPHDFSRHA-VGPRDVLIDILYAGICHSDIHSAYSE-------------KEGIYPMIPGHEIAGIIKEVGKGVKKFKIGDVVGVGCFVSCKA--------------CKPCKEHQEQFCTKVVFTYDCLHMGGYSNNIVVDENYVISVDKNAPLEKVA---PLLCAYSPLKFSKVTKGTKVGVAGFGGLGSMAVKYAVAMGA-EVSVFARNEHKKQDALSMGVKHFYTDPKQC------------KEELDFIISTIPTHYDLKDYLKLLTYNGDLALVGLPPVAPVLSVFDFIHLGNRKVYGSLIGGIKETQEMVDFSIKHNIYPE------IDLILGKD-IDTAYHNLTHGKAKF-RYVIDMKKSFD.. 348
54 -56.2006c49_A mol:protein length:350 Alcohol dehydrogenase  ali model follow..  20  8IQAYAAMQAGEKLVPYKFDAGE-LQPHQVEVKVEYCGLCHSDISVLNNE-------------HSTVYPVVAGHEIIGRIVALGSEAKGLQIGQRVGIG-AESCQA--------------CDECIGGQQVLCTGENIATIVGHAGGFADKVRAGWQWAIPLPEDLDPESAG---PLLCGFDPLLKHKIQATHHVGVIGIGGLGHIAIKLLKAWGC-EITAFSSNPDKTEELKAMGADHVVNSRDTEAVKAQ-------KGKFDLLLSTVNVTLNWRAFISTLAPNGSLHFLGL-TLEPVPVSVGSLIDGAKSVTGSPTGSPAALRQLLKFAARKKIAP------QIELFPMSQ-LNEAIERLHSGQARY-RIVLKADFAE... 344
55 -56.1001cdo_A mol:protein length:374 ALCOHOL DEHYDROGENASE  ali model follow..  19  9CKAAVAWEANKPLVIEEIEVDV-PHANEIRIKIIATGVCHTDLYHLFEGKHKDG------------FPVVLGHEGAGIVESVGPGVTEFQPGEKVIPLFISQCGE--------------CRFCQSPKTNQCVKGWANESPDV-STFSQYTVVNQIAVAKIDPSAPLDTVCLL--VSTGFGAANTAKVEPGSTCAVFGLGAVGLAAVMGCHSAGAKRIIAVDLNPDKFEKAKVFGATDFVNPNDHSEPISQVLSKMTNG-GVDFSLECVGNVGVMRNALESCLKGWGVSVLVGWTDLHDVATRPIQLIAGRTWKGSMFKGKDGVPKMVKAYLDKKVK---LDEFITHRMPLES-VNDAIDLMKHGK--CIRTVLS........ 373
56 -56.0005vkt_A mol:protein length:362 Cinnamyl alcohol dehydrogenases (SbCAD4)  ali model follow..  23  10AHGWAARDASGHLSPYSFSARI-QGDADVTIKVLFCGICHTDLHVIKNE-------------GNAMYPVVPGHEVVGVVTDVGHGVTKFKAGDTVGVGYFVSCRT--------------CESCSTGHENYCPDLVLTSNGTTKGGFSDVLVVSQDFVVRVPESLPLDGAAPLLCAGVTVYSAQYALNEPGKHLGVVGLGGLGHMAVKFAKAFGMTVTVISSSPGKRDEALGRLGADAFLVSHDAAQMKAA-------AATLDGIIDTVSAGHQIVPLLALLKPMGQMVVVGA-PSTPLELPAYAIITGGKRVAGNGVGSVADCQAMLDFAGEHGVTA------DIEVVQMDY-VNTAIERLEKNDVRYRFVIDVAGSKMEET 356
57 -55.1001e3e_A mol:protein length:376 ALCOHOL DEHYDROGENASE, CLASS II  ali model follow..  23  9CKAAIAWKTGSPLCIEEIEVSP-PKACEVRIQVIATCVCPTDINATD-------------PKKKALFPVVLGHECAGIVESVGPGVTNFKPGDKVIPFFAPQCKR--------------CKLCLSPLTNLCGKLRNFKYPTIDSSFSQYTVVSEANLARVDDEANLERVCLI--FSSGYGAANTAKVTPGSTCAVFGLGCVGLSAIIGCKIAGASRIIAIDINGEKFPKAKALGATDCLNPRELDKPVQDVITELTAG-GVDYSLDCAGTAQTLKAAVDCTVLGWGSCTVVGAKVDEMTIPTVDVILGR-SINGTFWKSVDSVPNLVSDYKNKKFD---LDLLVTHALPFES-INDAIDLMKEGK--SIRTILT........ 375
