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Query: gi|6319279|ref|NP_009362.1| Pyruvate kinase, functions as a homotetramer in glycolysis to convert phosphoenolpyruvate to pyruvate, the input for aerobic (TCA cycle) or anaerobic (glucose fermentation) respiration; Cdc19p (YAL038W) [Saccharomyces cerevisiae], from S.cerevisiae

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MSRLERLTSLNVVAGSDLRRTSIIGTIGPKTNNPETLVALRKAGLNIVRMNFSHGSYEYHKSVIDNARKSEELYPGRPLAIALDTKGPEIRTGTTTNDVDYPIPPNHEMIFTTDDKYAKACDDKIMYVDYKNITKVISAGRIIYVDDGVLSFQVLEVVDDKTLKVKALNAGKICSHKGVNLPGTDVDLPALSEKDKEDLRFGVKNGVHMVFASFIRTANDVLTIREVLGEQGKDVKIIVKIENQQGVNNFDEILKVTDGVMVARGDLGIEIPAPEVLAVQKKLIAKSNLAGKPVICATQMLESMTYNPRPTRAEVSDVGNAILDGADCVMLSGETAKGNYPINAVTTMAETAVIAEQAIAYLPNYDDMRNCTPKPTSTTETVAASAVAAVFEQKAKAIIVLSTSGTTPRLVSKYRPNCPIILVTRCPRAARFSHLYRGVFPFVFEKEPVSDWTDDVEARINFGIEKAKEFGILKKGDTYVSIQGFKAGAGHSNTLQVSTVLast
1 -126.000[G] KOG2323 Pyruvate kinase  ali follow..  39  1...........MAMIEQRPKTKIVCTLGPASRSVPMVEKLLRAGMNVARFNFSHGSHEYHQETLDNLHQAMLNT-GILCAVMLDTKGPEIRTGFLKDGKPIQLKQGQEITISTDYDL--KGDENTICMSYKKLAVDVNPGMVILCADGTISLLVLSCDENGTVRCRCENSAMLGERKNVNLPGVVVDLPTLTEKDKEDIQWGVPNQIDMIALSFVRKGSDLVQVRKLLGKHAKNILLMSKVENQEGVANFDDILVNSDAFMIARGDLGMEIPIEKIFLAQKVMIYKCNIQGKPVVTATQMLESMIKSPRPTRAEATDVANAVLDGTDCVMLSGETAAGAYPELAVRTMAKICVEAESTLDYGDVFKRIMLYSPVPMSPLESLASSAVRTANSARATLIMVLTRGGSTARLVAKYRPGMPILSVVSDESPARHSLIFRGLIPVLYAGSARASHDESTEEAIEFATQYGKEKELCKTGDSVVALLRV----GNASVIKILTV 497
2 -118.000[G] COG0469 Pyruvate kinase  ali follow..  35  2..............SSTLRRTKIVATLGPSTESPEILEAIIRAGANVVRMNFSHGTAEDHKNRAQKVREIAAKL-GRHVALLGDLQGPKIRVSTFKEG-KIILNEGEHFILDAELA-KGEGTQESVGIDYKKLPQDVCNDDILLLDDGRVQLQVMRV-EGNKIHTKVLVGGPLSNNKGINKKGGGLSADALTEKDKNDIRLAAEIQVEYLAVSFPRNGEDMKFARRLAQESGLYARMVAKVETVSCDENIDDIVRASDVIMVARGDLGVEIGDPELIAVQKKLISRAKKLNRVVITATQMMESMISNPMPTRAEVMDVANAVLDGTDAVMLSGETAAGKYPVETVKAMAEVCIGAEKMIESNEQNYRIKS---VFRTEEEAIAMSTIYAANHLGVKAMVTLTESGRTALMTSRLNSVFPIFAMSANQATLNRCALLRGVIPFYFDTKQ-----ASGLEAAIAALDALKERNLLEEGDLVIITQGDIMGEGSTNCMRILPV 480
3 -9.050[G] COG3836 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase  ali follow..  20  71..........................................................................................................................................................................................PVIRPVEGSKPLIKQVLDIGAQTLLIPMVDTAEQARQVENYMAQVNDSLCLLVQVESKTALDNLDEILDVEDGVFIGPADLSASLGYPEVQRIIETSIRRIRAAGKAA--------FLAVAPDMAQQCLAWGANFVAVGVDTMLYSDALD.................................................................................................................................................................... 248
4 -8.920[G] COG2301 Citrate lyase beta subunit  ali follow..  15  18....................................................................................................................................LSTSFVYGADAVMFDLEDAVALREKDTARLLVHHALQHPFYQDVE------KVVRINPLTPFGLADLEAVVRGGADIVRLPKTDSKNDVLELEAQVERIERETRLMAAIESAKGVVNAVDIATSSPAIALAAFDYVMDMGTSELFYARCAVLHAARVAG---IAAYDVVWSDINNEEGFLKEVQLAKGLGFNGKSLV----------NPRQ-IELLHQAYSPTRKEVEHAYEVIAAAEEAESRGLGVVSLNGKMIDGPIIDHARKVVALSAS................................................................................................ 285
