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Query: [K] COG3432 Predicted transcriptional regulator, from VFDB

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
    .   10    .   20    .   30    .   40    .   50    .   60    .   70    .   80    .   90    .  100    .  110    .  120    .  130
# Score Template Links and tools%idFirst MTYGYNIFTVIKFSDNVYKLQLIYYSMQLERRKRGTMEIMFDILRNCEPKCGITRVIYGAGINYVVAQKYLDQLVKVGALNIKTENDRKIYEITEKGKLLRTHIEEFIKIRENLYSAKEKVSELLRTDSELast
1 -56.500[K] COG3432 Predicted transcriptional regulator  ali follow..  100  1MTYGYNIFTVIKFSDNVYKLQLIYYSMQLERRKRGTMEIMFDILRNCEPKCGITRVIYGAGINYVVAQKYLDQLVKVGALNIKTENDRKIYEITEKGKLLRTHIEEFIKIRENLYSAKEKVSELLRTDSE 130
2 -19.600[S] COG3373 Uncharacterized protein conserved in archaea  ali follow..  10  14..............................NRSELRRKVLFYLLSIYPYRSYLSEISRAVKSDPSNVKGCLESLIGLGLVIVEQSKNGKYFKINPEIVEEVRNMKNMFS..................... 103
3 -17.800[K] COG4742 Predicted transcriptional regulator  ali follow..  10  11...............................RSQKRRDLLLLL---GEEPRTMEDIKVLLDVSPTAILPQIKRLTDSNLVIQKNGS----YELTDMGEQVFKKARALVDVLTLVEKDNYWIEHDLGG... 99
4 -17.700[K] COG5631 Predicted transcription regulator, contains HTH domain (MarR family)  ali follow..  19  88.......................................ILHSIRHRDREKKLADICLALDIE-HIATYAIRKLEKAGLLTTGKAAKEKTVKITAKGAEACAHYAQLVDSTANARPSEETLSELAALLRF 184
5 -17.400[KH] COG1339 Transcriptional regulator of a riboflavin/FAD biosynthetic operon  ali follow..  17  2................................KMKTLFLLIKLAKM-EITVTMRELSRELDVSPQTVLRWLEELKEQGYIHKRESRKGTLVELTEKGINLLEKLYE........................ 79
6 -16.800[K] COG1497 Predicted transcriptional regulator  ali follow..  17  11..................................TRFQILSEIAMR-QPYVRQKDIADKLGVTVQAVSENIKSLIAEGLVESG--SGRSHYKITRRG------AEKIKEAAMDLRRYADEVLESMSFYRS 97
7 -16.800[K] COG0640 Predicted transcriptional regulators  ali follow..  12  1....................................................MNEITMQTQADQPKVSSNLAILSEARLVDSIQMGREKIYRIAP------EKFEDMVDWLDSILHSKSSGGSANYGLSP 72
8 -16.400[K] COG1695 Predicted transcriptional regulators  ali follow..  14  3.....................................RYAIKALVLLSKKPRSKEISTGVQVSHGTLMPMIRKLLQERYIDFETRGREKVYHLTERGSRFVESLGK........................ 76
9 -15.500[S] COG3398 Uncharacterized protein conserved in archaea  ali follow..  14  184...............................QNATNQRIISEIQN--GKCNTNLALAREIGVSRATISWYVKNLKETGLIDETRSGRSIIYSINPSYEPLIEKY.......................... 254
10 -15.300[K] COG1846 Transcriptional regulators  ali follow..  9  47..........................................TIDAIDEGLLMKELAERLGVTKGAVSQLVDRLEAKALVRRTKVSRGIQVVLTDKGREAYRAHADMKEEIAIFEQCVSKLRDILSE... 149
11 -14.400[K] COG5625 Predicted transcription regulator containing HTH domain  ali follow..  16  20................................KKNEIRIYRLLVEK-RRGMRIREIQRELGISERSVRTHVLNLYRRGLLKRELVQSGYIYTPVSPLEILQKIKEHLMKSIEELERDLKNQTR....... 112
12 -14.300[S] COG2469 Uncharacterized conserved protein  ali follow..  22  203.........................................QILTMVYTGVDSVSVESILGVTTEELNKMYDRLVNLGLARVVKIRKE--IELTPRGVALVSEIMK........................ 265
13 -13.700[K] COG4190 Predicted transcriptional regulator  ali follow..  15  70..................................RVLELIEAIRQ--EEPASINETARVVDRDVKNVHEELSRLAHLGIIFFEEDGQRKRPVVW.................................... 127
14 -13.600[K] COG1321 Mn-dependent transcriptional regulator  ali follow..  13  2.........................VLMHTDRIEEYLETILYLITKNQGPAKTKQIAEELNVSSPSVTEMIKKLHSMGFVEYKPYQG---VELTEKGAEEAVRIKRKHQVLETF................ 87
15 -13.300[K] COG2345 Predicted transcriptional regulator  ali follow..  18  16.................................DTRRKILLILLE--RAPVIASDIAEQLQLSTVGVRRHLDNLVEENLAEAANPRQNKTYRLTDKGRS............................... 90
16 -13.200[K] COG3327 Phenylacetic acid-responsive transcriptional repressor  ali follow..  16  12............................VNAVPVSGTSLISSLYGDSLSHGSLAALLEGLGFGERFVRTALFRLNKEGWLDVSRIGRRSFYSLSDKGLRLTRRAES........................ 96
17 -12.900[K] COG1777 Predicted transcriptional regulators  ali follow..  14  16..................................TRREIIRMLTQ--FERSYALELSRSIGLSQQAILKQLEMLERANLVTSIGFVPRKLYEPTGFSTLIVDQRIPLENDSERVSVSFDEAISKLESIQH 123
