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Query: TM0005 TM0005 281886 Purified-2001-01-30, from T.maritima

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MTVQQFIKKLVRLVELERNAEINAMLDEMKRLSGEEREKKGRAVLGLTGKFIGEELGYFLVRFGRRKKIDTEIGVGDLVLISKGNPLKSDYTGTVVEKGERFITVAVDRLPSWKLKNVRIDLFASDITFRRQIENLMTLSSEGKKALEFLLGKRKPEESFEEEFTPFDEGLNESQREAVSLALGSSDFFLIHGPFGTGKTRTLVEYIRQEVARGKKILVTAESNLAVDNLVERLWGKVSLVRIGHPSRVSSHLKESTLAHQIETSSEYEKVKKMKEELAKLIKKRDSFTKPSPQWRRGLSDKKILEYAEKNWSARGVSKEKIKEMAEWIKLNSQIQDIRDLIERKEEIIASRIVREAQVVLSTNSSAALEILSGIVFDVVVVDEASQATIPSILIPISKGKKFVLAGDHKQLPPTILSEDAKDLSRTLFEELITRYPEKSSLLDTQYRMNELLMEFPSEEFYDGKLKAAEKVRNITLFDLGVEIPNFGKFWDVVLSPKNVLVFIDTKNRSDRFERQRKDSPSRENPLEAQIVKEVVEKLLSMGVKEDWIGIITPYDDQVNLIRELIEAKVEVHSVDGFQGREKEVIIISFVRSNKNGEIGFLEDLRRLNVSLTRAKRKLIATGDSSTLSVHPTYRRFVEFVKKKGTYVIFLast
1 -124.000[L] KOG1803 DNA helicase  ali follow..  24  42.KFLDNVREWPKIFEAEIEAQFEKLDEMIRNVGWRVIEERGLCVGNLIVTSKYYDSYCGEV--GDAILRTRWLKAGTPVLLNKLNEDGHLSDGHVVDCTAGIVKVCADKNVDFSTLNYILTPSTNSGALKFLQSVIKSLSSDSVHLVNLAYRSIPMPSIHDRKIGNLPETLNPSQVAAVSAAMNTQRLLCIQGPPGTGKTRVIAEIVHQLMKKKKKVLVCAPTHVAVRNAMDATTGRIEEMPEEKAEQQLCLLANTKDEFQNHKSASKL-------------------------------------------------EEIKKQLSTMSTSDPLYKKMSYEYYLIRNSIFRSIFYPKLAVFSTLGTSSIQKLPEYNADVMIVDEAAQCTEPATWVPVLTCKKLILVGDQKQLPAVVLSDKAMNFKLSLMEKLAEEFNNINILLNEQYRMNKKIMNWSNEVFYENQLTAHSTVSDITLRDICPNLP-------EDHVLNNPIMMINMENVK-DRSHEEFESHSFTNTDELNLVTEYVNRLVVDGINPKAIAVISPYYAQIEKLRRSIPFRVDVNTVDAFQGHERQVVIFCLVRDNDEGQIGFLNETRRLNVAVTRARRQFVLIGNGRMMKGNKHLLKLYKHLQSEKVIFG. 672
2 -111.000[A] KOG1802 RNA helicase nonsense mRNA reducing factor (pNORF1)  ali follow..  27  234.DAYEYQRSYGPLIKLEADYDKQLKESQALE-------------ISVSWSLALNNRHLASFTLSTFESNELKVAIGDEMILWYSGMQHPDYIVRLPNSFQDTFTLELKPSKTHLTTGFTAEFIWKGTSYDRMQDALKKFAIDKKSISGYLYYKSFDVPLPKEFSIPNFAQLNSSQSNAVSHVL-QRPLSLIQGPPGTGKTVTSATIVYHLSKIHKRILVCAPSNVAVDHLAAKLRDKVVRLTAKSREDVESSVSNLALHNLVGRGAK---------------------------------------------------GELKNLLKLKDEVGELSASDTKRFVKLVRKTEAEILNKADVVCCTCVGAGDKRLDT-KFRTVLIDESTQASEPECLIPIVKGKQVILVGDHQQLGPVILERKAAGLKQSLFERLISL-GHVPIRLEVQYRMNPYLSEFPSNMFYEGSLQNGVTIEQRTVPNSKFPWPIRGI----------PMMFWANYG----REEISANGTSFLNRIEAMNCERIITKLFRDGVKPEQIGVITPYEGQRAYILQYMQMKVEVASVDAFQGREKDYIILSCVRANEQQAIGFLRDPRRLNVGLTRAKYGLVILGNPRSLARNTLWNHLLIHFREKGCLVE. 836
3 -86.500[A] KOG1804 RNA helicase  ali follow..  23  90LNMSNYKEKFSTLLWLEEIYAEMELKE-----------------YNMSGIILRRNGDLLVLEVPGLAEGRPSLYAGDKLILKTYNGHAIEYISYVTEIHEEDVTLKINPEQAYNFEPMDVEFTYNRTTSRRCHFALEHVIHLGVKVLFPEEWVDEIQTPKARKMEFFNPVLNENQKLAVKRILSGDC-YILFGPPGTGKTVTIIEAVLQVHFADSRILVCAPSNSAADLVCLRLHES-TMVRVNATCRFEEIVIDAVKPY------------------------------------------------------------------------------------CRDGEDIWKASRFRIIITTCSSSGLFYVRVGHFTHVFVDEAGQASEPECLIPLGISGQIVLAGDPMQLGPVIKSRLAMGLNVSFLERLMSR-PLLVTKLVKNYRSHEALLMLPSRLFYHRELEVCADPTVVTSLLGWEKLPKKG-----------PLIFHGVRG----SEAREGKSPSWFNPAEAVQVLRYCCLLAHSQVSASDIGVITPYRKQVEKIRILLRNDIKVGSVEEFQGQEYLVIIISTVRSNDRYFLGFLSNSKRFNVAITRPKALLIVLGNPHVLVRDPCFGALLEYSITNGVYMG. 738
