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Query: [J] COG0013 Alanyl-tRNA synthetase, from VFDB

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MKTMTSAEVRQMFLDFFKSKGHTVEPSQSLVPVNDPTLLWINSGVATLKKYFDGSVVPENPRLTNAQKAIRTNDIENVGKTARHHTMFEMLGNFSIGDYFRKEAIAFAWELLTSSEWFEFPAEKLYITYYPADKDTYNRWVEVGVDPTHLVPIEDNFWEIGAGPSGPDTEIFFDRGEVYDPEHVGLKLLAEDIENDRYIEIWNIVLSQFNADPSIPRSEYPELPQKNIDTGMGLERMVCIIQGGKTNFDTDLFLPIIREIEKLSGKTYSPDSENMSFKVIADHIRSLSFAIGDGALPGNEGRGYVLRRLLRRAVMHGKKLGIQGKFLASLVPTVGKIMQSYYPEVLEKEDFIMQIIDREEETFNRTIDAGQKLIDELLLNLKSEGKDRLEGADIFRLYDTYGFPVELTEELAEDEGFKIDHEGFKVAMKAQQERARAAVVKGGSMGAQNETLSSIEVESEFLYEDKTTQGKLLVSIQDDEIVDEVSGKAQLVFDVTPFYAEMGGQVADHGVIKDAEGQVVANVLDVQHAPHGQNLHSVETLSPLKVGESYTLEIDKERRAAVVKNHTATHLLHAALHNIVGNHALQAGSLNEVEFLRFDFTHFAQVTKEELAEIERQVNEVIWQSLKVETVETDIATAKEMGAMALFGEKYGKNVRVVKIGDYSIELCGGTHTQTTSEIGLFKIVKEEGIGSGVRRIIAVTGQKAYEAFKDAENTLNEVATMVKAPQTSQVLAKVTSLQDELKTAQKENDALAGKLAASQSDEIFKNVQTAGSLNFIASEVTVPDANGLRNLADIWKQKELSDVLVLVAKIGEKVSLLVASKSSDVKAGNLVKELAPFVDGRGGGKPDMAMAGGSKAAGIPELLAAVAEKLALast
1 -238.000[J] COG0013 Alanyl-tRNA synthetase  ali follow..  100  1MKTMTSAEVRQMFLDFFKSKGHTVEPSQSLVPVNDPTLLWINSGVATLKKYFDGSVVPENPRLTNAQKAIRTNDIENVGKTARHHTMFEMLGNFSIGDYFRKEAIAFAWELLTSSEWFEFPAEKLYITYYPADKDTYNRWVEVGVDPTHLVPIEDNFWEIGAGPSGPDTEIFFDRGEVYDPEHVGLKLLAEDIENDRYIEIWNIVLSQFNADPSIPRSEYPELPQKNIDTGMGLERMVCIIQGGKTNFDTDLFLPIIREIEKLSGKTYSPDSENMSFKVIADHIRSLSFAIGDGALPGNEGRGYVLRRLLRRAVMHGKKLGIQGKFLASLVPTVGKIMQSYYPEVLEKEDFIMQIIDREEETFNRTIDAGQKLIDELLLNLKSEGKDRLEGADIFRLYDTYGFPVELTEELAEDEGFKIDHEGFKVAMKAQQERARAAVVKGGSMGAQNETLSSIEVESEFLYEDKTTQGKLLVSIQDDEIVDEVSGKAQLVFDVTPFYAEMGGQVADHGVIKDAEGQVVANVLDVQHAPHGQNLHSVETLSPLKVGESYTLEIDKERRAAVVKNHTATHLLHAALHNIVGNHALQAGSLNEVEFLRFDFTHFAQVTKEELAEIERQVNEVIWQSLKVETVETDIATAKEMGAMALFGEKYGKNVRVVKIGDYSIELCGGTHTQTTSEIGLFKIVKEEGIGSGVRRIIAVTGQKAYEAFKDAENTLNEVATMVKAPQTSQVLAKVTSLQDELKTAQKENDALAGKLAASQSDEIFKNVQTAGSLNFIASEVTVPDANGLRNLADIWKQKELSDVLVLVAKIGEKVSLLVASKSSDVKAGNLVKELAPFVDGRGGGKPDMAMAGGSKAAGIPELLAAVAEKLA 872
2 -196.000[J] KOG0188 Alanyl-tRNA synthetase  ali follow..  33  1MKLLTAKEVRNAYLDFFKEQKHIYVHSSSTIPLDDPTLLFANAGMNQFKPIFLGTADPNWVRVANTQKCIRANDLDDVGKDVYHHTFFEMLGNWSFGDYFKKEICSWAWEFLT--QRLALPKDRLYVTYFGGDLECKQMWLDLGLKPEHILPGKDNFWEMGTGPCGPCSELHFDRIGGRSVPE------LVNMDDPDVLEIWNLVFIQYNRES---DGSLKQLPKKHIDCGMGFERLVSVIQNKRSNYDTDLFVPLFDAIQAGTGAPPDVDGIDMAYRVLADHARTITIALADGGTPDNTGRGYVLRRILRRAVRYATELNAKPGFFATLVNTVVDLLGDAFPEVKKDPQHIIDIINEEELQFLKTLTRGRNLLNRTIEKLG--NQTTIPGDVAWRLYDTYGFPVDLTQLMAEEKSLKIDMDGYEAAKHNSYVLSQGKGASKITNDTFKYKYEAVSDERDSAYNYGVCNSKIVALRFENQFVNESGQKAGIVLDKTNFYAESGGQIYDQGALVKVNDEANEFLVDRVYNRGGYILHIGVVEGTLKVGDELELHIDVERRWLTMKNHSATHALNHCLLQVLGKDTEQKGSLVVPEKLRFDFNSKAAMTIEQVSKTEQLTKEMVYKNVPIYAKESKLALAKKIGLRSVFDEVYPDPVRVISFGQTSVEFCGGTHLRRSGHIMDFVISSEEAIAKGIRRIVALTGPEALKALKKSEAFEQEIVRLKATIDNDKSGKDSKSHVKEIVELTEQIRALRAAVSVTVVERAKTLCEANPNATVLVEQLEFNNTKALDAALKQVRSQLPDAAAMFLSVDSKKIFCLSSVPKSGLKANEWVQHVSATLGGKGGGKPESAQASGTNYEKVDEIVQLASKFAQ 962
