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Query: d1z63a1 c.37.1.19 (A:432-661) Helicase of the SNF2/Rad54 hamily {Sulfolobus solfataricus [TaxId: 2287]}, from SCOP207

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst FQLLEPYNIKANLRPYQIKGFSWMRFMNKLGFGICLADDMGLGKTLQTIAVFSDAKKENELTPSLVICPLSVLKNWEEELSKFAPHLRFAVFHEDRSKIKLEDYDIILTTYAVLLRDTRLKEVEWKYIVIDEAQNIKNPQTKIFKAVKELKSKYRIALTGTPIENKVDDLWSIMTFLNPGLLGSYSEFKSKFATPIKKGDNMAKEELKAIISPFILRRTKYDKAIINDLPLast
1 -65.400[KL] COG0553 Superfamily II DNA/RNA helicases, SNF2 family  ali follow..  42  691.FQDVPQQIQATLRSYQTEGVHWLERLRKMHLNGILADDMGLGKTLQAIIAVTQSKLEKGSGCSLIVCPTSLVYNWKEEFRKFNPEFRTLVIDGVPSQRALADRDVAITSYNLLQKDVEYKSFRFDYVVLDEAHHIKNRTTRNAKSVKMIQSDHRLILTGTPIENSLEELWSLFDFLMPGLLSSYDRFVGKYIRTGNYNKADNMVALKKKVSPFILRRMKED--VLKDLP 925
2 -59.400[B] KOG0389 SNF2 family DNA-dependent ATPase  ali follow..  32  277..VEQPKLLSSQLADYQIIGLNWLTVMHKQEMNGILADEMGLGKTIQVIAFLAYLKENGLSAAHLIVVPSSTLDNWEAEISRWCPELVVEKYHGSQDERRFTGFDVLLTTYHIVGSTPEFRVCKLDYVIFDEAHMLKNMTTQRYANLITINARMRILLTGTPLQNNLLELISLLCFVMPKFAKSIEDIKSLFAKKGKSDQETQIQRAKRIMKPFVLRRLKKD--VLKNLP 529
3 -53.000[KL] KOG0387 Transcription-coupled repair protein CSB/RAD26 (contains SNF2 family DNA-dependent ATPase domain)  ali follow..  34  267..FTIPGDIRPHLFRYQVTCVQWLWELYCQEAGGIIGDEMGLGKTIQIVSFLSSLHHSGKFKPALIVCPATLMKQWVNEFHTWWAPLRVVVLHATGSGQRATRGHILITTYAGLRIYGDILPREWGYCVLDEGHKIRNPDSEISISCKQIRTVNRIILSGTPIQNNLTELWNLFDFVFPGRLGTLPVFQNQFALPINIGGYKCACMLRDLISPYLLRRMKLD--VAADLP 550
4 -35.500[L] KOG1002 Nucleotide excision repair protein RAD16  ali follow..  30  128.TAEPPSDLIMPLLRYQKEFLAWATKQEQSVAGGILADEMGMGKTIQAISLVLARREVDRAGCTLVLCPLVAVSQWLNEIARFTSSTKVLVYHGAKRAKNIKEYDFVLTTYSTVESEYRLHSVKWNRIILDEAHYIKERRSNTARAVFALEATYRWALSGTPLQNRVGELYSLIRFLQ-NAVRHFCWWNKYVAKPITVYGRAMILLKHKVLKDILLRRTKLGRAADLALP 494
5 -22.200[KL] COG1061 DNA or RNA helicases of superfamily II  ali follow..  15  68.PIDLVPSLEMEPYPHQSEA---LAAWKLAGRQGVVVLPTAAGKTYLAQLAMQATPRT-----TLIVVPTDLMHQWYAHLVAAFPDAEVGLLGGGSRDKS----PVLVATYDSAAIHAEALGNQYALIVFDECHHL--PTDFSKVIAEYAIAPYRLGLSATPERT................................................................. 218
6 -19.500[KL] COG4646 DNA methylase  ali follow..  18  489...........VLYGHQKRGIWRIIS----AGSTYLAHAVGAGKTMTMAASIMEQRRLGLVAKAMQVVPGHCLAQAAREFLALYPTARILVADETNSRAATATWDAIIITHSAFRF-LTIAEIGVDQIIVDEAQEFRK-DPNGSQRAWDLYVKSRVLASGTPITNTLGEMFSVQRLMGHPALHEFDAWASTFGDTTTELELQPSRKYKPVSRPELIA-VVMPADLREYVK 811