4 -74.300[L] COG1112 Superfamily I DNA and RNA helicases and helicase subunits  ali follow..  20  160.SFEDYLSIHYRLLREDAVSPLRESVLRYKVNPNYITGSSLAVYDHVRIDGYTISSSVIAAKLSFSVATSRRLISGSLVLLSNDD--QTFRIGTVCARPLSEIDVKFEDISISLDPREEYVMIEATSAYKHVLRSLQRLSASTFPMKDYLVHCKSNQETALEPFGPGEYILDSSQLKAYQSML-TKRLSIIQGPPGTGKSFVTLKAIETLLENTHPILVACQTNHAVDQILIRLLHGASVMRLGSRTK-DPEIAAVTIFQKAKKHSFKAAYNEIRHKKQRLIKQITNIMHNFNLEFVTLSYLHSKGIITTSQLES-LESAYAAAEKELNRLYRFYLKVDRERIGFSNKRAAILLRGANVIGMTTTGLNRDILERINPKICFIEEAADVLEGPIIPAVFPSEQLVLIGDHKQLRPGCLRQDPFNLSISMFERLVEN-DMEYTRLTMQRRMHPQIRRLVSSVYED--LSDYEITKYWP---------------------EIRRFFLT-----HSRIEDNDGFASKINLFEAQMLVQFAVYLINNGVEPQKITCLTFYAAQKDLIERLLSESIKVATVDGYQGEENDVVLLSLVRNNDRTEVGFLSSPHRVCVSLSRARRGLFIFGNAQLVAESPLWWDAINTLMNDETIQGL 968
5 -33.600[R] COG3972 Superfamily I DNA and RNA helicases  ali follow..  13  206..........................................................................................................................................................................FDQKQRRAALVTIDGP--QRIRGLAGSGKTVILAMKAAHLHMTNDKILVTFFTKSLRSPIKDLVTKFYRHYKEIDPDWNNIHIRHG-------------------------------------------------------SNSSGTYADACRRSGRMPRSYSSARDAAPRGVEPFSFACEELINSAQS--------------LEYYDHILIDEG-QDFPDGFYKLCFEKKNIVWAYDELQ---NILNVKMRRISLARAEKNLPPGATNDTVLSKCYRNQREVLVA-AHALGFGIYSNIVQLSPDHWRDVGYDVLTPDFQVGNDIEILRPVENSPVALDTDGLPPLIGNFIASSFEKEISWITKEIINFLDMGLLPEDIIVVALDDRHMRNYFRYLSGKITLSTVYRAKGNEAAVVFALGVDALSL---RLRADRNKIFAAFTRTKAWLRVSGLGDSARR---VAVEIDTALRNFPHLKF 657
6 -26.600[R] COG3973 Superfamily I DNA and RNA helicases  ali follow..  12  199............................................................................................................................................................SHHSDTQMKNIVSTIQKEQNQIIRN--EKSKILIVQGAAGSGKTSAALQRVAYLL-DAGQIVLFSPNFLFNSYVSSVLPE------LGEENMEQATFQEYIEHRLGRKFKCESPFDQLEYCLTETKGGDFPTRLAGITWKAGLSFQQFINEYVTRLSSEGMIFKNIIFRGQKLITKEQIQSYFYSGELTRSAFTDNKLLYEDAAFLYMQDLIEGRKKNTKIKHLFIDEAQDPFQMAYMRSIFPAASMTVLGDINQ---SIYAHTINGDQR--MDACFEDEPAEYVRLKRTYRSTRQIVEFTKAMLQDGADIEPFN-----------------------------------------RSGEMPLVVKTEGHESCQKLAQEIGRLKKKG--HETIAVICKTAHQCIQAHAHMSEYTDVRLIHK-KGIEFDAVLVYDASEEHYHT----HDRRLLYTACTRAMHMLAVFYTGEA....................... 758
7 -22.900[L] COG0507 ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member  ali follow..  13  37.........................................................................................................................................................................QFAPQQDEALKAVSQRSQLFRLFGYAGTGKTTLARHFAENV---DGEVVFAAFTGKAAQVLRSK-----------------GATNAKTIHSLIYRPRGEEEVEDEETGKTSIAPMFAINRQ-------------------------------------------------------------SPVAKAALI--------------------IVDECSMVDEALGKDLMSFGTPILVLGDPGQLPPVSGGGYFTNHEPDFLLTDIHRQARDNPIIQLAMQVREGKEIMHGDYGTAQVISKGQVTQPLVLEADQVLVGTNRTRRRYNQ------RLRELKGFTSEYPQSGDKLVCLRNDPAKGLLNGSLWQVMSSSKETVKPGIFEDVEGEIPWSTRKRYDEFDYGTVHKAQGSQWNNVVLFDESWAFR-----DTRERWLYTAITRAAERLTIV............................ 409
