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Query: TM0018 TM0018 281899 Purified-2001-08-24, from T.maritima

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MPVNIKQLAQEFDKKEIGITQGHRLCPGCGAPITVKFVMMIARHLGYEPVVGLATGCLEVSTSIYPYTAWSVPYIHNAFENVAATMSGVETAYKALKNKGKIPEDKKYAFIAFGGDGGTYDIGLQSLSGMLERGHKVLYVLYDNEGYMNTGNQRSGSTPPGSDTTTAPVGKKLPGKVQLKKNIVEIVAAHENVYAATASLSEPMDFFAKVEKALNFDGPSFLAVFSPCVRFWRVNDDKTVEISKLAVETKYWPLYEVERGVYRVTRKPRQFKPVEEFLKAQGRFRKLLSRPDAKEIVDELQEYVDRRWERLLTLEEVTKDKPIRLast
1 -74.100[C] COG1013 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit  ali follow..  19  1...........MPTSEDYKGQVPAWCPGCGNFQILSAVKQALVELGWEVLAVSGIGQSG-----KLPHYMKCHTFNGLHGRTLPVATAAKLAN------------HSLHVIAVAGDGDCYGEGGNHFLHAIRRNPNITLIVHDNQIYGLTKGQASPTTAKGTRTKVQPSG-----VPAEPMNPLALAISQDCSFVARGFAGDPEYLKELMKAAITHKGFSLLDILQPCVTFNKVNTFKWYRERVYKLEAEYDPYDRMKAFERVLEWGEKDKDTLEEMFP-TIREEPLVRQ---KFSIEDVKSEIEKFY................ 283
2 -35.800[C] COG4231 Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits  ali follow..  18  357.....GIVAESQKLAAKAPPRPPVLCPGCPHSASFYAIRRVVDELG-DAALPSDIGCYTLGI----NKPLEGVDITICMGASVGVSNGLAHVLNN-------------KIIATIGDSTFIHAGIPPLINAVYNHADFVLVILDNSTTGMTGHQPHPGT-----------GFRGCGEAGKAVRIEDIVRGCGVEFVEVVNPYNVRKMVDVLRRALNHDGVAVVIARQPCAILWSRARRR...................................................................................... 560
3 -13.500[GHR] COG3961 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes  ali follow..  15  369...................................WMWNHLGNFLREGDIVIAETGTSAFGINQTTFVYAIVQVLWGSIGFTVGALLGATMAAEELD--------PKKRVILFIGDGS-LQLTVQEISTMIRWGLKPYIFVLNNNGYTIE------------------HGPHAEYNEIQGWDHLALLPTFGARNYETHRVATTGEWEKLTQDKQDNSKIRMIEVMLP................................................................................................. 541
4 -13.200[EH] KOG4166 Thiamine pyrophosphate-requiring enzyme  ali follow..  12  474.................................VIQELDKQTSDIKDKVTITTGVGAHQMWAATF--SSLVTSGGLGTMGFGLPAAIGASVA------------APKDIVIDIDGDAS-FSMTGMELATVRQFDIPVKILILNNEEQGMV-----------TQWQNLFYEKRYSHTHQKNPNFVKLADAMG---IKALRVEKREDLAKKMKEFLSTKGPVLMEVLVA................................................................................................. 644
5 -13.100[EH] COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]  ali follow..  15  398...................................RLVSDIRAAMGDSDIALVDTGALKMWMARL--NTCVISNGLATMAFAVPGAIGAKLAY------------PDRKVLAVTGDGS-FLMNSQELETAIRERIPFVVLVWVDDAYGLIKWKMDLELGRHSFVDFG------------NPDLVKYAESFG---ARGYRIEVAADLLPTLKKALAEDVVSVVVC.................................................................................................... 562
6 -12.700[E] COG3962 Acetolactate synthase  ali follow..  15  394...................................QVIGAVQRQSRDNTVVMCAAGTMPGELHQL--LSYHMEYGFSCMGYEVAGGLGIKMA------------EPDRDVIVMVGDGS-YMMMNSELATSVAMGVKITLVITDNRGYGCINRLQMETGGAEFNNLYAHTNVNPIA------DFVAHAGSMG---ADARKVSTITELEEALAAARASSRTTVVVI.................................................................................................... 565
