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Query: [K] COG2378 Predicted transcriptional regulator, from VFDB

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MPTDNVVSVVSPYHMEMYNMRKASRLFEIIQILRLARRPVTAQTIADMLEVTARSVYRDIAALQTMRVPIEGERGVGYILRPGFNLPPLMFSIEETEAIVLALAMVDRSGDAELRQAAKKVSDKIAASLPEPLSKTLSANALHAWGSIAPAPAGIDLATVRRAVRDEERLDLCYSDESGVETQRRIRPIAVIYYSETVNIVAWCELRHAIRNFRSDRVLDCAATGSFFKMEGEKLRRLWMSGWQSGQPGGELGRPISGVTLPLast
1 -104.000[K] COG2378 Predicted transcriptional regulator  ali follow..  100  1MPTDNVVSVVSPYHMEMYNMRKASRLFEIIQILRLARRPVTAQTIADMLEVTARSVYRDIAALQTMRVPIEGERGVGYILRPGFNLPPLMFSIEETEAIVLALAMVDRSGDAELRQAAKKVSDKIAASLPEPLSKTLSANALHAWGSIAPAPAGIDLATVRRAVRDEERLDLCYSDESGVETQRRIRPIAVIYYSETVNIVAWCELRHAIRNFRSDRVLDCAATGSFFKMEGEKLRRLWMSGWQSGQPGGELGRPISGVTLP 262
2 -26.600[K] COG1654 Biotin operon repressor  ali follow..  15  1...................MKDTTVPLTLISLLADGE--HSGEQLGERLGMSRAAINKHIQTLRDWGVDVFTVPGKGYSLPE----PIQLLDADRIHSQLDS................................................................................................................................................................ 78
3 -17.400[S] COG4519 Uncharacterized protein conserved in bacteria  ali follow..  8  1................MELSPVFARRLYLALLVE-SLERPNVPKLIEKTGWPRRTIQDVIKAMPGIGIELNFVQDGRRHNDGYYQL................................................................................................................................................................................ 69
4 -13.700[S] COG3388 Uncharacterized protein conserved in archaea  ali follow..  12  12.................NDMDTLKRHISVINVLL-REQPIGIIKLSQETGIPEHKIRYSLRILEQENIISPSREGA.......................................................................................................................................................................................... 69
5 -12.700[KG] COG1349 Transcriptional regulators of sugar metabolism  ali follow..  13  1...................MKPRQRQAAILEHLQ-KQGKCSVEELAQYFDTTGTTIRKDLVILENAGT-VIRTYGGVVLNKEESDPPKTLINTHKKALIAAAAVKYIHDGDSIILDAGSTVL-QMVPLLSRFSNITVMTNSLHIVNALSELDNEQTILMPGGTFRKKS------ASFHGQLAENAFEQFSF....................................................................... 166
6 -10.500[K] COG1414 Transcriptional regulator  ali follow..  18  10...............DRYRAPALDKGLDILELLASVDGGLTQAEIAKHLDRSPNEFYRMLDRLVKRGY-VTKLDGDRYSL---------------LKLFGLAQLHAPVR---RLASFATPFMRELADRSKQA.................................................................................................................................. 108
7 -10.400[S] COG4344 Uncharacterized protein conserved in archaea  ali follow..  11  1.........MSEYEKEIDELINDYDMLRVLKHFT-IAHVDYAKNITRYTEIPQMRVREYLKRLKDLGL-LDYYTNTSIK....................................................................................................................................................................................... 68
8 -10.200[K] COG1959 Predicted transcriptional regulator  ali follow..  17  1................MQLTSFTDYGLRALIYMLPEGRMTSISEVTDVYGVSRNHMVKIINQLSRAGY-VTAVRGGGIRLGK----PASAIRIGDVVRELEPLSLVNCSSEFRLKQALSKAVQSFLTELDNYTLADL............................................................................................................................. 127
9 -10.000[K] COG2345 Predicted transcriptional regulator  ali follow..  15  20...........................KILLILL-ERAPVIASDIAEQLQLSTVGVRRHLDNLVEENLAEAANPRQNPYEPKMRGRPAKTYRLTDKGR-SLAAAALATLREVGGDDAVRQFARKRIETIVEGITPADV----------TDQSIEDTAKSLVEAFSRHGYAATVDATRNGLQLCQHHCPISTVATEF-----ELCEAEHQA.................................................... 194
