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Query: gi|41629666|ref|NP_009345.2| Multistep regulator of cAMP-PKA signaling; inhibits PKA downstream of Gpa2p and Cyr1p, thereby increasing cAMP dependency; inhibits Ras activity through direct interactions with Ira1p/2p; regulated by G-alpha protein Gpa2p; homolog of Gpb1p; Gpb2p (YAL056W) [Saccharomyces cerevisiae], from S.cerevisiae

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MEISSSPWNDGGYSPYERNRVAVSPFSSALEGEERIETSRSLGDHCFEPLPYVTNYLSIFALFGKEIFGDKGNVSSRNEYLLKKYYSLKKPFVLRHNGHALKNPDMPLQRNDILQTNFMVDKFLNRTVRSVNFNNFKIISDMQSKSGRGTKSGTNQNQSADAIQNICLPSIPSALPYFQYYRKLLTVNTKEWDILKLHSLWVPKLRKDFKDFSLYGDKNSLKPIDSHYDEDNTMKKNLFFERSPSRQTLDGKGCASKGYDISSGNMIIPSLFSEDKLPALTYHCSVELNGNIYIFGGLMPCYSYEEDAPMLNDFFVDGIKNLPPPLLPQVINNPSMVNNPHLYVASIPSCRFSKPKMGGYIPPPLLCVQGSKLTDRHIFFYGGFEIRTETRGDENGKYHLKKRLYVNNTGYILDIMSFKFTKIDIIVQPSKYNAYPTMSSRFGHLQISIDNPNRRASVHSSSMNEIHKMGSASMKQGSSITSGRLEKAAVLSSLPHNTVHTVIIFGGYRQTGDDRYEAMNDLWKIEIPVIRRGKKGYCKFSETANAILLTPSEKDKSDWPEERAFSAFSVHGTSLMDRSSLDMRLLNNLKNHFVLKPSYISQDRVVSPKPVFPMMVHGTHQDLFNSGSAAQESPKAGASASSASAASFDPDMDDNLENYIINPGRKSSSIPMTAIGRQRLILSQEKPVGKTVVLHGGSNGLNVLDDMWLMDLECETWTPIETFAKADSSEDGDEKLDSVNVGLVGHRMESIGRICVCIGGMVQEDVDQFYSENDDEPPRKRKVDTLPLGGNFLNTIDLSTQFWEEHKITLSKKAADEDRQDSENEDTNSNIVVGVGGTSLQCDKSIILIGGLISRRSNVKEIYLHGTITKSIFPSVNPSALast
1 -46.800[R] KOG1230 Protein containing repeated kelch motifs  ali follow..  13  1........................................................................................................................................................................................................................................................................MGKKTKKPGKGKEK-TERKTAKADEKKARREGKKLSPEDD-----------------------------------IDAILLNIQKEEAKHVEENVAAPSPRSNCSLTINKETELILYGGEFYNG-------------QKTYVYGDLYRYDVEKQEWKLVSSPNSPP---------PRSSHQAVAWKN-------------------------------------------------YLYIFGGETSPNQERFHHYKDFWMLDVKTNQWEQ--------------------NLKGCPSPRSGHRMVLYKHKIIIFGGFYDTLRERYYNDLYVFDLDQYKWQEIKPKP--------------------------------------------------------------GAMWPTARSGFQFFVYQDEIFLYGGYSKEVVHADLWSLDPRTWEWNKVKKIG-------------MPPSSRAGFSVCVHKKRALLFGGVVDME--------------MEGDVMMSLFLNELYGFQLDNRRWSDKSKALQGAKTRLDPQV-SVSEEVVKPCGRINSCMVVGKDTLYIYGGMMEKEVTLDDLYSLN.............. 407
2 -46.600[R] KOG0379 Kelch repeat-containing proteins  ali follow..  10  3..................................................................................................................................................................................................................................................................FKKFRRSLNFII--CLPKLKECARGQILGYKMETKAIGFHHLSPPQNIVLWLLINL-------------------------INIHLLRMNRYRPFTIP-DEDWPGPRCGHTLTAVNSHQLILFGGSTTAVANHNSSLPEISLDG---VTNSVHSFDVLTRKWTRLNPIGDVPS--------PRACHAAALYGTLILIQGGIGPSDGDVYMLDMTNNKWIKFLVGGETPSPRYGHVMDIAAQRWLVIFSGNNGMLQVVLEKLGDTYGLKMDSDNVWT-------------------PVPAVAPSPRYQHTAVFGGSKLHVIGGILN----------------------------------------------------RARLIDGEAVVAVLDTETGEWVDTNQPETSASGANRQNQYQLMRRCHHAAASFGSHLYVHGGIREDVLLDDLLVAETSQSSSPEPEEDN-------------PDNYMLLDDYLMDEPKPLSSEPEASS-----------------------------FIMRSTSEIAMD------------------RLAEAHNLPTIENAFYDSAIEGYVPLQHGAETTQDLHKKVISTLLRPKTWTP...... 472