7 -16.400[KL] KOG1123 RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, 3`-5` helicase subunit SSL2  ali follow..  19  321.DINIDLKPAAVLRPYQEKSLRKMFGNGRARSG-VIVLPCGAGKSLVGVTACCTVRK-----RALVLCNSGSVEQWKQQFKMWSTDDSMICRFTSEAKDKPMGCGILVTTYSMITHTRWLQEQEWGIMVLDEVHTI--PAKMFRRVLTIVQSHCKLGLTATLLDDKIADLNFLIELQKKGYIARVQCAEVWCPMSPEFYREYLTTKTSKKMLLYVMNPSKFR........ 558
8 -15.000[L] COG1111 ERCC4-like helicases  ali follow..  15  16...........EARTYQQL----LAADVIRKGNSMIVAPTALGKTVVAVLVAAERLRKYRGSKVLILSPSKPLAIQHEESFREFMLATCTSLTGSERKERWIKSQIISATPQTVESDILYDLRDVSLIVFDECHRASYSYVFLASNYIQNARHPLIGLTASPGAD-EDKIKTVCENLFMNEVVVKTEGDPDVRPYLKPIKIE............................ 211
9 -13.000[S] COG3421 Uncharacterized protein conserved in bacteria  ali follow..  12  49......RNLKYPFFEWQKSALENFVIFDRAS---LFNMATGAGKTMMMAALILYYFEKG-YRHFLFFVNQNNIVD--KTENNFIDP-VIPIRKVEMFSPHSDGIEIKFTSIQKLYNDIHTEREN--VMLGDEAHHLNAQTKGKKQDELDLEVELKANAGNAEIERKGWE--MVLELLLNKNGNPGQNVLLEFTATLPENADVQQKYADKIITKFGLKEFLQKGYT..... 300
10 -12.200[R] KOG0354 DEAD-box like helicase  ali follow..  16  72...........SFRDYQFNIVQ-----KALFENVLVALPTGLGKTFIAAVVMMNYLRWFPKSYIVFMAPTKPLVTQQMEACYKITGIPKSQTAETTRNQYYQSRNVFFVTPQTILNDIKCDRTRISCLVIDEAHRSNYAYVEVVHLLSLSNKNFRIALSATPGNKL-EAIQNVIDSLHISRIEIRTENSIDISQYVQKKEVDFRDRFSSILEPMLQKLNKGNYYRIQNA. 308
11 -12.200[R] COG4889 Predicted helicase  ali follow..  13  175...........SPRPHQQTAIEKAIEGFQTHDRGKLIMACGTGKTFTALRLSEEVRLNGNKARILFLVPSQTLKEWTAQKTMDLRPVAVLIAEKLEHRKRAAGLTVVFSTYPAVHAAQEAGAEPFDLVICDEAHRTTGITLAGEDP-SYIKAAKRLYMTATPVKGKAADHSAEVSSMDDEAIYGPEFHRLGFGEAVEKG----------LLTDYKVVVMTVDEQVAASA. 432
12 -11.700[V] COG4096 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases  ali follow..  20  454...DNPGMSELGLRYYQEDAVRAVEKAIVKG--ILLAMATGTGKTRTAIAMMFRLIQSQRFKRILFLVDRSLGEQALGAFEDTRINGDTFNIKGLTDKFPEDSTKIHVATVQSLVKRTPMPVARYDCIVVDEAHRSQLDYVSAYRRILDHFDAVKIALTATPALHTVQIFYTYRTAVIDGFL................................................ 665
13 -11.200[L] COG4098 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein)  ali follow..  13  90.......KWRGQLTPFQEKVSEGLLQVVDKQKPTLVHAVTGAGKTEMIYQVVAKVINAGGA--VCLASPRIDVCLELYKRLQQDFSCGIALLHGESEPYFRTPL-VVATTHQLLKFYQAF-----DLLIVDEVDAFDNPMLYHAVKNSVKENGLRIFLTATSTNELDKKV-ELKRLNLPRRFHGNPLIIPKPIWLSDFNRYLDKNRLSPKLKSYIEKQRKTAYPLLIFAS 309