8 -19.000[L] KOG2108 3`-5` DNA helicase  ali follow..  12  237................................................................................................................................................................PDECSKYMLSLNDRQRDAACSNIST-PLMVIAG-PGSGKGLL-----------PSNILAMTFTKAATSEMRERIGKAAKDITISTFHSFSLQLCRMHADKLRTSEFSVYGHGQQRRAIIEAVRLYEEEKKNGSKTSVPCESGEGLNGAGAGAGKASGKSPEQCRKMGNEIGAKILGNYNDILKACDALDYHDLISCSVTLLSDFPEVFKEC--QDTWKAIIVDE-TSTMQYKLLRMLGSHNHITIVGDDDQ---ITVKECHNEEAQCAYV-------IDKIIEITNDGSTPCCSHGDIAILYRRQVSG--KVFQNAFRQRKIPFNVHGVAFYRKKVVQVILAMLKTT--NEDNDLRSVLQYLMDDVAEFISTHCTTTEEEDAIKEKKGCNQLHSFINYISERETE-ENSVTLTTIHQANENEIPLLHESNGNASESGT---LEEERRL-VAMTRARKKLFFLGDMSVNDCRKVHENL............. 825
9 -17.000[L] COG0210 Superfamily I DNA and RNA helicases  ali follow..  16  1...................................................................................................................................................................MNPLLNGMNDRQAQAVQTT--EGPLLIMAG-AGSGKTRVLTHRIAYLIDEKFNILAITFTNKAAREMKERALA------NPATKDTLIATFHSMCVRILRREADHIGYNR------TIVDPGEQRTLMKRILKQLNIDPKKWNERSILGTISNAKNDLLDEKGYEAQAADMYSQIVARCYKAEELRRSEALDFDDLIMMTLFDANPDVLAYYQYQYIHVDEYQDTNHAQQLIKLLASKNICVVGDADQ---SIYGWRGADMQNILFEK--DYPDAKVVLLEENYRSTKKILQAANDVINNNRNRRPKKL------------------------------------TQNADGEQLVYYRANDERDEAVFVASTISNMSELGKNFKDFAVLYRTNAQSRTIEEALKSNIPYTMVGGYSRKERDLIAYLTIVANPADNISF---ERIVNEP-KRG------VGPGTL-------DKLRQFAYESDQSL.. 436
10 -16.400[L] COG1074 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains)  ali follow..  14  10.........................................................................................................................................................................TWTDDQWNAIVSTGQD---ILVAAAAGSGKTAVLVERMIRKITAEERLLVVTFTNASAAEMKHRIAEALQVLK-TEGELIGDEVLDELFEDLVDRYTTDRHDLDLQFLVKQVYEYSRSHPNPEAWLESFVHLYDVSEKSAIEPAVSFKRAKAVKGDEFDPALLDEATDLRNGAKKLAAKQEKSIIDFSDLILTAENDKGEREPSEAQFHEVLVDEYTNLVQESILQLVTSTGNLFMVGDVKQ---SIYRFRLA--EPLLFLSKYKRFTERKIDLNKNFRSRADILDSTNFLF--------KQLMGGKIGEVDYDEQAELKLGAAYPDNDETETELLLIDNAEDTDASEEAEELETVQFEAKAIAKEIRKLISSPIQYRDIVILLRSMPWAPQIMEELRAQVYANLTSGYFEAVEVAVALSVLKDNPYQDIPLASVLRSPIVGADENELSLIRLEN----KKAPYYEAMKDYLAAGD..... 682
