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Query: TM0010 TM0010 281891 Purified-2005-03-03, from T.maritima

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MPLTTNTILICAGGACISAGEKSVKDAFEEELRKYGLDEVVRVIETGCMGACTLGPIAVIYPESVFYQKLTPDAAREIVEEHILKGRIVEKYLYKASEGKPVPRVHEEVPFFKKQVRIVTRNLGVIDPTKIEEYIARDGYFALAKALQMKPEDVIKEIKDSGLRGRGGAGFPTGLKWELAARQKAEKKFVVCNADEGDPGAFMDRSVLEGDPHAVIEGMAIAAYAIGAQKGFVYVRAEYPLAIERLNIALNQAREYGFLGGNIMGTDFSFDIEIRIGAGAFVCGEETALMASIEGERGQPKVKPPYPVEKGLWGYPTVINNVETLANVPWIIRNGAKEFRKYGTENSPGTKVFALAGKVKNTGLVEVPMGITLRELIYEIGGGIAGDKKLKAIQTGGPSGGCIPAEYVDTPVDFESLQKLGAIMGSGGMIVMDEDDCMVDVARFFLEFTVEESCGKCTPCREGTKKMLEILEKITSGEGTEEDIEELEKLAHVVKDTSLCGLGQTAPNPVLSTLRYFRDEYLAHVKEKRCPSKKCKALISYVIDPEKCVGCTACARVCPVQCISGQVRQPHVIDQAECVRCGSCIEVCRFGAISKVTPALPVEEAVELast
1 -103.000[C] KOG2658 NADH:ubiquinone oxidoreductase, NDUFV1/51kDa subunit  ali follow..  33  2.............................................APVRGILGLQRAVSIWKESNLTPALRSFSTQAASTSTTPQPP-----------PPPPPPEKTHFGGLKDEDRIFTNLYGLHDP-FLKGAMKRGDWHRTKDLVLKGTDWIVNEMKKSGLRGRGGAGFPSGLKWSFMPKVSGRPSYLVVNADESEPGTCKDREIMRHDPHKLLEGCLIAGVGMRASAAYIYIRGEYVNERLNLEKARREAYAAGLLGKNACGSGYDFEVYIHFGAGAYICGEETALLESLEGKQGKPRLKPPFPANAGLYGCPTTVTNVETVAVSPTILRRGPEWFSSFGRKNNAGTKLFCISGHVNKPCTVEEEMSIPLKELIERHCGGVRGGWDNLLAIIPGGSSVPLKNICEDVLMDFDALKAVQSGLGTAAVIVMDKSTDVVDAIARLSYFYKHESCGQCTPCREGTGWLWMIMERMKVGNAKLEEIDMLQEVTKQIEGHTICALGDAAAWPVQGLIRHFRPELERRIRERAERELLQAA...................................................................... 485
2 -97.000[C] COG1894 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit  ali follow..  40  4.....................................................................................................NSGTTKEIIRTPEMHPLTWRLRDDKQPVWLDEYRSKNGYAGAEKALGMAPTDVVNVVKDAGLKGRGGAGFSTGLKWSLMPKDDSMNRYLLCNADEMEPGTYKDRLLMEQLPHLLVEGMLISAFALKAYRGYIFLRGEYIEAAVHLRRAIAEATEAGLLGKNIMGSGFDFELIVHTGAGRYICGEETALINSLEGRRANPRSKPPFPASSGVWGKPTCVNNVETLCNVPAIIEHGVEWYQGIGKSNDAGTKLMGFSGRVKNPGLWELPFGITAREILEDYAGGMRDGLKFKAWQPGGAGTDFLTADHLDLPMDFENIAKAGSRLGTALAMAVDHEIGMVSLVRNLEEFFSRESCGWCTPCRDGLPWSVKILRALERGEGQPGDIETLEQLCRFLPGKTFCAHAPGAVEPLQSAIKYFRDEFEAGIAVKAYESGMTSGNTRAIIQPNLLKAR........................................................ 460
3 -43.300[C] COG4656 Predicted NADH:ubiquinone oxidoreductase, subunit RnfC  ali follow..  19  113...................................................................................................................................DGEDRWREQQPWADYRQRDKMALLDRIHQAGIAGLGGAGFPTASKLQG---GLNGIITLIINAAECEPYITADDRLMQEHADEVITGIHILRHLLQPQQVLIGIEDNKPEAIAALQRALRGQD----------------DIHLRVVPTKYPSGGAKQLTKILTGKEVPFGKHSS--------SIGVLMQNVGTVVAIKRAVIDDEPLI----------ERVVTLTGDLSSPGNFWARIGTPVLYLLKLAGFKPQNPPM---VIMGGPLMGFTLPS-LDVPIV----------KISNCILAPAET--------EMGLSEPEQSCIRCGLCVDACPAGLLPQQLYWFSRGEEHEKARNHNLFDCIE-CGACAYVCPSNIPLVQYYRQEKAEIRALDQESARAAEAKAR...................................................................... 459
4 -27.000[C] COG2878 Predicted NADH:ubiquinone oxidoreductase, subunit RnfB  ali follow..  25  1......................................................................................................................................................................................................................................................................................................................................................................................................................MNAIWIAVAAVXLLGAILGYASRRFAVEDDPVVEKIDEILPQS---QCGQC---------------------GYPGCRPYAEAISCNGEKINRCAPGGEAVMLKIAELLNVEPQPLDGEAQELTPARMVA-----VIDENNCIGCTKCIQACPVDAIVGATRAMHTVMSDLCTGCNLCVDPCPTHCISLQPVAETPDS... 173