58 -55.0001uuf_A mol:protein length:369 ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN YAHK  ali model follow..  21  17IKAVGAYSAKQPLEPMDITRRE-PGPNDVKIEIAYCGVCHSDLHQVRSE-------------AGTVYPCVPGHEIVGRVVAVGDQVEKYAPGDLVGVGCIVSCKH--------------CEECEDGLENYCDHMTGTYNSPTLGGYSQQIVVHERYVLRIRHPQEQLAAVA--PLLCAYSPLRHWQAGPGKKVGVVGIGGLGHMGIKLAHAMGA-HVVAFTTSEAKREAAKALGADEVVNSRNADEMAAH-------LKSFDFILNTVAAPHNLDDFTTLLKRDGTMTLVGAPATPHKSPEVFNLIMKRRAIAGSMIGGIPETQEMLDFCAEHGIVAD------IEMIRADQ-INEAYERMLRGDVKYRFVI.......... 356
59 -55.0002cf5_A mol:protein length:357 CINNAMYL ALCOHOL DEHYDROGENASE  ali model follow..  24  10TTGWAARDPSGILSPYTYTLRE-TGPEDVNIRIICCGICHTDLHQTKND-------------GMSNYPMVPGHEVVGEVVEVGSDVSKFTVGDIVGVGCLVCCGG--------------CSPCERDLEQYCPKKIWSYNDVTQGGFAKATVVHQKFVVKIPEGMAVEQAAPLLCAGVTVYSSHFGLKQPGLRGGILGLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGSDQAKMSEL-------ADSLDYVIDTVPVHHALEPYLSLLKLDGKLILMGV-INNPLQFLTPLLMLGRKVITGSFIGSMKETEEMLEFCKEKGLSS------IIEVVKMDY-VNTAFERLEKNDVRYRFVVDVEGSNLDA. 357
60 -54.7001p0c_A mol:protein length:373 NADP-dependent ALCOHOL DEHYDROGENASE  ali model follow..  21  10CKAAVAWEPHKPLSLETITVAP-PKAHEVRIKILASGICGSDSSVLK-------------EIIPSKFPVILGHEAVGVVESIGAGVTCVKPGDKVIPLFVPQCGS--------------CRACKSSNSNFCEKNDMGAKTGL-STFTEYTVVADIAVAKIDPKAPLESCLIGCGFATGYGAANTAKVTPGSTCAVFGLGGVGFSAIVGCKAAGASRIIGVGTHKDKFPKAIELGATECLNPKDYDKPIYEVICEKTNG-GVDYAVECAGRIETMMNALQSTYCGGVTVVLGLASPNERLPLDPLLLLTGRSLKGSVGFKGEEVSRLVDDYMKKKIN---VNFLVSTKLTLDQ-INKAFELLSSGQ--GVRSIM......... 371
61 -54.7001yqd_A mol:protein length:366 sinapyl alcohol dehydrogenase  ali model follow..  20  17AFGWAARDQSGHLSPFNFSRRA-TGEEDVRFKVLYCGVCHSDLHSIKND-------------GFSMYPLVPGHEIVGEVTEVGSKVKKVNVGDKVGVGCLVACHS--------------CESCANDLENYCPKMILTYASITYGGYSNHMVANERYIIRFPDNMPLDGGAPLLCAGITVYSKYFGLDEPGKHIGIVGLGGLGHVAVKFAKAFGSKVTVISTSPSKKEEALKNFGADSFLVSRDQEQMQAA-------AGTLDGIIDTVSAVHPLLPLFGLLKSHGKLILVGA-PEKPLELPAFSLIAGRKIVAGSGIGGMKETQEMIDFAAKHNITA------DIEVISTDY-LNTAMERLAKNDVRYRFVIDVGNTLAATK 365
