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Query: gi|6319258|ref|NP_009341.1| NAD-dependent (R,R)-butanediol dehydrogenase, catalyzes oxidation of (R,R)-2,3-butanediol to (3R)-acetoin, oxidation of meso-butanediol to (3S)-acetoin, and reduction of acetoin; enhances use of 2,3-butanediol as an aerobic carbon source; Bdh1p (YAL060W) [Saccharomyces cerevisiae], from S.cerevisiae

Results of FFAS03 search in SCOP207
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MRALAYFKKGDIHFTNDIPRPEIQTDDEVIIDVSWCGICGSDLHEYLDGPIFMPKDGECHKLSNAALPLAMGHEMSGIVSKVGPKVTKVKVGDHVVVDAASSCADLHCWPHSKFYNSKPCDACQRGSENLCTHAGFVGLGVISGGFAEQVVVSQHHIIPVPKEIPLDVAALVEPLSVTWHAVKISGFKKGSSALVLGAGPIGLCTILVLKGMGASKIVVSEIAERRIEMAKKLGVEVFNPSKHGHKSIEILRGLTKSHDGFDYSYDCSGIQVTFETSLKALTFKGTATNIAVWGPKPVPFQPMDVTLQEKVMTGSIGYVVEAFEEVVRAIHNGDIAMEDCKQLITGKQRIEDGWEKGFQELMDHKESNVKILLTPNNHGEMKLast
1 -68.700d1pl8a1 b.35.1.2 (A:1-145,A:317-356) Ketose reductase (sorbitol dehydrogenase) {Human (Homo sapiens) [TaxId: 9606]}  ali model 3D-neighbors follow..  25  8NLSLVVHGPGDLRL-ENYPIPE-PGPNEVLLRMHSVGICGSDVHYWEYGRI---------GNFIVKKPMVLGHEASGTVEKVGSSVKHLKPGDRVAIEPGAPREN--------------DEFCKMGRYNLSPSIFFCATPPDDGNLCRFYKHNAAFCYKLPDNXVKPLVTHRFPLEKALEAFETFKKGLGLKIML-KCDPSDQ................................................................................................................................................................................... 184
2 -63.800d1kola1 b.35.1.2 (A:2-160,A:356-397) Formaldehyde dehydrogenase {Pseudomonas putida [TaxId: 303]}  ali model 3D-neighbors follow..  23  2NRGVVYLGSGKVEV-QKIDYPKMKIEHGVILKVVSTNICGSDQHMV-------------RGRTTAQVGLVLGHEITGEVIEKGRDVENLQIGDLVSVPFNVACGR--------------CRSCKEMHTGVCLTVNPARAGDWTGGQAEYVLVPDFNLLKLPDRDKAMEKXINIAEVVGVQVISLDDAPRGYG--EFDAGVPKKFVIDPHKTFSA........................................................................................................................................................................ 202
3 -63.200d1h2ba1 b.35.1.2 (A:17-154,A:327-359) Alcohol dehydrogenase {Aeropyrum pernix [TaxId: 56636]}  ali model 3D-neighbors follow..  25  1.KAARLHEYNKPLRIEDVDYPRLEGRFDVIVRIAGAGVCHTDLHLVQGMWH---------ELLQPKLPYTLGHENVGYIEEVAEGVEGLEKGDPVILHPAVTDGT--------------CLACRAGEDMHCENLEFPGLN-IDGGFAEFMRTSHRSVIKLPKDXVRVEVDILDEINDVLERLEKGEV-LGRAVLI........................................................................................................................................................................................... 171
4 -60.300d1jvba1 b.35.1.2 (A:1-143,A:314-347) Alcohol dehydrogenase {Sulfolobus solfataricus [TaxId: 2287]}  ali model 3D-neighbors follow..  23  1MRAVRLVEIGKPLSLQEIGVPK-PKGPQVLIKVEAAGVCHSDVHMRQGRF----GNLRIVEDLGVKLPVTLGHEIAGKIEEVGDEVVGYSKGDLVAVNPWQGEGN--------------CYYCRIGEEHLCDSPRWLGIN-FDGAYAEYVIVPHKYMYKLRRXVKPMITKTMEEANEAIDNLENFKA-IGRQVLI........................................................................................................................................................................................... 177