5 -19.300[C] COG1144 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, delta subunit  ali follow..  35  47.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................VIDESKCVKCYICWKFCPEPAIYIKEDGFVAIDYDYCKGCGICANECPTKAITMVREEK....... 105
6 -16.800[C] COG1146 Ferredoxin  ali follow..  30  40.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................TIDYDKCVTCGICFVTCGRRVFDKEGKVIVARPYNCMVACQTCMNLCPTGAIS............. 95
7 -15.700[C] COG1905 NADH:ubiquinone oxidoreductase 24 kD subunit  ali follow..  23  89.PVGRHVIRYCDSVVCHITGYQGIQAALEKKLGQTTFDGRFTLLPTCCLGNCDRGPTMMIDDD--THSYLKPEEIEKLLEQY............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 171
8 -13.500[C] KOG3196 NADH:ubiquinone oxidoreductase, NDUFV2/24 kD subunit  ali follow..  20  119.PTGKYHIQVCTTTPCWLRGSDDILETCKKQLGDTTKDRKFTISEVECLGACVNAPMVAINDD--YYEDLTSKDMQDILNDLKADKIS....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 207
9 -13.200[C] KOG3256 NADH:ubiquinone oxidoreductase, NDUFS8/23 kDa subunit  ali follow..  19  1...............................................................................................................................................................................................................................................................................................................................................................................................................................................MSLTMRIFTASRN----RLFGSHG--ARLLAAQRAEPKDIVEVPKGYVYVNNKELSMEFADITDRAASTMFFGELLRGFAVTLAHITINYPFEKGPLSPRFRGEHALRRYPSGEERCIACKLCEAICPAQAITSRRTTRYDIDMTKCIYCGFCQEACPVDAIV............. 173
10 -13.100[C] COG1143 Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I)  ali follow..  23  1..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................MIKEIINVVHG------FTQLRSLVMIFGHAFRKRDTLQYPEEPVYLPPRYRGRIV---------------LTRDPDGEERCVACNLCAVACPVGCISRWYPEFFRINFSRCIFCGLCEEACPTTAIQ............. 117
11 -12.800[C] COG1145 Ferredoxin  ali follow..  15  2......................................................................................................................................................................................................................................HHSHHLEIYEKLREKLNKA---------IGLPKTVSGVEKEL------SVLFDEEEAKIAVHMPFI----------RFTAEQLAERTGKSLEYVEKILNEMAKKG------VWKGEKDGQTYYRLFPVI--VGFAETPFWPGPGKDPRQ--------EKLARLWSQYRKEGFLDEIGDREHPIMRALPERDTISEKSEILPYEDAVKLVKERDYI-------AVGYCP-CRVMARLVGEGCRHVEHGLGRRISADEAIEILRQSNREGLVHLTERSKHVATICN------FFKAVHEAKHPNTIAHSSYLATVDTSRCIACGICMLRCPMKAIKKINREPASVDAEKCLGCGVCVPTCPMEAIELVERDELLELP.. 347
12 -12.600[S] COG5469 Predicted metal-binding protein  ali follow..  15  7LGVAEHTLFVCKTKRVGESGGQKLLNQLQQLAQEWELRDKFPIQEVECMSACNRSCVVAFTGKGYLFGDLAVDDHASAVLECAG........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 101
13 -12.600[C] COG3411 Ferredoxin  ali follow..  29  193NPLKHSYISVCTSTRCPSRKWQPTFDALKSAVENAGLD--IEVRTSGCLEVCQLGPVVFYSNDRTWYTRVNPNVAENIVNEHLIKGNKITENLYPPQT............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 289