62 -54.7004rqt_A mol:protein length:375 Alcohol dehydrogenase class-P  ali model follow..  20  6CKAAVAWEAGKPLVIEEVEVAP-PQKHEVRIKILFTSLCHTDVYFWEAK------------GQTPLFPRIFGHEAGGIVESVGEGVTDLQPGDHVLPIFTGECGE--------------CRHCHSEESNMCDLLRINTERGG-STFSEYTVVHSGQVAKINPDAPLDKVCIV--LSTGLGATNVAKPKKGQSVAIFGLGAVGLGAAEGARIAGASRIIGVDFNSKRFDQAKEFGVTECVNPKDHDKPIQQVIAEMTDG-GVDRSVECTGSVQAMIQAFECVHDGWGVAVLVGVPSKDDAFKTHPMFLNERTLKGTFYKPKTDIPGVVEKYMNKELE---LEKFITHTVPFSE-INKAFDYMLKGE--SIRCIITMGA..... 375
63 -54.5001mc5_A mol:protein length:374 Alcohol dehydrogenase class III chi chain  ali model follow..  20  8CKAAVAWEAGKPLSIEEIEVAP-PKAHEVRIKIIATAVCHTDAYTLSGADPEGC------------FPVILGHEGAGIVESVGEGVTKLKAGDTVIPLYIPQCGE--------------CKFCLNPKTNLCQKIRVTQGKGL-STFSEYTVVADISVAKIDPLAPLDKVCLL--ISTGYGAANTAKLEPGSVCAVFGLGGVGLAVIMGCKVAGASRIIGVDINKDKFARAKEFGATECINPQDFSKPIQEVLIEMTDG-GVDYSFECIGNVKVMRAALEACHKGWGVSVVVGVAASGEEIATRPFLVTGRTWKGTAWKSVESVPKLVSEYMSKKIK---VDEFVTHNLSFDE-INKAFELMHSGK--SIRTVVK........ 373
64 -54.5005z0c_A mol:protein length:374 Nerol dehydrogenase  ali model follow..  22  14AVGWAARDPSGHLSPFTFSRRA-TGELDVTFKVLYCGICHSDLHYIKNE-------------SNTIYPALPGHEIVGEVTEVGSKVNKFKVGDKVGVGCIVSCHS--------------CPNCNNHLENYCPNRILTFGSRNHGGYSDLMVVQEHFAVRIPDALPLDSAAPLLCAGITVYSRYYGLDKPGLHVGVVGLGGLGHMAVKFAKAFGVKVTVVSTSPAKKEDAISGLGAHSFILSTDAEQMQAA-------VGTMDGIIDTVSASHPLPPLISLLKSHGKLVMVGD-PPKPLELPVFPLLLGRKMVAGSAIGGMKETQEMIDFAAKEGVRA------DVEVIPMDY-VNTAMQRVSKSDVKYRFVIDIGNTFNDSL 362
65 -53.7002eih_A mol:protein length:343 Alcohol dehydrogenase  ali model follow..  24  1MRAVVMRARGGPEVLEDLPVPE-PGPKEVRVRLKAAALNHLDVWVRKGVA-----------SPKLPLPHVLGADGSGVVDAVGPGVEGFAPGDEVVINPGLSCGR--------------CERCLAGEDNLCPRYQILGEH-RHGTYAEYVVLPEANLAPKPKNLSFEEAAAI-PLTTAWQMVDKLGVRPGDDVLVMAGSGVSVAAIQIAKLFGA-RVIATAGSEDKLRRAKALGADETVN--THPDWPKEVRRLTGGK-GADKVVDHTG-ALYFEGVIKATANGGRIAIAGASSGYEGTLPFAHVFYRQLSILGSTMASKSRLFPILRFVEEGKL-----KPVVGQVLPLEAA-AEGHRLLEERRV---KVVLQVG...... 343
66 -53.7003uko_A mol:protein length:378 Alcohol dehydrogenase class-3  ali model follow..  21  9CKAAVAYEPNKPLVIEDVQVAP-PQAGEVRIKILYTALCHTDAYTWSGK------------DPEGLFPCILGHEAAGIVESVGEGVTEVQAGDHVIPCYQAECRE--------------CKFCKSGKTNLCGKVRSATGVGI-STFSQYTVVHDVSVAKIDPTAPLDKVCLL--VPTGLGAVNTAKVEPGSNVAIFGLGTVGLAVAEGAKTAGASRIIGIDIDSKKYETAKKFGVNEFVNPKDHDKPIQEVIVDLTDG-GVDYSFECIGNVSVMRAALECCHKGWGTSVIVGVAASGQEISTRPFLVTGRVWKGTAFKSRTQVPWLVEKYMNKEIK---VDEYITHNLTLGE-INKAFDLLHEGT--CLRCVLDTSK..... 378