5 -58.900d1jqba1 b.35.1.2 (A:1001-1139,A:1314-1351) Bacterial secondary alcohol dehydrogenase {Clostridium beijerinckii [TaxId: 1520]}  ali model 3D-neighbors follow..  21  1MKGFAMLGINKLGW-IEKERPVA-GSYDAIVRPLAVSPCTSDIHTVFEGAL------------GDRKNMILGHEAVGEVVEVGSEVKDFKPGDRVIVPCTTPDWR--------------SLEVQAGFQQHSNGMLAGWKNFKDGVFGEYFHVNDANLAILPKDXV-DLSKLVTHVYHGFDHI-------EEALLLMKDKPKDLIKAVVI............................................................................................................................................................................. 177
6 -56.000d1vj0a1 b.35.1.2 (A:2-155,A:338-367) Hypothetical protein TM0436 {Thermotoga maritima [TaxId: 2336]}  ali model 3D-neighbors follow..  17  5AHAMVLEKFNQPLVYKEFEISD-IPRGSILVEILSAGVCGSDVHMFRGE------------DPRVPLPIILGHEGAGRVVEVNGEKRDLKPGDLIVWNRGITCGE--------------CYWCKVSKPYLCPNRKVYGINRLRGCYSSHIVLPETDVLKVSEKXITH----RLPLKEANKALELMESREALKVILYPE........................................................................................................................................................................................ 185
7 -49.200d1pl8a2 c.2.1.1 (A:146-316) Ketose reductase (sorbitol dehydrogenase) {Human (Homo sapiens) [TaxId: 9606]}  ali model 3D-neighbors follow..  23  1...................................................................................................................................................................VTFEEGALIEPLSVGIHACRRGGVTLGHKVLVCGAGPIGMVTLLVAKAMGAAQVVVTDLSATRLSKAKEIGADLVLQISKESPQEIARKVEGQLGCKPEVTIECTGAEASIQAGIYATRSGGTLVLVGL-GSEMTTVPLLHAAIREVDIKGVFRYC-NTWPVAISMLASKSVN.............................................. 171
8 -47.800d1uufa1 b.35.1.2 (A:3-144,A:313-349) Hypothetical protein YahK {Escherichia coli [TaxId: 562]}  ali model 3D-neighbors follow..  25  1IKAVGAYSAKQPLEPMDITRRE-PGPNDVKIEIAYCGVCHSDLHQVRSE-------------AGTVYPCVPGHEIVGRVVAVGDQVEKYAPGDLVGVGCIVSCKH--------------CEECEDGLENYCDHMTGTYNSHTLGGYSQQIVVHERYVLRIRXVADIE-MIRADQINEAYERMLRGDVK.................................................................................................................................................................................................. 168
9 -45.300d1piwa1 b.35.1.2 (A:1-152,A:321-360) Cinnamyl alcohol dehydrogenase, ADH6 {Baker`s yeast (Saccharomyces cerevisiae) [TaxId: 4932]}  ali model 3D-neighbors follow..  24  7FEGIAIQSHEDWKNPKKTKYDKPFYDHDIDIKIEACGVCGSDIHCAAGH-------------GNMKMPLVVGHEIVGKVVKLGPKSSGLKVGQRVGVGAQVSCLE--------------CDRCKNDNEPYCTKFVTTYSQPSQGGYANYVRVHEHFVVPIPENXIWVETLGEAGVHEAFERMEKGDVRYRFTLVGYDKE-FS.................................................................................................................................................................................... 192
10 -37.700d1f8fa1 b.35.1.2 (A:4-162,A:337-371) Benzyl alcohol dehydrogenase {Acinetobacter calcoaceticus [TaxId: 471]}  ali model 3D-neighbors follow..  20  4IIAAVTPCKGADFELQALKIRQ-PQGDEVLVKVVATGMCHTDLIVRD-------------QKYPVPLPAVLGHEGSGIIEAIGPNVTELQVGDHVVLS---YCGK--------------CTQCNTGNPAYCSEFFGRNFSGAQSSFATYALSRENNTVKVTKDXFPFDQLVK--FDEINQAADSRKGITLKPIIKIA......................................................................................................................................................................................... 195
