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Query: [HE] COG0111 Phosphoglycerate dehydrogenase and related dehydrogenases, from VFDB

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MNLAWLQGLSLGLLSPPAPALLIFRSFTMAKVLVSDSIDQVGIDILKQVAQVDVKTGLSEAEIIDIVPEYDAIMLRSATKVTEKIIQAGSQLKIIGRAGVGVDNIDVPAATRQGIVVVNSPEGNTIAAAEHALAMMMALARHIPDANKSVKESKWERKQFIGTEVYKKTLGVVGLGKIGSHVAGVAKAMGMKLLAYDPFISQERADQIGCTLVDLDLLFSEADFITLHIPKTPETANLINAETLAKMKPTARIINCSRGGIIDEEALVTAIETAQIGGAALDVFAQEPLGESRLREFSNVILTPHLGASTEEAQVNVAVDVAEQIRDVLLGLPARSAVNIPGLTPDVMEKLRPYLKLAETLGTLVGQLAGGRIDRLTVCLQGDLAEYTNSQPLVVAAIKGLLSQALRERVNYVNAAIEAKERGIRVIETKDASVRDYSGSLHLKATGTMGEHSATGALLSNGEIRITDVDEFPINVPPNNYMLFTLHRDMPGIIGKIGSLLGSFNVNIASMQVGRKIVRGDAIMALSLDDPLPDGLLSEITKVAGIRDAYTVKLLast
1 -148.000[HE] COG0111 Phosphoglycerate dehydrogenase and related dehydrogenases  ali follow..  100  1MNLAWLQGLSLGLLSPPAPALLIFRSFTMAKVLVSDSIDQVGIDILKQVAQVDVKTGLSEAEIIDIVPEYDAIMLRSATKVTEKIIQAGSQLKIIGRAGVGVDNIDVPAATRQGIVVVNSPEGNTIAAAEHALAMMMALARHIPDANKSVKESKWERKQFIGTEVYKKTLGVVGLGKIGSHVAGVAKAMGMKLLAYDPFISQERADQIGCTLVDLDLLFSEADFITLHIPKTPETANLINAETLAKMKPTARIINCSRGGIIDEEALVTAIETAQIGGAALDVFAQEPLGESRLREFSNVILTPHLGASTEEAQVNVAVDVAEQIRDVLLGLPARSAVNIPGLTPDVMEKLRPYLKLAETLGTLVGQLAGGRIDRLTVCLQGDLAEYTNSQPLVVAAIKGLLSQALRERVNYVNAAIEAKERGIRVIETKDASVRDYSGSLHLKATGTMGEHSATGALLSNGEIRITDVDEFPINVPPNNYMLFTLHRDMPGIIGKIGSLLGSFNVNIASMQVGRKIVRGDAIMALSLDDPLPDGLLSEITKVAGIRDAYTVKL 554
2 -125.000[E] KOG0068 D-3-phosphoglycerate dehydrogenase, D-isomer-specific 2-hydroxy acid dehydrogenase superfamily  ali follow..  38  72..................DSDEYNPTLPKPRILVTEKLGEAGVNLLREFGDVDCSYDLSPEDLKKKVAESDALIVRSGTKVTREVFEAAKRLKVVGRAGVGIDNVDLQAATEHGCLVVNAPTANTVAAAEHGIALLASMARNVAQADASIKAGKWERSKYVGVSLVGKTLAVMGFGKVGTEVARRAKGLGMTVISHDPYAPADRARALGVDLVSFDQAISTADFVSLHMPLTPATKKVFNDETFSKMKKGVRLINVARGGVIDEDALVRALDAGIVAQAALDVFCEEPPSDSRLIQHENVTVTPHLGASTKEAQEGVAIEIAEAVAGALKGELSATAVNAPMVAPEVLSELTPYIVLAEKLGRLAVQLASGGVQSIRVVYRSARDDDLDTRLLRAMITKGIIEPISDSYVNLVNADFIAKQKGLRISEERMVVDEYPVDSIQVQILSDAGDISIEGKVKY-GVPHLTCVGSFGVDVSLEGNLILCRQVDQPGMIGQVGNILGEQNVNVNFMSVGRTVLRKQAIMAIGVDEEPDNKTLERIGGVSAIEEFVFLKL 624
3 -92.800[K] KOG0067 Transcription factor CtBP  ali follow..  23  22.................RPQIMNGPLHPRPLVALLDGRDTVEMPILKDLATVAFDAQSTQEIHEKVLNEAVGAMMYHTITLTREDLEKFKALRVIVRIGSGYDNVDIKAAGELGIAVCNIPSAAVEETADSTICHILNLYRRNTWLYQALREGTRVQSASGAARIRGETLGLIGFGRTGQAVAVRAKAFGFSVIFYDPYLQDGIERSLGVQRVTLQDLLYQSDCVSLHCNLNEHNHHLINDFTIKQMRQGAFLVNAARGGLVDEKALAQALKEGRIRGAALDVHESEPFAQGPLKDAPNLICTPHTAWYSEQASLEMREAAATEIRRAITGRIPESLRNC--VNKEFFVTSAPWSVIDQQAI-------HPELNGATYRYPPGIVGVAPG--GLPAAMEGIIPGGIPVTHNLPTVAHPSQAPSPNQPTKHGDNRE....................................................................................................................... 440
4 -84.400[CHR] COG1052 Lactate dehydrogenase and related dehydrogenases  ali follow..  26  2............................RCVVFNLREEEAPYVEKWKQSHVVDTYEEPLTAKNKELLKGYEGLVVMQFLAMEDEVYDGACKLKVLSTRTAGFDMYNATLLKKHGIRLTNVPSYSPNAIGEYALAAALQLTRHAREIETFVRKRDFRQKPILSKELRCSRVGILGTGRIGQAAARLFKGVGAQVVGFDPYPNDA--AKEWLTYVSMDELLSTSDVISLHMPATKDSHHLINAKTIAQMKDGVYLVNTARGAVIDSQALLDSLDKGKIAGAALDAYEFEGPVYARLVAHERIIYTPHIAFYTETAIENMVFNSLDACTTVLRGEPCAAEIKL...................................................................................................................................................................................................................... 331
