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Query: [S] COG4121 Uncharacterized conserved protein, from VFDB

Results of FFAS03 search in COG1018
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MFIMSSISHAQLGWNDAGTPVSDQFDDVYFSNVNGLAETRYVFLEQNHLPQRWHNDDQRRFVIAETGFGTGLNFLAVWQAFVAFREANPDAKLKELHFISFEKYPLSKSDLIQAHQAWPELAQFAQKLHKHYPLAIPECQRIVLNDGLVTLDLWFGDIKDCLPKVATQEQGLVDAWFLDGFAPSKNPEMWNQNLFAGMAKLAKHGCTCATFTSAGFVRRGLIDAGFAMKKVKGFGTKREMIAGSLSEKVPYTNIAPEFRFEATHGLQEVAIIGGGIASATLATTLALast
1 -117.000[S] COG4121 Uncharacterized conserved protein  ali follow..  100  1MFIMSSISHAQLGWNDAGTPVSDQFDDVYFSNVNGLAETRYVFLEQNHLPQRWHNDDQRRFVIAETGFGTGLNFLAVWQAFVAFREANPDAKLKELHFISFEKYPLSKSDLIQAHQAWPELAQFAQKLHKHYPLAIPECQRIVLNDGLVTLDLWFGDIKDCLPKVATQEQGLVDAWFLDGFAPSKNPEMWNQNLFAGMAKLAKHGCTCATFTSAGFVRRGLIDAGFAMKKVKGFGTKREMIAGSLSEKVPYTNIAPEFRFEATHGLQEVAIIGGGIASATLATTLA 286
2 -12.300[R] COG2521 Predicted archaeal methyltransferase  ali follow..  15  120.....................................................RKVERAWGRVFECCTGLGYTAIEALK-----------KGARHVITVEVD------PHVLTLASLNPYSRGLWSP----------------------AVDVILGDCYAFVQTVR---DSSIDFIIHDPPRLSHATQLYSEALYREFYRILKRGGGVFHYVSQSGVAERLRRVGFAVEKIKGIYARRR............................................... 278
3 -10.400[R] KOG2361 Predicted methyltransferase  ali follow..  9  36LREEEPERLTSTNTDKYERDAKKYWDIFYKHHGDRFFKDRHYLDK----EWNSYFSVSGKSVILEVGCGAGNTIFPLIA------------TYPDIFVYACD---FSPRAVELVKAHDEYTETRVCAF----------------------ACDLTGDGLDK-------SPSSVDIVTMIFVLSAVSPE--MSSVLQNIRKVLKPNGCIAFYFSNEFLETLFSEQGFEVNRSRELVMNRRWVQATFRRTNGNKNPCDSLTPAKLDKSEQ.................. 301
4 -9.220[I] COG3963 Phospholipid N-methyltransferase  ali follow..  15  55.............................................................PVLELGPGTGV---ITKAILARGIKPE--------SLTAIEYST-----------------DFYNQLLRSYP----------------GVNFVNGDAFDLDATLGEHKGQMFDSV-ISAVPMLNFPMAARIKLLDELLKRVPHGRPVVQISYGPISPIVAQPHLYHIRHFD...................................................... 180
5 -8.990[R] KOG3115 Methyltransferase-like protein  ali follow..  12  1MSATAKKSAAQLQREEEEARKKLKRLSKQGGVEGRLPMKRLF-MDWSPYYPDFDVESNKKVEIVDIGCGYG-GLTVAL-----------GPQFPDTLVLGMEIRMQVSDYLKEKIQALRYRADHEEPV----------------PGGYKNISVLRMNCQKFLPNFFEKGQSKMFFCFPDPHFKARKHKIITSTLASEYAYFIRPHGTLYTITDVEELHVWMAQH.............................................................. 220
6 -7.970[R] KOG2940 Predicted methyltransferase  ali follow..  11  65.............................RDRAAWLSRQKNDSFVADNLLDRLEDCKKSFPTAFCLGGSLGMDTSYDMIKSCRDAQDDSLDNSIETSYFDEEFLPVKESSVDLI------ISSLGLHWTNDLPGSMIQCKLALKPDGLFLAAILGGETLKELRIACTLAHMEREG----GISPRLSPLAQVRDAGNLLTRAVDVDEYVVKYKRAMDLIEHLRAMG............................................................. 278
7 -7.860[R] COG0220 Predicted S-adenosylmethionine-dependent methyltransferase  ali follow..  17  36........................................................GNDHPIHIEVGCGKG-AFITGMA-----------ALHPEINYIAIDMQLSVLSYALDKAI----------------------------EADLPNVQMMLVDGAALSEYFADGEIDQVYLNFSDPWPKGRHEKLTYKSFLATYEKILRPEGEIHFKTLFEYSLVSLANYGMELKKV....................................................... 176
8 -7.280[Q] KOG1663 O-methyltransferase  ali follow..  14  94.............................................................NTMEIGVYTGYSLLATALALPEDG-----------KILAMDVNRENYELGLPIIEKAGVAH---------------------------KIDFREGPALPVLDEIVADNHGTYDFIFVDADKDN-------INYHKRLIDLVKIGGVIGY--------DNTLWNGSVVAPPDAPMRKYVRYYRDFVLELNK------ALAADPRIEICMLPVGDGIT......... 253
9 -7.160[E] COG0421 Spermidine synthase  ali follow..  14  30LKVKKVLYAGKSKYQDVLVFESETYGHVLVLDGAIQATERDEFSYQEMIAHLALNSHPNPKKVLVIGGGDGGVL------------------REVVKHECVEEAILCDIDEDVIKVSKQYLPEMSAGFNHP------------------KVKVHIGDGFKFLQD----YQNTFDVIITDSSDPGPAEALFQKPYFQLLSDALRGGGVITTQAECMWIHLGV................................................................. 211
10 -7.090[R] KOG2960 Protein involved in thiamine biosynthesis and DNA damage tolerance  ali follow..  14  9.....................................................................................................................................................................................TPQTAFKT-PVEKTAHNTVVKSEMGALSKAYPTYSLDESFSFAPIRESTV-----SRAMTRRYFSD--------------DKYAESDIVIVGAGSAGLTAAYYIG 96
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Jaroszewski L, Rychlewski L, Godzik A. Improving the quality of twilight-zone alignments. Protein Sci. 2000 Aug;9(8):1487-96.