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Query: gi|6319258|ref|NP_009341.1| NAD-dependent (R,R)-butanediol dehydrogenase, catalyzes oxidation of (R,R)-2,3-butanediol to (3R)-acetoin, oxidation of meso-butanediol to (3S)-acetoin, and reduction of acetoin; enhances use of 2,3-butanediol as an aerobic carbon source; Bdh1p (YAL060W) [Saccharomyces cerevisiae], from S.cerevisiae

Results of FFAS03 search in PfamA32U
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MRALAYFKKGDIHFTNDIPRPEIQTDDEVIIDVSWCGICGSDLHEYLDGPIFMPKDGECHKLSNAALPLAMGHEMSGIVSKVGPKVTKVKVGDHVVVDAASSCADLHCWPHSKFYNSKPCDACQRGSENLCTHAGFVGLGVISGGFAEQVVVSQHHIIPVPKEIPLDVAALVEPLSVTWHAVKISGFKKGSSALVLGAGPIGLCTILVLKGMGASKIVVSEIAERRIEMAKKLGVEVFNPSKHGHKSIEILRGLTKSHDGFDYSYDCSGIQVTFETSLKALTFKGTATNIAVWGPKPVPFQPMDVTLQEKVMTGSIGYVVEAFEEVVRAIHNGDIAMEDCKQLITGKQRIEDGWEKGFQELMDHKESNVKILLTPNNHGEMKLast
1 -46.200PF08240.12; A9CHB7_AGRFC/24-130; Alcohol dehydrogenase GroES-like domain  ali follow..  32  1.........................EGEVLVRIRRIGVCGTDLHIFTGNQPY------------LSYPRIMGHELSGTVEEAPA-GSHLSAGDVVTIIPYMSCGK--------------CNACLKGKSNCCRNIGVLGVH-RDGGMVEYLSVPQQFVLK............................................................................................................................................................................................................................... 106
2 -42.000PF16912.5; I7BJ28_NATSJ/144-370; Glucose dehydrogenase C-terminus  ali follow..  19  2......................................................................................................................................................................PMGFLVEPISITEKAIQHARDWQPASALVLGTGSLGLLTAAMLTETLEYDRVYCDRPHPTIDIVDRLGATYIDSRETP------VSEIPAAYEPMDLVYEATGYAKHAFEAIEALAPNGVAALLGVPEDWAFEVDGGELVLSNKALVGSVNSNRGHFEAAIDTLSAL--PDWVLTEVVSGVYDLAA-LERAFPEVTAPVAATGGSTVSPDDDTTIK 222
3 -31.600PF00107.26; ADH_SULSO/182-311; Zinc-binding dehydrogenase  ali follow..  20  2........................................................................................................................................................................................................LGTMAVQIAKAVSGATIIGVDVREEAVEAAKRAGADYVINASM-QDPLAEIRRITESK-GVDAVIDLNNSEKTLSVYPKALAKQGKYVMVGLFGAD-LHYHAPLITLSEIQFVGSLVGNQSDFLGIMRLAEA.................................................. 130
4 -18.100PF13602.6; B7KCY1_CYAP7/190-331; Zinc-binding dehydrogenase  ali follow..  12  1........................................................................................................................................................................................................................................FGADYPIL--TQTDFSAAALEWTEGK-GVDVAFDTVG-GKTFFDTVPAVRVYGDLVTILEPDGSKGTLKVARNRNLRISLELMLEHQTEILSQCGTWIDEGKL-----NIHLSQTYPLADAVEA--HKQVETGSTTGKVAL......... 142
5 -11.400PF00670.21; SAHH_DICDI/191-351; S-adenosyl-L-homocysteine hydrolase, NAD binding domain  ali follow..  14  23.............................................................................................................................................................................................GKVAVVAGYGDVGKGCAQSLSKMGA-RVLVTEIDPINALQACMDGYQ--------------IVTMETAAPLSNIFVTTTGCRDIVRGEHFAVMKEDAIVCNIGHFDCEIDVAWLNANAKKDTVKPQVDRYTLANGVHIILLAEGRL............................................... 153
6 -10.900PF03059.16; A3DUI9_MALBX/3-277; Nicotianamine synthase protein  ali follow..  11  104..............................................................................................................................................................................SKLEFNILSQHFTRMPIKIAFVGSGPLPLTSIVLASNHLTKSFDNYDINASANSKALGLVSSDPDLSKRMVFHTTDIMDVTTALKDYEIVFLAALVLKIIDHLAKYMAPGATLML............................................................................................. 226
7 -9.980PF06080.12; Q8YZS2_NOSS1/8-210; Protein of unknown function (DUF938 topsan)  ali follow..  10  4........................................................................................................................................................................APATQRNREPILEVLLQVLPASGTILEIASGT-GEHAIFFAPRLKPRKWLPSDPNPELRASITAWIAQFPVELDASQPIWSVERDAILQDAPIAAIVNISACLGLLAGAGRILPPGGILYLYGPYKQGGEHTAPSNAAFDESLRSQNPEWGVRNLEDVIAAAKQQNLQLHKTYQMPANNLSV................................ 199
8 -9.830PF08704.10; Q6DFS3_XENTR/64-300; tRNA methyltransferase complex GCD14 subunit  ali follow..  10  1...............................................................................................................................................GWVYILYPTPELWTLNLP-----HRTQILYSTDISL-ITMMLELKPGSVVCESGTGS-GSLSHAIIRTVATGHLYTVEFHQQRAEKAIEEFRQHKVDHLVTVKNQDVCKHGFGVTGIADVFLDIPSPWEAIGHAKSAMKSEGGRICSFSPCIEQVQRTCLALEEHGFTEINTLEILLRVYDVRTINLQVADLGRAAEEKS-------LDGTDRTKQISAVQHGSALFKSGVPPRE.... 224
9 -9.470PF13847.6; B2J9C6_NOSP7/55-253; Methyltransferase domain  ali follow..  18  2...........................................................................................................................................................................................TKEKVILDAGCGT-GYKSLVLAEANPGAKIVGIDISEESIKLAQQRLEHHGFDNAE---HVLPIQELPKLNYQFDYIN-FPDLAAALQGMISVLKPNGIIRS............................................................................................. 106
10 -9.210PF01488.20; HEM1_PSEAE/169-304; Shikimate / quinate 5-dehydrogenase  ali follow..  17  3....................................................................................................................................................................................AKQIFSDLHRSQALLIGAGETITLVARHLFEQGVKRIVVANRTLERSLLAEQFGAHAV-----------LLSEIPEELANSDIVISSTASQLPI-ERALKQRKHKPMFMVDIAVPRDIEPEVG-------ELDDVYLYSVDDLHEV........................................................ 136

FFAS is supported by the NIH grant R01-GM087218-01
1 3 7 7 9 2   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Sikora S, Godzik A. Combination of multiple alignment analysis and surface mapping paves a way for a detailed pathway reconstruction--the case of VHL (von Hippel-Lindau) protein and angiogenesis regulatory pathway. Protein Sci. 2004 Mar;13(3):786-96. Epub 2004 Feb 06.