11 -36.800d2jhfa1 b.35.1.2 (A:1-163,A:340-374) Alcohol dehydrogenase {Horse (Equus caballus) [TaxId: 9796]}  ali model 3D-neighbors follow..  19  9CKAAVLWEEKKPFSIEEVEVAP-PKAHEVRIKMVATGICRSDDHVVS-------------GTLVTPLPVIAGHEAAGIVESIGEGVTTVRPGDKVIPLFTPQCGK--------------CRVCKHPEGNFCLKNDLSMPRGT-STFSQYTVVDEISVAKIDAAXFALDPLITHVLPFEKINEGFDLLRSGESIRTILT........................................................................................................................................................................................ 198
12 -35.300d1kola2 c.2.1.1 (A:161-355) Formaldehyde dehydrogenase {Pseudomonas putida [TaxId: 303]}  ali model 3D-neighbors follow..  19  3......................................................................................................................................................................DLTCLSDILPTGYHGAVTAGVGPGSTVYVAGAGPVGLAAAASARLLGAAVVIVGDLNPARLAHAKAQGFEIADLSLD-TPLHEQIAALLGEP-EVDCAVDAVGFEAVLNSLMQVTRVAGKIGIPGLYVTGSLSIRFGLGWAKSHSFHTGQTPVMKYNRALMQAIMWDR................................................ 195
13 -34.000d1vj0a2 c.2.1.1 (A:156-337) Hypothetical protein TM0436 {Thermotoga maritima [TaxId: 2336]}  ali model 3D-neighbors follow..  17  5......................................................................................................................................................................VLAMAMCSGATAYHAFEYPESFAGKTVVIQGAGPLGLFGVVIARSLGAENVIVIAGSPNRLKLAEEIGADLTLNRRETEERRKAIMDITHG-RGADFILEATGDSRALLEGSELLRRGGFYSVAGVAPQDPVPFKVYELVLKNATFKGIWVSDTSHFVKTVSITSRNYQLLSKL.......................................... 182
14 -32.200d1jvba2 c.2.1.1 (A:144-313) Alcohol dehydrogenase {Sulfolobus solfataricus [TaxId: 2287]}  ali model 3D-neighbors follow..  22  5......................................................................................................................................................................EAAPLTCSGITTYRAVRKASLDPTKTLLVVGAGGLGTMAVQIAKAVSGATIIGVDVREEAVEAAKRAGADYVINASM-QDPLAEIRRITESK-GVDAVIDLNNSEKTLSVYPKALAKQGKYVMVGLFGAD-LHYHAPLITLSEIQFVGSLVGNQSDFLGIMRLAEAGK................................................ 170
15 -30.900d1jqba2 c.2.1.1 (A:1140-1313) Bacterial secondary alcohol dehydrogenase {Clostridium beijerinckii [TaxId: 1520]}  ali model 3D-neighbors follow..  22  1...................................................................................................................................................................MPLENAVMIDMMTTGFHGAELADIEMGSSVVVIGIGAVGLMGIAGAKLRGAGRIIGVGSRPICVEAAKFYGATDILNYKN-GHIEDQVMKLTNG-KGVDRVIMAGGGSETLSQAVKMVKPGGIISNINYHGSGLIPRVEWGCGMAHKTIKGGLCPGGRLRAERLRDMV................................................... 170
16 -30.900d1h2ba2 c.2.1.1 (A:155-326) Alcohol dehydrogenase {Aeropyrum pernix [TaxId: 56636]}  ali model 3D-neighbors follow..  19  1...............................................................................................................................................................ISREKLVEMAPLADAGITAYRAVKKAALYPGAYVAIVGVGGLGHIAVQLLKVMTPATVIALDVKEEKLKLAERLGADHVVDAR--RDPVKQVMELTRGR-GVNVAMDFVGSQATVDYTPYLLGRMGRLIIVGY--GGELRFPTIRVISSEVSFEGSLVGNYVELHELVTLALQGK................................................ 172
