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Query: d1ygya1 c.2.1.4 (A:99-282) Phosphoglycerate dehydrogenase {Mycobacterium tuberculosis [TaxId: 1773]}, from SCOP207

Results of FFAS03 search in SCOP207
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst NIHSAAEHALALLLAASRQIPAADASLREHTWKRSSFSGTEIFGKTVGVVGLGRIGQLVAQRIAAFGAYVVAYDPYVSPARAAQLGIELLSLDDLLARADFISVHLPKTPETAGLIDKEALAKTKPGVIIVNAARGGLVDEAALADAITGGHVRAAGLDVFATEPCTDSPLFELAQVVVTPHLGLast
1 -103.000d1ygya1 c.2.1.4 (A:99-282) Phosphoglycerate dehydrogenase {Mycobacterium tuberculosis [TaxId: 1773]}  ali model 3D-neighbors  100  1NIHSAAEHALALLLAASRQIPAADASLREHTWKRSSFSGTEIFGKTVGVVGLGRIGQLVAQRIAAFGAYVVAYDPYVSPARAAQLGIELLSLDDLLARADFISVHLPKTPETAGLIDKEALAKTKPGVIIVNAARGGLVDEAALADAITGGHVRAAGLDVFATEPCTDSPLFELAQVVVTPHLG 184
2 -93.600d1sc6a1 c.2.1.4 (A:108-295) Phosphoglycerate dehydrogenase {Escherichia coli [TaxId: 562]}  ali model 3D-neighbors follow..  34  1NTRSVAELVIGELLLLLRGVPEANAKAHRGVGNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIE--NKLPLGNATQVQHLSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALADALASKHLAGAAIDVFPTEPPFTSPLAEFDNVLLTPHIG 187
3 -91.000d1gdha1 c.2.1.4 (A:101-291) D-glycerate dehydrogenase {Hyphomicrobium methylovorum [TaxId: 84]}  ali model 3D-neighbors follow..  33  2.TVATAEIAMLLLLGSARRAGEGEKMIRTRSWEPLELVGEKLDNKTLGIYGFGSIGQALAKRAQGFDMDIDYFDTHRSSDEASYQATFHDSLDSLLSVSQFFSLNAPSTPETRYFFNKATIKSLPQGAIVVNTARGDLVDNELVVAALEAGRLAYAGFDVFAGEPNINEGYYDLPNTFLFPHIG 189
4 -88.400d1mx3a1 c.2.1.4 (A:126-318) Transcription corepressor CtbP {Human (Homo sapiens), Ctbp1 [TaxId: 9606]}  ali model 3D-neighbors follow..  37  1..EETADSTLCHILNLYRRATWLHQALREGTRVQSVSGAARIRGETLGIIGLGRVGQAVALRAKAFGFNVLFYDPYLSDGVERALGLQRVTLQDLLFHSDCVTLHCGLNEHNHHLINDFTVKQMRQGAFLVNTARGGLVDEKALAQALKEGRIRGAALDVHESEPFSQGPLKDAPNLICTPHAA 192
5 -86.200d2naca1 c.2.1.4 (A:148-335) Formate dehydrogenase {Pseudomonas sp., strain 101 [TaxId: 306]}  ali model 3D-neighbors follow..  28  1..ISVAEHVVMMILSLVRNYLPSHEWARKGGWNIADCVAYDLEAMHVGTVAAGRIGLAVLRRLAPFDVHLHYTDRHRLPESVEK--TWHATREDMYPVCDVVTLNCPLHPETEHMINDETLKLFKRGAYIVNTARGKLCDRDAVARALESGRLAGYAGDVWFPQPPKDHPWRTMPYNGMTPHIS 187
6 -82.700d1j4aa1 c.2.1.4 (A:104-300) D-lactate dehydrogenase {Lactobacillus helveticus [TaxId: 1587]}  ali model 3D-neighbors follow..  35  3...AIAEHAAIQAARILRQDKAMDEKVARHDLRWAPTIGREVRDQVVGVVGTGHIGQVFMQIMEGFGAKVITYDIFRNPE-LEKKGYYVDSLDDLYKQADVISLHVPDVPANVHMINDESIAKMKQDVVIVNVSRGPLVDTDAVIRGLDSGKIFGYAMDVYEGEVARLADLIARPNVLVTPKTA 196
7 -77.800d1qp8a1 c.2.1.4 (A:83-263) Putative formate dehydrogenase {Pyrobaculum aerophilum [TaxId: 13773]}  ali model 3D-neighbors follow..  27  1.ADAVAEFALALLLAPYKRIIQYGEKMKRGDYGRD-VEIPLIQGEKVAVLGLGEIGTRVGKILAALGAQVRGFSRTPKEGP----WRFTNSLEEALREARAAVCALPLNKHTRGLVKYQHLALMAEDAVFVNVGRAEVLDRDGVLRILKERPQFIFASDVWWGRNDKDAEFFSLPNVVATPWVA 180
8 -34.400d1li4a1 c.2.1.4 (A:190-352) S-adenosylhomocystein hydrolase {Human (Homo sapiens) [TaxId: 9606]}  ali model 3D-neighbors follow..  19  2NLYGCRESLIDGIK---------------------RATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVIITEI-INALQAAMEGYEVTTMDEACQEGNIFVT----TTGCIDIILGRHFEQMKDDAIVCNIGHFVEIDVKWLNENAVEKVNIKPQVDRYRLKNGRRIILLAEGRLV...... 156
