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Query: gi|6319279|ref|NP_009362.1| Pyruvate kinase, functions as a homotetramer in glycolysis to convert phosphoenolpyruvate to pyruvate, the input for aerobic (TCA cycle) or anaerobic (glucose fermentation) respiration; Cdc19p (YAL038W) [Saccharomyces cerevisiae], from S.cerevisiae

Results of FFAS03 search in SCOP207
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MSRLERLTSLNVVAGSDLRRTSIIGTIGPKTNNPETLVALRKAGLNIVRMNFSHGSYEYHKSVIDNARKSEELYPGRPLAIALDTKGPEIRTGTTTNDVDYPIPPNHEMIFTTDDKYAKACDDKIMYVDYKNITKVISAGRIIYVDDGVLSFQVLEVVDDKTLKVKALNAGKICSHKGVNLPGTDVDLPALSEKDKEDLRFGVKNGVHMVFASFIRTANDVLTIREVLGEQGKDVKIIVKIENQQGVNNFDEILKVTDGVMVARGDLGIEIPAPEVLAVQKKLIAKSNLAGKPVICATQMLESMTYNPRPTRAEVSDVGNAILDGADCVMLSGETAKGNYPINAVTTMAETAVIAEQAIAYLPNYDDMRNCTPKPTSTTETVAASAVAAVFEQKAKAIIVLSTSGTTPRLVSKYRPNCPIILVTRCPRAARFSHLYRGVFPFVFEKEPVSDWTDDVEARINFGIEKAKEFGILKKGDTYVSIQGFKAGAGHSNTLQVSTVLast
1 -80.900d3hqna1 c.1.12.1 (A:1-87,A:187-357) Pyruvate kinase, N-terminal domain {Trypanosome (Leishmania mexicana) [TaxId: 5665]}  ali model 3D-neighbors follow..  58  1.SQLAHNLTLSIFDPVNYRAARIICTIGPSTQSVEALKGLIQSGMSVARMNFSHGSHEYHQTTINNVRQAAAE-LGVNIAIALDTKGP---------------------------------------------------------------------------------------------------XPAVSAKDRVDLQFGVEQGVDMIFASFIRSAEQVGDVRKALGPKGRDIMIICKIENHQGVQNIDSIIEESDGIMVARGDLGVEIPAEKVVVAQKILISKCNVAGKPVICATQMLESMTYNPRPTRAEVSDVANAVFNGADCVMLSGETAKGKYPNEVVQYMARICLEAQSAL............................................................................................................................................. 259
2 -44.200d1a3wa3 c.49.1.1 (A:367-500) Pyruvate kinase, C-terminal domain {Baker`s yeast (Saccharomyces cerevisiae) [TaxId: 4932]}  ali model 3D-neighbors follow..  100  1..............................................................................................................................................................................................................................................................................................................................................................................DMRNCTPKPTSTTETVAASAVAAVFEQKAKAIIVLSTSGTTPRLVSKYRPNCPIILVTRCPRAARFSHLYRGVFPFVFEKEPVSDWTDDVEARINFGIEKAKEFGILKKGDTYVSIQGFKAGAGHSNTLQVSTV 134
3 -43.500d2g50a3 c.49.1.1 (A:396-530) Pyruvate kinase, C-terminal domain {Rabbit (Oryctolagus cuniculus) [TaxId: 9986]}  ali model 3D-neighbors follow..  37  1..............................................................................................................................................................................................................................................................................................................................................................................ELARASSQSTDLMEAMAMGSVEASYKCLAAALIVLTESGRSAHQVARYRPRAPIIAVTRNHQTARQAHLYRGIFPVVCKDPVQEAWAEDVDLRVNLAMNVGKARGFFKKGDVVIVLTGWRPGSGFTNTMRVVPV 134
4 -41.400d3hqna3 c.49.1.1 (A:358-498) Pyruvate kinase, C-terminal domain {Trypanosome (Leishmania mexicana) [TaxId: 5665]}  ali model 3D-neighbors follow..  34  1.......................................................................................................................................................................................................................................................................................................................................................................NEYVFFNSIKKLQHIPMSADEAVCSSAVNSVYETKAKAMVVLSNTGRSARLVAKYRPNCPIVCVTTRLQTCRQLNITQGVESVFFDA-DKLGHDEGKEHRVAAGVEFAKSKGYVQTGDYCVVIHADHKVKGYANQTRILLV 140
5 -41.000d1e0ta3 c.49.1.1 (A:354-470) Pyruvate kinase, C-terminal domain {Escherichia coli [TaxId: 562]}  ali model 3D-neighbors follow..  29  1.........................................................................................................................................................................................................................................................................................................................................................................................ITEAVCRGAVETAEKLDAPLIVVATQGGKSARAVRKYFPDATILALTTNEKTAHQLVLSKGVVPQLVKE------ITSTDDFYRLGKELALQSGLAHKGDVVVMVSGALVPSGTTNTASVHVL 117
6 -35.300d3hqna2 b.58.1.1 (A:88-186) Pyruvate kinase (PK) {Trypanosome (Leishmania mexicana) [TaxId: 5665]}  ali model 3D-neighbors follow..  40  1........................................................................................EIRTGQFVGG-DAVMERGATCYVTTDPAFADKGTKDKFYIDYQNLSKVVRPGNYIYIDDGILILQVQSHEDEQTLECTVTNSHTISDRRGVNLPGCDVDL........................................................................................................................................................................................................................................................................................................................ 99