17 -29.700d1yb5a1 b.35.1.2 (A:6-120,A:295-329) Quinone oxidoreductase {Human (Homo sapiens) [TaxId: 9606]}  ali model 3D-neighbors follow..  26  3MRAVRVFGPEVLKLRSDIAVPI-PKDHQVLIKVHACGVNPVETYIRSGTYSRKP-----------LLPYTPGSDVAGVIEAVGDNASAFKKGDRV-----------------------------------------FTSSTISGGYAEYALAADHTVYKLPEKXLKPVIGSQYPLEAEAHENIHGSGATGKMILLL.......................................................................................................................................................................................... 151
18 -29.600d1gu7a1 b.35.1.2 (A:23-160,A:350-386) 2,4-dienoyl-CoA reductase {Yeast (Candida tropicalis) [TaxId: 5482]}  ali model 3D-neighbors follow..  16  4AQAVLYTQHGEPKDVFEIDDDN-LAPNEVIVKTLGSPVNPSDINQIQG--VYPSKPAKTTGFGTTEPAAPCGNEGLFEVIKVGSNVSSLEAGDWV-----------------------------------------IPSHVNFGTWRTHALGNDDDFIKLPNPAQSKANGKPXLTDAKSIETLYDGTKPLHELYQDGVSKDGKQLITY.............................................................................................................................................................................. 176
19 -28.700d1qora1 b.35.1.2 (A:2-112,A:292-327) Quinone oxidoreductase {Escherichia coli [TaxId: 562]}  ali model 3D-neighbors follow..  20  2.TRIEFHGGPEVLQAVEFTPAD-PAENEIQVENKAIGINFIDTYIRSG-------------YPPPSLPSGLGTEAAGIVSKVGSGVKHIKAGDRV-----------------------------------------VYAQSALGAYSSVHNIIADKAAILPAAXI-EQQKYPLKDAQRAHEILESRATQGSSLLI........................................................................................................................................................................................... 147
20 -28.100d1f8fa2 c.2.1.1 (A:163-336) Benzyl alcohol dehydrogenase {Acinetobacter calcoaceticus [TaxId: 471]}  ali model 3D-neighbors follow..  24  1.......................................................................................................................................................VPIELLGPLGCGIQTGAGAC----------INALKVTPASSFVTWGAGAVGLSALLAAKVCGASIIIAVDIVESRLELAKQLGATHVINSKT-QDPVAAIKEITDG--GVNFALESTGSPEILKQGVDALGILGKIAVVGAPQGTTAQFDVNDLLLGGKTILGVVGSPKKFIPELVRLYQQGK................................................ 174
21 -25.800d1rjwa2 c.2.1.1 (A:138-305) Alcohol dehydrogenase {Bacillus stearothermophilus [TaxId: 1422]}  ali model 3D-neighbors follow..  19  1...................................................................................................................................................................LSFEEAA---PIFCAYKALKVTGAKPGEWVAIYGIGGLGHVAVQYAKAMGL-NVVAVDIGDEKLELAKELGADLVVNPLK-EDAAKFMKEKVG---GVHAAVVTAVSKPAFQSAYNSIRRGGACVLVGL-PPEEMPIPIFDTVLNGIKIIGSIVGTRKDLQEALQFAAEGKVK.............................................. 168
22 -25.300d2jhfa2 c.2.1.1 (A:164-339) Alcohol dehydrogenase {Horse (Equus caballus) [TaxId: 9796]}  ali model 3D-neighbors follow..  18  1.......................................................................................................................................................SPLEKVCLIGCGFSTGYGSA----------VKVAKVTQGSTCAVFGLGGVGLSVIMGCKAAGAARIIGVDINKDKFAKAKEVGATECVNPQDYKKPIQEVLTEMSNG-GVDFSFEVIGRLDTMVTALSCCQEAGVSVIVGVPPDSQNLSMNPMLLLSGRTWKGAIFKSKDSVPKLVADFMAKK................................................ 176