11 -13.900[S] COG3421 Uncharacterized protein conserved in bacteria  ali follow..  54.........................................................................................................................................................................PFFEWQKSALENFVNRPTHLLFNMATGAGKTMMMAALILYYFEKGRHFLFFVNQNNIVDKTENNFIDPAHAKFL--TEKILQGDTVIPIRKVEMFSPHSDGIEIKFTSIQKLYNDIHTERENQTTLADLHKLNLVMLGDEAHHLNAQTKGKKQDELDLEVELKANAGNAEIERKGWEHMVLELLLNKNGLLEFTATLPENADVQQKYADKIITKGLKEFLQKG------YTKEINLVSSTLNKKERVLHALLFAWYRHQIALKYGIANFKPVMLFRSKTIDESKADYSAFLNWAENVQADDFEFLDTFSGSLNNSDNANEQGKTRTEQALKFMQDNKFGFAHLANWTNSETNKNKTEKTDSETEKLLNNLEA---ADNPIRAI-----------------FTVDRLT--EGWDLNLFDIVRLYEGQNGGGSNKKSGKTAAATVSEKQ----LIGRGVRY...................... 515
12 -12.400[KL] COG1061 DNA or RNA helicases of superfamily II  ali follow..  14  78.........................................................................................................................................................................EPYPHQSEALAAWKLAGRQGVVVLPTAAGKTYLAQLAMQAT---PRTTLIVVPTLDLMHQWYAHLVAAFPDAEVG-------------------------------------------------------------------------------------------------------LLGGGSRDKSPVLVATYDSAAIHAALGNQYALIVFDECHHLPTDFSKVIAEYAIAPYRLG----LSATPERTDGKHIGQEVYRKRAEDLAGKALAEHEIVQIKVKLSQQERERYNNLIQIRNDFLRQSKV--------------SLGSIQGWQMFVQMSARSQSGRRAMLAHREAKEIALGTDSKLRILANLLAKHYPERVL-IFTADNATVYKISQ----DLLIPAITHQTPVKERHEILTKFRE---GEYNTLVASHVLNVDVPAAAIAIILSGTGSTREYIQRLGRILRKGNIQNKQAIL 435
13 -11.600[V] COG4096 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases  ali follow..  13  462.........................................................................................................................................................................GLRYYQEDAVRAVEKAQQEILLAMATGTGKTRTAIAMMFRLIQSQKRILFLVDRRSLGEQALGAFEDTRI------------------------------------------------------------------------------------------------GDTFNSIFDIKGLTDKFPEDSTKIHVATVQSLVKRTLQSDEYDCIVVDEAHRGYILSAYRRILDHFDAVKIA----LTATPALHTVQIFGEPVY----------------RYTYRTAVIDIDQDPPI--QIITRNAQEGVYLSKGEQVERISPQGEVINDTLEDDQDF-----------EVADFNRGLVIPAFNRAVCNELTNYLDPTGSQKTL-VFCVTNAHADMVVEELRAAFK-TMITRFNKERLPNIVVTVDLLTT----GV--DIPSINIVFLRKVRSRIMKGRATRLCPE................... 851
14 -11.400[R] COG4889 Predicted helicase  ali follow..  14  174........................................................................................................................................................................YSPRPHQQTAIEKAFQTHDRGKLIMACGTGKTFTALRLSEEVARLNARILFLVPSISLLSQTLKEWTADLRPVAVCSDSKVSKAAEDIAAYDL--------------------------------------------------------------------PVSTDGALIAEKLEHRKRA------AGLTVVFSTYQSHAAQEAGAEPFDLVICDEAHRTTGIT------------LAGEDPSNFTRIHDASYIKAAKRLY-------------MTATPRLFDDVSSMDDEAIYGPRLGFGEAVEKGLLTDYKVV-----------------VMTVDEQVAASALTVLGSTPGEELTLDMTSAIIGAWNGLAKRSGKEQDTKTAVAFARDIKTSQQIAESSVACQHVDGMNALERNSRLTWLKAPTQSMETKILTNARCLSVIFFNPRNSMVSVGRVMRKSPGKNYGYII............ 610