10 -9.930[R] COG1827 Predicted small molecule binding protein (contains 3H domain)  ali follow..  11  18EPLVRKIGVSDGGEL-ERFLKILERDPARKSSLKRIYESVSGIHSHWISGPDRESIDAVIDELKSEGILLGVNLN-DEEIKEVARKHGRLVEIIIKPEMSIVENHGVDDIRREAEIIINHGCTIEDIEYYLPGFSEPLRRNVGVS---SMEEIDSFMKTLKSEPRKLESLDRLYTLSGGGIHSHRI............................................................................ 198
11 -9.890[K] COG1725 Predicted transcriptional regulators  ali follow..  13  28................................WKGEDKLPSVREMGVKLAVNPNTVSRAYQELERAGY-IYAKRGMGSFVTSD-EAKSIGLDDQTAIELL.................................................................................................................................................................. 114
12 -9.860[K] COG3355 Predicted transcriptional regulator  ali follow..  20  30..........................VEVLHIL-LQNGKMTTDDLSQKLNVTKASISKALNNLLDKGL-IQREK-----------------APAEKEERKGRPNYIYWVEKERLYRKLEADLEKLAGTVKEALQKHTALEIV........................................................................................................................ 126
13 -9.780[K] COG4190 Predicted transcriptional regulator  ali follow..  19  68......................TPRVLELIEAIR-QEEPASINETARVVDRDVKNVHEELSRLAHLGIIFFEEDG........................................................................................................................................................................................... 119
14 -9.710[K] COG2186 Transcriptional regulators  ali follow..  12  18......................ADQIRELID-FLPGTRLPAERELAQKLGVSRPSLREALIALEIDNT-VEIRMGSGVYVST--TTHHTKSLGDSPSELMQARAALEATIVLAANRMTDETIAALRQILNTMQKEIEALFHVTIAEQSGNSVLARLVANLFDERHSPISAQLRVKFEDRDTWTRALQEHEAILAA................................................................... 203
15 -9.580[K] COG5625 Predicted transcription regulator containing HTH domain  ali follow..  15  24..........................IRIYRLLVEKRRGMRIREIQRELGISERSVRTHVLNLYRRGLLKRELVQSG----------GYIYTPVSPLEIL-----------QKIKEHLMKSIEELERDLKNQTRS............................................................................................................................... 113
16 -9.490[P] COG0735 Fe2+/Zn2+ uptake regulation proteins  ali follow..  20  1................MVTPQLTKNQSLVMGALAHSDGPMSAYTILDKLRDNGFQVYRALDKLLEYGLVHRLESLNAFV....................................................................................................................................................................................... 67
17 -9.450[K] COG4742 Predicted transcriptional regulator  ali follow..  11  9...................VFRSQKRRDLLLLLG--EEPRTMEDIKVLLDVSPTAILPQIKRLTDSN--LVIQKNGSYELTD--------------MGEQVFKKARALVDVLTLVEKDNYWIEHDLGGIPQYLLDKIGEIKDCNLVKADPSQIFEPNTELLEYFASSRYLM........................................................................................... 142
18 -9.400[K] COG3711 Transcriptional antiterminator  ali follow..  13  3.......................GDNQQILREI-VLNPTIHGKELESIFGLSRRQLGYRIQKLEQEGYPKLERTSQGNFIV----------SSEIMTLFKRDVSEQQMLNGNNVIFSIETRRYYLMLML--SKENAMSLNHFSIDLQVSKNTVIHDINHVKEQLEDHG-LSLKYSRKHGEFEVRRF............................................................................ 162
19 -9.090[K] COG3432 Predicted transcriptional regulator  ali follow..  10  32....................RKRGTMEIMFDILRNCEPKCGITRVIYGAGINYVVAQKYLDQLVKVGALNIKTENDRYEITE-------------------GKLLRTHIEEIKIRENLYSAKEKVSELLRTDSE................................................................................................................................ 130
FFAS is supported by the NIH grant R01-GM087218-01
1 4 6 8 3 2   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Grynberg M, Erlandsen H, Godzik A. HEPN: a common domain in bacterial drug resistance and human neurodegenerative proteins. Trends Biochem Sci. 2003 May;28(5):224-6. Review.