9 -25.100d1kjqa2 c.30.1.1 (A:2-112) Glycinamide ribonucleotide transformylase PurT, N-domain {Escherichia coli [TaxId: 562]}  ali model 3D-neighbors follow..  22  1...................................TLLGTALAATRVMLLGSGELGKEVAIECQRLGVEVIAVDRYADAPAMHVAHINMLDGDALRRVVELEKPHY-IVPEIEAIATDMLIQLEEEGLNVVPCARATKLTM........................................... 111
10 -15.600d4ypoa1 c.2.1.0 (A:1-180) automated matches {Mycobacterium tuberculosis [TaxId: 1773]}  ali model 3D-neighbors follow..  19  12.........................................IQGRKVGVIGYGSQGHAHSLSLRDSGVQVRVGQGSRSRPKVEEQGLDVDTPAEVAKWADVVMVLAP-DTAQAEIFAGDIEPNLKPGDALFFGHGLNVHFGLIKPPADVA.................................. 121
11 -14.200d2cvza2 c.2.1.6 (A:2-157) Hydroxyisobutyrate dehydrogenase {Thermus thermophilus [TaxId: 274]}  ali model 3D-neighbors follow..  20  1............................................EKVAFIGLGAMGYPMAGHLARRFPTLVWNRTFEKALRHQEEFGSEAVPLERVAEARVIFTCLPTTREVYEVAEA--YPYLREGTYWVDATSGEPEASRRLAERLREKGVTYLDAPV........................ 115
12 -12.800d2i76a2 c.2.1.6 (A:2-154) Hypothetical protein TM1727 {Thermotoga maritima [TaxId: 2336]}  ali model 3D-neighbors follow..  12  1.............................................VLNFVGTGTLTRFFLECLKD--GYILSRSIDRARNLAEVYGGKAATLEKHPELNGVVFVIVP-----DRYIKTVANHLNLGDAVLVHCS--GFLSSEIFKKSGRAS................................. 101
13 -12.600d1qp8a2 c.23.12.1 (A:1-82,A:264-302) Putative formate dehydrogenase {Pyrobaculum aerophilum [TaxId: 13773]}  ali model 3D-neighbors follow..  15  82NXGYGNERVWRQMVMEA--------------------------VRNLITYATGGRPRNIAKREDYIG..................................................................................................................... 122
14 -12.100d4gwga1 c.2.1.0 (A:1-176) automated matches {Human (Homo sapiens) [TaxId: 9606]}  ali model 3D-neighbors follow..  13  3............................................ADIALIGLAVMGQNLILNMNDHGFVVCAFNDFLANEAKGTKVVGAQSLKEMVSKLKKPRRIILLVKAGQAVDDEKLVPLLDTGDIIIDGGNSEYRDTTRRCRDLKAKGILFVGSGV........................ 127
15 -12.100d5je8a1 c.2.1.0 (A:1-163) automated matches {Bacillus cereus [TaxId: 226900]}  ali model 3D-neighbors follow..  18  2............................................KKIGFIGLGNMGLPMSKNLVKSGYTVYGVDKEAEASFEKEGGIIGLSISKLAETCDVVFTSLPSPRAVEAVYFGAEFENGHSNVVFIDTSTVSPQLNKQLEEAAKEKKVDFLAAPV........................ 121
16 -12.000d4dlla1 c.2.1.0 (A:29-190) automated matches {Polaromonas sp. [TaxId: 296591]}  ali model 3D-neighbors follow..  14  4............................................RKITFLGTGSMGLPMARRLCEAGYALQVWNPARAASLAALGATIHEQARAAARDADIVVSMLENGAVVQDVLAQGVAAAMKPGSLFLDMASITPREARDHAARLGALGIAHLDTPVSGGTVGAEQGTLVI.......... 136
17 -11.600d1saya1 c.2.1.4 (A:136-303) L-alanine dehydrogenase {Phormidium lapideum [TaxId: 32060]}  ali model 3D-neighbors follow..  25  30.........................................VKPGKVVILGGGVVGTEAAKMAVGLGAQVQIFDINVERSRVELLYSNSAEIETAVAEADLLAVLVP-GRRAPILVPASLVEQMRTGSVIVDVAQGGCVE............................................ 140