67 -53.6001ee2_A mol:protein length:373 ALCOHOL DEHYDROGENASE  ali model follow..  22  9CKAAVLWEQKKPFSIEEVEVAP-PKAHEVRIKMVAAGICRSDDHVVS-------------GTLVAPLPVIAGHEAAGIVESIGEGVTTVRPGDKVIPLFIPQCGK--------------CSVCKHPEGNLCLKNLSMPRGTMQSTFSQYTVVDEISVAKIDAASPLEKVCLV--FSTGYGSAKVAKVTQGSTCAVFGLGGVGLSVIMGCKAAGAARIIGVDINKDKFAKAKEVGATECVNPQDYKKPIQEVLTEMSNG-GVDFSFEVIGRLDTMVAALSCCQEAGVSVIVGVPPDSQNLSMNPMLLLSGRTWKGAIFKSKDSVPKLVADFMAKKFA---LDPLITHVLPFEK-INEGFDLLRSGK--SIRTILT........ 372
68 -53.6001a71_A mol:protein length:374 LIVER ALCOHOL DEHYDROGENASE  ali model follow..  21  9CKAAVLWEEKKPFSIEEVEVAP-PKAHEVRIKMVATGICRSDDHVVS-------------GTLVTPLPVIAGHEAAGIVESIGEGVTTVRPGDKVIPLWTPQCGK--------------CRVCKHPEGNFCLKNDLSMPRGT-STFSQYTVVDEISVAKIDAASPLEKVCLI--FSTGYGSAKVAKVTQGSTCAVFGLGGAGLSVIMGCKAAGAARIIGVDINKDKFAKAKEVGATECVNPQDYKKPIQEVLTEMSNG-GVDFSFEVIGRLDTMVTALSCCQEAGVSVIVGVPPDSQNLSMNPMLLLSGRTWKGAIFKSKDSVPKLVADFMAKKFA---LDPLITHVLPFEK-INEGFDLLRSGE--SIRTIL......... 372
69 -53.6001qlh_A mol:protein length:374 ALCOHOL DEHYDROGENASE  ali model follow..  21  9CKAAVLWEEKKPFSIEEVEVAP-PKAHEVRIKMVATGICRSDDHVVS-------------GTLVTPLPVIAGHEAAGIVESIGEGVTTVRPGDKVIPLFTPQCGK--------------CRVCKHPEGNFCLKNDLSMPRGT-STFSQYTVVDEISVAKIDAASPLEKVCLI--FSTGYGSAKVAKVTQGSTCAVFGLGGVGLSVIMGCKAAGAARIIGVDINKDKFAKAKEVGATECVNPQDYKKPIQEVLTEMSNG-GVDFSFEVIGRLDTMVTALSCCQEAGVSVIVAVTPDSQNLSMNPMLLLSGRTWKGAIFKSKDSVPKLVADFMAKKFA---LDPLITHVLPFEK-INEGFDLLRSGE--SIRTIL......... 372
70 -53.5001qv6_A mol:protein length:374 Alcohol dehydrogenase E chain  ali model follow..  21  9CKAAVLWEEKKPFSIEEVEVAP-PKAHEVRIKMVATGICRSDDQVVS-------------GTLVTPLPVIAGHEAAGIVESIGEGVTTVRPGDKVIPLFTPQCGK--------------CRVCKHPEGNFCLKNDLSMPRGT-STFSQYTVVDEISVAKIDAASPLEKVCLI--FSTGYGSAKVAKVTQGSTCAVFGLGGVGLSVIMGCKAAGAARIIGVDINKDRFAKAKEVGATECVNPQDYKKPIQEVLTEMSNG-GVDFSFEVIGRLDTMVTALSCCQEAGVSVIVGVPPDSQNLSMNPMLLLSGRTWKGAIFKSKDSVPKLVADFMAKKFA---LDPLITHVLPFEK-INEGFDLLRSGE--SIRTIL......... 372
71 -53.4003cos_A mol:protein length:381 Alcohol dehydrogenase 4  ali model follow..  21  11CKAAIAWEAGKPLCIEEVEVAP-PKAHEVRIQIIATSLCHTDATVIDSKFEGLA------------FPVIVGHEAAGIVESIGPGVTNVKPGDKVIPLYAPLCRK--------------CKFCLSPLTNLCGKISNLKSPASDSTFSQYTVVSDINLAKIDDDANLERVCLL--FSTGYGAANNAKVTPGSTCAVFGLGGVGLSAVMGCKAAGASRIIGIDINSEKFVKAKALGATDCLNPRDHKPIQEVIIELTKG--GVDFALDCAGGSETMKAALDCTTAGGSCTFIGVAAGSKGLTVFPEELIIGRTINGTFWKSVDSIPKLVTDYKNKKFN---LDALVTHTLPFDK-ISEAFDLMNQGK--SIRTIL......... 379