5 -7.020[C] COG2225 Malate synthase  ali follow..  11  1MTDLNLPAGMTINAPIKPEYAEIL-----TPEALAFVAEL-------------HRRFEPRRRELMQKREERQQRLDAGELPDFLPETAEIRAGDWKISPLPDALKDRRVEITGPV-------------DRKMIINALNSGAKMFMADDAVRGTISLEQNGKSYKLNDTTATLLVRPRGWHLPEKHVQVDGETLY-HNAKEQLARGKGPYFYLPKMESHLEARLWNDVFNYAEDSIRATVLIETIVAAFEMDEILYELRGLNCGRWDYIFSYAVPMMQNYSKLAIQTCHKRG---APAIGGMSAFIPVKGDEEKNAAAFEQVRVDKEREATNGHDGTWVAHPGMVQLATEVFDRIMPQPNQIGSDKQKDFSLTATDLLQAPEGSVTEAGVRTNINGIQYLAAWLRGSGAVPIHNLMEDAATAEISRA.......................................................................... 454
6 -6.310[G] COG0269 3-hexulose-6-phosphate synthase and related proteins  ali follow..  12  32........................................................................................................................................IEVGTILCVGEGVRAVRLKALYPHKIVLADAK----------------------IADAGKILSRMCFEANADWVTVICCADINTAKGALDVAKEFN--GDVQIELTGYWTWEQAQQWRDAGIGQVVYHRSRDAQAAGVAWGEADITAIKRLSDMGFKVTVTGGL-------------ALEDLPLFKGIPIHVFIAGRSIRDAASPVEAARQFKRSIAEL................................................................................................................................................. 214
7 -6.170[C] KOG1261 Malate synthase  ali follow..  10  2.........................................DEIFSLTAPPVPGDEKILTPDALRFLHDLNIEFNPRRLKLLSK----NKVQEDINNSIWFPDFNKETQVLRDDQGWKGSQIPDDLPPDRKSVINALNSGANVFMEDSN-NISYTHPTTKKEYKLDEKHAVLMVRPRGWHLTEKHVQIHNQP---HNAKALISKGSGPYFYLPKLQNAEEAQLWSDVFKFTEDTIKCTVLIEHLLATFQLHEIIHSLKGLNCGRWDFFCSHRHQIMRNYSLELIKTCHQRGIHAMGGMPIKHDQIANDKAFALVTSDKQREVTDGHDGTWIA-------HP-GLVPVAQRVFNEMMPRPNQIDKLLNRPIATKEQLTMVPEGTRTDLGFRNNISVTLGYLDYLRGVGCVPLDNLMEDLATAEISRA.......................................................................... 438
8 -6.150[E] COG1410 Methionine synthase I, cobalamin-binding domain  ali follow..  9  38.............NVTGSAKFKRLIKEEKYSEALDVARQQVESGAQIIDINMDEGMLDAEAAMVRFLSLIAGEPDIARVPIMIDSSKWEVIEKGLK--NSISMKEGVEVVMAFDEQGQADTRARKIEICRRAYKILTEPPEDIIFDPNIFAVATGIEEHNNYAQDFIGACEDIKR----ELPHALISG------GVSNVSFSFRGN-EAIHAVFLYYAIRNGMDMGIVNA--GQLAIYDDLPAELRDAVEDVILNRRDDGTERLLDLAEKYRGSKTDEAANAQQAEWRSWDVKKRLEYSLVKGITEFIEQDTEEARQQAARPIEVIEGPLMDGMNVVGDLFGEGKMFLPQVVKSARVMKQAVAYLEPFIEASKEKGSSNGKMVIATVK-VHDIGKNIVVVLQCNNYEIVDLGVMVPAEKILRTAREVNA--------GLSGLITPSL----------DEMVNVAKEMERQGF----TIPLLIGGATTSKAHTAV...... 518
9 -5.510[F] COG0516 IMP dehydrogenase/GMP reductase  ali follow..  13  23.............................................................................................................................................................................................GITNDTFVRVEKLIEAGVDAIVIDTAHHSAGVINKISEIRQTFKDVVIVANVATAEGARAL--FEVGVDIVKVGIGPGSI-------------TTRVVAGVGVPQITAIDCATVAREFGKTIIADSGDIVKALAAGGNAVMLGSDESPGETEIFQGRQFKTYRGMGSLAAMEHGSKDRYFQADAKKLVPEGIEGRVPYKGSVADIIFQLVGGIRSGMGSPDLRHLREEAAFVRMTGA.......................................................................... 261
10 -5.440[G] COG0574 Phosphoenolpyruvate synthase/pyruvate phosphate dikinase  ali follow..  18  665................................................................................................................................................................................................................IPMIPFCRTPDEGRKVIAEMAKHGNGLEIYVMCELPSNVILADEFSEVFDGFSIGSNDLGLDRDSSLVLGVKRMVIETAKANGRKIGICGQA------------SDYPEFAEFLVEGIDSISLNPD---------SVLKTVLRIAEVEKAL............................................................................................................................................. 817
FFAS is supported by the NIH grant R01-GM087218-01
1 4 8 3 1 6   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Dunbrack RL Jr, Dunker K, Godzik A. Protein structure prediction in biology and medicine. Pac Symp Biocomput. 2000;(12):93-4.