3 -43.100[T] KOG2437 Muskelin  ali follow..  10  19............................................................................................................................................................................ALHKWSSFSSTYLPENILVDKPNDQSSRWSSESNYPPQYLILKLER--------------------------------------------------PAIVQNITFG-KYEKTHVCNLKKFKVFGGMNEENMTELLSSGLKNFPCRFIKIVPLLSWGPSFNFSIWYKYREQEAIRLQHNYTEAFESLQKKTKIALEHPMLTDIHDKLVLKGDFDACEELIEKAVNDGLF-------NQYISQQEYKPRWSQIIPKSTKGDGED-NRPGMRGGHQMVIDVQTE-----------------------------------------------TVSLFGGWDGTQD-----LADFWAYSVKENQWTC----------------SRDTEKENGPSARSCHKMCIQRRQIYTLGRYLDSSVRNSKSRYDIDTNTWMLLSEDTAADGGPKLVFDHQMCMDSKHMIYTFGGRNLTCNGGVDDSRASEPQFSGLFAFNCQCKTWKDSCNAGPEDIQSRIGHCMLFKNRCLYVFAGQRSKTYLNDFFSYDVDSDHVDIISDGNKKDSG--------MVPMTGFTQRATIELNEIHVLSGLSKD-----------------KEKREENVRNSFWIYDIVRNSWSCVY-----KNDQAAKDNPTKSLQEEEPCPRFAHQLVYLHKVHYLFGGNPGKSCSLDDFWSLK.............. 622
4 -43.100[R] KOG4693 Uncharacterized conserved protein, contains kelch repeat  ali follow..  13  4.............................................................................................................................................................................................................................................................................TVHLDGGPQ-RVNHAAVGVGDFIYSFGGYCTGYDYRYNE-------------------------------IDVHALNAHTMRWTLVPQYPLVPFQRYGHTVVAYKDR-IYIWGGRNDEN-----------------LCNTLYCFDPKTAQWSRPQVTGCLPG--------ARDGHSACVIGNSMYIFGGFVDESSDVHSLNLDTMEWRYVQTFGVPPSYRDFHASVAYEQERMYIFGGRGDKHSPYHSQCHEIVYLDMKTKVWHR------------------PFTAGKVPVGRRSHSMFVYNKLIYVFGGYNGLLDQHFNDLYTFD-----------------------------------------------------------------PRTKLWNLIRANGKAPTARRRQCAIVMGTRMFLFGGTSPRSSSSSPAAVSPTQETGGAAAAGG-------------VVPPGVALID----YSDLHVLDFE-----------------------------PTLKTLATMVVLKH------------------QLDISGLPRSFRSDLQMLTQPNSIINQAG............................. 403
5 -26.900[S] COG3055 Uncharacterized protein conserved in bacteria  ali follow..  12  5.....................................................................................................................................................................................................................................................................................TVRVFTTAEIIYRKTVIALVCHLNCSRQETVTMNKTIT------------------------ALAIMMASFAANASVLP---ETPVPFKSGTGAIDNDT-VYIGLGSAGTAWYKLD-------------------TQAKDKKWTALA-----------------------------------------------------------AFPGGPRDQATSAFIDGNLYVFGGIGKNSEGLTQVFNDVHKYNPKTNSWVKLM--------------------SHAPMGMAGHVTFVHNGKAYVTGGVNQNIFNGYFEDLNEAGKDSTAIDKI-------------------NAHYFDKKAEDYFFNKFLLSFDPSTQQWSYAGES----------------PWYGTAGAAVVNKGDKTWLINGEAKPGLRTDALDFTGNNLKWNKLAPV--------------SSPDGVAGGFAGISNDSLIFAGGAGFKGSRENYQNGKNYAHEGLKKS------YSTDIHLWHNGKWD---------------------KSGELSQGRAYGVSLPWNNSLLIIGGETAGGKAVTDSVLIT.............. 394
