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Query: TM0017 TM0017 281898 Purified-2003-03-05, from T.maritima

Results of FFAS03 search in SCOP207
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MRMERVVERVAVTGAEAVANAMRQIEPDVVAAYPITPQTPIVEYFARFVADGVVRTEMIPVESEHSAMSAVVGAAAAGARAMTATSANGLALMHEIVYIAASYRLPIVMPVVNRALSGPINIHCDHSDAMAERDSGWIQLFAETNQEAYDFTILAVRLAEHEDVRLPVMVNLDGFILSHGVEPVEFYPDELVKKFVGELKPMYPLLDTEHPVTWGPLDLYDYYFEHKRQQIEAMENVKKVFPEIAKEFEETFGRKYWFVEPYRMEDAEHVMVALGSTNSTIKYVVDELREEGYKVGSLKIWMFRPFPKEQLQELLNGRKSVVVLDRAVSFGAEAPLYEAVKSALYEVAARPMLGSYVYGLGGRDIKPEHIRKAFEDAINGNLIADEQRYLGLRELast
1 -70.900d2c42a1 c.36.1.8 (A:2-258) Pyruvate-ferredoxin oxidoreductase, PFOR, domain I {Desulfovibrio africanus [TaxId: 873]}  ali model 3D-neighbors follow..  28  2......KKMMTTDGNTATAHVAY-AMSEVAAIYPITPSSTMGEEADDWAAQGRKNITIREMQSEAGAAGAVHGALAAGALTTTFTASQGLLLMIPNMYKISGELLPGVFHVTARAIAAHASIFGDHQDIYAARQTGFAMLASSSVQEAHDMALVAHLAAIESNVPFMHF--FDGFRTSHEIQKIEVLDYADMASLVNQKALRAKSMNPEHPHVRGTAQNPDIYFQGREAANPYYLKVPGIVAEYMQKVASLTGRSY.......................................................................................................................................... 257
2 -37.600d2c42a3 c.48.1.3 (A:259-415) Pyruvate-ferredoxin oxidoreductase, PFOR, domain II {Desulfovibrio africanus [TaxId: 873]}  ali model 3D-neighbors follow..  29  1................................................................................................................................................................................................................................................................KLFDYVGAPDAERVIVSMGSSCETIEEVINHLAAKGEKIGLIKVRLYRPFVSEAFFAALASAKVITVLDRTKEPGAPDPLYLDVCSAFVRGEAMPKILAGRYGLGSKEFSPAMVKSVYDNMSGAKKNH---FTVGIED 138
3 -15.400d2ozlb2 c.48.1.2 (B:192-329) E1-beta subunit of pyruvate dehydrogenase, C-domain {Human (Homo sapiens) [TaxId: 9606]}  ali model 3D-neighbors follow..  13  12........................................................................................................................................................................................................................................................................QGTHITVVSHSRPVGHCLEAAAVLSKEGVECEVINMRTIRPMDMETIEASVMKTNHLVTVEGGWPQFGVG---AEICARIMEGPAFNFLDAPAVRVTGADVQVKDIIFAIKKTLN............... 137
4 -14.200d1umdb2 c.48.1.2 (B:188-324) Branched-chain alpha-keto acid dehydrogenase {Thermus thermophilus [TaxId: 274]}  ali model 3D-neighbors follow..  15  14........................................................................................................................................................................................................................................................................EGKDLTLICYGTVMPEVLQAAAELAKAGVSAEVLDLRTLMPWDYEAVMNSVAKTGRVVLVDAPRHASFVSEVAATIAEDLLDM-----LLAPPIRVTGFDTTVTRILNAAKRALD............... 136
5 -14.200d4fega1 c.36.1.0 (A:9-182) automated matches {Lactobacillus plantarum [TaxId: 644042]}  ali model 3D-neighbors follow..  14  3...........ILAGAAVIKVLEAWGVDHLYGIPGGSINSIMDALSAERDR----IHYIQVRHEEVGAMAAAAAKLTGKIGVCGSAGPGGTHLMNGLYDAREDHVPVLALIGQFGTTGMNMDTFQEMNENPIADVADYNVTAVNAATLPHVIDEAIRRAYAHQGVAVVQIPVD............................................................................................................................................................................................................................. 163