15 -11.300[R] KOG0354 DEAD-box like helicase  ali follow..  11  72.........................................................................................................................................................................SFRDYQFNIVQKALFENVLVAL--PTGLGKTFIAAVVMMNYLRPKSYIVFMAPTKPLVTQQMEACYKITGI---------------------------------------------------------------------------------------------PKSQTAELSGHVPVTTRNQYYQSRNVFFVTLNDIKHGICDRTRISCLVIDEAHRSTGNYAYVEVVHNKNFRILA--LSATPGNKLEAIQNVIDSLHISRIEIRTENSIDISFPVDLSAEITDIRDQKLNKGNYYRIQNAKDITSFTVVQAKQAFLAMSGQNATFAYPLNLLLNHGIRPFYQILLRDQSFVGHPKLEHLERIVTEYFEKEQTKDTRIMIFVEIRSSAEEILRFLGKFYPNVRPAIFIGQSAVRKAAGMSQKLQNETV-FQKGEVNTLIATSIGEEGL--IGEVDMIICYDASASPIRMLQRMG..... 531
16 -10.600[L] COG3857 ATP-dependent nuclease, subunit B  ali follow..  11  2..........................................................................................................................................................................................TLQIIAGKAGTGKTTHLMDEVGEKIKKTKTYIFIVPDQMTFQSFLNKQNLAGMLTQIFSFSRLAWKILQETGGLSKTFLSQTGIEMVIRKAALDQKDKLKIFSRATS--KKGFYSELAKLFKEMKQEEISVDELEKSAANLSTSVSSKVHDISLIYQKYEELLAGKFLENEDYLRLLADKIIESDY--LNQTEIIIDTSFSKQELTVIEKLMQKCDKVTVSNVPEIHKGLEDFSMFKASTEAYFALLEMAKLNKIQVEPKRANSDSLAFLANAWGDNKYSSYEGGANDLTI-------------------------------------------QANNRRAEMEGVAREIRQLALNGYRYRDIAILT---RNIGDYDILCETVMESFDIPIFIDKKRAMAFIEFIRS-----IDAILFNWKYEPIFQAVKTEFFFDVAENATIMRRKADILENYVLENGI.... 428
17 -10.300[T] COG1702 Phosphate starvation-inducible protein PhoH, predicted ATPase  ali follow..  16  121...........................................................................................................................................................................TLGQKHYVD-AIDTNTIVFGLGPAGSGKTYLAMAKAVQALQSKSRIILTRPAVEAGEKL---------------PGTLNEKIDPY--------------LRPLHDALRDMVEPEV---------------------------------------------------------------IPKLMEAGIVEVAPLAYMRGRTLND---AFVILDEAQNTTQMKMFLTLGFGSKMVVTGDITQVDLPGGQKSGLRL---VRHILRGVDDVHFSELTSSDVVRHQLVGHIVDAYEDYEEREARELKRKR.............................................................................................................................................................................. 334
18 -10.100[L] COG4098 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein)  ali follow..  13  94.........................................................................................................................................................................QLTPFQEKVLLQVVDKQKPTLVHAVTGAGKTEMIYQVVAKVINAGGAVCLASPRIDVCLELYKRLQQDFSC------------------------------------GIALLHGESEPY------------------------------------------------------------------FRTPLVVATT----HQLLKFYQFDLLIVDEVKNSVKENTATSTNELDKKVRLGERLNLPRRFHGNPLIIPKPIWLSDFNRYLDKNRLSPKLKSYIEKQRKTAYPLLIFASEIKKGEQLAEILQE------------------------QFPNEKIGFVSSVTEDRLEQVQAFRDGELTILISTTILERGVTFPCVDVF------VVEANHRLFTKSSLIQIGGRVGRSMD---------RPTGDLLFFHD--GLNASIKKAIKEIQMMNKEAGL...................... 432