18 -11.400d2gf2a1 c.2.1.0 (A:41-201) automated matches {Human (Homo sapiens) [TaxId: 9606]}  ali model 3D-neighbors follow..  21  2..............................................VGFIGLGNMGNPMAKNLMKHGYPLIIYDPDACKEFQDAGEQVVSSPADVAEKADRIITMLPTSINAIEAYSGANLKKVKKGSLLIDSSTIDPAVSKELAKEVEKMGAVFMDAPV........................ 119
19 -11.400d3fr7a1 c.2.1.0 (A:86-307) automated matches {Oryza sativa [TaxId: 39947]}  ali model 3D-neighbors follow..  14  20.......................EYIVRGGRNLFPLLPEAFKGIKQIGVIGWGSQGPAQAQNLRDSLAEAKSDIVVKRAAGFTEESGTLGDIWETVSGSDLVLLLIS--DAAQADNYEKIFSHMKPNSILGLSH.................................................. 141
20 -11.400d3g0oa1 c.2.1.0 (A:6-169) automated matches {Salmonella typhimurium [TaxId: 602]}  ali model 3D-neighbors follow..  19  4..............................................VGIVGLGSMGMGAARSCLRAGLSTWGADQACANLLAEGACGAAASAREFAGVVDALVILVVNAAQVRQVLFGEDAHLMKPGSAVMVSSTISSADAQEIAAALTALNLNMLDAPV........................ 122
21 -11.300d1c1da1 c.2.1.7 (A:149-349) Phenylalanine dehydrogenase {Rhodococcus sp., M4 [TaxId: 1831]}  ali model 3D-neighbors follow..  27  24........................................SLDGLTVLVQGLGAVGGSLASLAAEAGAQLLVADTDTERAHAVALGHTAVALEDVLSPCDV----------------------------FAPCAMGGVITTEVA-RTLDCSVVAGAANNVIADE--AASDILHARGILYAPDF. 137
22 -11.300d1l7da1 c.2.1.4 (A:144-326) Nicotinamide nucleotide transhydrogenase dI component {Rhodospirillum rubrum [TaxId: 1085]}  ali model 3D-neighbors follow..  22  27.........................................VPPARVLVFGVGVAGLQAIATAKRLGAVVMATD-YAKEMGEEFRKKQAEAVLKELVKTDIATALIP-GKPAPVLITEEMVTKMKPGSVIIDLAAGGNCPLSEPGKIVVKHGVKIVGHT......................... 178
23 -11.200d1ygya2 c.23.12.1 (A:3-98,A:283-316) Phosphoglycerate dehydrogenase {Mycobacterium tuberculosis [TaxId: 1773]}  ali model 3D-neighbors follow..  12  98ASTAEAQDRAGTDVAESVRLALAGEFVPDAVNV....................................................................................................................................................... 130
24 -11.200d3etja2 c.30.1.1 (A:1-78) N5-carboxyaminoimidazole ribonucleotide synthetase PurK (AIRC), N-domain {Escherichia coli [TaxId: 562]}  ali model 3D-neighbors follow..  23  2............................................KQVCVLGNGQLGRMLRQAGEPLGIAVWPVGL--------------AEPAAVPFQQSVITAEIERWPET........................................................................ 56
25 -11.200d2uyya1 c.2.1.0 (A:262-429) automated matches {Human (Homo sapiens) [TaxId: 9606]}  ali model 3D-neighbors follow..  16  7............................................KKIGFLGLGLMGSGIVSNLLKMGHTVTVWNRTAEKDLFIQEGARLGTPAEVVSTCDITFACVSDPKAAKDLVLGPSLQGIRPGKCYVDMSTVDADTVTELAQVIVSRGGRFLEAPVSGNQQLSNDGMLVI.......... 140
26 -11.100d2f1ka2 c.2.1.6 (A:1-165) Prephenate dehydrogenase TyrA {Synechocystis sp. PCC 6803 [TaxId: 1148]}  ali model 3D-neighbors follow..  22  3..............................................IGVVGLGLIGASLAGDLRRRGHYLIGVSRQQSTEKAVERQLEAGQDLSLLQTAKIIFLCTPIQLILPTL--EKLIPHLSPTAIVTDVAKTAIAESQLWSGFIGGHPMAGTAAQGIDG---AEENLFVNAPYVLTP... 139