6 -13.900d5hyva3 c.48.1.0 (A:532-677) automated matches {Scheffersomyces stipitis [TaxId: 322104]}  ali model 3D-neighbors follow..  15  19........................................................................................................................................................................................................................................................................DKADIIIVATGSEVSLAVDALKVLEGQGIKAGVVSLPDQLTFDKQSEESVLPDGVPILSVEVMSTFGWSKYSHQQFGLNRFGASGKAPEIFKLFE-----FTPEGVAERAAKTVAFYKGKD......... 137
7 -13.400d2r5na3 c.48.1.1 (A:528-663) Transketolase (TK), C-domain {Escherichia coli [TaxId: 562]}  ali model 3D-neighbors follow..  14  21........................................................................................................................................................................................................................................................................GQPELIFIATGSEVELAVAAYEKLTAEGVKARVVSMPSTDAFDKQDAAYRESVLPKAVTARVAVEAGIADYWYKYVGLGMTTFGESAPAELLFEEFG---FTVDNVVAKAKELL................ 136
8 -13.000d1ozha2 c.36.1.5 (A:7-187) Catabolic acetolactate synthase {Klebsiella pneumoniae [TaxId: 573]}  ali model 3D-neighbors follow..  16  2........RQWAHGADLVVSQLEAQGVRQVFGIPGAKIDKVFDSLLD------SSIRIIPVRHEANAAFMAAAGRITGKAGVAVTSGPGCSNLITGMATANSEGDPVVALGGAVKRADKAKQVHQSMDTVAMSPVTKYAIEVTAPDALAEVVSNAFRAAEQGR-PGSAFVSLPQDVVDGPVS.................................................................................................................................................................................................................... 171
9 -12.900d2bfdb2 c.48.1.2 (B:205-342) Branched-chain alpha-keto acid dehydrogenase {Human (Homo sapiens) [TaxId: 9606]}  ali model 3D-neighbors follow..  14  14........................................................................................................................................................................................................................................................................EGSDVTLVAWGTQVHVIREVASMAKEKGVSCEVIDLRTIIPWDVDTICKSVIKTGRLLISEAPLTGGFASEISSTVQEECFLN-----LEAPISRVCGYDTDKWKCYDALRKMIN............... 137
10 -12.800d2ji7a2 c.36.1.5 (A:7-194) Oxalyl-CoA decarboxylase {Oxalobacter formigenes [TaxId: 847]}  ali model 3D-neighbors follow..  13  4...........TDGFHVLIDALKMNDIDTMYGVVGIPITNLARMWQD------DGQRFYSFRHEQHAGYAASIAGYIEGKVCLTVSAPGFLNGVTSLAHATTNCFPMILLSGSSEREIVDLQQGDYEEMDQMNVARPHCFRINSIKDIPIGIARAVRTAVSGR-PGGVYVDLPAKLFGQTIS.................................................................................................................................................................................................................... 172
11 -12.600d1q6za2 c.36.1.5 (A:2-181) Benzoylformate decarboxylase {Pseudomonas putida [TaxId: 303]}  ali model 3D-neighbors follow..  16  2............SVHGTTYELLRRQGIDTVFGNPGSNALPFLKDFPE-------DFRYILALQEACVVGIADGYAQASRKFINLHSAAGTGNAMGALSNAWNSHSPLIVTAGQRAMIGVEALLTNVDAANLPRPLVKWSYEPASAAEVPHAMSRAIHMASMAP-PVYLSVPYD............................................................................................................................................................................................................................. 160