23 -25.000d1uufa2 c.2.1.1 (A:145-312) Hypothetical protein YahK {Escherichia coli [TaxId: 562]}  ali model 3D-neighbors follow..  20  2................................................................................................................................................................PQEQLAAVAPLLCAGITTYSPLRHWQAGPGKKVGVVGIGGLGHMGIKLAHAMGA-HVVAFTTSEAKREAAKALGADEVVNSRNADEMAAHLK-------SFDFILNTVAAPHNLDDFTTLLKRDGTMTLVGAPATPHKSPEVFNLIMKRRAIAGSMIGGIPETQEMLDFCAEHGI............................................... 168
24 -24.800d1o89a1 b.35.1.2 (A:2-115,A:293-323) Hypothetical protein YhdH {Escherichia coli [TaxId: 562]}  ali model 3D-neighbors follow..  13  1.QALLLEDGKTLASVQTLDESR-LPEGDVTVDVHWSSLNYKDALAITGKGKIIR-----------NFPMIPGIDFAGTVRTSE--DPRFHAGQEVLLTGW---------------------------------------ENHWGGLAEQARVKGDWLVAMPQGXQAAKEISL--NFAEAIINNQIQGRTLVKV............................................................................................................................................................................................. 146
25 -24.700d1iz0a1 b.35.1.2 (A:1-98,A:270-302) Quinone oxidoreductase {Thermus thermophilus [TaxId: 274]}  ali model 3D-neighbors follow..  23  1MKAWVLKRLGGPLELVDLPEPE-AEEGEVVLRVEAVGLNFADHLMRLGAYLTRL-----------HPPFIPGMEVVGVVE-----------GRRYAA-------------------------------------------VPQGGLAERVAVPKGALLPLPEGXRPVVGPFPFAEAEAAFRALLDRGHTGKVVVRL.......................................................................................................................................................................................... 132
26 -22.700d1iz0a2 c.2.1.1 (A:99-269) Quinone oxidoreductase {Thermus thermophilus [TaxId: 274]}  ali model 3D-neighbors follow..  18  5......................................................................................................................................................................EAAAFPVSFLTAYLALKRAQARPGEKVLVQAAGALGTAAVQVARAMGL-RVLAAASRPEKLALPLALGAEEAATYAEVP-------ERAKAWGGLDLVLEVRG--KEVEESLGLLAHGGRLVYIGAAEGEVAPIPPLRLMRRNLAVLGFWLTPLLREGALVEEALGFLLPRLG........................................... 168
27 -22.100d1piwa2 c.2.1.1 (A:153-320) Cinnamyl alcohol dehydrogenase, ADH6 {Baker`s yeast (Saccharomyces cerevisiae) [TaxId: 4932]}  ali model 3D-neighbors follow..  20  1...................................................................................................................................................................IPSHLAA---PLLCGYSPLVRNGCGPGKKVGIVGLGGIGSMGTLISKAMGA-ETYVISRSSRKREDAMKMGADHYIATLEEGDWGEKYFDTF----DLIVVCASSLTDIDFNIMPKAMKVGGRIVSISI-PEQHEMLSLKPYGLKAVSISYSALGSIKELNQLLKLVSEKDIK.............................................. 168
28 -20.600d1qora2 c.2.1.1 (A:113-291) Quinone oxidoreductase {Escherichia coli [TaxId: 562]}  ali model 3D-neighbors follow..  21  1...................................................................................................................................................................ISFEQAAFLKGLTVYYLLRKTYEIKPDEQFLFHAAGGVGLIACQWAKALGA-KLIGTVGTAQKAQSALKAGAWQVINYRE-EDLVERLKEITGGK-KVRVVYDSVG-RDTWERSLDCLQRRGLMVSFGNSSGAVTGVNLGILNQKGSLYVTRPSLQTEASNELFSLIASG................................................. 178
29 -20.500d1gu7a2 c.2.1.1 (A:161-349) 2,4-dienoyl-CoA reductase {Yeast (Candida tropicalis) [TaxId: 5482]}  ali model 3D-neighbors follow..  12  1...................................................................................................................................................................LTINQGATVNPLTAYLMLTHYVKLTPGKDWFIQNGSAVGKYASQIGKLLNFNSISVIPNLDEVVASLKELGATQVITEDQNEFGPTIKEWIKQSGGEAKLALNCVGGKSS-TGIARKLNNNGLMLTYGGMSFQPVTIPTSLYIFKNFTSAGFWELKTSTLNQIIAWYEEGK................................................ 189