5 -72.500[C] KOG0069 Glyoxylate/hydroxypyruvate reductase (D-isomer-specific 2-hydroxy acid dehydrogenase superfamily)  ali follow..  18  2.......................CRKSRGAKSPVNNDVVDGSSRRFHKAFKVLISHPPAPALELLRSRGAETIICQSVPPSRDEILQKVPGLRCVSTMSSGIDFVDIPEFQKRGIPLGHTPGVVKNAVADLAIGLMIAAGRHFHAGRTEIERSQWKIEQMMGQEIRDSVIGFFGFGGISQAIAKRLQCWDVAKIIYHTRTRKENDGDFKAEHVSFEQLLQESDFLVVAAPLTNETREKFNGKAFNLMKRSSVFVNVARGG--------------------LDVTTPEPPANSPLLNVPNCEGLKMSTTKPFKVLIAHTDVPPEGIEILKEQCEILQVINEPPKNRPEILEKIRGAHIWGGRDILNAEILDAAGPQLKAV------------------------STMSSGINNVDVPE-LKKRGIPLGSTPAMLTVAVAD-LTVGLLIAAARRFQEGRRKIDSDKWDKDHLNWMLGQDIRDSTVGFYG------FGGIGQAVAKR.................................................. 441
6 -29.000[R] COG2150 Predicted regulator of amino acid metabolism, contains ACT domain  ali follow..  14  3..........................................................................................................................................................................................................................................................................................................................................................................................EMIHILEEYFRGYPARKKVVKFLWE----AGLSVKNGKIYVK--DVEVPITGIAEVTGVNRKIVYHTIEYIESKPALKILFE-NLAPRQSLISIAPLMGWEVLELTISKKAYESTVAMVLNGLAKRRIRVIEI-FGTNTYEGKAKVYIVIEGVLPFDMIAELKKTNTIEKIVIRT. 169
7 -12.900[H] KOG1370 S-adenosylhomocysteine hydrolase  ali follow..  12  82.................................AAAAIAKAGISASTGIPVLPLPRLACLEGRNRRGVPVTGDLTNLIHSEYSQLLLS---RGISKETTIGVHNLKMMVNGILKVPAIDVNDSATKSKFDNLYGCGIKQA--------------------TDVMIAGKVAVVAGYGDKGKSCAQALRGFRASVIITKT-IKALQAAMEGYEVTTMDEACQEGDVFVT----TTGCVDIILGQHFEQTKDDTIVCNTGYFDVMDVKWLNKNTVEKVNVKLQVDPYRLKNGRGIILLAEGRLV---NLACAMGHPSFVRSNSFTSQVMAQLWTHPDKYPVGVHFLPKKLDESVA---AHLGKLNMKLTKLTEKQAQYLGMSCYCPF.......................................................................................................................................................................... 406
8 -11.300[H] COG0499 S-adenosylhomocysteine hydrolase  ali follow..  16  172.................................................................AFLGMLREVLAAEPGKWGKIAEA---KGVTEETTTGVHRLHFAEEGVLPFPAMNVNDAVTKSKFDNKYGTRHSLIDGINRA--------------TDMLMGGKNVLVCGYGDVGKGCAEAFDGQGARVKVTEA-INALQALMDGYSVVTVDEAIEDADIVIT----ATGNKDIISFEQMLKMKDHALLGNIGHFDNIDMHSLLHDDVTRTTIKPQVDEFTFSTGRSIIVLSEGRLL---GNATGHPSFVMSNSFADQTIAQIELFQNEGQYENEVYRLPKVLDEKVAR--IHVEALGGQLTELTKEQAEYIGVDVAG............................................................................................................................................................................ 469
9 -8.640[E] KOG2380 Prephenate dehydrogenase (NADP+)  ali follow..  11  206.................................FLEIFVREGCEMVEMSVT-------DHDKFAAESQFITHTLGRLLGMLKLISTPINTKLDLAENICGDSFDL-------YGLFVYNN---NSLEVLERIDLAFEALRKELFSRLHGVVRKQSFEGEAKKVHVFPNKIGIVGFGNFGQFLGKTMVKQGHTVLAYSRSDYTDEAAKLGVSYFS-DLFEEHPEVIILCTSI-LSTEKVLESLPFQRLKRSTLFVDVLSVKEFPRNLFLQTLPQD------FDILCTHP-NNLAFVFDKVRIGMDDRRKSRCNSFLDIFAREGCRMVE---------------MSCAEHDWHAAGSQITHTVGRLLEKLSLESTPIDTKGYETLLKLVENTAGDSFDLYYGLF........................................................................................................................................................ 590
10 -8.440[S] COG3978 Acetolactate synthase (isozyme II), small (regulatory) subunit  ali follow..  13  4................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................HQVNVSARFNPETLERVLRVVRHRGFHVCSMNMAAASDAQNINIELTVASPRSDLLFSQLNKLVDVAHVAICQ. 77
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Pawlowski K, Pio F, Chu Z, Reed JC, Godzik A. PAAD - a new protein domain associated with apoptosis, cancer and autoimmune diseases. Trends Biochem Sci. 2001 Feb;26(2):85-7.