18 -12.700[K] COG3355 Predicted transcriptional regulator  ali follow..  12  26................................SKSDVEVLHILLQ--NGKMTTDDLSQKLNVTKASISKALNNLLDKGLIQREKEKEERKGRPNYIYWV------EKERLYRKLEADLEKLAGTVKEALQ 118
19 -12.600[S] COG3388 Uncharacterized protein conserved in archaea  ali follow..  17  22.........................................SVINVLEQPIGIIKLSQETGIPEHKIRYSLRILEQENIISPSREGA----ILTPDFIEHKEQIIAAEKVLEEATKIAEDVRKMLE.... 105
20 -12.600[K] COG1414 Transcriptional regulator  ali follow..  12  23.......................................ILELLASVDGGLTQAEIAKHLDRSPNEFYRMLDRLVKRGYVTKLDGDR---YSLTLKLFGLAQLHAPVRRLASFATPFMRELADRSKQ... 107
21 -12.400[K] COG1733 Predicted transcriptional regulators  ali follow..  22  22.................................RWTMVLMRELVA---GSTRFNDLRRGVKMSPTLLSQRLKELELAGIVERKGEKGIFDYRLTEAGRDLRPVVEAMGF..................... 98
22 -11.800[S] COG4344 Uncharacterized protein conserved in archaea  ali follow..  19  19.........................................RVLKHFTHVDYAKNITRYTEIPQMRVREYLKRLKDLGLLDYYTNTHHTYYQINKKAEAVLKEI.......................... 100
23 -11.700[K] COG4738 Predicted transcriptional regulator  ali follow..  14  35................................NRPVALTLACLSKG--DEISSQRIEMVSGLRQPEVSIAMRYLRENEWVDMREEKKNKLYKLTVQMETIIDTIENVIAESKTILQNIERLKSL...... 132
24 -11.600[K] COG1510 Predicted transcriptional regulators  ali follow..  6  36.......................................VLGIIYMNRKPMTLSELSEATGMSKTRMSQVVREMIDANIAEKEKGVRKDLYDVEQDYYQTFLFAANWTKVVSKNKVLYKKLNRELSDLLQ 130
25 -11.300[S] COG4754 Uncharacterized conserved protein  ali follow..  9  15....................................VGLLYVMNNIFDGKTDLYQLEKEMEVDIDDLMPIVYTASRLGFVSAESGD----IIVTEEGKEYIRA-KRRKEIIREALRNIEPFRTALDLRNF 105
26 -11.100[S] COG2512 Uncharacterized membrane-associated protein/domain  ali follow..  15  253.......................................VLDIIRGHKGRITQKDLRSKLDYSEVKVSLMLSELEKRGLIRKLRNGRENILVLVDEEH................................ 311
27 -10.800[S] COG4519 Uncharacterized protein conserved in bacteria  ali follow..  9  2...............................ELSPVFARRLYLALLVEERPNVPKLIEKTGWPRRTIQDVIKAMPGIGIELNFVQDGRRYYQLSDWGQWVTERKKDIAASLG.................. 92
28 -10.200[R] COG1568 Predicted methyltransferases  ali follow..  15  1...................MKEIVERVKSKTKIPVYERSIENVLSAILASNDIWRIVDLSEEPLPLVVSILEALNELGYVSFEDG-----VKLTEKGEDLIAEL.......................... 80
29 -10.100[J] COG5045 Ribosomal protein S10E  ali follow..  13  1............................MLIPKENRKAIHQALFSLVAKKDFNLPKHPEVGVPNLQVIKACQSLDSRGYLKTRYNWGWFYYTLTNEGVEYLREYLHLPAEV................... 86
30 -10.100[J] KOG3344 40s ribosomal protein s10  ali follow..  8  1............................MLMPKKNRIAIYELLFKVAKKDVHMPK-LADKNVPNLHVMKAMQSLKSRGYVKEQFAWRHFYWYLTNEGIQYLRDYLHLPPEI................... 89
31 -9.930[J] KOG2784 Phenylalanyl-tRNA synthetase, beta subunit  ali follow..  8  68.....................................NLPQQILDFLQNEFNSIQLAQQWNLDHQKVIGAIKSLLANEGVLTTKDVTEKRLELTNEGVQFANEGSPEYLVFEFVGTDGAAQADIQKKPF. 161
32 -9.800[R] COG2005 N-terminal domain of molybdenum-binding protein  ali follow..  16  22........................................ISLLKHIALSGSISQGAKDAGISYKSAWDAINDMNQL-LVERATGGKG---VLTRYGQRLIQLYDLLGQIQQKA................ 99
33 -9.460[K] COG0583 Transcriptional regulator  ali follow..  12  8..................................DKLRIFHAAAEA-----SFTHAAQTLHLSQSAISRQVSAL-EQDVGVPLFHRHARGLILTEQGETLYRTAHDVLMKLENVRSKLAESREKPSGRLR 98
34 -9.070[K] COG2378 Predicted transcriptional regulator  ali follow..  10  21...............................RKASRLFEIIQILRLARRPVTAQTIADMLEVTARSVYRDIAALQTMRVPIEGERGVG--YILRP-ALAMVDRSGD-AELRQAAKKVSDKIAASLPEPLS 134
FFAS is supported by the NIH grant R01-GM087218-01
1 4 6 8 2 5   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Luz JG, Hassig CA, Pickle C, Godzik A., Meyer BJ, Wilson IA. XOL-1, primary determinant of sexual fate in C. elegans, is a GHMP kinase family member and a structural prototype for a class of developmental regulators. Genes Dev. 2003 Apr 15;17(8):977-90. Epub 2003 Apr 02.