30 -20.400d1o89a2 c.2.1.1 (A:116-292) Hypothetical protein YhdH {Escherichia coli [TaxId: 562]}  ali model 3D-neighbors follow..  16  1...................................................................................................................................................................LDARKAMIIGTAGFTAMLCDAGVRPQDGEIVVTGAGGVGSTAVALLHKLGY-QVVAVSGRESTHEYLKSLGASRVLPRDEFAESRPL------EKQVWAGAIDTVG-DKVLAKVLAQMNYGGCVAACGLAGGFTLPTTVMPFILRNVRLQGVDERRAQAWQRLVADLPESFYT.............................................. 177
31 -18.300d1yb5a2 c.2.1.1 (A:121-294) Quinone oxidoreductase {Human (Homo sapiens) [TaxId: 9606]}  ali model 3D-neighbors follow..  18  1...................................................................................................................................................................LDFKQGAAIGPYFTAYRALHSACVKAGESVLVHGAGGVGLAACQIARAYGL-KILGTAGTEEGQKIVLQNGAHEVFN-HREVNYIDKIKKYVGEK-GIDIIIEMLANV-NLSKDLSLLSHGGRVIVVG--SRGTIEINPRDTMAKESSIIGV................................................................... 149
32 -15.100d4okia1 c.2.1.1 (A:670-849) automated matches {Mycobacterium tuberculosis [TaxId: 83332]}  ali model 3D-neighbors follow..  14  2......................................................................................................................................................................EAATFGVAYLTAWHSLEVGRLSPGERVLISATGGVGMAAVSIAKMIGA-RIYTTAGSDAKREMLSRLGVEYVGD-SRSVDFADEILELTDGY-GVDVVLNSLAGE-AIQRGVQILAPGGRFIELGVYADASLGLAALSASFSVVDLDLNLKLQPARLQHILQHVADGKLEV............................................. 179
33 -14.400d1v3va2 c.2.1.1 (A:113-294) Leukotriene b4 12-hydroxydehydrogenase/prostaglandin 15-keto reductase {Guinea pig (Cavia porcellus) [TaxId: 10141]}  ali model 3D-neighbors follow..  19  3...................................................................................................................................................................LSLALGTIGMPGLTAYFGLEVCGVKGGETVLVSAAGAVGSVVGQIAKLKGC-KVVGAAGSDEKIAYLKQIGFDAAFNYKTVNSLEEALKKAS--PDGYDCYFDNVGGE-FLNTVLSQMKDFGKIAICGAISVYNRM-SPESIIYKQLRIEGFIDVREKALRDLMKWVLEG................................................. 182
34 -11.200d1li4a1 c.2.1.4 (A:190-352) S-adenosylhomocystein hydrolase {Human (Homo sapiens) [TaxId: 9606]}  ali model 3D-neighbors follow..  14  24.............................................................................................................................................................................................GKVAVVAGYGDVGKGCAQALRGFGA-RVIITEIDPINALQAAMEGYE--------------VTTMDEACQEGNIFVTTTGCIDIILGRFEQMKDDAIVCNIGHFDVEIDVKWLNENAVEKVNIKPQVDRYRLKNGRRIILLAEGRL............................................... 155
35 -10.700d1gpja2 c.2.1.7 (A:144-302) Glutamyl tRNA-reductase middle domain {Methanopyrus kandleri [TaxId: 2320]}  ali model 3D-neighbors follow..  18  4.............................................................................................................................................................................AVSIGSAAVELAERELGSTVLVVGAGEMGKTVAKSLVDRGVRAVLVANRTYERVELARDLGGEAV-----------RFDELVDHLARSDVVVSATAAPDDVREALRKRDRRSPILIIDIANPRDVEEGVE-------NIEDVEVRTIDDLRVIAR...................................................... 151