14 -12.400[C] COG2440 Ferredoxin-like protein  ali follow..  23  14..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LYQNRYLVDPGRPHIK----------------VRPHERPSALALTHICPAKCYELNDKGQVETTSDGCMECGTCRVLCEASG............... 81
15 -12.200[C] COG1726 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrA  ali follow..  14  108...............................................................................................................................................EQLNQLTSEQVRQNLQASGLWTALRTRPFSKVP-----AVDATPVSIFVNAMDTNPLCADPQVIVQQSAQAFEAGLTVLSRLHEGKVYLCKAANASIPSPSIAN------------------------LDVKEFAGPHPAGLSGTHIHFIDPVS----------------TKFVWYINYQDVIAVGKLFTTG----------ELDVSRVVSLAGPVKNPRLVRTVLGANLSQLTANISGSVLSGAKAAGLGRYALQVSVLEEGREKEFLGWIMPGANKYSLSRTVLGHFSKKLFNFTTALNGGE-----PIGAYERVMPLDIIPTLLLRDLAAGDTDSAQALGCLELDE--EDLALCTFVCPGKNEYGPLLRQALDKIEKE................................................................................... 445
16 -10.700[C] COG0348 Polyferredoxin  ali follow..  14  73.....................................................................................................................................................................................................................................................................................................................................................................................................................................ESLATGFMPTMTALLGALIVVVLYAILGSRVFCA----CPLNI--VTDASAWLRRKLEIRQSAKLPRSLRYAILVMILSALSGLLLWEWLNPVAALGRALEHGWCGHLCPIGAAYGVIGAK-HRQQCDNCMDCYNVCPEPQLHAKKSESPLVLSKDCISCGRCIDVCPEKVFIFTTRFNHSVNHSG 290
17 -9.400[C] COG0437 Fe-S-cluster-containing hydrogenase components 1  ali follow..  17  1........................................................................................................................................................................................................................................................................................................................................................................................................................................................MTTQYGFFIDSSRCTGCKTCELACKDFKDLGPEVSFRRIYEYAGGDWQEDNGVWHQ---------------NVFAYYLSISCNHCDDPAC-TKVCPSGAMHKVDEDVCIGCRYCHMACPYGAPQYNAEKGHM---TKCDGC-ICVESCPLRALE............. 151
18 -9.050[C] COG1142 Fe-S-cluster-containing hydrogenase components 2  ali follow..  26  10...................................................................................................................................................................................................................................................................................................................................................................................................................................................................TLCIGCHTCEAA------------------------------------CSETHRQHGLQSMPRLRVMLNEKESA-------------------PQLCHHCAPCAVVCPVNAIT-RVDGAVQLNESLCVSCKLCGIACPFGAIE............. 98

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Li W, Wooley JC, Godzik A. Probing metagenomics by rapid cluster analysis of very large datasets. PLoS ONE. 2008;3(10):e3375. Epub 2008 Oct 10.