3 -61.400[R] KOG2105 Predicted metal-dependent hydrolase, contains AlaS domain  ali follow..  20  2.......................................................................................................................................................................................................................................................................................................................................................................................................................................................ELAHVEHYAELLKKVSTKRPPPAMDDLDFTTTVVSCCPAELQTEEVLSGFQVVLEDTVLFPEGGGQPDDRGTIND------ISVLRVTRRGEQADH---FTQTPLDPGSQVLVRVDWERRFDHMQQHSGQHLITAVADHLFKLKTTSWE--LGRFRSAIEL-DTPSMTAEQVAAIEQSVNEKIRDRLPVNVRELSLDDPEEQVSGRGLPDDHAGPIRVVNIEGVDSNMCCGTHVSNLSDLQVIKILGTEKGKKNRTNLIFLSGNRVLKWMERSHGTEKALTALLKCG-AEDHVEAVKKLQNSTKILQKNNLNLLRDLAVHIAHSLRNSPD---WGGVVILHRKEGDSEFMNIIANEIGSEETLLFLTVGDEKGGGLFLLAGPPAS---VETLGPRVAEVLEGKGAGKKGRFQGKATKMSRRMEAQALLQDYIS 422
4 -59.800[R] COG2872 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain  ali follow..  28  16..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................EAIVEKVTDDKYVVLDRTAFYPESGGQPSDTGKLVREEDGAEFEVVYVGKFNGDISHEITPVDGNLKAGDRVRGIIDWDRRYRHMRMHTATHVIANVIEKEAGAQI--TGNQLGLDKSRVDFSL-EAFDRDKFAEYEKIANKVITENHPVNLYLVSRKEAEEKSRLTTLAKGFSEEVRLVEIEGITIEACGGTHLKNTGEIKGIKIEKLQNKGKSNRRMYFTLLD......................................................................................................................................................................... 245
5 -57.800[J] COG0752 Glycyl-tRNA synthetase, alpha subunit  ali follow..  15  3.KKLTFQEIILTLQQFWNDQDCMLMQAYDNEK---------GAGTMSPY-TFLRAIGPEPWNAAYVEPSRRPAD----GRYGENPNRLYQHHQFQVVMPSPSNIQELYLESLEKLGI----------------------------PLEHDIRFVEDNWENPSGSAGLGWEVWLD------------------------MEITQFTYFQQVGG--------LATGPVTAEVTYGLERLASYIQEVDSVYDIEWADGVFDKFEKEAGRALEEGLVHPAYDYVLKCSHTFNLLDARGAVSVTERAGYIAR--IRNLARVVAKTFVAE----------RKRLG--YPLLDEETRAKLLAEDAE................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 305
6 -8.730[J] COG0441 Threonyl-tRNA synthetase  ali follow..  18  51...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................IENDAQLSIITAKDEEGLEIIRHSCAHLLGHAIKQLWPHTKMAIGPVID-NGFYYDVDLDRTLTQEDVEALEKRMHELAEKNYDVIKKKVSWHEARET--FANRGESYDDKPGLYFHEEY-VDMCRGPHVPNMRFCHHFKLMKTAGANKMLQRIYGTA........................................................................................................................................................................... 222