12 -12.500d1jsca2 c.36.1.5 (A:83-270) Acetohydroxyacid synthase catalytic subunit {Baker`s yeast (Saccharomyces cerevisiae) [TaxId: 4932]}  ali model 3D-neighbors follow..  17  2...DMDTSFVGLTGGQIFNEMMSRQNVDTVFGYPGGAILPVYDAIHN-----SDKFNFVLPKHEQGAGHMAEGYARASGKVVLVTSGPGATNVVTPMADAFADGIPMVVFTGQVPTSAIGTDAFQEADVVGIRSCTKWNVMVKSVEELPLRINEAFEIATSGR-PGPVLVDLPKDVTAAILR.................................................................................................................................................................................................................... 177
13 -12.500d4c7va3 c.48.1.0 (A:527-662) automated matches {Lactobacillus salivarius [TaxId: 362948]}  ali model 3D-neighbors follow..  13  21......................................................................................................................................................................................................................................................................AENEADGILIATGSEVGLALKAKEELQKKGKDVIVVSLPSWERFEAQSEEYKNTVIPPELKKRMTIEAGTTYGWAKYAGDGIDEFGMSAPSDIVLRELG---MSVENIVDKYLE.................. 136
14 -12.100d2vk8a1 c.36.1.0 (A:2-181) automated matches {Baker`s yeast (Saccharomyces cerevisiae) [TaxId: 4932]}  ali model 3D-neighbors follow..  11  3...........ITLGKYLFERLKQVNVNTVFGLPGDFNLSLLDKIYE-----VEGMRWAGNANELNAAYAADGARIKGMSCIITTFGVGELSALNGIAGSYAEHVGVLHVVGVPSISAQAKQLLLHHTLGNGDFTVFHRMSANDIATAPAEIDRCIRTTYVTQRPVYLGLPANLVDLNVPAKLL.................................................................................................................................................................................................................. 180
15 -11.200d2ihta2 c.36.1.5 (A:11-197) Carboxyethylarginine synthase {Streptomyces clavuligerus [TaxId: 1901]}  ali model 3D-neighbors follow..  16  2...........PTAAHALLSRLRDHGVGKVFGVVGREAASILFDEVE-------GIDFVLTRHEFTAGVAADVARITGRPQACATLGPGMTNLSTGIATSVLDRSPVIALAAQSESHDIFPNDTHQCDSVAIAPMSKYAVELQRPHEITDLVDSAVNAAMTEP-VGPSFISL.............................................................................................................................................................................................................................. 158
16 -11.100d2wvga1 c.36.1.0 (A:2-187) automated matches {Zymomonas mobilis [TaxId: 542]}  ali model 3D-neighbors follow..  15  2...........YTVGTYLAERLVQIGLKHHFAVAGDYNLVLLDNLLL-----NKNMEQVYCCNELNCGFSAEGARAKGAAAAVVTYSVGALSAFDAIGGAYAENLPVILISGAPNNNDHAAGHVLHHALGKTDYHYQLEMAKNTPEEAPAKIDHVIKTALREKKPVYLEIACN............................................................................................................................................................................................................................. 168
17 -9.830d2ozlb1 c.36.1.7 (B:2-191) E1-beta subunit of pyruvate dehydrogenase, Pyr module {Human (Homo sapiens) [TaxId: 9606]}  ali model 3D-neighbors follow..  15  9..............NQGMDEELERDEKVFLLGEEVAQYDGAYKVSRGLWKKYGDKRIIDTPISEMGFAGIAVGAAMAGLRPICEFMTFNFSMIDQVINSAAKTYVPIVFRGPNGASAGVAAQHSQCFAAWYGHCPGLKVVSPWNSEDAKGLIKSAIRDNN----PVVVLENELMYGVPFEFPP................................................................................................................................................................................................................... 183
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Luz JG, Hassig CA, Pickle C, Godzik A., Meyer BJ, Wilson IA. XOL-1, primary determinant of sexual fate in C. elegans, is a GHMP kinase family member and a structural prototype for a class of developmental regulators. Genes Dev. 2003 Apr 15;17(8):977-90. Epub 2003 Apr 02.