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Query: TM0007 TM0007 281888 Purified-2004-07-19, from T.maritima

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MEFLIYSLPEEVLREEMLGNFSVALKLIDDFLKKDLPLLQRERLIYEKERIERLLEDYPFTEKEAMEKMREMFEGFSEGEFQYLMNEGVLDYIVVEGEKRFERRFFHNLAFVRSEYRERLRKDERSEKARRILHERLERLIKGEDPKRYRIRARITLKLKETSSKHRVWLPFPKESLQIESVKLLRTSHKSYYISPNDVPQRTIYFEGEDSTFFVEFEYIVREWVNHVDPERVSEKVAGFEEFLKEEPPHIVFTPKLRWLTQTVVGSEVNPYLKAKRIYDWITLNVRYSYVKPYALYENITDFVVNNLKGDCGFQALLFITMCRIAGVPARWQSGWYINPIFGSPHDWALFYVEPYGWLPADLSFGGARRDNESFRSFYFGNLDGFRMVANDGFMKDFDPKTRFVRSDPTDNQVGEAESEEKRLPFESTIEVISFEEVLast
1 -45.000[E] COG1305 Transglutaminase-like enzymes, putative cysteine proteases  ali follow..  15  1....................................................................................................................................................MLIRLGYEIAIECAEATPVISLLEIHKDRQADIKRVLTSPSVPTKLYHDLHGNGCRRFTAPAGTFRILYDAVIEDSGETDEVNTVAELPDEVLFYLLGSRYCE--TDHLSSLAWQLFGHLPSGWARVQAIVDYVHNRLSFG--YGYARSTRTAAQAHEERVGVCRDFAHLAITLCRCMNIPARYVNGYLGDPAPMDFSAWMEVFLDG-KWYTFDPR----------------NQPRTGRIVIARGRDTDVPLLHSFGPHRLCLFKVWTYEQEGRSFN............. 273
2 -32.200[R] COG1800 Predicted transglutaminase-like proteases  ali follow..  9  3........................................................EYKELIKECAKELEGLMPEISQKLVNIAKDRAFLEYLKVVEQVSLMKTERKQ-------------------------------------------KNKALIILWRYGEALEKELYSDVKFFAKPL-------HKRIFRFVDWKIIGMLFLVFIILPAITSNLWSFRSEHYVLYLNENVDFPRELCNYRTSWLYDTSMVCVLKYGYGSINVTLRGNSWEKGVEAQRFISDMEYDFDRVKSPITYTPKETLRYKKGVCSDFALLVANILLDNNVSPVYIVHTVVRKEPSGGHAAAGIYVNG-TLWILDWGSKPTKFQE.................................................................. 275
3 -25.000[D] KOG4575 TGc (transglutaminase/protease-like) domain-containing protein involved in cytokinesis  ali follow..  10  1..................................DTQTRLELLHRKDEDDLYE---SFQDKRVREAEEFEKENTEEWEKALAEFAKK-------------YEKGQSNMKKDDLIRQLTIKREKKLETLHTKRKVCNFFCFYSYIHHELSKICSLIITEASELKSSFRPQGWSRAEERERHQTAELVDRQAKEMLELFKASRSEYSNLQYPSTPPPPVPPSCSKREIYTTTDYFSSIDEVAIHCARNEV------ASFTDLIRTLSSGARSDVDVARAIYRWITIKNLNTMIFDDSIQNDTPMGLLRGIKYGTESYHVLFKRLCSYAGLHCVVIKGFSKSDDHRFRNTWNAVFLDG-SWRFVQCNWGARHLVNAEYDDHYF--TDSEEFIYE............................................... 357
4 -21.800[D] COG5279 Uncharacterized protein involved in cytokinesis, contains TGc (transglutaminase/protease-like) domain  ali follow..  13  447.............................................................................................................................................................................................................................................EYIDKMTWKRCIRDGTMTLDSWAQTTFSARYSTVLEKLRGIYIFCTEMFALTDDNDFSAEPQNLEKILYRKHCTPYELTWLFKKLANSLGITCEIVIGFLKTPSAINWHCWLRILVNK-EWRFIDVILGNNNRKIKKAENSYF--MAPLEMIYTH.............................................. 616
5 -21.200[O] KOG0909 Peptide:N-glycanase  ali follow..  14  1............MAAAALGSSSGSASPAVAELCQNTPETFLEASKLLLTYADNILRN---PNDEKYRSIRIGNTAFSTRLLP----RGAVECLFEMG---FEEGETHLIFPKKASVEQLQKIRDLIAIERSSRLDGSNKSHKVKSSQQPAASTQLPTTPSSNPSGLNQHTRNRQGQSSDPPSASTVAADSAILEVLQSNIQHVLVYENPALQEKALACIPVQELKRKSQEKLSRARKLDKGHWFKEEFFHWVNNVLCSKCGGQTRSSDDELKWGAKEVEDHYCDACQFSNRFPR----NNPEKLLETRCGRCGEWANCFTLCCRAVGFEARYVW-------DYTDHVWTEVYSPSQQWLHCDACED........................................................................ 357
6 -15.400[S] COG3672 Predicted periplasmic protein  ali follow..  11  54...............................................................................................................................................................................................................................................................AAIGADHGPSVLTRDSWKKILEVNYEVNQAIAPMTDMEIHGVE--ENWSYPDAVGDCEDYVLLKRRRLIESGFSPADLLITVVLQPNGDGHAVLTVRTDR-GDFILD............................................................................ 157
7 -12.000[Q] COG2162 Arylamine N-acetyltransferase  ali follow..  14  8...............................................................................................................................................................................................................................................................DLDAYLARITGPRNASLDTLKALHFAHPQAIPFERPVRLDLAALQDKIVLGGRGGYCFEHNLLFMHALKALGFEVGGLAARVLWGQSEDAHMLLRVELDGRTYI-ADVGFG........................................................................ 131
8 -11.100[S] COG2912 Uncharacterized conserved protein  ali follow..  8  1....................................................................................................................................................................................................................MATKVLDYFSALVADDDSIPLTETALSIAQDAYPDLDLQAELAAIDMLVARLIVEGTPAIQRLRVLNQFFYRELGFGPNANYDPENSYLNAVLQTRRGIPISLAVLLMEIGQQIGLPNHFLVRM...................................................................................................... 136
9 -7.410[S] COG4991 Uncharacterized protein with a bacterial SH3 domain homologue  ali follow..  12  1..................................................................................................................................................................................................................................................................................MKLSARASIFTLALLVSTNAYASSAIVTSTVNLRTGPGTQYGTI--AIPNGVGIM---VAG-------TRGYGWCQVSYGGTGWAASR............................................................................ 79
10 -7.290[R] COG3942 Surface antigen  ali follow..  13  2.............................................................................................................................................................................................................................................KKFHRFLVSGVILLGFNGLVPTMPSTLISQQENLVHAAVLGDNY---------PSKWKKGNGIDSWNM---IRQCTSFAA----LSSANGFQLPKGYG--------NACTWGH--AKNQGYVNKTPSIGA--DKNAYQSNAAYG-----HVAWVADIRGD......................................... 137
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Awobuluyi M, Yang J, Ye Y, Chatterton JE, Godzik A, Lipton SA, Zhang D. Subunit-specific roles of glycine-binding domains in activation of NR1/NR3N-methyl-D-aspartate receptors. Mol Pharmacol. 2007 Jan;71(1):112-22. Epub 2006 Oct 17.