19 -9.770[KL] KOG1123 RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, 3`-5` helicase subunit SSL2  ali follow..  13  331.........................................................................................................................................................................VLRPYQEKSLRKMFGNGR-GVIVLPCGAGKSLVGVTACCTV---RKRALVLCNSGVSVEQWKQQF--------------------------------------------------------------------------------------------------KMWSTADDSMICRFTSEAKDKPMGCGILVTTYSMITHRWLQEQEWGIMVLDEVHTIPAKMFRRVLTIVQSHCKLG----LTATLLREDD---------------------------KIADLNFLIGPKLYEANWLE---QKKGYIARVQCAEVWCPMSPEFYRE-------------YLTTKTSKKMLLYVMNPSKFRSCQFLIKYHEQRG---DKTIVFSDNVFALKHYAIKMNKPF----IYGPTSQNERIQILQNFKFNSKVNTSF--DLPEANVLIGGSRRQEA-LGRILRAKKGAIAEEYNAFFYT....... 677
20 -9.730[L] COG1111 ERCC4-like helicases  ali follow..  10  16.........................................................................................................................................................................EARTYQQLLAADVIRKGN-SMIVAPTALGKTVVAVLVAAERLRRGSKVLILSPSKPLAIQHEESFREFMLA------------------------------------------------------------------------------------------------TCTSLTGSIKPEERKERWIKSQIISATESDILAGRYDLRDVSLIVFDECHRAVGSYSYVFLASARHPLILGGDPDVRPYLKPIKIEWVKVRMTPELEDIRELLRKVLKNRLKMLKNLGVIDTISVGKKDLLKARGRVQNRIARSTSPPRACYRALASCINVEHALELLETQGIRPLHQYLLRLKEKKTKAAKGLLLDRLMEILKRELKGDEARIIVTQFRDTLEEIYQRCKQKQQRDIIKSFRMGNHDVLLSTSV-----AEEGI--DIPSVDLVVGRKRKGRMVV............................ 472
21 -9.560[KL] COG0553 Superfamily II DNA/RNA helicases, SNF2 family  ali follow..  13  698......................................................................................................................................................................IQATLRSYQTEGVHERLRKMHLNILADDMGLGKTLQAIIAVTQSKLEKGSSLIVCPTSLVYN--FRKFNPEFRTLVIDGVPS-------------------------------------------------------------------------------------------------QRRKQLTALADRDVAITSLLQKDVELYKSFRFDYVVLDEA-HHIKAKSVKMIQSDHRLILTGTPIELMPGLLSSYDR-FVGKYIRTGNYMGNKADNMVALKKKVSPFIKDLPPVELYQSYAASAKQELSRLVKQEGFERIHIHVLATLTR---HPAIFAK-------------DAPEPGDSAKYDMLMDLLSSLVDSG---HKTVVFSQYTKMLGIIKKDLESRIPFVYLDGFNDPSLLVFLISL----KAGGTG-------LNLATDRVHR----IGQSRSVTLNTIEEKILTLQNRKKSLVK. 1142
22 -9.560[R] COG1203 Predicted helicases  ali follow..  15  13.........................................................................................................................................................................SPYEYQKEAMDNLLEGKSL-IIRAPTGAGKTEASLIPFIYGLNDYPQLIYSLPTRTLVESIGERA-------------------------------------------------------------------------------------------------IKYASFKKLRVAIHHGKKATSSLFEEDIIVTTIDQTAGAYLSGIASALTVFDEV-HTLDPEKGLQTAAGLPSIIMS--ATLPDVFIERVKERIEKN--GKVEIMDVKNESEIKSRRNRKVELINRPDEMLTADTVLKEAENCRKLVVVVNTVERAQNLYLDLRKKIDYPIFLL----------------HSRYLEKDRAEKEKSFEKVFGKNGKGECIFIST----QVIEVGMDISSPIEVAPIDALQGRNGEFHVFGLARDSSNPYAPYLKELIESTITEIRSKGDFPLDWQTELQLVNNVLSSHFEFFMDSKFFYQ. 408
