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Query: gi|16758997|ref|NP_454614.1| threonine synthase (STY0004) [Salmonella enterica subsp. enterica serovar Typhi str. CT18], from S.typhi

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MKLYNLKDHNEQVSFAQAVTQGLGKQQGLFFPHDLPEFSLTEIDEMLNQDFVSRSAKILSAFIGDEIPQQILEERVRAAFAFPAPVAQVESDVGCLELFHGPTLAFKDFGGRFMAQMLTHISGDKPVTILTATSGDTGAAVAHAFYGLENVRVVILYPRGKISPLQEKLFCTLGGNIETVAIDGDFDACQALVKQAFDDEELKTALGLNSANSINISRLLAQICYYFEAVAQLPQGARNQLVISVPSGNFGDLTAGLLAKSLGLPVKRFIAATNINDTVPRFLHDGKWAPKATQATLSNAMDVSQPNNWPRVEELFRRKIWRLTELGYAAVDDTTTQQTMRELKAKGYISEPHAAVAYRALRDQLNPGEYGLFLGTAHPAKFKESVESILGETLALPEALAERADLPLLSHHLPADFAALRKLMMTRQLast
1 -103.000[E] COG0498 Threonine synthase  ali follow..  28  1MKYISTRGETAHKPFSEVLLMGLAPDGGLMLPEHYPQIGRETLDKWRGLAYPELAFEIMRLFV-TDIPEDDLRDILNRTYTEATPVRTLSDGIKIQALSNGPTLAFKDMAMQFLGNAFEYVLNKEKLNILGATSGDTGSAAEYALRGKKGVNVFMLSPDGKMSAFQRAQMYSLDENIHNIAVKGMFDDCQDIVKAVQNDAAFKEKYHIGTVNSINWGRIVAQVVYYFAGYFNATSSNDETVSFCVPSGNFGNVCAGHIAKQMGLPIRRLIVATNENDVLDEFFKTGAYRSAHTYVTSSPSMDISKASNFERFVFDLMDRDPAEINTLWKSTHADRLATIKQVYEQDQELIDPHTADGVKVAREVREEGEMVVCLETALAAKFDATIREAVGAAIPRPAALEGLENLPQRVQTVPNSADAVKGIIEQT. 467
2 -101.000[E] KOG2616 Pyridoxalphosphate-dependent enzyme/predicted threonine synthase  ali follow..  30  5VSYLSTRGGSSNFSFEEAVLKGLANDGGLFIPSEIPQLPSGWIEAWKDKSFPEIAFEVMSLYIPSEISADELKKLVDRSYSTFTPLKSLKNGLNVLELFHGPTFAFKDVALQFLGNLFEFFLTRDHLTVVGATSGDTGSAAIYGLRGKKDVSVFILFPNGRVSPIQEAQMTTVDPNVHCITVNGVFDDCQDLVKQIFGDVEFNKKHHIGAVNSINWARILSQITYYLYSYLSVYKQGADDVRFIVPTGNFGDILAGYYAKRMGLPTKQLVIATNENDILNRFFKTGRYGPISAKETYSPAMDILVSSNFERYLWYLALATERRDFVSERVSNDETIDAIKKIYESDHYIIDPHTAVGVETGLRCLEQDITYICLSTAHPAKFDKAVNLALSSYSDLPIEFDGLLDEERTCIFGKPNIDILKQIIEVT. 508
3 -38.800[E] COG0133 Tryptophan synthase beta chain  ali follow..  11  37.......................GIFGGRFVAETLMPLILE-----LQQAYETAKNDPEFKAELNALSTFYAGRPSKLYYAEGLSKHLGGAKIYFKREDLNHTGSHKINNCLGQILLAKRMGKTR--IIAETGAGQHGVA-SATVAARFGLPCIVYVGASDVERQKPNVFRMKLLGAEVKPVSAGNGTLKDAMNEALRDWVTNVEDTAAGPHPYPELVRDFQSVIGTEARQQIEGRLPDVIVAAVGGGSHPFLDDASVKIVGVEAGGRGLEGEEHCASMSAGRPGVLHADGQILEGHSVSAGLDYPGVGPEHSWLKD----SGRVDYVPILDNEALDAFQLCTRTEGIIPALESAHAIAQAVKMMGKDKVMIVNLSGRGDKDVHTVGKLLGMDI.................................. 422
4 -37.000[E] KOG1395 Tryptophan synthase beta chain  ali follow..  11  85..........................GGKYVPETLMHALSELESAFYALATDDDFQRELAGILKDYVGRESPLYFAERLTEHYRRENGEGPLIYLKREDLNHTGAHKINNAVAQALLAKRLGKKR--IIAETGAGQHGVA-TATVCARFGLECIIYMGAQDMERQALNVFRMRLLGAEVRGVHSGTATLKDATSEAIRDWVHYILGSVAGPHPYPMMVRDFHAVIGKETRKQAWGGKPDVLVACVGGGSHEFVNDTEVRMIGVEAAGFGLDSGKHAATLTKGDVG-QDDDGQIIEPHSISAGLDYPGVGPEHSFFKD----MGRAEYYSITDEEALEAFKRVSRLEGIIPALETSHALAYLEKLLSDGTRVVLNFSGRGDKDVQTVAKYLD..................................... 469