72 -53.3004dl9_A mol:protein length:396 Alcohol dehydrogenase class III  ali model follow..  20  21CKAAVAWEPNKPLVIEDVQVAP-PQAGEVRVKVLYTALCHTDAYTWSGK------------DPEGLFPCVLGHEAAGIVESVGEGVTEVQPGDHVIPCYQAECRE--------------CKFCKSGKTNLCGKVRAATGVGV-STFSQYTVVHDVSVAKIDPVAPLEKVCLL--VPTGLGAVNTAKVEPGSIVAVFGLGTVGLAVAEGAKAAGASRIIGIDIDSKKFDRAKNFGVTEFINPKEHEQPIQQVIVDLTDG-GVDYSFECIGNVSVMRSALECCHKGWGTSVIVGVAASGQEISTRPFLVTGRVWKGTAFKSRSQVPSLVDKYLKKEIK---VDEYITHNMTLAD-INKAFDLMHDGD--CLRVVLD........ 387
73 -53.0005tnx_A mol:protein length:383 Alcohol dehydrogenase zinc-binding domain protein  ali model follow..  21  12VTAAVARAAGAPFSIEPARIRA-PRGDEVLVRVVATGLCHTDLIVRD-------------QYYPVPLPAVLGHEGAGVVEAVGPNVKTLAAGDHVVLT--GACGH--------------CASCAGGHGAYCRQFFALNFGGAQSSFASYALARENNAIKVPKEAPLELLGPL--IQTGAGAVNSLAVRTGSSFASFGAGAVGMSAVMAARIAGATTIIAVDIVPSRLALALELGATHAINSKE-VDVVDAIREITGG--GVDYALESTGLPAVLSQGIDALGSRGTMGVVGAPKGTKAEFDVNSLLLGGHTIRGIVSVPQTFIPQLVQLHLQGRFPFDR----LVKFYPLEQ-INQAAADSSSGI--TLKPILRLPH..... 377
74 -52.9001agn_A mol:protein length:373 HUMAN SIGMA ALCOHOL DEHYDROGENASE  ali model follow..  22  9CKAAVLWEQKQPFSIEEIEVAP-PKTKEVRIKILATGICRTDDHVIK-------------GTMVSKFPVIVGHEATGIVESIGEGVTTVKPGDKVIPLFLPQCRE--------------CNACRNPDGNLCIRSDITGRGVLASTFTEYTVVDESSVAKIDDAAPPEKVCLI--FSTGYGAAKTGKVKPGSTCVVFGLGGVGLSVIMGCKSAGASRIIGIDLNKDKFEKAMAVGATECISPKDSTKPISEVLSEMTGN-NVGYTFEVIGHLETMIDALASCMNYGTSVVVGVPPSAKMLTYDPMLLFTGRTWKGCVLKSRDDVPKLVTEFLAKKF---DLDQLITHVLPFKK-ISEGFELLNSGQ--SIRTVLT........ 372
75 -52.9001f8f_A mol:protein length:371 BENZYL ALCOHOL DEHYDROGENASE  ali model follow..  22  7IIAAVTPCKGADFELQALKIRQ-PQGDEVLVKVVATGMCHTDLIVRDQK-------------YPVPLPAVLGHEGSGIIEAIGPNVTELQVGDHVVLS--GYCGK--------------CTQCNTGNPAYCSEFFGRNFSGAQSSFATYALSRENNTVKVTKDVPIELLGPL--IQTGAGACNALKVTPASSFVTWGAGAVGLSALLAAKVCGASIIIAVDIVESRLELAKQLGATHVINSKT-QDPVAAIKEITDG--GVNFALESTGSPEILKQGVDALGILGKIAVVGAPQGTTAQFDVNDLLLGGKTILGVVGSPKKFIPELVRLYQQGKFPFDQ----LVKFYAFDE-INQAAIDSRKGI--TLKPIIK........ 369

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Robinson-Rechavi M, Godzik A. Structural Genomics of Thermotoga maritima Proteins Shows that Contact Order Is a Major Determinant of Protein Thermostability. Structure (Camb). 2005 Jun;13(6):857-60.