7 -7.900[J] KOG0402 60S ribosomal protein L37  ali follow..  13  3...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................KRTKKVGITGKYGVRYGSSLRIQQHARYDCSFCGKKTVKRGA-AGIWTCSCKKTVAGGAYTVSTAAAATVRSTIRRLREMVEA.......................................................................................................................................................... 92
8 -7.570[J] COG1997 Ribosomal protein L37AE/L43A  ali follow..  16  7...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................KKGRISRSAGRFGPRYGRKDRERMRAPHVCTKCARPTVERIG-TGIWKCSKGHTFAGGTYIPYTSVGQTLLRTMKNIAEA............................................................................................................................................................. 93
9 -7.300[J] KOG1637 Threonyl-tRNA synthetase  ali follow..  17  58....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................DGKQVDATSWETTPYEVARGISQGLADNTVISKVNGEVWD-------------------------------LDRVLEGNCTLQLLKFDDPEAQAVFWHSSAHIMGEAMERIYGGHLCYGPPI--ENGFYYDMHLEGGISTNDYGAMEGLVKQIVKEKQNFERLEMKKSDLLEM-KVRILNEKVTTDRTTVYKCGSLIDLCRGPHVRHTGKVKALKITKNSSTAETLQRVYGIS........................................................................................................................................................................... 270
10 -6.620[Q] COG3321 Polyketide synthase modules and related proteins  ali follow..  11  4......................................................................SVTPIAVIGMGCR------LPGGINSPDKL--------WESLLRNLVTEVPPDRWDVDDFYDPEPGVRSVSRWGGFLDDVAGFDAEFFGISEREADPQQRLLLETSWEAIEQGGLDPASLAGSSTAVFTGLTHEDYLVLTTAAGGLASPYVVTPAMTFDTACS-SGLMAVHLACRSLHDGESDLALAGGCAVLLEPHASVA---SAQGMLSSTGRCKSFADADGFVRS-EGCAMVLLKRLPDALRDGNRI------FAMILGTATNQDGGT-PSEDAQVAVYQAAVEPETIGVVEAHGTGTPIGDRSLARVYGAGTPCALGSAKSNMGHS-GTVGLIKAILSLRNGLLLHFDRLSDDLTEIETGLFVPQEVTPWPVGGYNTPKRVAVSSF------------------------SGTNVHVIVEEAP--EACAPDVPETSPGTGDATVGRQLFMLSSTSIAALRETARQLATWVEEHQDSVVLSDLAYTLARGRAHRPVRTLVEGLCEIAGDALYDAVVGHGDRGPVWVFSANEPVFAATITKLEPVIAAESSFSVTEAITAPETVTGIDKVQPSVFAVQVALATTMEQTYGVRPGAVIG-H--SMGESAAAVVAGALSLEDAARVINRVAGSGAMGSVELPAKQVNSEISVVASPQSTVIGGATETVRDLIAQWEQRQVDPILDDLAAALADIAPMTPKVPYYSATLFDPRELPVCNGAYWVDNLRNTVQFAAAVQAAMEDGYRVFA------ELSPHPLLTHAVEQTARNLDMSVAALAGMRREQSMPYGLRGLLADL.. 850
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Jaroszewski L, Rychlewski L, Godzik A. Improving the quality of twilight-zone alignments. Protein Sci. 2000 Aug;9(8):1487-96.