5 -28.500[R] COG1350 Predicted alternative tryptophan synthase beta-subunit (paralog of TrpB)  ali follow..  12  106...........................................................................................RIYFKYEGATVTGSHKINTALAQAYYAKKQGIER--LVTETGAGQWGTA-LSLAGALLGLKVRVYMARASYQQKPYRKTLMRIYGAEVFPSPSENTEVGKRFLKEDPNHPLKDEKARYSLGSVLNHVLMHQTVIGLEAKEQMEFEEPDVIIGCVGGGSAGLAYPFVKDVLDGKSEFIAVEPKAAPTMTRGVYTYDYLKMHTLGHRYYVPPIHAGGLRYHGLAPTLSVLINHGIVKPIAYHQTEVFEAAVLFAKAEGIVPAPESAHAVKAVIDKAGKEMVILFNLSGHGLLDLKGYEDYLDGKLE................................. 440
6 -26.400[TE] KOG1251 Serine racemase  ali follow..  13  41...........................................................................................HVLFKCEHLQKTGSFKARGALNSAILAKEKNAKGMIAHSSGNHGQALAWAAQKI----GLPCTIVVPKNAPIS---KIEGMREYNANIVFCEPTVTSRESVCADLTEKLEYYCVEPY------CVSMINGHSSVAFEILEQVG---NEIDSIFLSVGGGGLASSVAFLIGNLRPDIEVYLVQPAQKELSNFLENGIKCPVDTLDTIADGVRVARVGPLC-----EPILKQYCAQKVISVKEDEIKEGLKLIWTRMKQRIEPTAALAFAGVLYHKPHIKRPLVILCG................................................... 307
7 -20.700[E] COG1171 Threonine dehydratase  ali follow..  11  33......................................................................................DRLGAQIYFKGENFQRVGAFKFRGANAVSKLSDEKRSKGVIAFSSGNHAQAIALSAKLL----NVPATIVMPEDAPAL---KVAATAGYGAHIIRYNRYTEDREQIGRQLAAEHGFALIPPY------HPDVIAGQGTSAKELLEEV----GQLDALFVPLGGGGLLSGSALAARSLSPGCKIFGVEPEANDGQQSFRSGSIVHINTPKTIADGAQTQHLGEYTFAI-------RENVDDILTVSDQELVKCMHFLAERMKVVVEPTACLGFAGALLKKEEGKKVGIILSG................................................... 305
8 -20.300[E] COG3048 D-serine dehydratase  ali follow..  12  97......................................................................................QPISGQLLLKDSHLPISGSIKARGGIYEVLAHEFKQFFSQYSIAVGSTGNLGLSIGIM-SARIGFKVTVHMSAD---ARAWKKAKLRSHGVTVVEYEQDYGVAVEEGRKAAQS----DPNCFFIDDENSRTLFLGYSVAGQRLKAQFDADNPLFVYLPCGVGGGPGGVAFGLKLAFG-VHCFFAEPTHSPCMLLGVHTGLHDQISVDNLTAADGLAVGRASGFV-------RAMERLLDGFYTLSDQTMYDMLGWLAQEEGIRLEPSALAGMAGPQRVCARNATHLVWATGGGMVPEEEMEQYLAK.................................... 440
9 -17.800[E] KOG1250 Threonine/serine dehydratases  ali follow..  13  121......................................................................................KRLGVRMYLKREDLQPVFSFKLRGANMMVKLPADQLAKGVICSSAGNHAQGVALSASKL----GCTAVIVMPVTTPEI---KWQAVENLGATVVLFGDSYDQAQAHAKIRAEEEGLTFIPPF------HPDVIAGQGTVGMEITRQAKGPL-HAIFVPVGGG--GLIAGIAAYVKRVSPEVKIIGVEPADNAMALSLHHGERVILDQVGGFADGVAVKEVGEETFRI-------RNLMDGVVLVTRDAICASIKDMFEEKRNILEPAGALALAGAEAYCKKDVNVVAITSGANMNF-DKLRIVTELANVGRQQEAVLA---TLMPEKPGSFKQFCELVGPMN 443