23 -9.520[KL] KOG0387 Transcription-coupled repair protein CSB/RAD26 (contains SNF2 family DNA-dependent ATPase domain)  ali follow..  12  276.........................................................................................................................................................................HLFRYQVTCVQELYCQEAGGIIGDEMGLGKTIQIVSFLSSLHHSGKPALIVCPATLMKQ--FHTWWAPLRVVVLHATGSGQRASREKRQ----------------------------------------------------------YESDASESEAEESKTSIKLRGASSSFHRYAKNLVESVFTRGHILITTGLRIYGDLILPREWGYCVLDEGHKIRNPDSEIQIRTVNRIILSGTPIQVFPGRLGTNASNVQVQTAYKCACMLRDSPYLLR---RMKLDVAA--QRKAYQDFLQGSDMQKIL-----NGKRQMLYGIDILRKICNHPDLV----TREYLLHKEDYNYGDPEKSGKLKVIRALLTLWKKQG---HRTLLFSQTRQMLDILEIGLKPDVHYCRMDGFNKNEYFDVFLLTTRV---GGLGVLTGADRVILARERAWR----LGQKKDVV---VYRLMTAGTIEEKIY... 760
24 -9.510[S] COG3854 Uncharacterized protein conserved in bacteria  ali follow..  11  113...............................................................................................................................................................................IGMIRDLVETGKSILMLGRPGVGKTTALREIARVLADELHKRVVIMPEVIVIDEIRTIAERGVQLVGTAHGNQIENLIKNPTLSDLVGGIQAVTLGDDEARRRGSQKTVLERKAPPTFEIAVEMLERQRWVVHESVADTVDTLLRGRQPSPQTRTVDEQGKVAITRQLSVVNGRGGQLATPEESFAPARPSNGWRASGQML------SEFDRLLDESFNYPEAIDFGSSARQPGPNGEDLPLHVYPYGVSRHQLEQVISV-------LTLPVVLTKDIDNADAILALRSHVKNHAKLRQMAKARHVPIHVIKSSTIPQITRGLRRLLNMEDPEVADDRELQLFLHNGSDDEMDAEEARLAVEQIVIPKGQPVE---LLPRSPQVRKMQHELVEHYRLKS-----GEEPN---------------------RRLRI........................................ 576
25 -9.470[R] COG0433 Predicted ATPase  ali follow..  11  23................................................................HADVSVEEMRVGKFLVI---QGRRSRFFCLLTDVSLGTANPRILANPPNINDDFLIDVLAGSGTYDVELLPVKTIPAHFSQVFEASERDFRLVFGWEDDPFRRNFAIGEPLDMAVPVCLDLDRFNGVFGKSGTGKSFLTRLLISGIIHKQAAVNLMFDMHSEYGWEAMR-EGKTVSTVKGLRQLFPGEVEIFTLDAESTKRRGVRGAQELYLSFDQIEIEGFELGLSEAALDNANILFSEFGSSWISRLLVMSNEEIKVFCEEKQGHPGSIMSLQRKLKRLENL-LLQCLEAGKHVVIEFGSQSNLMITRRIHSVITIEEAHRFLDSAI---AREMRKLVVDQRPSGIDNEVMSQ----IGTRITCLLNDEKDIEAIFTGVAGGQNLRSVLAKL-------DSKQQAL.................................................................................................................................................................................. 528