14 -10.800[V] COG3587 Restriction endonuclease  ali follow..  12  75..................................DISMETGTGKTYTYTQTMFELHRWLGVFKFIVVVPTLSIKAGTQQFDYEGVRLKTYVVESAKKNKNKKEIHVLLINAGMVNSSVDALAAVRPFMIVDEPHKFPTRDSAKTGNIKRLKPQYILRYGATFNDEYYNLLYR---------LTAVDAFNDGLVKGVR................................. 279
15 -10.700[LK] COG1200 RecG-like helicase  ali follow..  13  263......ATLPFQPTNAQKRVVSDIELIKDYPMMRLVQGDVGSGKTL--VAALAALTAIDNGKQVALMAPTEILAEQHANNFR---GIEVGWLAGKVKGKSRQAVQMVVGTHALFQEEVEFSDL--ALVIIDEQHRVHQRLMLREKGEKAGFYPHQLIMTATPIPRTLADL-SIIDELPPGRTPITTVVRRAEIVMRVKNACVNEKRQAYWVCTLIDESEVLEAQAAEA.. 506
16 -10.000[T] COG1875 Predicted ATPase related to phosphate starvation-inducible protein PhoH  ali follow..  11  271..................................SIGGPAGTGKSALALCAGLEAVMERRIQRKIIVFRPLFAVGGQEQEEKMGPWAQLSSMVSQNIIDEALSRGLIEVLPLTHIRGRSLHD---AFVIVDEAQSLERNVLLT--MLSRIGQNSRVVLTHDVAQRDNLRV-------YDGIVSVVEALKDHELFGHITLQRSERSRIAELVTQVL............... 453
17 -9.710[A] KOG0332 ATP-dependent RNA helicase  ali follow..  13  221............LKALDTMNFQFPTRIQETALPLLLMEPSGTGKTAAVLTMLCRIDVNLMCPQCICLAPTL-IGEVVEKMGKFIDNLKIHYAIKGGNMAAMRGEQIVIGTPGYLQKYKCIDPSKIRCLVLDEADVMTDISTTIYNMVEDASDSVQSMLFSATYDEPVINFATKI-IKNAIVV-ALPNIKQFYVQ---ACRDSKYAAIVNLYSSVIFCHTKASVMWLYE.. 473
18 -9.250[LK] COG1197 Transcription-repair coupling factor (superfamily II helicase)  ali follow..  15  624...............................MDRLVCGDVGFGKT---VAMRAAFLAVMNHKQVAVLVPTTLLANFKDRFANLPVNVEVLSRFKTAKEQK-GKVDILIGTHKLIQSDVKFNDL--GLLIIDEEHRF---GVGQKEKIKQLRAN--LTLTATPIPRTLN--MAMNGIRDLSIISTPPARRLSIKTFVRQNDDLVREAILREIL-YLHNDVASIENTAEKL. 831
19 -9.070[R] COG1205 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster  ali follow..  19  70...NFFPNLTLPFPPHAHQARAFQRLGSDAPQPTLVATGTGSGKTFPLLNHCAGASQAG---KAIIIYPMNALAT--DQASRFAKKVTVGLFVGDSEIEPSKKMDILLTNYKMLDGDQPLQPGSLRYLVVDELHTFDGAQSDLACLVRRLKHHQRFACVGTSAT-----------------VGDELGQLLDYAKTIFDQPFTDDAVIRE..................... 301
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Luz JG, Hassig CA, Pickle C, Godzik A., Meyer BJ, Wilson IA. XOL-1, primary determinant of sexual fate in C. elegans, is a GHMP kinase family member and a structural prototype for a class of developmental regulators. Genes Dev. 2003 Apr 15;17(8):977-90. Epub 2003 Apr 02.