10 -17.300[E] COG0031 Cysteine synthase  ali follow..  13  29...........................................................................................TILAKIEGRNPGYSVKCRIGANMIWDAEASGRKSGMTLVEPTSGNTGIG-LAFVAAARGYKLILTMPA-SMSLERRKVLKALGAELVLTEPAKGMKGAIQKAEELVAGDPGKYFMPQQFDNPANP------AIHEKTTGPEIWNDTEGAVVLVSGVGTGGTLTVSRYIKNTRGKPILAVAVEPVTSPVISQTLAGEEVKPAPHKIQGIGAGF-VPKNLDL----------SLVDRVEKIGDDEAKNMALRLMQEEGILCGISSGAAMAAAVRLAEQGKTIVVILPDSGERYLSSM.......................................... 311
11 -15.800[E] KOG1481 Cysteine synthase  ali follow..  66...........................................................................................EILGKCEFLNPGGSVKDRVAVKIIQEALESGKFPGGIVTEGSAGSTAIS-LATVAPAYGCKCHVVIPD---DAAIEKSQIIEALGASVERVRPV-DHYVNIARRRADEANELASKRRLGSNLANY------RAHYEGTGPEIWHQTQGNIAFVAAAGTGGTLAGVSRFLQDKNERVKCFLIDPPGSGLYNKVTRGVMYTREEAEGRRLKNPFDTITEGIGINRLTKNFLMAKLDGGFRGTDKEAVEMSRFLLKNDGLFVGSSSAMNCVGAVRVAQPGHTIVTILCDSGMRHLSKF.......................................... 397
12 -15.600[E] KOG1252 Cystathionine beta-synthase and related enzymes  ali follow..  10  32...........................................................................................SIAVKVEYMNPACSVKDRIAFNMIDTAEKAGTPGKTVLIEPTSGNMGIA-LAYCGKLRGYKVILTMPA-SMSIERRCLLKAYGAEVILTDPATAVKGAVQRAEELRDVIP-------QFGNPANP------EAHYKTTGPEIWRQTQGKVIVCFGVGSGGTCTGVGRFLKEKNPSVQVFPVEPFESSVINGLPHSPHKIQGMGTGMIPDI------------------DLTLFSEALRVHSDDAIAMAKKLADEESILGGISSGANVCAAVQLAKKGKLIVTTVNSFGERYLSTA.......................................... 307
13 -11.100[E] COG2515 1-aminocyclopropane-1-carboxylate deaminase  ali follow..  12  66...........................................................................................EIFIKDVTPMAMGGNKLRKLEFLAADALREGADTL--ITAGAIQSNHVRQTAAVAAKLGLHCVALLENPIGTTAENYLTNGNRLLLDLFNTQDALTDPNAQLEELATRVEAQGFRPYVIVGGSNALGALGYVESALEIAQQCEGAVNSSVVVASGSATHAGLAVGLEHLMPESELIGVTVSRSVADQLPKVVNLQQAIAKELELTASAEILL----------------WDDYFAPGYGVPNDEGMEAVKLLARLEGILLDPYTGKAMAGLIDGISQEGPILFIHTG................................................... 348

FFAS is supported by the NIH grant R01-GM087218-01
1 4 6 6 2 8   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Plewczynski D, Tkacz A, Godzik A., Rychlewski L. A support vector machine approach to the identification of phosphorylation sites. Cell Mol Biol Lett. 2005;10(1):73-89.