26 -9.330[O] COG0464 ATPases of the AAA+ class  ali follow..  11  222........................................................................................................................................................................KDAISKVREMIELPLKHPELVLLQGPPGTGKTMLA-EIMSKYYGESERAIKNAPAIIFLDEIMDGLKARKNVIVIGATNRPE------ALDIALRRPGRFDREIELTEGRLEIFQIHTRGMPLADNVNLMDFAQITYGFVGADIAALCREAAMSALRRILPKINLNEPEISKEILDALQVTREDFENALKDVQPSAIREILIEVPNVSWEDV-LERVKELLKEVVEWPLKNPESYRDIG---EAPKGVLLYGPPGTGKTLLAKAIAH------------ESDANFITAKGSDLLSKWYGESEKRIAEVFTRARQVAPS--------------IIFLDELDSLAPIRGTSVGEPQVTARILNQLLSEM-PALLRPGRFDELILVPVPDEGARREIFRVLAEDVDIEKLDQYTGADKKAGRHALREDLHAKKV----RQKHFLQAIEETGPSV--MKYYEAIKGE................... 749
27 -9.310[O] KOG0741 AAA+-type ATPase  ali follow..  10  223......................................................................................................................................................................LDKEFSDIFRRAFAFRVFPPEIILLYGPPGCGKT-LLARQIGKMLNAREPKVVNGPSEANIRKLFADAEEEQR--RLGANSGLHIIIFD-EIDAICKQRGSMAGSTGVHDTVVNQLLSKIDGVEQLNNILVIGMTNRPDLIDEALLRPGRLEVKMEIGLPDEKGRLQILHIHTARMRGHQLLSADVDIKELAVETKNFSGAELEGLVRAA-QSTAMNRHIKASTKVEVDMEKAESLQVTRGD-ENDIKPAFGTNQEDYASYIMNGIIKWGDPVTRVLDDGELLVQQTKNSDRTPLVSVLLEGPPHSGKTALA--------------AKIAEESNFPFIKICSPDKM--------IGFSETAKCQAMKKIFDDAYKSQLS-DDIERLLDYVPIGPRFSNLVLQAL-LVLLKKAPPQGRKLLIIGTTSRKDVLQEMEMLNATTIHVPNIATGEQLLEALELLGNLKDKERTTIAQQVKGKKVWIGI 707
28 -9.200[B] KOG0389 SNF2 family DNA-dependent ATPase  ali follow..  10  288.........................................................................................................................................................................QLADYQIIGLNTVMHKQEMNILADEMGLGKTIQVIAFLAYLKENGLAHLIVVPSST-LDNWEAEISRWCPELVVGSQ--------------------------------------------------------------------------------------DERRRMRGRFAKDGFTGFDVLLTTYHIVGSTPEER--KMFRVCKLDYVIFDEAMTTQRYANLITINARMRILLTGTPLQVMPKFFAKSIEDIKSLFAKKGKSDGDQDEVSQFQE-RAKRIMKPF-QKIYYHELVDYYSNNKGEVCSS--SERAGIAIMMEMRRIANHPLLMRHYFTDANLRGFSKRLANAICDSGKFLYLDTLLPKLKAEG---HRVLLFSQFTMMLDIVEEYLRRKFGFCRLDGFNGDDSIFVFLLSTKA---GGVGHDIDFNPYN-AEDRCHR----MGQQRPISESTIEEGILMAAEEK...... 792
29 -9.120[R] COG1202 Superfamily II helicase, archaea-specific  ali follow..  14  215........................................................................................................................................................................TELLPVQVLAIKNGLLKGENLLVVSATASGKTLIGELAGIPKALEGKKMLFLVPLVALANQKYEDFKRRYSKLGLKVAIRVGMS----------------------------------------------------------------------------------------RIKTREEPVVVDTGIDADIIVGTYEGVDYLLRSGKKIGTVVIDEI-------------------MIDDEER-GPRL---------DGLIARLRKLYPKAQFILSATVGNPQELARSLGMKLVLYDERPIARNESEKWRIIAKLCKAEVMRKSSKGFKGQTIVFTYSRKRCHELASFLTGKGLKAKPYHSGLPYKITEMEFQAQTAALGAGVDFPASQVIFESLAMGNKWLSVREFHQMLGRKGKVYLI--VEPGKKYSAQMDETEDEVALKLLTS................................... 573

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Li W, Wooley JC, Godzik A. Probing metagenomics by rapid cluster analysis of very large datasets. PLoS ONE. 2008;3(10):e3375. Epub 2008 Oct 10.