36 -9.930d3cmco1 c.2.1.3 (O:0-148,O:313-333) Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) {Bacillus stearothermophilus, nca 1503 [TaxId: 1422]}  ali model 3D-neighbors follow..  11  3...............................................................................................................................................................................................KVGINGFGRIGRNVFRAALKNPDIEVVAVNDLTDANTLAHLLKYDSVHGRLDAEVSVNGNNLVVNGKEGVDIVVESTGRFTKREDAAKHLEAGAKKVIISAPAKNEMGVNQDKYDPKAHHVISNASXNETGYSHRVVDLAA.................................................. 165
37 -9.910d1gtea4 c.4.1.1 (A:184-287,A:441-532) Dihydropyrimidine dehydrogenase, domain 2 {Pig (Sus scrofa) [TaxId: 9823]}  ali model 3D-neighbors follow..  16  2...........................................................................................................................................................................................AYSAKIALLGAGPASISCASFLARLGYSDITIFDVVNFEIELMKDLGVKIICGKSLSENEITLNTLKEE---GYKAAFIGIGLPEXVLRDPKVKEALSPIKFNR----DLPEVDPETMQTSEPWVFAG-GDIVGMANTTVESVNDGKQASWYIHKYIQAQYGAS............................... 179
38 -9.860d2o57a1 c.66.1.18 (A:16-297) Putative sarcosine dimethylglycine methyltransferase {Red algae (Galdieria sulphuraria) [TaxId: 130081]}  ali model 3D-neighbors follow..  40.................................................................................................................................................................DQDEIREASLRTDEWLASELAMTGVLQRQAKGLDLGAG-YGGAARFLVRKFGV-SIDCLNIAPVQNKRNEEYNNQAGLA-DNITVKYGSFLEIPCEDNSYDFIWHSPDKLKVFQECARVLKPRGVMAITDPMKEDGIDKSSIQPILDRIKLHDM---SLGLYRSLAKECGLVTLRTFSRPDSLVHHYS................................. 228
39 -9.680d1cf2o1 c.2.1.3 (O:1-138,O:304-336) Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) {Methanothermus fervidus [TaxId: 2180]}  ali model 3D-neighbors follow..  11  3...............................................................................................................................................................................................AVAINGYGTVGKRVADAIAQQDDMKVIVSKTRPDFEARMALKKGYDLYVAIPEKAGIEVAGTVDDMLDEADIVIDCTPEGIGAKNLKMYKEKGIKAIFQGGEKHEDIGLSFNSLSNYE-------ESYGKDYTRVVXIVPENVDAVRAILEMEEDKYKSINKTNKAMNIL..................... 172
40 -9.540d1xxla1 c.66.1.41 (A:2-228) Hypothetical protein YcgJ {Bacillus subtilis [TaxId: 1423]}  ali model 3D-neighbors follow..  12  4.....................................................................................................................................................................................IKTAECRAEHRVLDIGAGA-GHTALAFSPYVQ--ECIGVDATKEMVEVASSFAQEKGVENVR---QQGTAESLPFPDDSFDIITCRYAARKAVREVARVLKQDGRFLLVDHYAPEDPVLDEFVNHLNRLRDPSHVRESSLS--EWQAMFSANQLAYQDIQKW....................................... 164