6 -23.700[TR] KOG4441 Proteins containing BTB/POZ and Kelch domains, involved in regulatory/signal transduction processes  ali follow..  9  41...NGLSCISSELTDASYGPNLLEGLSKMRQENFLCDLVIGTKTKSFDVMASCSEYFYNI-----KKDPSIQRVDLNDATVIAYAYTGK--------TLSLYTIGSIISAAVYLQIHTLVKDFLIREMSVENCMYVVNIAETYSLKNAKAAAQKFIRDNFLEFAESDQFMKLTFEQINELLIDDDLQLPSEIVAFQIAMKWLEFDQKRVKYAADLLSNIRFGTISAQDLVNYVQSVPRMMQDADC------HRLLVDAMNYHLLPYHQNTLQSRRTRIRGG-------CRVLVTVGG----------------------------------PGLTEKSLSRDILYRDPENGWSKLT---EMPAKSFNQCVAVMDG-FLYVAGGEDQNDARNQAKH----------AVSNFCRYDPRFNTWIHLASMNQK------------------------------------------------------------RTHFSLSVFNGLVYAAGGRNAEGSECYVPSTNQWQ------------------------------PKTPLEVARCCHASAVADGRVLVTGGYIANAYSRSVCAYDPASDSWQE----------------------------------------------------------------------LPNLSTPRGWHCAVTLSDRVYVMGGSQLGPDVLTVECYSPATGQWSYAA----------------PLQVGVSTAGVSALHGRAYLVGGWNEGEKKYK---------------------KCIQCFSPELNEWT---------------------EDDELPEATVGVSCCTLSMPNNVTRESRASSVSSVPVSI................ 634
7 -13.300[R] KOG4350 Uncharacterized conserved protein, contains BTB/POZ domain  ali follow..  9  1MSNSHPLRPFTAVGEIDHVHILSEHIGALLIGEEYGDVTFVVEKKRFPALAARCQYFRALLYGGMRESQPEAEIPLQDTMLLKYIYTGRATLTDEKEEVLLD----FLSLAHKYGFPELEDEYLCTILNIQNVCMTFDVASLYSLPKLTCMCCMFMDRNAQEVLSSEGFLSLSKTALLNIVLR--SFAAPEKDIFLALLNWCKHNSKENHAEIMQAVRLPLMSLTELLNV----------------VRPSGLLSPDAILDAIKVRSESRDMDLNYRGMLIPEENIATMKYGAQVVKGELKSALLDGD------------------------------------TQNYDLDHGFSRH-----PIDDDCRSGIEIKLGQPSIINHIRILL------------DRDSRSYSYFIEVSMDELDWVRV-------------------------------------------------------IDHSQYLCRSWQKLYFPARVCRYIRIVGTHNTVNK-----IFHIVAFECMFTNKTFTLEKGLIVPMEN--------------------VATIADCASVIEGVSRSR-------------------------------------------------------------------NALLNGDTKNYDWDSGYTCHQLGSGAIVVQLAQPYMIGSIRLLLWDCDDRSYSYYVEVST-NQQQWTMV----------------ADRTKVSCKSWQSVTFSFIRIVGTHNTAHCVHFECPEQQSSQKEENSEESGTGDTSLAGQQLDS................................................................................ 585
8 -10.200[R] KOG1072 FOG: Kelch repeat  ali follow..  10  112..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................PILSRYAPPAHWSSVVAVDYNIYAIGGPINDAPSSSVSVLDCQCEKWREAP----------------SMRVARNYPTATVLDGKIYVAGGCEDCT-----------------------SLDCIEVFDPKTQTWDSVAFGGAGHVAYDPKEGRWDSVGMDMEMGRTWVSYCVINNILFYYND............................. 276
9 -7.410[R] KOG1777 Putative Zn-finger protein  ali follow..  15  1MSSSSSPF----FHP-DTTQQSPSYSQNSNSPSQHTFESMEPAAGGSTSMRYSPSGSS------EADNPTLGLFSAQASY-----YSLRKRRPCLTKDEDLCFPITAATADETPQPT--MKKFKLECLSPGEARDFSIEDESGTNLEAKMETTECEPEEEEAVEEEDQQDHINRLPVFSFLPACSSVSYRFNQISNSHEVW....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 202
10 -7.290[A] KOG1609 Protein involved in mRNA turnover and stability  ali follow..  11  524AEITNK-WYDGLVYGFCSKEDAENILRCIPRSVLLVRFSDIEYGKI--KISVKNR-KLSKSSNEFKEVREKRRVSIPVISVFLFKYTFMNRTALNRRRNIFKYSKNNINLSYSNIVASNILRTFTFINSKSNNFCSENRINSVCFLEIRHHWYEHADLNARSLNSELLSNHKFSDVDLIYPDIDLEKECCDKILLLIHFLCVAFLIGYFSNVFRMIRYLQLALIPCFLAVHVVGDSNEVTV-PAVRVVRLQVDYRNASVSDLQKIHKWNAIMRNSVLASLKF-----INKHWLICGG-SPSDTPTSSNADCGKAQVTGE-----------------IVGDRHYRINVT------IAERDPVKNAKVGATSTVYAVAHIGLKGGYTNALKTLGKPEPKLAFDEAFFCYRGATLVDTDKCR............................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 940
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Zhang B, Jaroszewski L, Rychlewski L, Godzik A. Similarities and differences between nonhomologous proteins with similar folds: evaluation of threading strategies. Fold Des. 1997;2(5):307-17.