27 -10.800d3ws7a1 c.2.1.0 (A:1-161) automated matches {Pyrobaculum calidifontis [TaxId: 410359]}  ali model 3D-neighbors follow..  17  3..............................................VGFIGLGIMGGPMATHLLKAGFLAAVYNREKTKPFAEAGVYVAESPADLAKRVDVVIVMVSDAPDVEQVLFGPSVEGARPGLIVVDMSTNSPDWARKFAERLAQYGIEFLDAPVTGGQKGAIEGTLTI.......... 134
28 -10.600d1i36a2 c.2.1.6 (A:1-152) Conserved hypothetical protein MTH1747 {Methanobacterium thermoautotrophicum [TaxId: 145262]}  ali model 3D-neighbors follow..  16  2.............................................RVGFIGFGEVAQTLASRLRSRGVEVVTSLEGRSPSTIERARTVGVTSEEDVYSCPVVISAVTPGVA----LGAARRAGRHVRGIYVDINNISPETVRMASSLIEKGGFVDAAI.......................... 112
29 -10.600d3vpxa2 c.2.1.0 (A:145-363) automated matches {Sporosarcina psychrophila [TaxId: 1476]}  ali model 3D-neighbors follow..  15  19.................................KEAFGDDSLAGKTVAVQGVGNVAYALCEYLHEEGAKLIITDINEEARAVDAFGATAVGINEIYSEADI----------------------------FAPCALGAIINDETI-PQLKAKVIAGSANNQLKET--RHGDLIHEMGIVYAPDY. 140
30 -10.400d2dapa1 c.2.1.3 (A:1-118,A:269-320) Diaminopimelic acid dehydrogenase (DAPDH) {Corynebacterium glutamicum [TaxId: 1718]}  ali model 3D-neighbors follow..  13  1.........................................MTNIRVAIVGYGNLGRSVEKLIAKQDMDLVGIFSRRATLDTKTPVFDVADVDKHADDVDVLFLCMGFAQFACTVDTYDNHRDIPRHRQVMNEAATAIAFGRAAHRMKQQGQSGAFTV.......................... 150
31 -9.960d1mx3a2 c.23.12.1 (A:28-125,A:319-352) Transcription corepressor CtbP {Human (Homo sapiens), Ctbp1 [TaxId: 9606]}  ali model 3D-neighbors follow..  14  97SVXYSEQASIEMREEAAREIRRAITGRIPDSLKNCV.................................................................................................................................................... 132
32 -9.940d2pv7a2 c.2.1.6 (A:92-243) Prephenate dehydrogenase TyrA {Haemophilus influenzae [TaxId: 727]}  ali model 3D-neighbors follow..  17  2....................................FKTINSDIHKIVIVGYGKLGGLFARYLRASGYPISILDR------------DWAVAESILANADVVIVSVPINLTLETI--ERLKPYLTENMLLADLTSVKREPLAKMLEVHTGAVLGLHPM--------ADIASMAKQVVVRCD... 128
33 -9.660d1edza1 c.2.1.7 (A:149-319) Methylenetetrahydrofolate dehydrogenase/cyclohydrolase {Baker`s yeast (Saccharomyces cerevisiae) [TaxId: 4932]}  ali model 3D-neighbors follow..  17  23.....................................EGNRLYGKKCIVINRSEVGRPLAALLANDGATVYSVDVNNIQKFTRGESLKLNLLKKCSLDSDVV---ITGVPSENYKFPTE---YIKEGAVCINFACTKNFSDDVKEKASLYVPMTGK............................ 149
34 -9.480d1j4aa2 c.23.12.1 (A:2-103,A:301-332) D-lactate dehydrogenase {Lactobacillus helveticus [TaxId: 1587]}  ali model 3D-neighbors follow..  9  102SXYTTHAVRNMVVKAFDNNLELVEGKEAETPVK....................................................................................................................................................... 134
35 -9.470d2x5oa1 c.5.1.0 (A:1-93) automated matches {Escherichia coli [TaxId: 668369]}  ali model 3D-neighbors follow..  22  1.......................................ADYQGKNVVIIGLGLTGLSCVDFFLARGVTPRVMDTRMTPPGLDKLPEAV---DEWLMAADLIVASPGIALAHPSLSAAAD................................................................ 86