7 -12.400[R] COG3960 Glyoxylate carboligase  ali follow..  13  374...................................RVYEEMNKAFGRDVCYVTTIGLSQIAAAQM--RHWINCGQAGPLGWTIPAALGVCAA------------DPKRNVVAISGDFD-FQFLIEELAVGAQFNIPYIHVLVNNAYLGLI--QSQRAFDMDYCVQLAFENINSSEVNGYGVDHVKVAEGLG---CKAIRVFKPEDIAPAFEQAKQYRVPVVVEVILE................................................................................................. 556
8 -11.600[EH] KOG1184 Thiamine pyrophosphate-requiring enzyme  ali follow..  20  413...................................TMFQHIQKMLSSETAVIAETGDSWFNCQKLKLCGYEFQMQYGSIGWSVGATLGYAQA------------SPEKRVLAFIGDGS-FQVTVQDISTMLRNGQKTIIFLINNGGYTIEVEIHDGP------------------NVIKNWNYTGLVDAIHNGECWTAKVRYEEELVEAITTATKKDCLCFIEVILH................................................................................................. 581
9 -11.100[EH] KOG1185 Thiamine pyrophosphate-requiring enzyme  ali follow..  16  436...................................AAYQPIREFLANNDVIVINEGANTMDIG---RTMMPSRLPKRRLDAGTFGTMGVGHGFSLAAALWARDHSPKTKVLVVQGDSA-FGFSAMELETIARYNLPVVTVIINNSGIYRGLLPEDDKAIEGDRTLALPVLSLTAE------RYEEMCKAFG---GAGTVVRTVPEIKAALEKAFQKDGPTVINAL................................................................................................... 614
10 -10.400[H] COG1165 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase  ali follow..  12  371...................................QLAHRISDYLPEQGQLFVGNSLVVRLIDALGYPVYSNRGASGI-DGLLSTAAGVQRA-------------SGKPTLAIVGDLSALY-DLNALALLRQVSAPLVLIVVNNN-----GGQIFSLLPTPKSERERFYLM------PQNVHFEHAAAMFELKYHR---PQNWQELETVLADAWRTPTTTVIEMVVNDTDGAQTLQQLLAQVSHL............................................................................... 556
11 -10.100[C] KOG0225 Pyruvate dehydrogenase E1, alpha subunit  ali follow..  13  138.................................................LTGRKGGCAKGKGGSMHMYAKNFYGGNGIVGAQVPLGAGIALACKYNGK--------DEVCLTLYGDGAA-NQG-EAYNMAALWKLPCIFICENNR-YGMG----TSVERAAASTDYYKRGDFIPGLRVDGMDILCVREA----------------TRFAAAYCRSGKGPILMELQTYRYHGHSMSDPGVS--------------YRTREEIQEVRSKSDPIMLLKDRMVNSNLAS--------VEELKEIDVEVRKEIEDAAQFATADPEPPLE 362
12 -9.350[C] KOG1182 Branched chain alpha-keto acid dehydrogenase complex, alpha subunit  ali follow..  12  233..........................................................................ISSPIATQLPQAAGVGYSLKMDKK--------NACTVTFIGDGGT-SEG-AGLNFAAVMEAPVVFICRNNG-WAISTHISEQFRSDGIVVKGQAYG--IRSIRVDGNDALAVYSA----------------VRSAREMAVTEQRPVLIEMMTYRVGHHSTSDDSTKYRAADEIQYNRFRKWVEDNGWWSEEDESKLRSNARKQLLQAIQAAEKWEKQPLTELFNDVYDVLEEQELGLKELVKKQPQD... 465
13 -9.020[C] COG1071 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit  ali follow..  15  122...........................................................................SSPVTTQVPHAVGIALAGRMEKK--------DIAAFVTFGEGSS-NQG-EGANFAAVHKLPVIFMCENNK-YAISVPYDKQVACENISDRAIGYG--MPGVTVNGNDPLEVYQA----------------VKEARERARRGEGPTLIETISYRLTPHSSDDDDSSYRGREEVEE----------------KKSDPLLTYQAYLKETGLLS--------DEIEQTMLDEIMAIVNEATDEAENAPYAAPE 321

FFAS is supported by the NIH grant R01-GM087218-01
1 4 6 4 7 1   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Li W, Wooley JC, Godzik A. Probing metagenomics by rapid cluster analysis of very large datasets. PLoS ONE. 2008;3(10):e3375. Epub 2008 Oct 10.