7 -34.600d2g50a1 b.58.1.1 (A:116-217) Pyruvate kinase (PK) {Rabbit (Oryctolagus cuniculus) [TaxId: 9986]}  ali model 3D-neighbors follow..  41  1.......................................................................................PEIRTGLIKGSAEVELKKGATLKITLDNAYMEKCDENILWLDYKNICKVVDVGSKVYVDDGLISLQVKQK-GPDFLVTEVENGGFLGSKKGVNLPGAAVDL........................................................................................................................................................................................................................................................................................................................ 102
8 -34.400d1e0ta1 b.58.1.1 (A:70-167) Pyruvate kinase (PK) {Escherichia coli [TaxId: 562]}  ali model 3D-neighbors follow..  32  1.......................................................................................PEIRTMKLEGGNDVSLKAGQTFTFTTDKSV--IGNSEMVAVTYEGFTTDLSVGNTVLVDDGLIGMEVTAI-EGNKVICKVLNNGDLGENKGVNLPGVSIAL........................................................................................................................................................................................................................................................................................................................ 98
9 -11.000d3qlla_ c.1.12.0 (A:) automated matches {Yersinia pestis [TaxId: 632]}  ali model 3D-neighbors follow..  14  17..................................................................................................................................DRFAKAAENGADVAIIDLEDSVSQADKEQARQKAISYLSSRPATSLP------LALRINGLTRAGIEDIHALLECGPDYLVLPKTESAAHLQILDRLMMFAGSDTRLIGIIESVRGLNAVESIAAATPKLALIFGDIGAASTWEPLALARARLVSACAMNGIPAIDAPFF----VHDVSGLQSETLRASDFGFSAKAAI----------HPAQ-ISTINTLFTPTAAEIR............................................................................................................................................ 236
10 -10.700d1sgja_ c.1.12.5 (A:) Citrate lyase, beta subunit {Deinococcus radiodurans [TaxId: 1299]}  ali model 3D-neighbors follow..  17  27...........................................................................................................................................PDAVVID---LEDAVPGTAEAKAAARPVAHDAARDLIAAAPHLAVFVRVNALHSPYFEDDLSVLTPELSGVVVPKLEMGAEARQVAQMLQERSLPLPILAGLETGAGVWNAREIMEVPAWAYFGAEDYTTDLGGKEVLYARSQVALAARLTG---VAALDIVVTALNDPETFRADAEQGRALGYSGKLCI----------HPAQ-VALAHEY..................................................................................................................................................... 229
11 -9.710d4tv5a_ c.1.12.0 (A:) automated matches {Staphylococcus aureus [TaxId: 426430]}  ali model 3D-neighbors follow..  14  67...........................................................................................................................................................................................IVRVTAVIDRDIIKVLDMGARGIIVPHVKDRETVEHILDAMEMANEHIMVIAMIEDVEGVMAIDDIAQVEDMIVEGAADLSQSLGIDQVTSHVQHIFEVVNAHGKHF--------ALPREDEDIAKWQAQGVQTFILGDDRGKIYRHLSA................................................................................................................................................................... 244
12 -9.600d3qz6a1 c.1.12.0 (A:1-258) automated matches {Desulfitobacterium hafniense [TaxId: 272564]}  ali model 3D-neighbors follow..  17  67...........................................................................................................................................................................................LVRIPQVDRAHVQRLLDIGAEGFMIPGVQSAETMRETAEWVQERNDEIFIMAQIEHVKAVEDIDSILAVQDAVIFGPRDLSNDLGIPKVYECYEKVYRAADRQGVVKAADAAKMGWAVERGAQMLLWSGDVA-ALQTYTAKGVKTIKELPGFNP............................................................................................................................................................... 258
13 -9.430d1izca_ c.1.12.5 (A:) Macrophomate synthase {Macrophoma commelinae [TaxId: 108330]}  ali model 3D-neighbors follow..  15  32.............KDAMADPSKTLMGVAHGIPSTFVTKVLAATKPDFVWIDVEHGMFNR-LELHDAIHAAQHHSEGRSLVIV-----------RVPKHDEVSLST--------------------------------------ALDAGAAGIVIPHVETVEEVREFV---------KEMYYGPI-----------------GRRSFSPWTFSPGIADASLFPNDPYNVATSNNHVCIIPQIESVKGVENVDAIAAMPHGLMFGPGDYMIDAGLDTFVEAMTKFSTAAQRNGVPIALSVDMVPSLIEQGYRAIAVQFDLSRLVHGSLAQARASAKQFAG.................................................................................................................................................................. 299
14 -9.100d2vwsa_ c.1.12.0 (A:) automated matches {Escherichia coli K-12 [TaxId: 83333]}  ali model 3D-neighbors follow..  20  71..........................................................................................................................................................................................PVIRPVEGSKPLIKQVLDIGAQTLLIPMVDTAEQARQVENYMAQVNDSLCLLVQVESKTALDNLDEILDVEDGVFIGPADLSASLGYPEVQRIIETSIRRIRAAGKAA--------FLAVAPDMAQQCLAWGANFVAVGVDTMLYSDALD.................................................................................................................................................................... 248
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Dunbrack RL Jr, Dunker K, Godzik A. Protein structure prediction in biology and medicine. Pac Symp Biocomput. 2000;(12):93-4.