41 -9.470d5cvda1 c.66.1.42 (A:1-223) automated matches {Human (Homo sapiens) [TaxId: 9606]}  ali model 3D-neighbors follow..  15  54.....................................................................................................................................................................................REGPNKTGTSCALDCGAG-IGRITKRLLLPLFR-EVDMVDITEDFLVQAKTYLGEE--GKRVRNYFCCGLQDFTPEPDSYDVILTDQHLAEFLRRCKGSLRPNGIIVIKDNMAQEGVILD---------DVDSSVCRDLDVVRRIICSAGLSLLAEERQENLPDEIYHVY............................... 218
42 -9.390d1vl5a_ c.66.1.41 (A:) Hypothetical protein BH2331 {Bacillus halodurans [TaxId: 86665]}  ali model 3D-neighbors follow..  8.....................................................................................................................................................................................MQIAALKGNEEVLDVATGG-GHVANAFAPFVK--KVVAFDLTEDILKVARAFIEGNGHQQVE---VQGDAEQMPFTDERFHIVTCRIAAASFVSEAYRVLKKGGQLLLVDNSAPENDAFDVFYNYVEKERDYSHHRAWKKS--DWLKMLEEAGFELEELHCF-CDRMNVTTEKKQELSDFIKSKPTEYYQKFKIVVEDGR. 214
43 -9.160d1ps9a3 c.4.1.1 (A:331-465,A:628-671) 2,4-dienoyl-CoA reductase, middle domain {Escherichia coli [TaxId: 562]}  ali model 3D-neighbors follow..  18  2.....................................................................................................................NTCIGCNQA----CLDQIFVGKV---------------------------TSCLVNPRACHETKMPILPAVQKKNLAVVGAGPAGLAFAINAAARG-HQVTLFDAHSE-RRMIEVTGVTLKLNHTVTADQLQ----------AFDETILASGIXPNRALAQPLIDSGKTVHLIG........................................................................................... 156
44 -9.130d2yvla_ c.66.1.0 (A:) automated matches {Aquifex aeolicus [TaxId: 224324]}  ali model 3D-neighbors follow..  11  3........................................................................................FKEGEYVLIRF----------GEKKFLRKLLPKQSLSVKKSVLKFDEVIGKP-EGVKINGFEVYRPTLEEIILLGFE-RKTQIIYPKDSFY-IALKLNLNKEKRVLEFGTGS-GALLAVLSEVAG--EVWTFEAVEEFYKTAQKNLKKFNLGKNVKFFNVDFKDAEVPEGIFHAAFVDVREPWHYLEKVHKSLMEGAPVGFL............................................................................................ 188
45 -9.120d1o54a1 c.66.1.13 (A:2-263) Hypothetical protein TM0748 {Thermotoga maritima [TaxId: 2336]}  ali model 3D-neighbors follow..  12  1..................................................................................GKVADTLKPGDRVLLS-------------------------EDESEFLVDLEKDKKLHTHLGIIDLNEVFEKGPGEIIRTSAGKRRTQIVYPKDSSF-IAMMLDVKEGDRIIDTGVGS-GAMCAVLARAVGSGKVFAYEKREEFAKLAES-NLTKWGLIERVTIKVRDISEGFDEKDVDALFLDVPDPWNYIDKCWEALKGGGRFA--------------------------TVCPTTNQVQETLKKLQELPFIRIEVWESLFRPYKPVPERLRPVDRMVAHTA................ 249
46 -9.010d4e12a1 c.2.1.0 (A:1-189) automated matches {Acinetobacter baylyi [TaxId: 202950]}  ali model 3D-neighbors follow..  12  5..............................................................................................................................................................................................TNVTVLGTGVLGSQIAFQTAFHGF-AVTAYDINTDALDAAKEVAGAADGAAQKALGGIRYSDDLAQAVKDADLVIEAVPESLDLKRDIKLGELAPAKTIFATNSSTLLPSDLVGYTGRGDKFLALHFANHVWVNNTAEVMGTTKTDPEVYQQVVEFASAIGMV............................. 180

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Sikora S, Godzik A. Combination of multiple alignment analysis and surface mapping paves a way for a detailed pathway reconstruction--the case of VHL (von Hippel-Lindau) protein and angiogenesis regulatory pathway. Protein Sci. 2004 Mar;13(3):786-96. Epub 2004 Feb 06.