36 -9.450d1j5pa4 c.2.1.3 (A:1-108,A:220-241) Hypothetical protein TM1643 {Thermotoga maritima [TaxId: 2336]}  ali model 3D-neighbors follow..  12  3..............................................VLIIGMGNIGKKLVELG---NFEKIY---AYDRISKDIPGVVRLDEFQVPSDVSTVVECAS-----PEAVKEYSLQILKNPVNYIIISTSAFADEVFRERFFSELKNSPARVFF........................ 105
37 -9.410d1dlja3 c.26.3.1 (A:295-402) UDP-glucose dehydrogenase (UDPGDH), C-terminal (UDP-binding) domain {Streptococcus pyogenes [TaxId: 1314]}  ali model 3D-neighbors follow..  17  6..................................NVLKEQESPVKVVGVYRLISAIKDVIDILKSKDIKIIIYEPMLNKLESEDQSVLVNDLENFKKQANIIVT................................................................................ 85
38 -9.370d1pjqa1 c.2.1.11 (A:1-113) Siroheme synthase CysG, domain 1 {Salmonella typhimurium [TaxId: 90371]}  ali model 3D-neighbors follow..  13  8.......................................CQLRDRDCLIVGGGDVAERKARLLLEAGARLTVNALTFIPQFTVWANEGMLTLEGPFDETLLDSCWLAIAATDDDTVNQRVSDAAESRRIFCNVV.................................................. 103
39 -9.370d1bg6a2 c.2.1.6 (A:4-187) N-(1-D-carboxylethyl)-L-norvaline dehydrogenase {Arthrobacter, strain 1c [TaxId: 1663]}  ali model 3D-neighbors follow..  17  2............................................KTYAVLGLGNGGHAFAAYLALKGQSVLAWDIDAQRAGTAHPDLLTSDIGLAVKDADVILIVVPAIHHASIA---ANIASYISEGQLIILNPGATGGALEFRKILRENGAPEVTIGETSSML................... 136
40 -9.320d1sc6a2 c.23.12.1 (A:7-107,A:296-326) Phosphoglycerate dehydrogenase {Escherichia coli [TaxId: 562]}  ali model 3D-neighbors follow..  16  102XSTQEAQENIGLEVAG-KLIKYSDNGSTLSAVN....................................................................................................................................................... 133
41 -9.300d1hwxa4 c.2.1.7 (A:209-501) Glutamate dehydrogenase {Cow (Bos taurus) [TaxId: 9913]}  ali model 3D-neighbors follow..  16  15......................IENFIENASYMSILGMTPGFGDKTFAVQGFGNVGLHSMRYLHRFGAKCVAVGE-SDGSIWNPDGIDPKELEDFKLQHGTILGFPKAKIYEGSILEVD---------ILIPAASEKQLTKSNAPRVKAKIIAEGANGPT----TPQADKIFLERNIMVIPDL. 163
42 -9.260d2g5ca2 c.2.1.6 (A:30-200) Prephenate dehydrogenase TyrA {Aquifex aeolicus [TaxId: 63363]}  ali model 3D-neighbors follow..  18  2............................................QNVLIVGVGFMGGSFAKRRSGFKGKIYGYDINPESSKAVDLGI-----KVEDFSPDFVMLSSPVRTFREIA--KKLSYILSEDATVTDQGSVKGKLVYDLENILGKRFVGGHPIAGTEKSEYSLDNLYEGKKVILTP... 145
43 -9.180d1dxya2 c.23.12.1 (A:1-100,A:300-330) D-2-hydroxyisocaproate dehydrogenase {Lactobacillus casei [TaxId: 1582]}  ali model 3D-neighbors follow..  13  101XTETAVHNMVYFSLQHLVDFLTKGETSTEVT......................................................................................................................................................... 131
44 -9.000d4e12a1 c.2.1.0 (A:1-189) automated matches {Acinetobacter baylyi [TaxId: 202950]}  ali model 3D-neighbors follow..  22  5............................................TNVTVLGTGVLGSQIAFQTAFHGFAVTAYDINTDALDAAKKRFESDDLAQAVKDADLVIEAVPESLDLKRDIYTKLGELAPAKTIFATNSSTLLPSDLV......................................... 130
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Friedberg I, Godzik A. Fragnostic: walking through protein structure space. Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W249-51.